Neuroscience bulletin最新文献_第2页

To Attack or Not: A Neural Circuit Coding Sexually Dimorphic Aggression. 攻击与否：编码两性二态攻击的神经回路。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-01-03 DOI: 10.1007/s12264-024-01345-5

Qiuhong Xin, Hailan Hu

引用次数: 0

Pseudogene Lamr1-ps1 Aggravates Early Spatial Learning Memory Deficits in Alzheimer's Disease Model Mice. 假基因Lamr1-ps1加重阿尔茨海默病模型小鼠早期空间学习记忆缺陷

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-01-02 DOI: 10.1007/s12264-024-01336-6

Zhuoze Wu, Xiaojie Liu, Yuntai Wang, Zimeng Zeng, Wei Chen, Hao Li

{"title":"Pseudogene Lamr1-ps1 Aggravates Early Spatial Learning Memory Deficits in Alzheimer's Disease Model Mice.","authors":"Zhuoze Wu, Xiaojie Liu, Yuntai Wang, Zimeng Zeng, Wei Chen, Hao Li","doi":"10.1007/s12264-024-01336-6","DOIUrl":"https://doi.org/10.1007/s12264-024-01336-6","url":null,"abstract":"Alzheimer's disease (AD), a neurodegenerative disorder with complex etiologies, manifests through a cascade of pathological changes before clinical symptoms become apparent. Among these early changes, alterations in the expression of non-coding RNAs (ncRNAs) have emerged as pivotal events. In this study, we focused on the aberrant expression of ncRNAs and revealed that Lamr1-ps1, a pseudogene of the laminin receptor, significantly exacerbates early spatial learning and memory deficits in APP/PS1 mice. Through a combination of bioinformatics prediction and experimental validation, we identified the miR-29c/Bace1 pathway as a potential regulatory mechanism by which Lamr1-ps1 influences AD pathology. Importantly, augmenting the miR-29c-3p levels in mice ameliorated memory deficits, underscoring the therapeutic potential of targeting miR-29c-3p in early AD intervention. This study not only provides new insights into the role of pseudogenes in AD but also consolidates a foundational basis for considering miR-29c as a viable therapeutic target, offering a novel avenue for AD research and treatment strategies.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crosstalk Between the Nervous System and Colorectal Cancer. 神经系统与结直肠癌之间的相互影响

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-01-01 Epub Date: 2024-06-16 DOI: 10.1007/s12264-024-01238-7

Xi Li, Chunshui Ye, Min Wang, Patrick Kwan, Xin Tian, Yanke Zhang

引用次数: 0

Cortical Morphological Networks Differ Between Gyri and Sulci. 神经节和脑室的皮层形态网络存在差异

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-01-01 Epub Date: 2024-07-23 DOI: 10.1007/s12264-024-01262-7

Qingchun Lin, Suhui Jin, Guole Yin, Junle Li, Umer Asgher, Shijun Qiu, Jinhui Wang

{"title":"Cortical Morphological Networks Differ Between Gyri and Sulci.","authors":"Qingchun Lin, Suhui Jin, Guole Yin, Junle Li, Umer Asgher, Shijun Qiu, Jinhui Wang","doi":"10.1007/s12264-024-01262-7","DOIUrl":"10.1007/s12264-024-01262-7","url":null,"abstract":"This study explored how the human cortical folding pattern composed of convex gyri and concave sulci affected single-subject morphological brain networks, which are becoming an important method for studying the human brain connectome. We found that gyri-gyri networks exhibited higher morphological similarity, lower small-world parameters, and lower long-term test-retest reliability than sulci-sulci networks for cortical thickness- and gyrification index-based networks, while opposite patterns were observed for fractal dimension-based networks. Further behavioral association analysis revealed that gyri-gyri networks and connections between gyral and sulcal regions significantly explained inter-individual variance in Cognition and Motor domains for fractal dimension- and sulcal depth-based networks. Finally, the clinical application showed that only sulci-sulci networks exhibited morphological similarity reductions in major depressive disorder for cortical thickness-, fractal dimension-, and gyrification index-based networks. Taken together, these findings provide novel insights into the constraint of the cortical folding pattern to the network organization of the human brain.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"46-60"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141752274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SARS-CoV-2 Inhibits Exo-Endocytosis and Enhances Short-Term Depression at a Central Synapse. SARS-CoV-2抑制中枢突触的外吞作用并增强其短期抑制作用

