Neuroscience bulletin最新文献_第9页

Non-invasive Modulation of Deep Brain Nuclei by Temporal Interference Stimulation. 颞叶干扰刺激对脑深部核的无创调节。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2025-02-08 DOI: 10.1007/s12264-025-01359-7

Long Li, Hao Bai, Linyan Wu, Liang Zheng, Liang Huang, Yang Li, Wenlong Zhang, Jue Wang, Shunnan Ge, Yan Qu, Tian Liu

引用次数: 0

"CATCH ME IF YOU CAN": Unlocking the Hidden Key in Obesity Intervention via the Vagus-Jejunum Axis. “如果你能抓住我”：通过迷走-空肠轴解开肥胖干预的隐藏钥匙。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2025-03-01 DOI: 10.1007/s12264-025-01368-6

Shuo Zhang, Lingyu Xu, Yila Ding, Cenglin Xu

引用次数: 0

Embracing Internal States: A Review of Optimization of Repetitive Transcranial Magnetic Stimulation for Treating Depression. 拥抱内在状态：重复经颅磁刺激治疗抑郁症的优化研究综述。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2025-02-20 DOI: 10.1007/s12264-024-01347-3

Tingting Wu, Qiuxuan Yu, Ximei Zhu, Yinjiao Li, Mingyue Zhang, Jiahui Deng, Lin Lu

引用次数: 0

Prediction of Pharmacoresistance in Drug-Naïve Temporal Lobe Epilepsy Using Ictal EEGs Based on Convolutional Neural Network. 基于卷积神经网络的癫痫发作脑电图预测Drug-Naïve颞叶癫痫患者药物耐药。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2025-01-27 DOI: 10.1007/s12264-025-01350-2

Yiwei Gong, Zheng Zhang, Yuanzhi Yang, Shuo Zhang, Ruifeng Zheng, Xin Li, Xiaoyun Qiu, Yang Zheng, Shuang Wang, Wenyu Liu, Fan Fei, Heming Cheng, Yi Wang, Dong Zhou, Kejie Huang, Zhong Chen, Cenglin Xu

{"title":"Prediction of Pharmacoresistance in Drug-Naïve Temporal Lobe Epilepsy Using Ictal EEGs Based on Convolutional Neural Network.","authors":"Yiwei Gong, Zheng Zhang, Yuanzhi Yang, Shuo Zhang, Ruifeng Zheng, Xin Li, Xiaoyun Qiu, Yang Zheng, Shuang Wang, Wenyu Liu, Fan Fei, Heming Cheng, Yi Wang, Dong Zhou, Kejie Huang, Zhong Chen, Cenglin Xu","doi":"10.1007/s12264-025-01350-2","DOIUrl":"10.1007/s12264-025-01350-2","url":null,"abstract":"Approximately 30%-40% of epilepsy patients do not respond well to adequate anti-seizure medications (ASMs), a condition known as pharmacoresistant epilepsy. The management of pharmacoresistant epilepsy remains an intractable issue in the clinic. Its early prediction is important for prevention and diagnosis. However, it still lacks effective predictors and approaches. Here, a classical model of pharmacoresistant temporal lobe epilepsy (TLE) was established to screen pharmacoresistant and pharmaco-responsive individuals by applying phenytoin to amygdaloid-kindled rats. Ictal electroencephalograms (EEGs) recorded before phenytoin treatment were analyzed. Based on ictal EEGs from pharmacoresistant and pharmaco-responsive rats, a convolutional neural network predictive model was constructed to predict pharmacoresistance, and achieved 78% prediction accuracy. We further found the ictal EEGs from pharmacoresistant rats have a lower gamma-band power, which was verified in seizure EEGs from pharmacoresistant TLE patients. Prospectively, therapies targeting the subiculum in those predicted as \"pharmacoresistant\" individual rats significantly reduced the subsequent occurrence of pharmacoresistance. These results demonstrate a new methodology to predict whether TLE individuals become resistant to ASMs in a classic pharmacoresistant TLE model. This may be of translational importance for the precise management of pharmacoresistant TLE.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"790-804"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Glutamate-gated Chloride Channel Facilitates Sleep by Enhancing the Excitability of Two Pairs of Neurons in the Ventral Nerve Cord of Drosophila. 谷氨酸门控氯离子通道通过增强果蝇腹侧神经索两对神经元的兴奋性来促进睡眠。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-04-30 DOI: 10.1007/s12264-025-01397-1

Yaqian Fan, Yao Tian, Junhai Han

{"title":"The Glutamate-gated Chloride Channel Facilitates Sleep by Enhancing the Excitability of Two Pairs of Neurons in the Ventral Nerve Cord of Drosophila.","authors":"Yaqian Fan, Yao Tian, Junhai Han","doi":"10.1007/s12264-025-01397-1","DOIUrl":"https://doi.org/10.1007/s12264-025-01397-1","url":null,"abstract":"Sleep, an essential and evolutionarily conserved behavior, is regulated by numerous neurotransmitter systems. In mammals, glutamate serves as the wake-promoting signaling agent, whereas in Drosophila, it functions as the sleep-promoting signal. However, the precise molecular and cellular mechanisms through which glutamate promotes sleep remain elusive. Our study reveals that disruption of glutamate signaling significantly diminishes nocturnal sleep, and a neural cell-specific knockdown of the glutamate-gated chloride channel (GluClα) markedly reduces nocturnal sleep. We identified two pairs of neurons in the ventral nerve cord (VNC) that receive glutamate signaling input, and the GluClα derived from these neurons is crucial for sleep promotion. Furthermore, we demonstrated that GluClα mediates the glutamate-gated inhibitory input to these VNC neurons, thereby promoting sleep. Our findings elucidate that GluClα enhances nocturnal sleep by mediating the glutamate-gated inhibitory input to two pairs of VNC neurons, providing insights into the mechanism of sleep promotion in Drosophila.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Upregulation of NR2A in Glutamatergic VTA Neurons Contributes to Chronic Visceral Pain in Male Mice. 谷氨酸能VTA神经元NR2A的上调与雄性小鼠慢性内脏疼痛有关。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-04-28 DOI: 10.1007/s12264-025-01402-7

