Neuroscience bulletin最新文献_第9页

Accurate Machine Learning-based Monitoring of Anesthesia Depth with EEG Recording 利用脑电图记录对麻醉深度进行基于机器学习的精确监测

IF 5.6 2区医学

Neuroscience bulletin Pub Date : 2024-09-17 DOI: 10.1007/s12264-024-01297-w

Zhiyi Tu, Yuehan Zhang, Xueyang Lv, Yanyan Wang, Tingting Zhang, Juan Wang, Xinren Yu, Pei Chen, Suocheng Pang, Shengtian Li, Xiongjie Yu, Xuan Zhao

{"title":"Accurate Machine Learning-based Monitoring of Anesthesia Depth with EEG Recording","authors":"Zhiyi Tu, Yuehan Zhang, Xueyang Lv, Yanyan Wang, Tingting Zhang, Juan Wang, Xinren Yu, Pei Chen, Suocheng Pang, Shengtian Li, Xiongjie Yu, Xuan Zhao","doi":"10.1007/s12264-024-01297-w","DOIUrl":"https://doi.org/10.1007/s12264-024-01297-w","url":null,"abstract":"General anesthesia, pivotal for surgical procedures, requires precise depth monitoring to mitigate risks ranging from intraoperative awareness to postoperative cognitive impairments. Traditional assessment methods, relying on physiological indicators or behavioral responses, fall short of accurately capturing the nuanced states of unconsciousness. This study introduces a machine learning-based approach to decode anesthesia depth, leveraging EEG data across different anesthesia states induced by propofol and esketamine in rats. Our findings demonstrate the model’s robust predictive accuracy, underscored by a novel intra-subject dataset partitioning and a 5-fold cross-validation method. The research diverges from conventional monitoring by utilizing anesthetic infusion rates as objective indicators of anesthesia states, highlighting distinct EEG patterns and enhancing prediction accuracy. Moreover, the model’s ability to generalize across individuals suggests its potential for broad clinical application, distinguishing between anesthetic agents and their depths. Despite relying on rat EEG data, which poses questions about real-world applicability, our approach marks a significant advance in anesthesia monitoring.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":"57 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142269035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GABAergic Retinal Ganglion Cells Projecting to the Superior Colliculus Mediate the Looming-Evoked Flight Response 投射到上丘的GABA能视网膜神经节细胞介导卢明诱发的飞行反应

IF 5.6 2区医学

Neuroscience bulletin Pub Date : 2024-09-16 DOI: 10.1007/s12264-024-01295-y

Man Yuan, Gao Tan, Danrui Cai, Xue Luo, Kejiong Shen, Qinqin Deng, Xinlan Lei, Wen-Bo Zeng, Min-Hua Luo, Lu Huang, Chaoran Ren, Yin Shen

{"title":"GABAergic Retinal Ganglion Cells Projecting to the Superior Colliculus Mediate the Looming-Evoked Flight Response","authors":"Man Yuan, Gao Tan, Danrui Cai, Xue Luo, Kejiong Shen, Qinqin Deng, Xinlan Lei, Wen-Bo Zeng, Min-Hua Luo, Lu Huang, Chaoran Ren, Yin Shen","doi":"10.1007/s12264-024-01295-y","DOIUrl":"https://doi.org/10.1007/s12264-024-01295-y","url":null,"abstract":"The looming stimulus-evoked flight response to approaching predators is a defensive behavior in most animals. However, how looming stimuli are detected in the retina and transmitted to the brain remains unclear. Here, we report that a group of GABAergic retinal ganglion cells (RGCs) projecting to the superior colliculus (SC) transmit looming signals from the retina to the brain, mediating the looming-evoked flight behavior by releasing GABA. GAD2-Cre and vGAT-Cre transgenic mice were used in combination with Cre-activated anterograde or retrograde tracer viruses to map the inputs to specific GABAergic RGC circuits. Optogenetic technology was used to assess the function of SC-projecting GABAergic RGCs (scpgRGCs) in the SC. FDIO-DTA (Flp-dependent Double-Floxed Inverted Open reading frame-Diphtheria toxin) combined with the FLP (Florfenicol, Lincomycin & Prednisolone) approach was used to ablate or silence scpgRGCs. In the mouse retina, GABAergic RGCs project to different brain areas, including the SC. ScpgRGCs are monosynaptically connected to parvalbumin-positive SC neurons known to be required for the looming-evoked flight response. Optogenetic activation of scpgRGCs triggers GABA-mediated inhibition in SC neurons. Ablation or silencing of scpgRGCs compromises looming-evoked flight responses without affecting image-forming functions. Our study reveals that scpgRGCs control the looming-evoked flight response by regulating SC neurons via GABA, providing novel insight into the regulation of innate defensive behaviors.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":"50 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142269029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autophagy in Oligodendrocyte Lineage Cells Controls Oligodendrocyte Numbers and Myelin Integrity in an Age-dependent Manner 少突胶质细胞系细胞的自噬以年龄依赖性方式控制少突胶质细胞数量和髓鞘完整性

