Neuroscience bulletin最新文献_第2页

Perifornical UCN3 Neurons Regulate Overeating-Induced Weight Gain. 皮层周围UCN3神经元调节暴饮暴食引起的体重增加。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-06-01 Epub Date: 2025-04-19 DOI: 10.1007/s12264-025-01400-9

Shanshan Lu, Xinran Zhang, Wanqi Chen, Baofang Zhang, Haiyang Jing, Yunlong Xu, Fengling Li, Chenyu Jiang, Gaowei Chen, Xiaofei Deng, Yingjie Zhu

引用次数: 0

Fto-dependent Vdac3 m6A Modification Regulates Neuronal Ferroptosis Induced by the Post-ICH Mass Effect and Transferrin. fto依赖性vdac3m6a修饰调控ich后质量效应和转铁蛋白诱导的神经元铁凋亡。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-06-01 Epub Date: 2025-02-14 DOI: 10.1007/s12264-025-01355-x

Zhongmou Xu, Haiying Li, Xiang Li, Jinxin Lu, Chang Cao, Lu Peng, Lianxin Li, John Zhang, Gang Chen

{"title":"Fto-dependent Vdac3 m6A Modification Regulates Neuronal Ferroptosis Induced by the Post-ICH Mass Effect and Transferrin.","authors":"Zhongmou Xu, Haiying Li, Xiang Li, Jinxin Lu, Chang Cao, Lu Peng, Lianxin Li, John Zhang, Gang Chen","doi":"10.1007/s12264-025-01355-x","DOIUrl":"10.1007/s12264-025-01355-x","url":null,"abstract":"During the hyperacute phase of intracerebral hemorrhage (ICH), the mass effect and blood components mechanically lead to brain damage and neurotoxicity. Our findings revealed that the mass effect and transferrin precipitate neuronal oxidative stress and iron uptake, culminating in ferroptosis in neurons. M6A (N6-methyladenosine) modification, the most prevalent mRNA modification, plays a critical role in various cell death pathways. The Fto (fat mass and obesity-associated protein) demethylase has been implicated in numerous signaling pathways of neurological diseases by modulating m6A mRNA levels. Regulation of Fto protein levels in neurons effectively mitigated mass effect-induced neuronal ferroptosis. Applying nanopore direct RNA sequencing, we identified voltage-dependent anion channel 3 (Vdac3) as a potential target associated with ferroptosis. Fto influenced neuronal ferroptosis by regulating the m6A methylation of Vdac3 mRNA. These findings elucidate the intricate interplay between Fto, Vdac3, m6A methylation, and ferroptosis in neurons during the hyperacute phase post-ICH and suggest novel therapeutic strategies for ICH.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"970-986"},"PeriodicalIF":5.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Follistatin, A Novel Therapeutic Target for Chronic Pain. 卵泡listatin：治疗慢性疼痛的新靶点。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-06-01 Epub Date: 2025-03-02 DOI: 10.1007/s12264-025-01369-5

Huimin Nie, Boyi Liu

引用次数: 0

Alpha-synuclein Fibrils Inhibit Activation of the BDNF/ERK Signaling Loop in the mPFC to Induce Parkinson's Disease-like Alterations with Depression. α -突触核蛋白原纤维抑制mPFC中BDNF/ERK信号回路的激活，诱导帕金森病样改变伴抑郁症

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-06-01 Epub Date: 2024-11-28 DOI: 10.1007/s12264-024-01323-x

Zhuoran Ma, Yan Xu, Piaopiao Lian, Yi Wu, Ke Liu, Zhaoyuan Zhang, Zhicheng Tang, Xiaoman Yang, Xuebing Cao

