Neuroscience bulletin最新文献_第10页

Combined Study of Behavior and Spike Discharges Associated with Negative Emotions in Mice. 小鼠负性情绪相关行为与脉冲放电的联合研究。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-15 DOI: 10.1007/s12264-025-01455-8

Jinru Xin, Xinmiao Wang, Xuechun Meng, Ling Liu, Mingqing Liu, Huangrui Xiong, Aiping Liu, Ji Liu

{"title":"Combined Study of Behavior and Spike Discharges Associated with Negative Emotions in Mice.","authors":"Jinru Xin, Xinmiao Wang, Xuechun Meng, Ling Liu, Mingqing Liu, Huangrui Xiong, Aiping Liu, Ji Liu","doi":"10.1007/s12264-025-01455-8","DOIUrl":"https://doi.org/10.1007/s12264-025-01455-8","url":null,"abstract":"In modern society, people are increasingly exposed to chronic stress, leading to various mental disorders. However, the activities of brain regions, especially neural firing patterns related to specific behaviors, remain unclear. In this study, we introduce a novel approach, NeuroSync, which integrates open-field behavioral testing with electrophysiological recordings from emotion-related brain regions, specifically the central amygdala and the paraventricular nucleus of the hypothalamus, to explore the mechanisms of negative emotions induced by chronic stress in mice. By applying machine vision techniques, we quantified behaviors in the open field, and signal processing algorithms elucidated the neural underpinnings of the observed behaviors. Synchronizing behavioral and electrophysiological data revealed significant correlations between neural firing patterns and stress-related behaviors, providing insights into real-time brain activity underlying behavioral responses. This research combines deep learning and machine learning to synchronize high-resolution video and electrophysiological data, offering new insights into neural-behavioral dynamics under chronic stress conditions.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liquid-Liquid Phase Separation in Hereditary Hearing Loss. 遗传性听力损失的液-液相分离。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-09 DOI: 10.1007/s12264-025-01446-9

Kefan Tao, Yanjun Zong, Xiaozhou Liu, Xinyu Shi, Zhengdong Zhao, Yu Sun

引用次数: 0

Astrocyte-Derived CXCL10 Induces Neuronal Tau Hyperphosphorylation and Cognitive Impairments in Sepsis. 星形胶质细胞衍生的CXCL10在败血症中诱导神经元Tau过度磷酸化和认知障碍。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-02 DOI: 10.1007/s12264-025-01445-w

Cuiping Guo, Hang Ruan, Wensheng Li, Yi Liu, Abdoul Razak Yacoubou Mahaman, Qian Guo, You Zhou, Rong Liu, Jianzhi Wang, Chenliang Zhou, Xiaochuan Wang, Shusheng Li

{"title":"Astrocyte-Derived CXCL10 Induces Neuronal Tau Hyperphosphorylation and Cognitive Impairments in Sepsis.","authors":"Cuiping Guo, Hang Ruan, Wensheng Li, Yi Liu, Abdoul Razak Yacoubou Mahaman, Qian Guo, You Zhou, Rong Liu, Jianzhi Wang, Chenliang Zhou, Xiaochuan Wang, Shusheng Li","doi":"10.1007/s12264-025-01445-w","DOIUrl":"https://doi.org/10.1007/s12264-025-01445-w","url":null,"abstract":"Sepsis-associated encephalopathy (SAE) is a severe neurological syndrome marked by widespread brain dysfunctions due to sepsis, yet the underlying mechanisms remain elusive. The current study, using a Lipopolysaccharide (LPS)-induced septic rat model, revealed the hyperphosphorylation of tau and cognitive impairments, accompanied by the release of inflammatory cytokines and activation of glial cells in the hippocampal dentate gyrus region of septic rats. Proteomic and bioinformatic analyses identified C-X-C motif chemokine ligand 10(CXCL10) as a central regulator of neuroinflammation. LPS triggered CXCL10 secretion in astrocytes, and astrocyte-conditioned medium from LPS-treated astrocytes induced tau hyperphosphorylation and synaptic deficits. Recombinant CXCL10 recapitulated these effects in vitro and in vivo. Blocking CXCL10-CXCR3 interaction reversed tau phosphorylation, synaptic impairment, and cognitive decline. Mechanistically, CXCL10-CXCR3 interaction activated CaMKII, driving tau hyperphosphorylation, while CaMKII inhibition restored synaptic protein levels. These findings establish CXCL10 as a key driver of tau pathology in SAE and suggest CXCL10-CXCR3 as a therapeutic target for sepsis-induced cognitive impairments.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144541605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The 5-HT Descending Facilitation System Contributes to the Disinhibition of Spinal PKCγ Neurons and Neuropathic Allodynia via 5-HT_2C Receptors. 5-羟色胺下降促进系统通过5-羟色胺受体参与脊髓pkc - γ神经元和神经性异常性疼痛的解除抑制。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-01 Epub Date: 2025-03-16 DOI: 10.1007/s12264-025-01383-7

