Neuroscience bulletin最新文献_第10页

Convergent Neuroimaging and Molecular Signatures in Mild Cognitive Impairment and Alzheimer's Disease: A Data-Driven Meta-Analysis with N = 3,118. 轻度认知障碍和阿尔茨海默病的神经影像学和分子特征：数据驱动的 Meta 分析，N = 3,118.

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-09-01 Epub Date: 2024-06-01 DOI: 10.1007/s12264-024-01218-x

Xiaopeng Kang, Dawei Wang, Jiaji Lin, Hongxiang Yao, Kun Zhao, Chengyuan Song, Pindong Chen, Yida Qu, Hongwei Yang, Zengqiang Zhang, Bo Zhou, Tong Han, Zhengluan Liao, Yan Chen, Jie Lu, Chunshui Yu, Pan Wang, Xinqing Zhang, Ming Li, Xi Zhang, Tianzi Jiang, Yuying Zhou, Bing Liu, Ying Han, Yong Liu

{"title":"Convergent Neuroimaging and Molecular Signatures in Mild Cognitive Impairment and Alzheimer's Disease: A Data-Driven Meta-Analysis with N = 3,118.","authors":"Xiaopeng Kang, Dawei Wang, Jiaji Lin, Hongxiang Yao, Kun Zhao, Chengyuan Song, Pindong Chen, Yida Qu, Hongwei Yang, Zengqiang Zhang, Bo Zhou, Tong Han, Zhengluan Liao, Yan Chen, Jie Lu, Chunshui Yu, Pan Wang, Xinqing Zhang, Ming Li, Xi Zhang, Tianzi Jiang, Yuying Zhou, Bing Liu, Ying Han, Yong Liu","doi":"10.1007/s12264-024-01218-x","DOIUrl":"10.1007/s12264-024-01218-x","url":null,"abstract":"The current study aimed to evaluate the susceptibility to regional brain atrophy and its biological mechanism in Alzheimer's disease (AD). We conducted data-driven meta-analyses to combine 3,118 structural magnetic resonance images from three datasets to obtain robust atrophy patterns. Then we introduced a set of radiogenomic analyses to investigate the biological basis of the atrophy patterns in AD. Our results showed that the hippocampus and amygdala exhibit the most severe atrophy, followed by the temporal, frontal, and occipital lobes in mild cognitive impairment (MCI) and AD. The extent of atrophy in MCI was less severe than that in AD. A series of biological processes related to the glutamate signaling pathway, cellular stress response, and synapse structure and function were investigated through gene set enrichment analysis. Our study contributes to understanding the manifestations of atrophy and a deeper understanding of the pathophysiological processes that contribute to atrophy, providing new insight for further clinical research on AD.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1274-1286"},"PeriodicalIF":5.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11365916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mapping the Behavioral Signatures of Shank3b Mice in Both Sexes. 绘制 Shank3b 雌雄小鼠的行为特征图

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-09-01 Epub Date: 2024-06-20 DOI: 10.1007/s12264-024-01237-8

Jingjing Liu, Jialin Ye, Chunyuan Ji, Wenting Ren, Youwei He, Fuqiang Xu, Feng Wang

引用次数: 0

The Role of Occipitotemporal Network for Speed-Reading: An fMRI Study. 枕颞网络在速读中的作用：fMRI研究

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-09-01 Epub Date: 2024-06-27 DOI: 10.1007/s12264-024-01251-w

Dexin Sun, Zhilin Zhang, Naoya Oishi, Qi Dai, Dinh Ha Duy Thuy, Nobuhito Abe, Jun Tachibana, Shintaro Funahashi, Jinglong Wu, Toshiya Murai, Hidenao Fukuyama

{"title":"The Role of Occipitotemporal Network for Speed-Reading: An fMRI Study.","authors":"Dexin Sun, Zhilin Zhang, Naoya Oishi, Qi Dai, Dinh Ha Duy Thuy, Nobuhito Abe, Jun Tachibana, Shintaro Funahashi, Jinglong Wu, Toshiya Murai, Hidenao Fukuyama","doi":"10.1007/s12264-024-01251-w","DOIUrl":"10.1007/s12264-024-01251-w","url":null,"abstract":"The activity of occipitotemporal regions involved in linguistic reading processes, such as the ventral occipitotemporal cortex (vOT), is believed to exhibit strong interactions during higher-order language processing, specifically in the connectivity between the occipital gyrus and the temporal gyrus. In this study, we utilized functional magnetic resonance imaging (fMRI) with psychophysiological interaction (PPI) and dynamic causal modeling (DCM) to investigate the functional and effective connectivity in the occipitotemporal network during speed reading. We conducted the experiment with native Japanese speakers who underwent and without speed-reading training and subsequently performed established reading tasks at different speeds (slow, medium, and fast) while undergoing 3-Tesla Siemens fMRI. Our activation analyses revealed significant changes in occipital and temporal regions as reading speed increased, indicating functional connectivity within the occipitotemporal network. DCM results further demonstrated more intricate effective connections and high involvement within the occipitotemporal pathway: (1) reading signals originated from the inferior occipital gyrus (iO), distributed to the vOT and the posterior superior temporal sulcus (pSTS), and then gathered in the anterior superior temporal sulcus (aSTS); (2) reading speed loads had modulation effects on the pathways from the aSTS to vOT and from the iO to vOT. These findings highlight the complex connectivity and dynamic interactions within the occipitotemporal network during speed-reading processes.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1261-1273"},"PeriodicalIF":5.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11365886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141469758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triggering Receptor Expressed on Myeloid Cells 2 Alleviated Sevoflurane-Induced Developmental Neurotoxicity via Microglial Pruning of Dendritic Spines in the CA1 Region of the Hippocampus. 髓系细胞上表达的触发受体2通过小胶质细胞修剪海马CA1区树突棘减轻七氟醚诱导的发育神经毒性

