Neuroscience bulletin最新文献_第9页

Temporal Variability Analysis of Cortical Blood Flow in Rats with Hyperacute Cerebral Ischemia. 超急性脑缺血大鼠皮质血流的时间变异性分析。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-25 DOI: 10.1007/s12264-025-01450-z

Bochao Niu, Benjamin Klugah-Brown, Yang Xia, Dezhong Yao, Bharat B Biswal

{"title":"Temporal Variability Analysis of Cortical Blood Flow in Rats with Hyperacute Cerebral Ischemia.","authors":"Bochao Niu, Benjamin Klugah-Brown, Yang Xia, Dezhong Yao, Bharat B Biswal","doi":"10.1007/s12264-025-01450-z","DOIUrl":"https://doi.org/10.1007/s12264-025-01450-z","url":null,"abstract":"Cerebral ischemia restricts cerebral blood flow (CBF), leading to unstable hemodynamics. Past studies of ischemia mainly focused on cortical CBF reduction. However, its impact on hemodynamic changes, especially temporal varying characteristics, remains poorly understood. Here, we collected cortical resting-state CBF in rats with left carotid artery blockage during occlusion-reperfusion, and measured the temporal variability and changes in laterality using a novel state-space method. This method was also applied to stroke EEG datasets to validate its effectiveness. After arterial occlusion, the left marginal motor, sensory, auditory, and visual cortices exhibited severe temporal variability impairments. The laterality analysis indicated that affected left regions showed inferior unilateral mean, inter-hemispheric transition probability, time fraction, and laterality duration, while the right side had a higher laterality time fraction and duration. These impairments recovered partially following blood flow restoration. Besides, the ischemic state-space metrics were positively correlated with the pre-occlusion baseline appearance. Stroke patients exhibited impaired temporal variability in the affected ischemic hemisphere. The state-space analysis revealed damaged CBF temporal variability during cerebral ischemia and predicted baseline-ischemia connections.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-Nucleus Transcriptomic Sequencing Revealed Cellular and Molecular Changes in a Pilocarpine-Induced Epilepsy Rat Model. 单核转录组测序揭示了匹洛卡品诱导癫痫大鼠模型的细胞和分子变化。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-24 DOI: 10.1007/s12264-025-01451-y

Ying Wang, Yue Wang, Fei Yu, Yidi Liu, Xin Liu, Zhengxu Cai

引用次数: 0

Dissecting Social Working Memory: Neural and Behavioral Evidence for Externally and Internally Oriented Components. 剖析社会工作记忆：外在和内在导向成分的神经和行为证据。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-23 DOI: 10.1007/s12264-025-01465-6

Hanxi Pan, Zefeng Chen, Nan Xu, Bolong Wang, Yuzheng Hu, Hui Zhou, Anat Perry, Xiang-Zhen Kong, Mowei Shen, Zaifeng Gao

{"title":"Dissecting Social Working Memory: Neural and Behavioral Evidence for Externally and Internally Oriented Components.","authors":"Hanxi Pan, Zefeng Chen, Nan Xu, Bolong Wang, Yuzheng Hu, Hui Zhou, Anat Perry, Xiang-Zhen Kong, Mowei Shen, Zaifeng Gao","doi":"10.1007/s12264-025-01465-6","DOIUrl":"https://doi.org/10.1007/s12264-025-01465-6","url":null,"abstract":"Social working memory (SWM)-the ability to maintain and manipulate social information in the brain-plays a crucial role in social interactions. However, research on SWM is still in its infancy and is often treated as a unitary construct. In the present study, we propose that SWM can be conceptualized as having two relatively independent components: \"externally oriented SWM\" (e-SWM) and \"internally oriented SWM\" (i-SWM). To test this external-internal hypothesis, participants were tasked with memorizing and ranking either facial expressions (e-SWM) or personality traits (i-SWM) associated with images of faces. We then examined the neural correlates of these two SWM components and their functional roles in empathy. The results showed distinct activations as the e-SWM task activated the postcentral and precentral gyri while the i-SWM task activated the precuneus/posterior cingulate cortex and superior frontal gyrus. Distinct multivariate activation patterns were also found within the dorsal medial prefrontal cortex in the two tasks. Moreover, partial least squares analyses combining brain activation and individual differences in empathy showed that e-SWM and i-SWM brain activities were mainly correlated with affective empathy and cognitive empathy, respectively. These findings implicate distinct brain processes as well as functional roles of the two types of SWM, providing support for the internal-external hypothesis of SWM.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parvalbumin and Somatostatin Neurons in the Thalamic Reticular Nucleus Modulate Visual Information Processing in V1 of Mouse. 丘脑网状核中的小白蛋白和生长抑素神经元调节小鼠V1视觉信息加工。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-21 DOI: 10.1007/s12264-025-01458-5

