Neuroscience bulletin最新文献_第2页

Inhibition of the cGAS‑STING Pathway Reduces Cisplatin-Induced Inner Ear Hair Cell Damage. 抑制 cGAS-STING 通路可减轻顺铂诱导的内耳毛细胞损伤

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-03-01 Epub Date: 2024-12-16 DOI: 10.1007/s12264-024-01334-8

Ying Sun, Shengyu Zou, Xiaoxiang Xu, Shan Xu, Haiying Sun, Mingliang Tang, Weijia Kong, Xiong Chen, Zuhong He

{"title":"Inhibition of the cGAS‑STING Pathway Reduces Cisplatin-Induced Inner Ear Hair Cell Damage.","authors":"Ying Sun, Shengyu Zou, Xiaoxiang Xu, Shan Xu, Haiying Sun, Mingliang Tang, Weijia Kong, Xiong Chen, Zuhong He","doi":"10.1007/s12264-024-01334-8","DOIUrl":"10.1007/s12264-024-01334-8","url":null,"abstract":"Although cisplatin is a widely used chemotherapeutic agent, it is severely toxic and causes irreversible hearing loss, restricting its application in clinical settings. This study aimed to determine the molecular mechanism underlying cisplatin-induced ototoxicity. Here, we established in vitro and in vivo ototoxicity models of cisplatin-induced hair cell loss, and our results showed that reducing STING levels decreased inflammatory factor expression and hair cell death. In addition, we found that cisplatin-induced mitochondrial dysfunction was accompanied by cytosolic DNA, which may act as a critical linker between the cyclic GMP-AMP synthesis-stimulator of interferon genes (cGAS-STING) pathway and the pathogenesis of cisplatin-induced hearing loss. H-151, a specific inhibitor of STING, reduced hair cell damage and ameliorated the hearing loss caused by cisplatin in vivo. This study underscores the role of cGAS-STING in cisplatin ototoxicity and presents H-151 as a promising therapeutic for hearing loss.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"359-373"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-Neuron Reconstruction of the Macaque Primary Motor Cortex Reveals the Diversity of Neuronal Morphology.

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-03-01 Epub Date: 2025-01-28 DOI: 10.1007/s12264-025-01352-0

Siyu Li, Yan Shen, Yefei Chen, Zexuan Hong, Lewei Zhang, Lufeng Ding, Chao-Yu Yang, Xiaoyang Qi, Quqing Shen, Yanyang Xiao, Pak-Ming Lau, Zhonghua Lu, Fang Xu, Guo-Qiang Bi

引用次数: 0

Correction to: Autophagy in Oligodendrocyte Lineage Cells Controls Oligodendrocyte Numbers and Myelin Integrity in an Age-dependent Manner. 更正：少突胶质细胞系细胞的自噬以年龄依赖的方式控制少突胶质细胞数量和髓磷脂完整性。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-03-01 DOI: 10.1007/s12264-024-01315-x

Hong Chen, Gang Yang, De-En Xu, Yu-Tong Du, Chao Zhu, Hua Hu, Li Luo, Lei Feng, Wenhui Huang, Yan-Yun Sun, Quan-Hong Ma

引用次数: 0

The Principle of Cortical Development and Evolution. 皮质发育和进化原理

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-03-01 Epub Date: 2024-07-18 DOI: 10.1007/s12264-024-01259-2

Zhengang Yang

{"title":"The Principle of Cortical Development and Evolution.","authors":"Zhengang Yang","doi":"10.1007/s12264-024-01259-2","DOIUrl":"10.1007/s12264-024-01259-2","url":null,"abstract":"Human's robust cognitive abilities, including creativity and language, are made possible, at least in large part, by evolutionary changes made to the cerebral cortex. This paper reviews the biology and evolution of mammalian cortical radial glial cells (primary neural stem cells) and introduces the concept that a genetically step wise process, based on a core molecular pathway already in use, is the evolutionary process that has molded cortical neurogenesis. The core mechanism, which has been identified in our recent studies, is the extracellular signal-regulated kinase (ERK)-bone morphogenic protein 7 (BMP7)-GLI3 repressor form (GLI3R)-sonic hedgehog (SHH) positive feedback loop. Additionally, I propose that the molecular basis for cortical evolutionary dwarfism, exemplified by the lissencephalic mouse which originated from a larger gyrencephalic ancestor, is an increase in SHH signaling in radial glia, that antagonizes ERK-BMP7 signaling. Finally, I propose that: (1) SHH signaling is not a key regulator of primate cortical expansion and folding; (2) human cortical radial glial cells do not generate neocortical interneurons; (3) human-specific genes may not be essential for most cortical expansion. I hope this review assists colleagues in the field, guiding research to address gaps in our understanding of cortical development and evolution.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"461-485"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141634122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conditional Tnfaip6-Knockout in Inner Ear Hair Cells Does not Alter Auditory Function. 内耳毛细胞条件敲除tnfaip6不会改变听觉功能

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-03-01 Epub Date: 2024-12-17 DOI: 10.1007/s12264-024-01326-8