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-09-01 Epub Date: 2024-07-29 DOI: 10.1007/s12264-024-01260-9

Li Deng, Shao-Yong Song, Wei-Ming Zhao, Xiao-Wen Meng, Hong Liu, Qing Zheng, Ke Peng, Fu-Hai Ji

{"title":"Triggering Receptor Expressed on Myeloid Cells 2 Alleviated Sevoflurane-Induced Developmental Neurotoxicity via Microglial Pruning of Dendritic Spines in the CA1 Region of the Hippocampus.","authors":"Li Deng, Shao-Yong Song, Wei-Ming Zhao, Xiao-Wen Meng, Hong Liu, Qing Zheng, Ke Peng, Fu-Hai Ji","doi":"10.1007/s12264-024-01260-9","DOIUrl":"10.1007/s12264-024-01260-9","url":null,"abstract":"Sevoflurane induces developmental neurotoxicity in mice; however, the underlying mechanisms remain unclear. Triggering receptor expressed on myeloid cells 2 (TREM2) is essential for microglia-mediated synaptic refinement during the early stages of brain development. We explored the effects of TREM2 on dendritic spine pruning during sevoflurane-induced developmental neurotoxicity in mice. Mice were anaesthetized with sevoflurane on postnatal days 6, 8, and 10. Behavioral performance was assessed using the open field test and Morris water maze test. Genetic knockdown of TREM2 and overexpression of TREM2 by stereotaxic injection were used for mechanistic experiments. Western blotting, immunofluorescence, electron microscopy, three-dimensional reconstruction, Golgi staining, and whole-cell patch-clamp recordings were performed. Sevoflurane exposures upregulated the protein expression of TREM2, increased microglia-mediated pruning of dendritic spines, and reduced synaptic multiplicity and excitability of CA1 neurons. TREM2 genetic knockdown significantly decreased dendritic spine pruning, and partially aggravated neuronal morphological abnormalities and cognitive impairments in sevoflurane-treated mice. In contrast, TREM2 overexpression enhanced microglia-mediated pruning of dendritic spines and rescued neuronal morphological abnormalities and cognitive dysfunction. TREM2 exerts a protective role against neurocognitive impairments in mice after neonatal exposures to sevoflurane by enhancing microglia-mediated pruning of dendritic spines in CA1 neurons. This provides a potential therapeutic target in the prevention of sevoflurane-induced developmental neurotoxicity.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1215-1229"},"PeriodicalIF":5.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11365924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treadmill Exercise Reshapes Cortical Astrocytic and Neuronal Activity to Improve Motor Learning Deficits Under Chronic Alcohol Exposure. 跑步机运动重塑皮质星形胶质细胞和神经元活动，改善慢性酒精暴露下的运动学习缺陷

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-09-01 Epub Date: 2024-05-28 DOI: 10.1007/s12264-024-01226-x

Linglin Liu, Lanzhi Luo, Ji-An Wei, Xintong Xu, Kwok-Fai So, Li Zhang

引用次数: 0

High Magnesium Promotes the Recovery of Binocular Vision from Amblyopia via TRPM7. 高镁通过 TRPM7 促进弱视患者双眼视力的恢复

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-09-01 Epub Date: 2024-06-04 DOI: 10.1007/s12264-024-01242-x

Menghan Dai, Jie Li, Xiangwen Hao, Na Li, Mingfang Zheng, Miao He, Yu Gu

{"title":"High Magnesium Promotes the Recovery of Binocular Vision from Amblyopia via TRPM7.","authors":"Menghan Dai, Jie Li, Xiangwen Hao, Na Li, Mingfang Zheng, Miao He, Yu Gu","doi":"10.1007/s12264-024-01242-x","DOIUrl":"10.1007/s12264-024-01242-x","url":null,"abstract":"Abnormal visual experience during the critical period can cause deficits in visual function, such as amblyopia. High magnesium (Mg2+) supplementary can restore ocular dominance (OD) plasticity, which promotes the recovery of amblyopic eye acuity in adults. However, it remains unsolved whether Mg2+ could recover binocular vision in amblyopic adults and what the molecular mechanism is for the recovery. We found that in addition to the recovery of OD plasticity, binocular integration can be restored under the treatment of high Mg2+ in amblyopic mice. Behaviorally, Mg2+-treated amblyopic mice showed better depth perception. Moreover, the effect of high Mg2+ can be suppressed with transient receptor potential melastatin-like 7 (TRPM7) knockdown. Collectively, our results demonstrate that high Mg2+ could restore binocular visual functions from amblyopia. TRPM7 is required for the restoration of plasticity in the visual cortex after high Mg2+ treatment, which can provide possible clinical applications for future research and treatment of amblyopia.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1245-1260"},"PeriodicalIF":5.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11365890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141238297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling Promising Neuroimaging Biomarkers for Schizophrenia Through Clinical and Genetic Perspectives. 从临床和遗传学角度揭示治疗精神分裂症的前景良好的神经影像生物标志物。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-09-01 Epub Date: 2024-05-04 DOI: 10.1007/s12264-024-01214-1