Jiamin Bu, Guangwei Xu, Yifeng Zhou

引用次数: 0

Single-Cell Sequencing Reveals Circadian Sensitivity of Noise-Induced Hearing Loss Mediated by Macrophage-Driven NLRP3 Inflammasome Activation. 单细胞测序揭示巨噬细胞驱动的NLRP3炎性体激活介导的噪声性听力损失的昼夜敏感性。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-07-20 DOI: 10.1007/s12264-025-01440-1

Qingping Ma, Qixuan Wang, Zixuan Zhu, Qian Zhou, Zhongying Wang, Minfei Qian, Teng Li, Xixi Gu, Zechuan Chen, Xueling Wang, Xiaoming Zhang, Zhiwu Huang

{"title":"Single-Cell Sequencing Reveals Circadian Sensitivity of Noise-Induced Hearing Loss Mediated by Macrophage-Driven NLRP3 Inflammasome Activation.","authors":"Qingping Ma, Qixuan Wang, Zixuan Zhu, Qian Zhou, Zhongying Wang, Minfei Qian, Teng Li, Xixi Gu, Zechuan Chen, Xueling Wang, Xiaoming Zhang, Zhiwu Huang","doi":"10.1007/s12264-025-01440-1","DOIUrl":"10.1007/s12264-025-01440-1","url":null,"abstract":"Circadian sensitivity significantly influences the severity of noise-induced hearing loss (NIHL), but the underlying mechanisms remain unclear. Here, we applied single-cell RNA sequencing to 97,043 cochlear cells, identifying macrophages as the primary immune responders to acoustic trauma, with a notable increase in their proportion in the cochlea. Immunofluorescence confirmed significant recruitment and activation of cochlear macrophages following noise exposure, while in vivo macrophage depletion resulted in the recovery of hearing. Furthermore, analyses of differentially-expressed genes and pathways revealed pronounced activation of NLRP3 inflammasome signaling in macrophages during night-time noise exposure. Measurements of elevated IL-1β and IL-18 expression in cochlear macrophages by multiplex immunohistochemistry correlated with heightened inflammation in the night-time exposure group. These findings were further confirmed by the administration of the selective NLRP3 inhibitor CY-09, which mitigated inflammasome activation, preserved synaptic integrity, and protect against hearing loss. In conclusion, our findings underscore the role of macrophage-driven NLRP3 inflammasome activation in mediating circadian variations in cochlear damage, offering a potential therapeutic target for mitigating NIHL.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Into the Spotlight: Microglia in the Peripheral Nervous System. 聚焦：周围神经系统中的小胶质细胞。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-18 DOI: 10.1007/s12264-025-01466-5

Ruichao E Liu, Coco Chu, Hai Qi

引用次数: 0

13-Docosenamide Enhances Oligodendrocyte Precursor Cell Differentiation via USP33-Mediated Deubiquitination of CNR1 in Chronic Cerebral Hypoperfusion. 13-Docosenamide通过usp33介导的CNR1去泛素化促进慢性脑灌注不足少突胶质前体细胞分化。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-18 DOI: 10.1007/s12264-025-01461-w

Yuhao Xu, Yi Tan, Zhi Zhang, Duo Chen, Chao Zhou, Liang Sun, Shengnan Xia, Xinyu Bao, Haiyan Yang, Yun Xu

{"title":"13-Docosenamide Enhances Oligodendrocyte Precursor Cell Differentiation via USP33-Mediated Deubiquitination of CNR1 in Chronic Cerebral Hypoperfusion.","authors":"Yuhao Xu, Yi Tan, Zhi Zhang, Duo Chen, Chao Zhou, Liang Sun, Shengnan Xia, Xinyu Bao, Haiyan Yang, Yun Xu","doi":"10.1007/s12264-025-01461-w","DOIUrl":"https://doi.org/10.1007/s12264-025-01461-w","url":null,"abstract":"Chronic cerebral hypoperfusion leads to white matter injury (WMI), which plays a significant role in contributing to vascular cognitive impairment. While 13-docosenamide is a type of fatty acid amide, it remains unclear whether it has therapeutic effects on chronic cerebral hypoperfusion. In this study, we conducted bilateral common carotid artery stenosis (BCAS) surgery to simulate chronic cerebral hypoperfusion-induced WMI and cognitive impairment. Our findings showed that 13-docosenamide alleviates WMI and cognitive impairment in BCAS mice. Mechanistically, 13-docosenamide specifically binds to cannabinoid receptor 1 (CNR1) in oligodendrocyte precursor cells (OPCs). This interaction results in an upregulation of ubiquitin-specific peptidase 33 (USP33)-mediated CNR1 deubiquitination, subsequently increasing CNR1 protein expression, activating the phosphorylation of the AKT/mTOR pathway, and promoting the differentiation of OPCs. In conclusion, our study suggests that 13-docosenamide can ameliorate chronic cerebral hypoperfusion-induced WMI and cognitive impairment by enhancing OPC differentiation and could serve as a potential therapeutic drug.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hippocampal Oligodendrocytes Regulate Mossy Fiber Development Involved in Epileptic Responses. 海马少突胶质细胞调节苔藓纤维发育参与癫痫反应。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-17 DOI: 10.1007/s12264-025-01452-x

