Neuroscience bulletin最新文献_第2页

Correction to: Autophagy in Oligodendrocyte Lineage Cells Controls Oligodendrocyte Numbers and Myelin Integrity in an Age-dependent Manner.

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-06 DOI: 10.1007/s12264-024-01315-x

Hong Chen, Gang Yang, De-En Xu, Yu-Tong Du, Chao Zhu, Hua Hu, Li Luo, Lei Feng, Wenhui Huang, Yan-Yun Sun, Quan-Hong Ma

引用次数: 0

NG2 Glia: The Guardians Against Prion-induced Neurotoxicity Through Prostaglandin E2 Blockade.

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-05 DOI: 10.1007/s12264-024-01333-9

Shu Feng, Emily Parker, Timon Cheng-Yi Liu, Luodan Yang

引用次数: 0

Histaminergic Innervation of the Ventral Anterior Thalamic Nucleus Alleviates Motor Deficits in a 6-OHDA-Induced Rat Model of Parkinson's Disease.

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-02 DOI: 10.1007/s12264-024-01320-0

Han-Ting Xu, Xiao-Ya Xi, Shuang Zhou, Yun-Yong Xie, Zhi-San Cui, Bei-Bei Zhang, Shu-Tao Xie, Hong-Zhao Li, Qi-Peng Zhang, Yang Pan, Xiao-Yang Zhang, Jing-Ning Zhu

{"title":"Histaminergic Innervation of the Ventral Anterior Thalamic Nucleus Alleviates Motor Deficits in a 6-OHDA-Induced Rat Model of Parkinson's Disease.","authors":"Han-Ting Xu, Xiao-Ya Xi, Shuang Zhou, Yun-Yong Xie, Zhi-San Cui, Bei-Bei Zhang, Shu-Tao Xie, Hong-Zhao Li, Qi-Peng Zhang, Yang Pan, Xiao-Yang Zhang, Jing-Ning Zhu","doi":"10.1007/s12264-024-01320-0","DOIUrl":"https://doi.org/10.1007/s12264-024-01320-0","url":null,"abstract":"The ventral anterior (VA) nucleus of the thalamus is a major target of the basal ganglia and is closely associated with the pathogenesis of Parkinson's disease (PD). Notably, the VA receives direct innervation from the hypothalamic histaminergic system. However, its role in PD remains unknown. Here, we assessed the contribution of histamine to VA neuronal activity and PD motor deficits. Functional magnetic resonance imaging showed reduced VA activity in PD patients. Optogenetic activation of VA neurons or histaminergic afferents significantly alleviated motor deficits in 6-OHDA-induced PD rats. Furthermore, histamine excited VA neurons via H1 and H2 receptors and their coupled hyperpolarization-activated cyclic nucleotide-gated channels, inward-rectifier K+ channels, or Ca2+-activated K+ channels. These results demonstrate that histaminergic afferents actively compensate for Parkinsonian motor deficits by biasing VA activity. These findings suggest that targeting VA histamine receptors and downstream ion channels may be a potential therapeutic strategy for PD motor dysfunction.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-Dependent Transcriptional Dynamics of Contextual Fear Memory Retrieval Reveals the Function of Dipeptidyl Peptidase 9 in Reconsolidation.

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-02 DOI: 10.1007/s12264-024-01324-w

Wen-Ting Guo, Wen-Xing Li, Yu-Chen Liu, Ya-Bo Zhao, Lin Xu, Qi-Xin Zhou

{"title":"Time-Dependent Transcriptional Dynamics of Contextual Fear Memory Retrieval Reveals the Function of Dipeptidyl Peptidase 9 in Reconsolidation.","authors":"Wen-Ting Guo, Wen-Xing Li, Yu-Chen Liu, Ya-Bo Zhao, Lin Xu, Qi-Xin Zhou","doi":"10.1007/s12264-024-01324-w","DOIUrl":"https://doi.org/10.1007/s12264-024-01324-w","url":null,"abstract":"Numerous studies on the formation and consolidation of memory have shown that memory processes are characterized by phase-dependent and dynamic regulation. Memory retrieval, as the only representation of memory content and an active form of memory processing that induces memory reconsolidation, has attracted increasing attention in recent years. Although the molecular mechanisms specific to memory retrieval-induced reconsolidation have been gradually revealed, an understanding of the time-dependent regulatory mechanisms of this process is still lacking. In this study, we applied a transcriptome analysis of memory retrieval at different time points in the recent memory stage. Differential expression analysis and Short Time-series Expression Miner (STEM) depicting temporal gene expression patterns indicated that most differential gene expression occurred at 48 h, and the STEM cluster showing the greatest transcriptional upregulation at 48 h demonstrated the most significant difference. We then screened the differentially-expressed genes associated with that met the expression patterns of those cluster-identified genes that have been reported to be involved in learning and memory processes in addition to dipeptidyl peptidase 9 (DPP9). Further quantitative polymerase chain reaction verification and pharmacological intervention suggested that DPP9 is involved in 48-h fear memory retrieval and viral vector-mediated overexpression of DPP9 countered the 48-h retrieval-induced attenuation of fear memory. Taken together, our findings suggest that temporal gene expression patterns are induced by recent memory retrieval and provide hitherto undocumented evidence of the role of DPP9 in the retrieval-induced reconsolidation of fear memory.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Method to Extract Task-Related EEG Feature Based on Lightweight Convolutional Neural Network. 基于轻量级卷积神经网络的任务相关脑电图特征提取方法

