Neuroscience bulletin最新文献_第9页

The 5-HT Descending Facilitation System Contributes to the Disinhibition of Spinal PKCγ Neurons and Neuropathic Allodynia via 5-HT_2C Receptors. 5-羟色胺下降促进系统通过5-羟色胺受体参与脊髓pkc - γ神经元和神经性异常性疼痛的解除抑制。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-03-16 DOI: 10.1007/s12264-025-01383-7

Xiao Zhang, Xiao-Lan He, Zhen-Hua Jiang, Jing Qi, Chen-Chen Huang, Jian-Shuai Zhao, Nan Gu, Yan Lu, Qun Wang

{"title":"The 5-HT Descending Facilitation System Contributes to the Disinhibition of Spinal PKCγ Neurons and Neuropathic Allodynia via 5-HT2C Receptors.","authors":"Xiao Zhang, Xiao-Lan He, Zhen-Hua Jiang, Jing Qi, Chen-Chen Huang, Jian-Shuai Zhao, Nan Gu, Yan Lu, Qun Wang","doi":"10.1007/s12264-025-01383-7","DOIUrl":"https://doi.org/10.1007/s12264-025-01383-7","url":null,"abstract":"Neuropathic pain, often featuring allodynia, imposes significant physical and psychological burdens on patients, with limited treatments due to unclear central mechanisms. Addressing this challenge remains a crucial unsolved issue in pain medicine. Our previous study, using protein kinase C gamma (PKCγ)-tdTomato mice, highlights the spinal feedforward inhibitory circuit involving PKCγ neurons in gating neuropathic allodynia. However, the regulatory mechanisms governing this circuit necessitate further elucidation. We used diverse transgenic mice and advanced techniques to uncover the regulatory role of the descending serotonin (5-HT) facilitation system on spinal PKCγ neurons. Our findings revealed that 5-HT neurons from the rostral ventromedial medulla hyperpolarize spinal inhibitory interneurons via 5-HT2C receptors, disinhibiting the feedforward inhibitory circuit involving PKCγ neurons and exacerbating allodynia. Inhibiting spinal 5-HT2C receptors restored the feedforward inhibitory circuit, effectively preventing neuropathic allodynia. These insights offer promising therapeutic targets for neuropathic allodynia management, emphasizing the potential of spinal 5-HT2C receptors as a novel avenue for intervention.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive Brain-wide Mapping of Afferent and Efferent Nuclei Associated with the Heart in the Mouse. 小鼠与心脏相关的传入和传出核的全脑综合制图。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-03-15 DOI: 10.1007/s12264-025-01384-6

Haiying Liu, Xin Huang, Ruixin Xia, Xin Zhao, Zimeng Li, Qian Liu, Congye Li, Honghui Mao, Wenting Wang, Shengxi Wu

{"title":"Comprehensive Brain-wide Mapping of Afferent and Efferent Nuclei Associated with the Heart in the Mouse.","authors":"Haiying Liu, Xin Huang, Ruixin Xia, Xin Zhao, Zimeng Li, Qian Liu, Congye Li, Honghui Mao, Wenting Wang, Shengxi Wu","doi":"10.1007/s12264-025-01384-6","DOIUrl":"https://doi.org/10.1007/s12264-025-01384-6","url":null,"abstract":"Normal heart function depends on complex regulation by the brain, and abnormalities in the brain‒heart axis affect various diseases, such as myocardial infarction and anxiety disorders. However, systematic tracking of the brain regions associated with the input and output of the heart is lacking. In this study, we injected retrograde transsynaptic pseudorabies virus (PRV) and anterograde transsynaptic herpes simplex virus (HSV) into the left ventricular wall of mice to identify the whole-brain regions associated with the input to and output from the heart. We successfully detected PRV and HSV expression in at least 170 brain subregions in both male and female mice. Sex differences were discovered mainly in the hypothalamus and medulla, with male mice exhibiting greater correlation and hierarchical clustering than female mice, indicating reduced similarity and increased modularity of virus expression patterns in male mice. Further graph theory and multiple linear regression analysis of different injection timelines revealed that hub regions of PRV had highly similar clusters, with different brain levels, suggesting a top-down, hierarchically transmitted neural control pattern of the heart. Hub regions of HSV had scattered clusters, with brain regions gathered in the cortex and brainstem, suggesting a bottom-up, leapfrog, multipoint neural sensing pattern of the heart. Both patterns contain many hub brain regions that have been previously overlooked in brain‒heart axis studies. These results provide brain targets for future research and will lead to deeper insight into the brain mechanisms involved in specific heart conditions.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Prefrontal and Posterior Parietal Cortex in Generating Multiple Step Saccades. 前额叶和后顶叶皮层在产生多步扫视中的作用。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-03-11 DOI: 10.1007/s12264-025-01377-5