Jing Guo, Changyi He, Huimiao Song, Huiwu Gao, Shi Yao, Shan-Shan Dong, Tie-Lin Yang

{"title":"Unveiling Promising Neuroimaging Biomarkers for Schizophrenia Through Clinical and Genetic Perspectives.","authors":"Jing Guo, Changyi He, Huimiao Song, Huiwu Gao, Shi Yao, Shan-Shan Dong, Tie-Lin Yang","doi":"10.1007/s12264-024-01214-1","DOIUrl":"10.1007/s12264-024-01214-1","url":null,"abstract":"Schizophrenia is a complex and serious brain disorder. Neuroscientists have become increasingly interested in using magnetic resonance-based brain imaging-derived phenotypes (IDPs) to investigate the etiology of psychiatric disorders. IDPs capture valuable clinical advantages and hold biological significance in identifying brain abnormalities. In this review, we aim to discuss current and prospective approaches to identify potential biomarkers for schizophrenia using clinical multimodal neuroimaging and imaging genetics. We first described IDPs through their phenotypic classification and neuroimaging genomics. Secondly, we discussed the applications of multimodal neuroimaging by clinical evidence in observational studies and randomized controlled trials. Thirdly, considering the genetic evidence of IDPs, we discussed how can utilize neuroimaging data as an intermediate phenotype to make association inferences by polygenic risk scores and Mendelian randomization. Finally, we discussed machine learning as an optimum approach for validating biomarkers. Together, future research efforts focused on neuroimaging biomarkers aim to enhance our understanding of schizophrenia.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1333-1352"},"PeriodicalIF":5.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11365900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140874752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxytocinergic Control of a Hypothalamic Social Fear Circuitry. 下丘脑社交恐惧回路的催产素能控制

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-09-01 Epub Date: 2024-05-20 DOI: 10.1007/s12264-024-01228-9

Junqiang Zheng, Xingying Wu, Han Xu

引用次数: 0

Morphological Tracing and Functional Identification of Monosynaptic Connections in the Brain: A Comprehensive Guide. 大脑单突触连接的形态追踪和功能鉴定：综合指南》。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-09-01 Epub Date: 2024-05-03 DOI: 10.1007/s12264-024-01196-0

Yuanyuan Li, Yuanyuan Fang, Kaiyuan Li, Hongbin Yang, Shumin Duan, Li Sun

{"title":"Morphological Tracing and Functional Identification of Monosynaptic Connections in the Brain: A Comprehensive Guide.","authors":"Yuanyuan Li, Yuanyuan Fang, Kaiyuan Li, Hongbin Yang, Shumin Duan, Li Sun","doi":"10.1007/s12264-024-01196-0","DOIUrl":"10.1007/s12264-024-01196-0","url":null,"abstract":"Behavioral studies play a crucial role in unraveling the mechanisms underlying brain function. Recent advances in optogenetics, neuronal typing and labeling, and circuit tracing have facilitated the dissection of the neural circuitry involved in various important behaviors. The identification of monosynaptic connections, both upstream and downstream of specific neurons, serves as the foundation for understanding complex neural circuits and studying behavioral mechanisms. However, the practical implementation and mechanistic understanding of monosynaptic connection tracing techniques and functional identification remain challenging, particularly for inexperienced researchers. Improper application of these methods and misinterpretation of results can impede experimental progress and lead to erroneous conclusions. In this paper, we present a comprehensive description of the principles, specific operational details, and key steps involved in tracing anterograde and retrograde monosynaptic connections. We outline the process of functionally identifying monosynaptic connections through the integration of optogenetics and electrophysiological techniques, providing practical guidance for researchers.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1364-1378"},"PeriodicalIF":5.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11365912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140868946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STED Imaging of Vesicular Endocytosis in the Synapse. 对突触中的囊泡内吞进行 STED 成像。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-09-01 Epub Date: 2024-07-08 DOI: 10.1007/s12264-024-01254-7

Shaoqin Hu, Zhenli Xie, Bianbian Wang, Yang Chen, Zexin Jing, Ying Hao, Jingyu Yao, Xuanang Wu, Jingxiao Huo, Anqi Wei, Yuhao Qin, Nan Dong, Chaowen Zheng, Qian Song, Jiangang Long, Xinjiang Kang, Changhe Wang, Huadong Xu

引用次数: 0