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Unveiling β Subunit-Dependent Gating Defects in CaV2.1 Channelopathies: Investigation of a de novo CACNA1A Variant. 揭示CaV2.1通道病变中β亚基依赖性门控缺陷：一种新的CACNA1A变异的研究
IF 5.8 2区 医学
Neuroscience bulletin Pub Date : 2025-09-18 DOI: 10.1007/s12264-025-01508-y
Kunpeng Ma, Haiyan Chen, Li Chen, Shuainan Zhao, Huafang Zou, Dongfang Zou, Qi Zeng, Dezhi Cao, Jianyuan Sun, Lin Li, Xuefeng Shen
{"title":"Unveiling β Subunit-Dependent Gating Defects in Ca<sub>V</sub>2.1 Channelopathies: Investigation of a de novo CACNA1A Variant.","authors":"Kunpeng Ma, Haiyan Chen, Li Chen, Shuainan Zhao, Huafang Zou, Dongfang Zou, Qi Zeng, Dezhi Cao, Jianyuan Sun, Lin Li, Xuefeng Shen","doi":"10.1007/s12264-025-01508-y","DOIUrl":"https://doi.org/10.1007/s12264-025-01508-y","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Astrocytic Cannabinoid Receptor 1 Governs Stress Resilience by Orchestrating Blood-Brain Barrier Integrity. 星形细胞大麻素受体1通过协调血脑屏障完整性来调节应激恢复能力。
IF 5.8 2区 医学
Neuroscience bulletin Pub Date : 2025-09-17 DOI: 10.1007/s12264-025-01514-0
Xiaopeng Ding, Yulan Li
{"title":"Astrocytic Cannabinoid Receptor 1 Governs Stress Resilience by Orchestrating Blood-Brain Barrier Integrity.","authors":"Xiaopeng Ding, Yulan Li","doi":"10.1007/s12264-025-01514-0","DOIUrl":"https://doi.org/10.1007/s12264-025-01514-0","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diuretic Hormone 31 Regulates Sleep and Memory via Distinct Signaling Pathways in Drosophila melanogaster. 利尿激素31通过不同信号通路调节黑腹果蝇的睡眠和记忆。
IF 5.8 2区 医学
Neuroscience bulletin Pub Date : 2025-09-16 DOI: 10.1007/s12264-025-01476-3
Lin Yan, Litao Wu, Xin Chen, Xiaojuan Su, Yuantao Li, Chang Liu
{"title":"Diuretic Hormone 31 Regulates Sleep and Memory via Distinct Signaling Pathways in Drosophila melanogaster.","authors":"Lin Yan, Litao Wu, Xin Chen, Xiaojuan Su, Yuantao Li, Chang Liu","doi":"10.1007/s12264-025-01476-3","DOIUrl":"https://doi.org/10.1007/s12264-025-01476-3","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting Microglial Connexin43 Hemichannels: A Novel Therapeutic Avenue for Alzheimer's Disease. 靶向小胶质细胞连接蛋白43半通道：阿尔茨海默病的新治疗途径
IF 5.8 2区 医学
Neuroscience bulletin Pub Date : 2025-09-15 DOI: 10.1007/s12264-025-01513-1
Chenju Yi, Yixun Su, Alexei Verkhratsky
{"title":"Targeting Microglial Connexin43 Hemichannels: A Novel Therapeutic Avenue for Alzheimer's Disease.","authors":"Chenju Yi, Yixun Su, Alexei Verkhratsky","doi":"10.1007/s12264-025-01513-1","DOIUrl":"https://doi.org/10.1007/s12264-025-01513-1","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction Note: Effect of Gastrodin on Early Brain Injury and Neurological Outcome After Subarachnoid Hemorrhage in Rats. 注：天麻素对大鼠蛛网膜下腔出血后早期脑损伤及神经转归的影响。
IF 5.8 2区 医学
Neuroscience bulletin Pub Date : 2025-09-15 DOI: 10.1007/s12264-025-01504-2
Xinzhi Wang, Shuyue Li, Jinbang Ma, Chuangang Wang, Anzhong Chen, Zhenxue Xin, Jianjun Zhang
{"title":"Retraction Note: Effect of Gastrodin on Early Brain Injury and Neurological Outcome After Subarachnoid Hemorrhage in Rats.","authors":"Xinzhi Wang, Shuyue Li, Jinbang Ma, Chuangang Wang, Anzhong Chen, Zhenxue Xin, Jianjun Zhang","doi":"10.1007/s12264-025-01504-2","DOIUrl":"https://doi.org/10.1007/s12264-025-01504-2","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dysregulation of the BRD2-FGF17 Signal Pathway Induces Abnormal Forebrain Development Associated with Schizophrenia. BRD2-FGF17信号通路失调诱导与精神分裂症相关的前脑发育异常