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-01-01 Epub Date: 2024-08-31 DOI: 10.1007/s12264-024-01293-0

Jiawei Hu, Yuhan Zhang, Qingzhuo Liu, Jiaqi Hu, Yichen Ru, Lu Zhang, Lixin Xie, Lei Xue

引用次数: 0

The Medial Prefrontal Cortex-Basolateral Amygdala Circuit Mediates Anxiety in Shank3 InsG3680 Knock-in Mice. 内侧前额叶皮层-基底外侧杏仁核环路介导 Shank3 InsG3680 基因敲入小鼠的焦虑情绪

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-01-01 Epub Date: 2024-08-29 DOI: 10.1007/s12264-024-01280-5

Jiabin Feng, Xiaojun Wang, Meidie Pan, Chen-Xi Li, Zhe Zhang, Meng Sun, Tailin Liao, Ziyi Wang, Jianhong Luo, Lei Shi, Yu-Jing Chen, Hai-Feng Li, Junyu Xu

{"title":"The Medial Prefrontal Cortex-Basolateral Amygdala Circuit Mediates Anxiety in Shank3 InsG3680 Knock-in Mice.","authors":"Jiabin Feng, Xiaojun Wang, Meidie Pan, Chen-Xi Li, Zhe Zhang, Meng Sun, Tailin Liao, Ziyi Wang, Jianhong Luo, Lei Shi, Yu-Jing Chen, Hai-Feng Li, Junyu Xu","doi":"10.1007/s12264-024-01280-5","DOIUrl":"10.1007/s12264-024-01280-5","url":null,"abstract":"Anxiety disorder is a major symptom of autism spectrum disorder (ASD) with a comorbidity rate of ~40%. However, the neural mechanisms of the emergence of anxiety in ASD remain unclear. In our study, we found that hyperactivity of basolateral amygdala (BLA) pyramidal neurons (PNs) in Shank3 InsG3680 knock-in (InsG3680+/+) mice is involved in the development of anxiety. Electrophysiological results also showed increased excitatory input and decreased inhibitory input in BLA PNs. Chemogenetic inhibition of the excitability of PNs in the BLA rescued the anxiety phenotype of InsG3680+/+ mice. Further study found that the diminished control of the BLA by medial prefrontal cortex (mPFC) and optogenetic activation of the mPFC-BLA pathway also had a rescue effect, which increased the feedforward inhibition of the BLA. Taken together, our results suggest that hyperactivity of the BLA and alteration of the mPFC-BLA circuitry are involved in anxiety in InsG3680+/+ mice.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"77-92"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Physiology to Pathology of Astrocytes: Highlighting Their Potential as Therapeutic Targets for CNS Injury. 星形胶质细胞从生理学到病理学：突显其作为中枢神经系统损伤治疗靶点的潜力。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-01-01 Epub Date: 2024-07-30 DOI: 10.1007/s12264-024-01258-3

Yimin Yuan, Hong Liu, Ziwei Dai, Cheng He, Shangyao Qin, Zhida Su

引用次数: 0

Dentate Gyrus Morphogenesis is Regulated by an Autism Risk Gene Trio Function in Granule Cells. 齿状回形态发生受颗粒细胞中自闭症风险基因三联体功能的调控

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-01-01 Epub Date: 2024-06-22 DOI: 10.1007/s12264-024-01241-y