Yue Qiu, Song Gao, Xiaoqiong Ding, Jie Lu, Xinya Ji, Wenli Hao, Siqi Cheng, Haolinag Du, Yajun Gu, Chenjie Yu, Cheng Cheng, Xia Gao

{"title":"Conditional Tnfaip6-Knockout in Inner Ear Hair Cells Does not Alter Auditory Function.","authors":"Yue Qiu, Song Gao, Xiaoqiong Ding, Jie Lu, Xinya Ji, Wenli Hao, Siqi Cheng, Haolinag Du, Yajun Gu, Chenjie Yu, Cheng Cheng, Xia Gao","doi":"10.1007/s12264-024-01326-8","DOIUrl":"10.1007/s12264-024-01326-8","url":null,"abstract":"Noise-induced hearing loss is a worldwide public health issue that is characterized by temporary or permanent changes in hearing sensitivity. This condition is closely linked to inflammatory responses, and interventions targeting the inflammatory gene tumor necrosis factor-alpha (TNFα) are known to mitigate cochlear noise damage. TNFα-induced proteins (TNFAIPs) are a family of translucent acidic proteins, and TNFAIP6 has a notable association with inflammatory responses. To date, there have been few reports on TNFAIP6 levels in the inner ear. To elucidate the precise mechanism, we generated transgenic mouse models with conditional knockout of Tnfaip6 (Tnfaip6 cKO). Evaluation of hair cell morphology and function revealed no significant differences in hair cell numbers or ribbon synapses between Tnfaip6 cKO and wild-type mice. Moreover, there were no notable variations in hair cell numbers or hearing function in noisy environments. Our results indicate that Tnfaip6 does not have a substantial impact on the auditory system.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"421-433"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142838594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: The Principle of Cortical Development and Evolution. 更正：皮质发育和进化的原理。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-03-01 DOI: 10.1007/s12264-024-01282-3

Zhengang Yang

引用次数: 0

A Method for Detecting Depression in Adolescence Based on an Affective Brain-Computer Interface and Resting-State Electroencephalogram Signals. 基于情感脑机接口和静息状态脑电信号的青少年抑郁症检测方法。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-03-01 Epub Date: 2024-11-20 DOI: 10.1007/s12264-024-01319-7

Zijing Guan, Xiaofei Zhang, Weichen Huang, Kendi Li, Di Chen, Weiming Li, Jiaqi Sun, Lei Chen, Yimiao Mao, Huijun Sun, Xiongzi Tang, Liping Cao, Yuanqing Li

{"title":"A Method for Detecting Depression in Adolescence Based on an Affective Brain-Computer Interface and Resting-State Electroencephalogram Signals.","authors":"Zijing Guan, Xiaofei Zhang, Weichen Huang, Kendi Li, Di Chen, Weiming Li, Jiaqi Sun, Lei Chen, Yimiao Mao, Huijun Sun, Xiongzi Tang, Liping Cao, Yuanqing Li","doi":"10.1007/s12264-024-01319-7","DOIUrl":"10.1007/s12264-024-01319-7","url":null,"abstract":"Depression is increasingly prevalent among adolescents and can profoundly impact their lives. However, the early detection of depression is often hindered by the time-consuming diagnostic process and the absence of objective biomarkers. In this study, we propose a novel approach for depression detection based on an affective brain-computer interface (aBCI) and the resting-state electroencephalogram (EEG). By fusing EEG features associated with both emotional and resting states, our method captures comprehensive depression-related information. The final depression detection model, derived through decision fusion with multiple independent models, further enhances detection efficacy. Our experiments involved 40 adolescents with depression and 40 matched controls. The proposed model achieved an accuracy of 86.54% on cross-validation and 88.20% on the independent test set, demonstrating the efficiency of multimodal fusion. In addition, further analysis revealed distinct brain activity patterns between the two groups across different modalities. These findings hold promise for new directions in depression detection and intervention.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"434-448"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NG2 Glia: The Guardians Against Prion-induced Neurotoxicity Through Prostaglandin E2 Blockade. NG2胶质细胞：通过阻断前列腺素E2抵抗朊病毒诱导的神经毒性的守护者。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-03-01 Epub Date: 2024-12-05 DOI: 10.1007/s12264-024-01333-9

Shu Feng, Emily Parker, Timon Cheng-Yi Liu, Luodan Yang

引用次数: 0

Psychoactive Substances: Transforming the Paradigm for Treating Mental Health Disorders in the Post-Pandemic Era. 精神活性物质：转变后大流行时代治疗精神健康障碍的范式。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-03-01 Epub Date: 2024-12-23 DOI: 10.1007/s12264-024-01341-9

Haojiang Zhai, Yibo Wang, Xiaohui Wang

引用次数: 0

Vascular Ossification in the Developing Brain: A Case Study of Pediatric Sturge Weber Syndrome. 发育中大脑的血管骨化：小儿斯特格-韦伯综合征病例研究》。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-03-01 Epub Date: 2024-11-06 DOI: 10.1007/s12264-024-01311-1

Ranxi Chen, Shuhui Xie, Jin Gao, Shuli Zhang, Xiaobin Zhang, Yi Yao, Gengxiu Zheng, Fengpeng Wang, Zili Liu, Xuefeng Shen

引用次数: 0