Meng-Ge Li, Shu-Ting Qu, Yang Yu, Zhenhua Xu, Fu-Chao Zhang, Yong-Chang Li, Rong Gao, Guang-Yin Xu

{"title":"Upregulation of NR2A in Glutamatergic VTA Neurons Contributes to Chronic Visceral Pain in Male Mice.","authors":"Meng-Ge Li, Shu-Ting Qu, Yang Yu, Zhenhua Xu, Fu-Chao Zhang, Yong-Chang Li, Rong Gao, Guang-Yin Xu","doi":"10.1007/s12264-025-01402-7","DOIUrl":"https://doi.org/10.1007/s12264-025-01402-7","url":null,"abstract":"Chronic visceral pain is a persistent and debilitating condition arising from dysfunction or sensitization of the visceral organs and their associated nervous pathways. Increasing evidence suggests that imbalances in central nervous system function play an essential role in the progression of visceral pain, but the exact mechanisms underlying the neural circuitry and molecular targets remain largely unexplored. In the present study, the ventral tegmental area (VTA) was shown to mediate visceral pain in mice. Visceral pain stimulation increased c-Fos expression and Ca2+ activity of glutamatergic VTA neurons, and optogenetic modulation of glutamatergic VTA neurons altered visceral pain. In particular, the upregulation of NMDA receptor 2A (NR2A) subunits within the VTA resulted in visceral pain in mice. Administration of a selective NR2A inhibitor decreased the number of visceral pain-induced c-Fos positive neurons and attenuated visceral pain. Pharmacology combined with chemogenetics further demonstrated that glutamatergic VTA neurons regulated visceral pain behaviors based on NR2A. In summary, our findings demonstrated that the upregulation of NR2A in glutamatergic VTA neurons plays a critical role in visceral pain. These insights provide a foundation for further comprehension of the neural circuits and molecular targets involved in chronic visceral pain and may pave the way for targeted therapies in chronic visceral pain.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancement of Ca²⁺ Signal Strength in Astrocytes in the Lateral Septum Improves Cognitive Disorders in Mice After Hemorrhagic Shock and Resuscitation. 外隔星形胶质细胞Ca2+信号强度的增强改善失血性休克和复苏后小鼠的认知障碍。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-04-25 DOI: 10.1007/s12264-025-01404-5

Wen-Guang Li, Lan-Xin Li, Rong-Xin Song, Xu-Peng Wang, Shi-Yan Jia, Xiao-Yi Ma, Jing-Yu Zhang, Gang-Feng Yin, Xiao-Ming Li, Li-Min Zhang

{"title":"Enhancement of Ca2+ Signal Strength in Astrocytes in the Lateral Septum Improves Cognitive Disorders in Mice After Hemorrhagic Shock and Resuscitation.","authors":"Wen-Guang Li, Lan-Xin Li, Rong-Xin Song, Xu-Peng Wang, Shi-Yan Jia, Xiao-Yi Ma, Jing-Yu Zhang, Gang-Feng Yin, Xiao-Ming Li, Li-Min Zhang","doi":"10.1007/s12264-025-01404-5","DOIUrl":"https://doi.org/10.1007/s12264-025-01404-5","url":null,"abstract":"Hemorrhagic shock is a common clinical emergency that can aggravate cell injury after resuscitation. Astrocytes are crucial for the survival of neurons because they regulate the surrounding ionic microenvironment of neurons. Although hemorrhagic shock and resuscitation (HSR) injury can impair cognition, it remains unclear how this insult directly affects astrocytes. In this study, we established an HSR model by bleeding and re-transfusion in mice. The social interaction test and new object recognition test were applied to evaluate post-operative cognitive changes, and the results suggest that mice experience cognitive impairment following exposure to HSR. In the HSR group, the power spectral density of β and γ oscillations decreased, and the coupling of the θ oscillation phase and γ oscillation amplitude was abnormal, which indicated abnormal neuronal oscillation and cognitive impairment after HSR exposure. In brief, cognitive impairment in mice is strongly correlated with Ca2+ signal strength in lateral septum astrocytes following HSR.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural Responses to Hypoxic Injury in a Vascularized Cerebral Organoid Model. 血管化脑类器官模型对缺氧损伤的神经反应。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-04-22 DOI: 10.1007/s12264-025-01396-2

Yang Li, Xin-Yao Sun, Peng-Ming Zeng, Zhen-Ge Luo

引用次数: 0

Evolution of the Rich Club Properties in Mouse, Macaque, and Human Brain Networks: A Study of Functional Integration, Segregation, and Balance. 富俱乐部属性在小鼠、猕猴和人类大脑网络中的进化：功能整合、分离和平衡的研究。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-04-13 DOI: 10.1007/s12264-025-01393-5

Xiaoru Zhang, Ming Song, Wentao Jiang, Yuheng Lu, Congying Chu, Wen Li, Haiyan Wang, Weiyang Shi, Yueheng Lan, Tianzi Jiang

引用次数: 0

Transcranial temporal interference stimulation precisely targets deep brain regions to regulate eye movements. 经颅颞干扰刺激精确地针对大脑深部区域来调节眼球运动。