Chunxia Jiang, Yunan Hu, Feng Zhang, Mengsheng Qiu, Xiaofeng Zhao

{"title":"Hippocampal Oligodendrocytes Regulate Mossy Fiber Development Involved in Epileptic Responses.","authors":"Chunxia Jiang, Yunan Hu, Feng Zhang, Mengsheng Qiu, Xiaofeng Zhao","doi":"10.1007/s12264-025-01452-x","DOIUrl":"https://doi.org/10.1007/s12264-025-01452-x","url":null,"abstract":"Although oligodendrocytes (OLs) are known to form the myelin sheath around neuronal axons for the saltatory conduction of action potentials, recent studies have suggested that OLs also modulate neuronal function and plasticity. In the present study, we found that OL maturation deficiency in Myrf-CKO mice caused spontaneous epileptogenesis and resulted in death. To further investigate the association between OL development and epilepsy, we examined the Adamts4 KO mouse line, which has a mild OL differentiation phenotype in the hippocampus. As a result, the differentiation defect in the mutant hippocampus reduced the expression of myelin-associated glycoprotein and lessened its inhibition of the dephosphorylation of phosphorylated tropomyosin-related kinase B, which is associated with retarded adolescent hippocampal mossy fiber development and higher susceptibility to epileptogenesis in adulthood. More importantly, enhancing differentiation by orally administered clemastine rescues the defective mossy fiber development in the early postnatal period and attenuates epilepsy susceptibility in adults. Together, these results strongly suggest that an OL differentiation defect in the hippocampus may contribute to susceptibility to epilepsy in adults.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suprachiasmatic Nucleus Vasoactive Intestinal Peptide Neurons Mediate Light-induced Transient Forgetting. 视交叉上核血管活性肠肽神经元介导光诱导的短暂遗忘。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-16 DOI: 10.1007/s12264-025-01456-7

Xiaoya Su, Yikai Tang, Yi Zhong, Yunlong Liu

引用次数: 0

Real-time Monitoring Unveils Three Distinct Neuronal Response Patterns to SAW Ultrasound via L-type Calcium Channels. 实时监测揭示了三种不同的神经元通过l型钙通道对SAW超声的反应模式。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-07-16 DOI: 10.1007/s12264-025-01457-6

Yiming Chen, Wenxu Tang, Yifan Wang, Ya Gao, Jiaqi Hu, Yixuan Lu, Long Meng, Hairong Zheng, Yi Feng, Liming Cheng, Wenyong Fan, Qian Cheng, Lei Xue

{"title":"Real-time Monitoring Unveils Three Distinct Neuronal Response Patterns to SAW Ultrasound via L-type Calcium Channels.","authors":"Yiming Chen, Wenxu Tang, Yifan Wang, Ya Gao, Jiaqi Hu, Yixuan Lu, Long Meng, Hairong Zheng, Yi Feng, Liming Cheng, Wenyong Fan, Qian Cheng, Lei Xue","doi":"10.1007/s12264-025-01457-6","DOIUrl":"https://doi.org/10.1007/s12264-025-01457-6","url":null,"abstract":"Ultrasound neuromodulation shows promise for treating neurological disorders, but the underlying mechanisms remain unclear. Here, we developed an integrated surface acoustic wave (SAW) ultrasound chip enabling simultaneous electrophysiological recording and Ca2+ imaging of cultured hippocampal neurons to investigate neuronal excitability and synaptic transmission during ultrasound stimulation. This study revealed, for the first time, three distinct neuronal response patterns induced by SAW ultrasound: an immediate response showing rapid activation, a delayed response exhibiting facilitation after several minutes, and a non-response maintaining baseline activity. Ultrasound stimulation increased action potential firing, enhanced excitatory postsynaptic currents, and elevated intracellular Ca2+ levels. These effects were dependent on extracellular Ca2+ influx and primarily dominated by L-type Ca2+ channels. Our findings suggest that individual neurons exhibit heterogeneous responses to SAW ultrasound stimulation based on their intracellular Ca2+ levels and L-type Ca2+ channel activity. This integrated approach provides new insights into the cellular mechanisms of ultrasound neuromodulation while highlighting the potential of SAW technology for precise, cell-type-specific neural control.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0