IF 5.8 2区 医学
Neuroscience bulletin Pub Date : 2025-09-14 DOI: 10.1007/s12264-025-01500-6
Xiao Yu, Jiacheng Du, Chenger Zhou, Yongheng Huang, Huijuan Li, Bruce M Cohen, Sangmi Chung, Zhicheng Shao
{"title":"Dysregulation of the BRD2-FGF17 Signal Pathway Induces Abnormal Forebrain Development Associated with Schizophrenia.","authors":"Xiao Yu, Jiacheng Du, Chenger Zhou, Yongheng Huang, Huijuan Li, Bruce M Cohen, Sangmi Chung, Zhicheng Shao","doi":"10.1007/s12264-025-01500-6","DOIUrl":"https://doi.org/10.1007/s12264-025-01500-6","url":null,"abstract":"<p><p>Schizophrenia (SCZ) is a severe and hereditary neurodevelopmental disorder with unknown etiology. Here, we found that the SCZ risk gene BRD2, as an epigenetic reader, is consistently expressed in developing mouse and human cortical astrocytes. Astrocyte-specific Brd2 knockout in mice leads to dysregulation of immune responses and reduces Fgf17 expression, resulting in SCZ-like behaviors, including impaired sensorimotor gating, memory, and cognitive deficits. Moreover, BRD2 inhibition using JQ1 in forebrain organoids leads to FGF17 reduction, inducing developmental deficits involved in neural patterning and gliogenesis. The decrease of FGF17 expression was also found in SCZ patient-derived forebrain organoids, similar to BRD2-inhibited forebrain organoids. FGF17 treatment partially rescued the disrupted gene expression in BRD2-inhibited human forebrain organoids. Taken together, these findings suggest that disrupting the BRD2-FGF17 signaling pathway in early brain development may contribute to the pathogenesis of schizophrenia and may represent a potential therapeutic target for SCZ.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Senescent Nociceptors: A Novel Therapeutic Target for Chronic Pain Treatment. 衰老伤害感受器：慢性疼痛治疗的新靶点。
IF 5.8 2区 医学
Neuroscience bulletin Pub Date : 2025-09-13 DOI: 10.1007/s12264-025-01511-3
Shi-Yu Sun, Xiu-Hua Miao, Guo-Kun Zhou, Tong Liu
{"title":"Senescent Nociceptors: A Novel Therapeutic Target for Chronic Pain Treatment.","authors":"Shi-Yu Sun, Xiu-Hua Miao, Guo-Kun Zhou, Tong Liu","doi":"10.1007/s12264-025-01511-3","DOIUrl":"https://doi.org/10.1007/s12264-025-01511-3","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145054809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transient Formation of Stress Granules Disturbs Neural Stem Cell Differentiation. 应激颗粒的瞬时形成干扰神经干细胞的分化。
IF 5.8 2区 医学
Neuroscience bulletin Pub Date : 2025-09-12 DOI: 10.1007/s12264-025-01503-3
Mengmeng Wang, Yarong Wang, Hongyu Ma, Hanze Liu, Yating Lu, Yaozhong Zhang, Zhihui Huang, Songqi Dong, Kun Zhang, Shengxi Wu, Yazhou Wang
{"title":"Transient Formation of Stress Granules Disturbs Neural Stem Cell Differentiation.","authors":"Mengmeng Wang, Yarong Wang, Hongyu Ma, Hanze Liu, Yating Lu, Yaozhong Zhang, Zhihui Huang, Songqi Dong, Kun Zhang, Shengxi Wu, Yazhou Wang","doi":"10.1007/s12264-025-01503-3","DOIUrl":"https://doi.org/10.1007/s12264-025-01503-3","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nr4a2, A Key Factor Controlling the Development and Functional Maintenance of Forebrain Car3 Neurons. 调控前脑Car3神经元发育和功能维持的关键因子Nr4a2
IF 5.8 2区 医学
Neuroscience bulletin Pub Date : 2025-09-08 DOI: 10.1007/s12264-025-01496-z
Yun-Chao Tao, Li Zhao, Qiong Zhang, Xi-Yue Liu, Wei-Tang Liu, Ze-Xuan Li, Ling Hu, Lei Zhang, Jia-Yin Chen, Yu-Qiang Ding, Ning-Ning Song