{"title":"Alpha-synuclein Fibrils Inhibit Activation of the BDNF/ERK Signaling Loop in the mPFC to Induce Parkinson's Disease-like Alterations with Depression.","authors":"Zhuoran Ma, Yan Xu, Piaopiao Lian, Yi Wu, Ke Liu, Zhaoyuan Zhang, Zhicheng Tang, Xiaoman Yang, Xuebing Cao","doi":"10.1007/s12264-024-01323-x","DOIUrl":"10.1007/s12264-024-01323-x","url":null,"abstract":"Depression (Dep) is one of the most common concomitant symptoms of Parkinson's disease (PD), but there is a lack of detailed pathologic evidence for the occurrence of PD-Dep. Currently, the management of symptoms from both conditions using conventional pharmacological interventions remains a formidable task. In this study, we found impaired activation of extracellular signal-related kinase (ERK), reduced levels of transcription and translation, and decreased expression of brain-derived neurotrophic factor (BDNF) in the medial prefrontal cortex (mPFC) of PD-Dep rats. We demonstrated that the abnormal phosphorylation of α-synuclein (pS129) induced tropomyosin-related kinase receptor type B (TrkB) retention at the neuronal cell membrane, leading to BDNF/TrkB signaling dysfunction. We chose SEW2871 as an ameliorator to upregulate ERK phosphorylation. The results showed that PD-Dep rats exhibited improvement in behavioral manifestations of PD and depression. In addition, a reduction in pS129 was accompanied by a restoration of the function of the BDNF/ERK signaling loop in the mPFC of PD-Dep rats.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"951-969"},"PeriodicalIF":5.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dysregulated Pathways During Pregnancy Predict Drug Candidates in Neurodevelopmental Disorders. 妊娠期间通路失调预测神经发育障碍的候选药物。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-06-01 Epub Date: 2025-02-06 DOI: 10.1007/s12264-025-01360-0

Huamin Yin, Zhendong Wang, Wenhang Wang, Jiaxin Liu, Yirui Xue, Li Liu, Jingling Shen, Lian Duan

{"title":"Dysregulated Pathways During Pregnancy Predict Drug Candidates in Neurodevelopmental Disorders.","authors":"Huamin Yin, Zhendong Wang, Wenhang Wang, Jiaxin Liu, Yirui Xue, Li Liu, Jingling Shen, Lian Duan","doi":"10.1007/s12264-025-01360-0","DOIUrl":"10.1007/s12264-025-01360-0","url":null,"abstract":"Maternal health during pregnancy has a direct impact on the risk and severity of neurodevelopmental disorders (NDDs) in the offspring, especially in the case of drug exposure. However, little progress has been made to assess the risk of drug exposure during pregnancy due to ethical constraints and drug use factors. We collected and manually curated sub-pathways and pathways (sub-/pathways) and drug information to propose an analytical framework for predicting drug candidates. This framework linked sub-/pathway activity and drug response scores derived from gene transcription data and was applied to human fetal brain development and six NDDs. Further, specific and pleiotropic sub-/pathways/drugs were identified using entropy, and sex bias was analyzed in conjunction with logistic regression and random forest models. We identified 19 disorder-associated and 256 regionally pleiotropic and specific candidate drugs that targeted risk sub-/pathways in NDDs, showing temporal or spatial changes across fetal development. Moreover, 5443 differential drug-sub-/pathways exhibited sex-biased differences after filling in the gender labels. A user-friendly NDDP visualization website ( https://ndd-lab.shinyapps.io/NDDP ) was developed to allow researchers and clinicians to access and retrieve data easily. Our framework overcame data gaps and identified numerous pleiotropic and specific candidates across six disorders and fetal developmental trajectories. This could significantly contribute to drug discovery during pregnancy and can be applied to a wide range of traits.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"987-1002"},"PeriodicalIF":5.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Graph Neural Networks and Multimodal DTI Features for Schizophrenia Classification: Insights from Brain Network Analysis and Gene Expression. 用于精神分裂症分类的图神经网络和多模态 DTI 特征：脑网络分析和基因表达的启示。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-06-01 Epub Date: 2025-03-18 DOI: 10.1007/s12264-025-01385-5

Jingjing Gao, Heping Tang, Zhengning Wang, Yanling Li, Na Luo, Ming Song, Sangma Xie, Weiyang Shi, Hao Yan, Lin Lu, Jun Yan, Peng Li, Yuqing Song, Jun Chen, Yunchun Chen, Huaning Wang, Wenming Liu, Zhigang Li, Hua Guo, Ping Wan, Luxian Lv, Yongfeng Yang, Huiling Wang, Hongxing Zhang, Huawang Wu, Yuping Ning, Dai Zhang, Tianzi Jiang