IF 5.6 2区医学

Neuroscience bulletin Pub Date : 2024-09-16 DOI: 10.1007/s12264-024-01292-1

Hong Chen, Gang Yang, De-En Xu, Yu-tong Du, Chao Zhu, Hua Hu, Li Luo, Lei Feng, Wenhui Huang, Yan-Yun Sun, Quan-Hong Ma

{"title":"Autophagy in Oligodendrocyte Lineage Cells Controls Oligodendrocyte Numbers and Myelin Integrity in an Age-dependent Manner","authors":"Hong Chen, Gang Yang, De-En Xu, Yu-tong Du, Chao Zhu, Hua Hu, Li Luo, Lei Feng, Wenhui Huang, Yan-Yun Sun, Quan-Hong Ma","doi":"10.1007/s12264-024-01292-1","DOIUrl":"https://doi.org/10.1007/s12264-024-01292-1","url":null,"abstract":"Oligodendrocyte lineage cells, including oligodendrocyte precursor cells (OPCs) and oligodendrocytes (OLs), are essential in establishing and maintaining brain circuits. Autophagy is a conserved process that keeps the quality of organelles and proteostasis. The role of autophagy in oligodendrocyte lineage cells remains unclear. The present study shows that autophagy is required to maintain the number of OPCs/OLs and myelin integrity during brain aging. Inactivation of autophagy in oligodendrocyte lineage cells increases the number of OPCs/OLs in the developing brain while exaggerating the loss of OPCs/OLs with brain aging. Inactivation of autophagy in oligodendrocyte lineage cells impairs the turnover of myelin basic protein (MBP). It causes MBP to accumulate in the cytoplasm as multimeric aggregates and fails to be incorporated into integral myelin, which is associated with attenuated endocytic recycling. Inactivation of autophagy in oligodendrocyte lineage cells impairs myelin integrity and causes demyelination. Thus, this study shows autophagy is required to maintain myelin quality during aging by controlling the turnover of myelin components.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":"34 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142269030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melatonin Ameliorates Abnormal Sleep-Wake Behavior via Facilitating Lipid Metabolism in a Zebrafish Model of Parkinson’s Disease 褪黑激素通过促进帕金森病斑马鱼模型中的脂质代谢改善异常睡眠-觉醒行为

IF 5.6 2区医学

Neuroscience bulletin Pub Date : 2024-09-16 DOI: 10.1007/s12264-024-01299-8

Meng-Zhu Pang, Han-Xing Li, Xue-Qin Dai, Xiao-Bo Wang, Jun-Yi Liu, Yun Shen, Xing Xu, Zhao-Min Zhong, Han Wang, Chun-Feng Liu, Fen Wang

引用次数: 0

Spatiotemporal Mapping of the Oxytocin Receptor at Single-Cell Resolution in the Postnatally Developing Mouse Brain 以单细胞分辨率绘制产后发育小鼠大脑中催产素受体的时空分布图

IF 5.6 2区医学

Neuroscience bulletin Pub Date : 2024-09-15 DOI: 10.1007/s12264-024-01296-x

Hao Li, Ying Li, Ting Wang, Shen Li, Heli Liu, Shuyi Ning, Wei Shen, Zhe Zhao, Haitao Wu

{"title":"Spatiotemporal Mapping of the Oxytocin Receptor at Single-Cell Resolution in the Postnatally Developing Mouse Brain","authors":"Hao Li, Ying Li, Ting Wang, Shen Li, Heli Liu, Shuyi Ning, Wei Shen, Zhe Zhao, Haitao Wu","doi":"10.1007/s12264-024-01296-x","DOIUrl":"https://doi.org/10.1007/s12264-024-01296-x","url":null,"abstract":"The oxytocin receptor (OXTR) has garnered increasing attention for its role in regulating both mature behaviors and brain development. It has been established that OXTR mediates a range of effects that are region-specific or period-specific. However, the current studies of OXTR expression patterns in mice only provide limited help due to limitations in resolution. Therefore, our objective was to generate a comprehensive, high-resolution spatiotemporal expression map of Oxtr mRNA across the entire developing mouse brain. We applied RNAscope in situ hybridization to investigate the spatiotemporal expression pattern of Oxtr in the brains of male mice at six distinct postnatal developmental stages (P7, P14, P21, P28, P42, P56). We provide detailed descriptions of Oxtr expression patterns in key brain regions, including the cortex, basal forebrain, hippocampus, and amygdaloid complex, with a focus on the precise localization of Oxtr+ cells and the variance of expression between different neurons. Furthermore, we identified some neuronal populations with high Oxtr expression levels that have been little studied, including glutamatergic neurons in the ventral dentate gyrus, Vgat+Oxtr+ cells in the basal forebrain, and GABAergic neurons in layers 4/5 of the cortex. Our study provides a novel perspective for understanding the distribution of Oxtr and encourages further investigations into its functions.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":"222 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142269034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting Brain Endothelial Gasdermin D: A Shortcut to Remodel the Blood-Brain Barrier 靶向脑内皮气敏素 D：重塑血脑屏障的捷径