Wenbo Ma, Zhaohuan Ding, Leixiao Feng, Xiaoli Li, Mingsha Zhang

引用次数: 0

Interleukin-33 Knockout Promotes High Mobility Group Box 1 Release from Astrocytes by Acetylation Mediated by P300/CBP-Associated Factor in Experimental Autoimmune Encephalomyelitis. 实验性自身免疫性脑脊髓炎中P300/ cbp相关因子介导的乙酰化介导的白细胞介素-33敲除促进星形胶质细胞高迁移率的Group Box 1释放

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-03-10 DOI: 10.1007/s12264-025-01374-8

Yifan Xiao, Liyan Hao, Xinyi Cao, Yibo Zhang, Qingqing Xu, Luyao Qin, Yixuan Zhang, Yangxingzi Wu, Hongyan Zhou, Mengjuan Wu, Mingshan Pi, Qi Xiong, Youhua Yang, Yuran Gui, Wei Liu, Fang Zheng, Xiji Shu, Yiyuan Xia

{"title":"Interleukin-33 Knockout Promotes High Mobility Group Box 1 Release from Astrocytes by Acetylation Mediated by P300/CBP-Associated Factor in Experimental Autoimmune Encephalomyelitis.","authors":"Yifan Xiao, Liyan Hao, Xinyi Cao, Yibo Zhang, Qingqing Xu, Luyao Qin, Yixuan Zhang, Yangxingzi Wu, Hongyan Zhou, Mengjuan Wu, Mingshan Pi, Qi Xiong, Youhua Yang, Yuran Gui, Wei Liu, Fang Zheng, Xiji Shu, Yiyuan Xia","doi":"10.1007/s12264-025-01374-8","DOIUrl":"https://doi.org/10.1007/s12264-025-01374-8","url":null,"abstract":"High mobility group box 1 (HMGB1), when released extracellularly, plays a pivotal role in the development of spinal cord synapses and exacerbates autoimmune diseases within the central nervous system. In experimental autoimmune encephalomyelitis (EAE), a condition that models multiple sclerosis, the levels of extracellular HMGB1 and interleukin-33 (IL-33) have been found to be inversely correlated. However, the mechanism by which IL-33 deficiency enhances HMGB1 release during EAE remains elusive. Our study elucidates a potential signaling pathway whereby the absence of IL-33 leads to increased binding of P300/CBP-associated factor with HMGB1 in the nuclei of astrocytes, upregulating HMGB1 acetylation and promoting its release from astrocyte nuclei in the spinal cord of EAE mice. Conversely, the addition of IL-33 counteracts the TNF-α-induced increase in HMGB1 and acetylated HMGB1 levels in primary astrocytes. These findings underscore the potential of IL-33-associated signaling pathways as a therapeutic target for EAE treatment.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain White Matter Changes in Non-demented Individuals with Color Discrimination Deficits and Their Association with Cognitive Impairment: A NODDI Study. 脑白质变化与认知障碍的关系：一项NODDI研究

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-03-07 DOI: 10.1007/s12264-025-01373-9

Jiejun Zhang, Peilin Huang, Lin Lin, Yingzhe Cheng, Weipin Weng, Jiahao Zheng, Yixin Sun, Shaofan Jiang, Xiaodong Pan