{"title":"Nr4a2, A Key Factor Controlling the Development and Functional Maintenance of Forebrain Car3 Neurons.","authors":"Yun-Chao Tao, Li Zhao, Qiong Zhang, Xi-Yue Liu, Wei-Tang Liu, Ze-Xuan Li, Ling Hu, Lei Zhang, Jia-Yin Chen, Yu-Qiang Ding, Ning-Ning Song","doi":"10.1007/s12264-025-01496-z","DOIUrl":"https://doi.org/10.1007/s12264-025-01496-z","url":null,"abstract":"<p><p>Nr4a2 (Nurr1) is well known to be vital for midbrain dopaminergic neurons. Recent single-cell RNA analyses reveal that Nr4a2 is expressed in lateral cerebral regions, within neurons named L4/L5/L6 IT Car3. These neurons have attracted intense attention for the molecular mechanisms underlying their development and functions. We classified Car3 neurons into neocortical (Ncx-Car3), claustral (CLA-Car3), and dorsal endopiriform nucleus (dEn-Car3) subpopulations, focusing on the characterization of Ncx-Car3 neurons. These neurons exhibit distinct birthdates and migratory morphologies compared to CLA- and dEn-Car3 neurons, but share a common transcriptomic profile when Nr4a2 is deleted at the embryonic stage or in adulthood. Notably, Nr4a2 misexpression ectopically induces Car3-enriched genes in vivo. Mice lacking Nr4a2 in Car3 ensembles during the embryonic stage or in adulthood display hyperactivity and reduced anxiety-like behaviors. Therefore, our results demonstrate that Nr4a2 is a key factor in regulating the development and functional maintenance of the forebrain Car3 neurons.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deletion of the SHORT Syndrome Gene Prkce Results in Brain Atrophy and Cognitive and Motor Behavior Deficits in Mice. SHORT综合征基因Prkce缺失导致小鼠脑萎缩、认知和运动行为缺陷。
IF 5.8 2区 医学
Neuroscience bulletin Pub Date : 2025-09-06 DOI: 10.1007/s12264-025-01497-y
Yu-Long Bao, Wei-Peng Duan, Yan Yang, Zhijie Lin, Ying Shen, Rui Zheng, Xin-Tai Wang
{"title":"Deletion of the SHORT Syndrome Gene Prkce Results in Brain Atrophy and Cognitive and Motor Behavior Deficits in Mice.","authors":"Yu-Long Bao, Wei-Peng Duan, Yan Yang, Zhijie Lin, Ying Shen, Rui Zheng, Xin-Tai Wang","doi":"10.1007/s12264-025-01497-y","DOIUrl":"https://doi.org/10.1007/s12264-025-01497-y","url":null,"abstract":"<p><p>The neurological manifestations of SHORT syndrome include intrauterine growth restriction, microcephaly, intellectual disability, hearing loss, and speech delay. SHORT syndrome is generally believed to be caused by PIK3R1 gene mutations and impaired PI3K-AKT activation. Recently, a clinical case report described a SHORT syndrome with a novel mutant in PRKCE gene encoding protein kinase Cε (PKCε). However, it remains unclear whether the down-regulation of PKCε gives rise to the symptoms of SHORT syndrome. In this study, we show that a deficiency of PKCε in the central nervous system leads to cerebral and cerebellar atrophy, as well as motor and social deficits. Mechanistically, the deletion of PKCε results in the down-regulation of VEGF/PI3K-induced AKT activation, thereby causing abnormal brain development and dysfunctions. These findings emphasize the roles of PKCε in the development and function of the brain, and offer new perspectives for understanding the neurological manifestations of SHORT syndrome.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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