Mengwen Sun, Weizhen Xue, Hu Meng, Xiaoxuan Sun, Tianlan Lu, Weihua Yue, Lifang Wang, Dai Zhang, Jun Li

{"title":"Dentate Gyrus Morphogenesis is Regulated by an Autism Risk Gene Trio Function in Granule Cells.","authors":"Mengwen Sun, Weizhen Xue, Hu Meng, Xiaoxuan Sun, Tianlan Lu, Weihua Yue, Lifang Wang, Dai Zhang, Jun Li","doi":"10.1007/s12264-024-01241-y","DOIUrl":"10.1007/s12264-024-01241-y","url":null,"abstract":"Autism Spectrum Disorders (ASDs) are reported as a group of neurodevelopmental disorders. The structural changes of brain regions including the hippocampus were widely reported in autistic patients and mouse models with dysfunction of ASD risk genes, but the underlying mechanisms are not fully understood. Here, we report that deletion of Trio, a high-susceptibility gene of ASDs, causes a postnatal dentate gyrus (DG) hypoplasia with a zigzagged suprapyramidal blade, and the Trio-deficient mice display autism-like behaviors. The impaired morphogenesis of DG is mainly caused by disturbing the postnatal distribution of postmitotic granule cells (GCs), which further results in a migration deficit of neural progenitors. Furthermore, we reveal that Trio plays different roles in various excitatory neural cells by spatial transcriptomic sequencing, especially the role of regulating the migration of postmitotic GCs. In summary, our findings provide evidence of cellular mechanisms that Trio is involved in postnatal DG morphogenesis.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1-15"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing Transcranial Magnetic Stimulation Comfort: The Role of Electrical Stimulation in Pain Reduction. 提高经颅磁刺激的舒适度：电刺激在减轻疼痛中的作用。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-01-01 Epub Date: 2024-08-23 DOI: 10.1007/s12264-024-01283-2

Zihui Qi, Zhengyi Yang, Hao Liu, Lingzhong Fan, Nianming Zuo, Tianzi Jiang

引用次数: 0

Computational Modeling of the Prefrontal-Cingulate Cortex to Investigate the Role of Coupling Relationships for Balancing Emotion and Cognition. 前额叶-扣带回皮层的计算建模，研究耦合关系在平衡情绪和认知方面的作用。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-01-01 Epub Date: 2024-06-13 DOI: 10.1007/s12264-024-01246-7

Jinzhao Wei, Licong Li, Jiayi Zhang, Erdong Shi, Jianli Yang, Xiuling Liu

{"title":"Computational Modeling of the Prefrontal-Cingulate Cortex to Investigate the Role of Coupling Relationships for Balancing Emotion and Cognition.","authors":"Jinzhao Wei, Licong Li, Jiayi Zhang, Erdong Shi, Jianli Yang, Xiuling Liu","doi":"10.1007/s12264-024-01246-7","DOIUrl":"10.1007/s12264-024-01246-7","url":null,"abstract":"Within the prefrontal-cingulate cortex, abnormalities in coupling between neuronal networks can disturb the emotion-cognition interactions, contributing to the development of mental disorders such as depression. Despite this understanding, the neural circuit mechanisms underlying this phenomenon remain elusive. In this study, we present a biophysical computational model encompassing three crucial regions, including the dorsolateral prefrontal cortex, subgenual anterior cingulate cortex, and ventromedial prefrontal cortex. The objective is to investigate the role of coupling relationships within the prefrontal-cingulate cortex networks in balancing emotions and cognitive processes. The numerical results confirm that coupled weights play a crucial role in the balance of emotional cognitive networks. Furthermore, our model predicts the pathogenic mechanism of depression resulting from abnormalities in the subgenual cortex, and network functionality was restored through intervention in the dorsolateral prefrontal cortex. This study utilizes computational modeling techniques to provide an insight explanation for the diagnosis and treatment of depression.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"33-45"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141311311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0