{"title":"Brain White Matter Changes in Non-demented Individuals with Color Discrimination Deficits and Their Association with Cognitive Impairment: A NODDI Study.","authors":"Jiejun Zhang, Peilin Huang, Lin Lin, Yingzhe Cheng, Weipin Weng, Jiahao Zheng, Yixin Sun, Shaofan Jiang, Xiaodong Pan","doi":"10.1007/s12264-025-01373-9","DOIUrl":"https://doi.org/10.1007/s12264-025-01373-9","url":null,"abstract":"Previous studies have found associations between color discrimination deficits and cognitive impairments besides aging. However, investigations into the microstructural pathology of brain white matter (WM) associated with these deficits remain limited. This study aimed to examine the microstructural characteristics of WM in the non-demented population with abnormal color discrimination, utilizing Neurite Orientation Dispersion and Density Imaging (NODDI), and to explore their correlations with cognitive functions and cognition-related plasma biomarkers. The tract-based spatial statistic analysis revealed significant differences in specific brain regions between the abnormal color discrimination group and the healthy controls, characterized by increased isotropic volume fraction and decreased neurite density index and orientation dispersion index. Further analysis of region-of-interest parameters revealed that the isotropic volume fraction in the bilateral anterior thalamic radiation, superior longitudinal fasciculus, cingulum, and forceps minor was significantly correlated with poorer performance on neuropsychological assessments and to varying degrees various cognition-related plasma biomarkers. These findings provide neuroimaging evidence that WM microstructural abnormalities in non-demented individuals with abnormal color discrimination are associated with cognitive dysfunction, potentially serving as early markers for cognitive decline.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Follistatin, A Novel Therapeutic Target for Chronic Pain. 卵泡listatin：治疗慢性疼痛的新靶点。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-03-02 DOI: 10.1007/s12264-025-01369-5

Huimin Nie, Boyi Liu

引用次数: 0

Correction to: Scorpion Venom Heat-Resistant Peptide is Neuroprotective Against Cerebral Ischemia-Reperfusion Injury in Association with the NMDA-MAPK Pathway. 更正：蝎毒耐热肽与NMDA-MAPK通路有关，对脑缺血再灌注损伤具有神经保护作用。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-03-01 DOI: 10.1007/s12264-024-01340-w

Xu-Gang Wang, Dan-Dan Zhu, Na Li, Yue-Lin Huang, Ying-Zi Wang, Ting Zhang, Chen-Mei Wang, Bin Wang, Yan Peng, Bi-Ying Ge, Shao Li, Jie Zhao

引用次数: 0

The Current State and Future Outlook of PET Tracers for AMPA Receptors. AMPA受体PET示踪剂的研究现状及展望。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-03-01 Epub Date: 2024-12-11 DOI: 10.1007/s12264-024-01332-w

Ling Li, Shenglin Wen, Ji Dai

引用次数: 0

YAP Signaling in Glia: Pivotal Roles in Neurological Development, Regeneration and Diseases. 胶质细胞中的 YAP 信号：神经发育、再生和疾病中的关键作用。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-03-01 Epub Date: 2024-11-06 DOI: 10.1007/s12264-024-01308-w

Lin Lin, Yinfeng Yuan, Zhihui Huang, Yongjie Wang

引用次数: 0

Single-Neuron Reconstruction of the Macaque Primary Motor Cortex Reveals the Diversity of Neuronal Morphology. 猕猴初级运动皮层单神经元重建揭示了神经元形态的多样性。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-03-01 Epub Date: 2025-01-28 DOI: 10.1007/s12264-025-01352-0

Siyu Li, Yan Shen, Yefei Chen, Zexuan Hong, Lewei Zhang, Lufeng Ding, Chao-Yu Yang, Xiaoyang Qi, Quqing Shen, Yanyang Xiao, Pak-Ming Lau, Zhonghua Lu, Fang Xu, Guo-Qiang Bi

引用次数: 0