Xiao Zhang, Xiao-Lan He, Zhen-Hua Jiang, Jing Qi, Chen-Chen Huang, Jian-Shuai Zhao, Nan Gu, Yan Lu, Qun Wang

{"title":"The 5-HT Descending Facilitation System Contributes to the Disinhibition of Spinal PKCγ Neurons and Neuropathic Allodynia via 5-HT2C Receptors.","authors":"Xiao Zhang, Xiao-Lan He, Zhen-Hua Jiang, Jing Qi, Chen-Chen Huang, Jian-Shuai Zhao, Nan Gu, Yan Lu, Qun Wang","doi":"10.1007/s12264-025-01383-7","DOIUrl":"10.1007/s12264-025-01383-7","url":null,"abstract":"Neuropathic pain, often featuring allodynia, imposes significant physical and psychological burdens on patients, with limited treatments due to unclear central mechanisms. Addressing this challenge remains a crucial unsolved issue in pain medicine. Our previous study, using protein kinase C gamma (PKCγ)-tdTomato mice, highlights the spinal feedforward inhibitory circuit involving PKCγ neurons in gating neuropathic allodynia. However, the regulatory mechanisms governing this circuit necessitate further elucidation. We used diverse transgenic mice and advanced techniques to uncover the regulatory role of the descending serotonin (5-HT) facilitation system on spinal PKCγ neurons. Our findings revealed that 5-HT neurons from the rostral ventromedial medulla hyperpolarize spinal inhibitory interneurons via 5-HT2C receptors, disinhibiting the feedforward inhibitory circuit involving PKCγ neurons and exacerbating allodynia. Inhibiting spinal 5-HT2C receptors restored the feedforward inhibitory circuit, effectively preventing neuropathic allodynia. These insights offer promising therapeutic targets for neuropathic allodynia management, emphasizing the potential of spinal 5-HT2C receptors as a novel avenue for intervention.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1161-1180"},"PeriodicalIF":5.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting 5-HT to Alleviate Dose-Limiting Neurotoxicity in Nab-Paclitaxel-Based Chemotherapy. 靶向5-HT减轻nab -紫杉醇化疗的剂量限制性神经毒性。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-01 Epub Date: 2025-05-14 DOI: 10.1007/s12264-025-01398-0

Shuangyue Pan, Yu Cai, Ronghui Liu, Shuting Jiang, Hongyang Zhao, Jiahong Jiang, Zhen Lin, Qian Liu, Hongrui Lu, Shuhui Liang, Weijiao Fan, Xiaochen Chen, Yejing Wu, Fangqian Wang, Zheling Chen, Ronggui Hu, Liu Yang

{"title":"Targeting 5-HT to Alleviate Dose-Limiting Neurotoxicity in Nab-Paclitaxel-Based Chemotherapy.","authors":"Shuangyue Pan, Yu Cai, Ronghui Liu, Shuting Jiang, Hongyang Zhao, Jiahong Jiang, Zhen Lin, Qian Liu, Hongrui Lu, Shuhui Liang, Weijiao Fan, Xiaochen Chen, Yejing Wu, Fangqian Wang, Zheling Chen, Ronggui Hu, Liu Yang","doi":"10.1007/s12264-025-01398-0","DOIUrl":"10.1007/s12264-025-01398-0","url":null,"abstract":"Chemotherapy-induced peripheral neurotoxicity (CIPN) is a severe dose-limiting adverse event of chemotherapy. Presently, the mechanism underlying the induction of CIPN remains unclear, and no effective treatment is available. In this study, through metabolomics analyses, we found that nab-paclitaxel therapy markedly increased serum serotonin [5-hydroxtryptamine (5-HT)] levels in both cancer patients and mice compared to the respective controls. Furthermore, nab-paclitaxel-treated enterochromaffin (EC) cells showed increased 5-HT synthesis, and serotonin-treated Schwann cells showed damage, as indicated by the activation of CREB3L3/MMP3/FAS signaling. Venlafaxine, an inhibitor of serotonin and norepinephrine reuptake, was found to protect against nerve injury by suppressing the activation of CREB3L3/MMP3/FAS signaling in Schwann cells. Remarkably, venlafaxine was found to significantly alleviate nab-paclitaxel-induced CIPN in patients without affecting the clinical efficacy of chemotherapy. In summary, our study reveals that EC cell-derived 5-HT plays a critical role in nab-paclitaxel-related neurotoxic lesions, and venlafaxine co-administration represents a novel approach to treating chronic cumulative neurotoxicity commonly reported in nab-paclitaxel-based chemotherapy.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1229-1245"},"PeriodicalIF":5.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oligodendrocyte Precursor Cell-Specific HMGB1 Knockout Reduces Immune Cell Infiltration and Demyelination in Experimental Autoimmune Encephalomyelitis Models. 实验性自身免疫性脑脊髓炎模型中少突胶质前细胞特异性HMGB1敲除减少免疫细胞浸润和脱髓鞘

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-01 Epub Date: 2025-03-20 DOI: 10.1007/s12264-025-01381-9