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-01 Epub Date: 2024-07-02 DOI: 10.1007/s12264-024-01247-6

Qi Huang, Jing Ding, Xin Wang

{"title":"A Method to Extract Task-Related EEG Feature Based on Lightweight Convolutional Neural Network.","authors":"Qi Huang, Jing Ding, Xin Wang","doi":"10.1007/s12264-024-01247-6","DOIUrl":"10.1007/s12264-024-01247-6","url":null,"abstract":"Unlocking task-related EEG spectra is crucial for neuroscience. Traditional convolutional neural networks (CNNs) effectively extract these features but face limitations like overfitting due to small datasets. To address this issue, we propose a lightweight CNN and assess its interpretability through the fully connected layer (FCL). Initially tested with two tasks (Task 1: open vs closed eyes, Task 2: interictal vs ictal stage), the CNN demonstrated enhanced spectral features in the alpha band for Task 1 and the theta band for Task 2, aligning with established neurophysiological characteristics. Subsequent experiments on two brain-computer interface tasks revealed a correlation between delta activity (around 1.55 Hz) and hand movement, with consistent results across pericentral electroencephalogram (EEG) channels. Compared to recent research, our method stands out by delivering task-related spectral features through FCL, resulting in significantly fewer trainable parameters while maintaining comparable interpretability. This indicates its potential suitability for a wider array of EEG decoding scenarios.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1915-1930"},"PeriodicalIF":5.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurotransmitter Switching: A Novel Mechanism for Fear Generalization. 神经递质转换：恐惧泛化的新机制

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-01 Epub Date: 2024-07-29 DOI: 10.1007/s12264-024-01264-5

Jiayuan Zheng, Zhanzhuang Tian

引用次数: 0

CGRP: Does A Novel Neuroimmune Modulator Facilitate Tissue Repair? CGRP：一种新型神经免疫调节剂是否能促进组织修复？

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-01 Epub Date: 2024-08-03 DOI: 10.1007/s12264-024-01275-2

Xiang Cui, Xinyan Gao, Bing Zhu

引用次数: 0

TAF15 Overexpression Impairs Memory in Mice by Inhibiting the Transcription of Npas4. TAF15过表达会抑制Npas4的转录，从而损害小鼠的记忆力

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-01 Epub Date: 2024-08-08 DOI: 10.1007/s12264-024-01273-4

Meijie Ding, Dingfeng Li, Juan Zhang, Qiang Liu

引用次数: 0

Modulating the Pronociceptive Effect of Sleep Deprivation: A Possible Role for Cholinergic Neurons in the Medial Habenula. 调节睡眠剥夺的知觉效应：内侧哈宾纳的胆碱能神经元可能发挥的作用

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-01 Epub Date: 2024-08-19 DOI: 10.1007/s12264-024-01281-4

Xiang-Sha Yin, Bai-Rong Chen, Xi-Chun Ye, Yun Wang

{"title":"Modulating the Pronociceptive Effect of Sleep Deprivation: A Possible Role for Cholinergic Neurons in the Medial Habenula.","authors":"Xiang-Sha Yin, Bai-Rong Chen, Xi-Chun Ye, Yun Wang","doi":"10.1007/s12264-024-01281-4","DOIUrl":"10.1007/s12264-024-01281-4","url":null,"abstract":"Sleep deprivation has been shown to exacerbate pain sensitivity and may contribute to the onset of chronic pain, yet the precise neural mechanisms underlying this association remain elusive. In our study, we explored the contribution of cholinergic neurons within the medial habenula (MHb) to hyperalgesia induced by sleep deprivation in rats. Our findings indicate that the activity of MHb cholinergic neurons diminishes during sleep deprivation and that chemogenetic stimulation of these neurons can mitigate the results. Interestingly, we did not find a direct response of MHb cholinergic neurons to pain stimulation. Further investigation identified the interpeduncular nucleus (IPN) and the paraventricular nucleus of the thalamus (PVT) as key players in the pro-nociceptive effect of sleep deprivation. Stimulating the pathways connecting the MHb to the IPN and PVT alleviated the hyperalgesia. These results underscore the important role of MHb cholinergic neurons in modulating pain sensitivity linked to sleep deprivation, highlighting potential neural targets for mitigating sleep deprivation-induced hyperalgesia.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1811-1825"},"PeriodicalIF":5.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress of the Impact of Terahertz Radiation on Ion Channel Kinetics in Neuronal Cells. 太赫兹辐射对神经元细胞离子通道动力学影响的研究进展

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-01 Epub Date: 2024-09-04 DOI: 10.1007/s12264-024-01277-0

Yanjiang Liu, Xi Liu, Yousheng Shu, Yuguo Yu

引用次数: 0