IF 5.6 2区医学

Neuroscience bulletin Pub Date : 2024-09-14 DOI: 10.1007/s12264-024-01300-4

Zhou-Yue Wu, Yi-Fan Luo, Ya-Ping Lu, Yi-Xuan Zhang, Feng Han

引用次数: 0

STIM Proteins: The Gas and Brake of Calcium Entry in Neurons STIM 蛋白：神经元钙离子输入的 "油门 "和 "刹车

IF 5.6 2区医学

Neuroscience bulletin Pub Date : 2024-09-12 DOI: 10.1007/s12264-024-01272-5

Ksenia Skobeleva, Guanghui Wang, Elena Kaznacheyeva

{"title":"STIM Proteins: The Gas and Brake of Calcium Entry in Neurons","authors":"Ksenia Skobeleva, Guanghui Wang, Elena Kaznacheyeva","doi":"10.1007/s12264-024-01272-5","DOIUrl":"https://doi.org/10.1007/s12264-024-01272-5","url":null,"abstract":"Stromal interaction molecules (STIM)s are Ca2+ sensors in internal Ca2+ stores of the endoplasmic reticulum. They activate the store-operated Ca2+ channels, which are the main source of Ca2+ entry in non-excitable cells. Moreover, STIM proteins interact with other Ca2+ channel subunits and active transporters, making STIMs an important intermediate molecule in orchestrating a wide variety of Ca2+ influxes into excitable cells. Nevertheless, little is known about the role of STIM proteins in brain functioning. Being involved in many signaling pathways, STIMs replenish internal Ca2+ stores in neurons and mediate synaptic transmission and neuronal excitability. Ca2+ dyshomeostasis is a signature of many pathological conditions of the brain, including neurodegenerative diseases, injuries, stroke, and epilepsy. STIMs play a role in these disturbances not only by supporting abnormal store-operated Ca2+ entry but also by regulating Ca2+ influx through other channels. Here, we review the present knowledge of STIMs in neurons and their involvement in brain pathology.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":"81 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Constructing A Theoretical Model to Bridge Neural Transition with a State Switch in Bipolar Disorder 构建理论模型，将双相情感障碍的神经转换与状态转换联系起来

IF 5.6 2区医学

Neuroscience bulletin Pub Date : 2024-09-12 DOI: 10.1007/s12264-024-01298-9

Xiaonan Guo, Lizichen Chen, Jianbo Lai, Shaohua Hu

引用次数: 0

Memory Reconsolidation Updating in Substance Addiction: Applications, Mechanisms, and Future Prospects for Clinical Therapeutics 物质成瘾中的记忆再巩固更新：临床疗法的应用、机制和未来前景

IF 5.6 2区医学

Neuroscience bulletin Pub Date : 2024-09-12 DOI: 10.1007/s12264-024-01294-z

Shihao Huang, Xiaoxing Liu, Zhonghao Li, Yue Si, Liping Yang, Jiahui Deng, Yixiao Luo, Yan-Xue Xue, Lin Lu

{"title":"Memory Reconsolidation Updating in Substance Addiction: Applications, Mechanisms, and Future Prospects for Clinical Therapeutics","authors":"Shihao Huang, Xiaoxing Liu, Zhonghao Li, Yue Si, Liping Yang, Jiahui Deng, Yixiao Luo, Yan-Xue Xue, Lin Lu","doi":"10.1007/s12264-024-01294-z","DOIUrl":"https://doi.org/10.1007/s12264-024-01294-z","url":null,"abstract":"Persistent and maladaptive drug-related memories represent a key component in drug addiction. Converging evidence from both preclinical and clinical studies has demonstrated the potential efficacy of the memory reconsolidation updating procedure (MRUP), a non-pharmacological strategy intertwining two distinct memory processes: reconsolidation and extinction—alternatively termed “the memory retrieval-extinction procedure”. This procedure presents a promising approach to attenuate, if not erase, entrenched drug memories and prevent relapse. The present review delineates the applications, molecular underpinnings, and operational boundaries of MRUP in the context of various forms of substance dependence. Furthermore, we critically examine the methodological limitations of MRUP, postulating potential refinement to optimize its therapeutic efficacy. In addition, we also look at the potential integration of MRUP and neurostimulation treatments in the domain of substance addiction. Overall, existing studies underscore the significant potential of MRUP, suggesting that interventions predicated on it could herald a promising avenue to enhance clinical outcomes in substance addiction therapy.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":"2016 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Cerebellum Modulates Mood with Movement. 小脑通过运动调节情绪

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-09-01 Epub Date: 2024-05-20 DOI: 10.1007/s12264-024-01221-2

Shaofei Jiang, Haitao Wu

引用次数: 0