{"title":"Graph Neural Networks and Multimodal DTI Features for Schizophrenia Classification: Insights from Brain Network Analysis and Gene Expression.","authors":"Jingjing Gao, Heping Tang, Zhengning Wang, Yanling Li, Na Luo, Ming Song, Sangma Xie, Weiyang Shi, Hao Yan, Lin Lu, Jun Yan, Peng Li, Yuqing Song, Jun Chen, Yunchun Chen, Huaning Wang, Wenming Liu, Zhigang Li, Hua Guo, Ping Wan, Luxian Lv, Yongfeng Yang, Huiling Wang, Hongxing Zhang, Huawang Wu, Yuping Ning, Dai Zhang, Tianzi Jiang","doi":"10.1007/s12264-025-01385-5","DOIUrl":"10.1007/s12264-025-01385-5","url":null,"abstract":"Schizophrenia (SZ) stands as a severe psychiatric disorder. This study applied diffusion tensor imaging (DTI) data in conjunction with graph neural networks to distinguish SZ patients from normal controls (NCs) and showcases the superior performance of a graph neural network integrating combined fractional anisotropy and fiber number brain network features, achieving an accuracy of 73.79% in distinguishing SZ patients from NCs. Beyond mere discrimination, our study delved deeper into the advantages of utilizing white matter brain network features for identifying SZ patients through interpretable model analysis and gene expression analysis. These analyses uncovered intricate interrelationships between brain imaging markers and genetic biomarkers, providing novel insights into the neuropathological basis of SZ. In summary, our findings underscore the potential of graph neural networks applied to multimodal DTI data for enhancing SZ detection through an integrated analysis of neuroimaging and genetic features.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"933-950"},"PeriodicalIF":5.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer-Associated Fibroblasts Interact with Schwann Cells for Tumor Perineural Invasion by Oral Squamous Cell Carcinoma. 癌相关成纤维细胞与雪旺细胞相互作用导致口腔鳞状细胞癌侵袭神经周围。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-06-01 Epub Date: 2025-02-25 DOI: 10.1007/s12264-025-01364-w

Xinwen Zhang, Yijia He, Shixin Xie, Yuxian Song, Xiaofeng Huang, Qingang Hu, Yanhong Ni, Yi Wang, Yong Fu, Liang Ding

{"title":"Cancer-Associated Fibroblasts Interact with Schwann Cells for Tumor Perineural Invasion by Oral Squamous Cell Carcinoma.","authors":"Xinwen Zhang, Yijia He, Shixin Xie, Yuxian Song, Xiaofeng Huang, Qingang Hu, Yanhong Ni, Yi Wang, Yong Fu, Liang Ding","doi":"10.1007/s12264-025-01364-w","DOIUrl":"10.1007/s12264-025-01364-w","url":null,"abstract":"Perineural invasion (PNI) by tumor cells is a key phenotype of highly-invasive oral squamous cell carcinoma (OSCC). Since Schwann cells (SCs) and fibroblasts maintain the physiological homeostasis of the peripheral nervous system, and we have focused on cancer-associated fibroblasts (CAFs) for decades, it's imperative to elucidate the impact of CAFs on SCs in PNI+ OSCCs. We describe a disease progression-driven shift of PNI- towards PNI+ during the progression of early-stage OSCC (31%, n = 125) to late-stage OSCC (53%, n = 97), characterized by abundant CAFs and nerve demyelination. CAFs inhibited SC proliferation/migration and reduced neurotrophic factors and myelin in vitro, and this involved up-regulated ER stress and decreased MAPK signals. Moreover, CAFs also aggravated the paralysis of the hind limb and PNI in vivo. Unexpectedly, leukemia inhibitory factor (LIF) was exclusively expressed on CAFs and up-regulated in metastatic OSCC. The LIF inhibitor EC330 restored CAF-induced SC inactivation. Thus, OSCC-derived CAFs inactivate SCs to aggravate nerve injury and PNI development.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1003-1020"},"PeriodicalIF":5.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Generation of the Ci1 Reporter Mouse Strain with Enhanced Fluorescence for Tissue Clearing Applications. 用于组织清除的增强荧光小鼠Ci1报告品系的产生。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-06-01 DOI: 10.1007/s12264-025-01421-4

Manyu Chen, Youqi Li, Juan Huang, Yilong Wang, Hu Zhao