Gyuree Kim, JiHye Seo, Bokyung Kim, Young-Ho Park, Hong Jun Lee, Fuzheng Guo, Dong-Seok Lee

{"title":"Oligodendrocyte Precursor Cell-Specific HMGB1 Knockout Reduces Immune Cell Infiltration and Demyelination in Experimental Autoimmune Encephalomyelitis Models.","authors":"Gyuree Kim, JiHye Seo, Bokyung Kim, Young-Ho Park, Hong Jun Lee, Fuzheng Guo, Dong-Seok Lee","doi":"10.1007/s12264-025-01381-9","DOIUrl":"10.1007/s12264-025-01381-9","url":null,"abstract":"Infiltration and activation of peripheral immune cells are critical in the progression of multiple sclerosis and its experimental animal model, experimental autoimmune encephalomyelitis (EAE). This study investigates the role of high mobility group box 1 (HMGB1) in oligodendrocyte precursor cells (OPCs) in modulating pathogenic T cells infiltrating the central nervous system through the blood-brain barrier (BBB) by using OPC-specific HMGB1 knockout (KO) mice. We found that HMGB1 released from OPCs promotes BBB disruption, subsequently allowing increased immune cell infiltration. The migration of CD4+ T cells isolated from EAE-induced mice was enhanced when co-cultured with OPCs compared to oligodendrocytes (OLs). OPC-specific HMGB1 KO mice exhibited lower BBB permeability and reduced immune cell infiltration into the CNS, leading to less damage to the myelin sheath and mitigated EAE progression. CD4+ T cell migration was also reduced when co-cultured with HMGB1 knock-out OPCs. Our findings reveal that HMGB1 secretion from OPCs is crucial for regulating immune cell infiltration and provides insights into the immunomodulatory function of OPCs in autoimmune diseases.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1145-1160"},"PeriodicalIF":5.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Strategies for Cognitive Enhancement via Noninvasive Neuromodulation. 通过无创神经调节增强认知的新策略。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-01 Epub Date: 2025-04-21 DOI: 10.1007/s12264-025-01394-4

Hongwei Li, Kun Zhao, Yong Liu

引用次数: 0

Psilocybin and Obsessive-Compulsive Disorder: Exploring New Therapeutic Horizons. 裸盖菇素和强迫症：探索新的治疗视野。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-01 Epub Date: 2025-05-14 DOI: 10.1007/s12264-025-01415-2

Longwei Yang, Haohong Li, Xiaohui Wang

引用次数: 0

Imaging and Quantifying the Diversity of Native NMDA Receptors. 天然NMDA受体的成像和定量多样性。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-01 Epub Date: 2025-04-30 DOI: 10.1007/s12264-025-01395-3

Sophie Shi, David Stroebel, Laetitia Mony, Pierre Paoletti

引用次数: 0

Single-Nucleus Transcriptomics of the Nucleus Accumbens Reveals Cell-Type-Specific Dysregulation in Adolescent Macaques with Depressive-Like Behaviors. 伏隔核的单核转录组学揭示了具有抑郁样行为的青春期猕猴细胞类型特异性失调。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-01 Epub Date: 2025-05-21 DOI: 10.1007/s12264-025-01412-5

Teng Teng, Qingyuan Wu, Bangmin Yin, Jushuang Zhang, Xuemei Li, Lige Zhang, Xinyu Zhou, Peng Xie

{"title":"Single-Nucleus Transcriptomics of the Nucleus Accumbens Reveals Cell-Type-Specific Dysregulation in Adolescent Macaques with Depressive-Like Behaviors.","authors":"Teng Teng, Qingyuan Wu, Bangmin Yin, Jushuang Zhang, Xuemei Li, Lige Zhang, Xinyu Zhou, Peng Xie","doi":"10.1007/s12264-025-01412-5","DOIUrl":"10.1007/s12264-025-01412-5","url":null,"abstract":"Adolescent depression is increasingly recognized as a serious mental health disorder with distinct clinical and molecular features. Using single-nucleus RNA sequencing, we identified cell-specific transcriptomic changes in the nucleus accumbens (NAc), particularly in astrocytes, of adolescent macaques exhibiting depressive-like behaviors. The level of diacylglycerol kinase beta was significantly reduced in neurons and glial cells of depressed macaques, while FKBP5 levels increased in glial cells. Disruption of GABAergic synapses and disruption of D-glutamine and D-glutamate metabolism were linked to depressive phenotypes in medium spiny neurons (MSNs) and subtypes of astrocytes. Communication pathways between astrocytes and D1/D2-MSNs were also disrupted, involving factors like bone morphogenetic protein-6 and Erb-B2 receptor tyrosine kinase-4. Bulk transcriptomic and proteomic analyses corroborated these findings, and FKBP5 upregulation was confirmed by qRT-PCR, western blotting, and immunofluorescence in the NAc of rats and macaques with chronic unpredictable mild stress. Our results highlight the specific roles of different cell types in adolescent depression in the NAc, offering potential targets for new antidepressant therapies.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1127-1144"},"PeriodicalIF":5.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0