Neuroscience bulletin最新文献_第8页

The Role of Neuroinflammation and Network Anomalies in Drug-Resistant Epilepsy. 神经炎症和网络异常在耐药癫痫中的作用。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2025-02-24 DOI: 10.1007/s12264-025-01348-w

Jianwei Shi, Jing Xie, Zesheng Li, Xiaosong He, Penghu Wei, Josemir W Sander, Guoguang Zhao

{"title":"The Role of Neuroinflammation and Network Anomalies in Drug-Resistant Epilepsy.","authors":"Jianwei Shi, Jing Xie, Zesheng Li, Xiaosong He, Penghu Wei, Josemir W Sander, Guoguang Zhao","doi":"10.1007/s12264-025-01348-w","DOIUrl":"10.1007/s12264-025-01348-w","url":null,"abstract":"Epilepsy affects over 50 million people worldwide. Drug-resistant epilepsy (DRE) accounts for up to a third of these cases, and neuro-inflammation is thought to play a role in such cases. Despite being a long-debated issue in the field of DRE, the mechanisms underlying neuroinflammation have yet to be fully elucidated. The pro-inflammatory microenvironment within the brain tissue of people with DRE has been probed using single-cell multimodal transcriptomics. Evidence suggests that inflammatory cells and pro-inflammatory cytokines in the nervous system can lead to extensive biochemical changes, such as connexin hemichannel excitability and disruption of neurotransmitter homeostasis. The presence of inflammation may give rise to neuronal network abnormalities that suppress endogenous antiepileptic systems. We focus on the role of neuroinflammation and brain network anomalies in DRE from multiple perspectives to identify critical points for clinical application. We hope to provide an insightful overview to advance the quest for better DRE treatments.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"881-905"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Model of Traumatic Optic Neuropathy Under Direct Vision Through the Anterior Orbital Approach in Non-human Primates. 非人类灵长类动物经眶前入路直接视觉下创伤性视神经病变的新模型。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2025-03-10 DOI: 10.1007/s12264-025-01372-w

Zhi-Qiang Xiao, Xiu Han, Xin Ren, Zeng-Qiang Wang, Si-Qi Chen, Qiao-Feng Zhu, Hai-Yang Cheng, Yin-Tian Li, Dan Liang, Xuan-Wei Liang, Ying Xu, Hui Yang

引用次数: 0

Triple-Target Inhibition of Cholinesterase, Amyloid Aggregation, and GSK3β to Ameliorate Cognitive Deficits and Neuropathology in the Triple-Transgenic Mouse Model of Alzheimer's Disease. 三靶点抑制胆碱酯酶、淀粉样蛋白聚集和GSK3β改善阿尔茨海默病小鼠模型的认知缺陷和神经病理学

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2025-02-05 DOI: 10.1007/s12264-025-01354-y

Junqiu He, Shan Sun, Hongfeng Wang, Zheng Ying, Kin Yip Tam

{"title":"Triple-Target Inhibition of Cholinesterase, Amyloid Aggregation, and GSK3β to Ameliorate Cognitive Deficits and Neuropathology in the Triple-Transgenic Mouse Model of Alzheimer's Disease.","authors":"Junqiu He, Shan Sun, Hongfeng Wang, Zheng Ying, Kin Yip Tam","doi":"10.1007/s12264-025-01354-y","DOIUrl":"10.1007/s12264-025-01354-y","url":null,"abstract":"Alzheimer's disease (AD) poses one of the most urgent medical challenges in the 21st century as it affects millions of people. Unfortunately, the etiopathogenesis of AD is not yet fully understood and the current pharmacotherapy options are somewhat limited. Here, we report a novel inhibitor, Compound 44, for targeting cholinesterases, amyloid-β (Aβ) aggregation, and glycogen synthase kinase 3β (GSK-3β) simultaneously with the aim of achieving symptomatic relief and disease modification in AD therapy. We found that Compound 44 had good inhibitory effects on all intended targets with IC50s of submicromolar or better, significant neuroprotective effects in cell models, and beneficial improvement of cognitive deficits in the triple transgenic AD (3 × Tg AD) mouse model. Moreover, we showed that Compound 44 acts as an autophagy regulator by inducing nuclear translocation of transcription factor EB through GSK-3β inhibition, enhancing the biogenesis of lysosomes and elevating autophagic flux, thus ameliorating the amyloid burden and tauopathy, as well as mitigating the disease phenotype. Our results suggest that triple-target inhibition via Compound 44 could be a promising strategy that may lead to the development of effective therapeutic approaches for AD.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"821-836"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: A Virtual Reality Platform for Context-Dependent Cognitive Research in Rodents. 更正：用于啮齿动物情境依赖认知研究的虚拟现实平台。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 DOI: 10.1007/s12264-025-01382-8

Xue-Tong Qu, Jin-Ni Wu, Yunqing Wen, Long Chen, Shi-Lei Lv, Li Liu, Li-Jie Zhan, Tian-Yi Liu, Hua He, Yu Liu, Chun Xu

引用次数: 0

Anterior Cingulate Cortex Contributes to the Hyperlocomotion under Nitrogen Narcosis. 前扣带回皮层有助于氮麻醉下的过度运动

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2024-08-19 DOI: 10.1007/s12264-024-01278-z

Bin Peng, Xiao-Bo Wu, Zhi-Jun Zhang, De-Li Cao, Lin-Xia Zhao, Hao Wu, Yong-Jing Gao

{"title":"Anterior Cingulate Cortex Contributes to the Hyperlocomotion under Nitrogen Narcosis.","authors":"Bin Peng, Xiao-Bo Wu, Zhi-Jun Zhang, De-Li Cao, Lin-Xia Zhao, Hao Wu, Yong-Jing Gao","doi":"10.1007/s12264-024-01278-z","DOIUrl":"10.1007/s12264-024-01278-z","url":null,"abstract":"Nitrogen narcosis is a neurological syndrome that manifests when humans or animals encounter hyperbaric nitrogen, resulting in a range of motor, emotional, and cognitive abnormalities. The anterior cingulate cortex (ACC) is known for its significant involvement in regulating motivation, cognition, and action. However, its specific contribution to nitrogen narcosis-induced hyperlocomotion and the underlying mechanisms remain poorly understood. Here we report that exposure to hyperbaric nitrogen notably increased the locomotor activity of mice in a pressure-dependent manner. Concurrently, this exposure induced heightened activation among neurons in both the ACC and dorsal medial striatum (DMS). Notably, chemogenetic inhibition of ACC neurons effectively suppressed hyperlocomotion. Conversely, chemogenetic excitation lowered the hyperbaric pressure threshold required to induce hyperlocomotion. Moreover, both chemogenetic inhibition and genetic ablation of activity-dependent neurons within the ACC reduced the hyperlocomotion. Further investigation revealed that ACC neurons project to the DMS, and chemogenetic inhibition of ACC-DMS projections resulted in a reduction in hyperlocomotion. Finally, nitrogen narcosis led to an increase in local field potentials in the theta frequency band and a decrease in the alpha frequency band in both the ACC and DMS. These results collectively suggest that excitatory neurons within the ACC, along with their projections to the DMS, play a pivotal role in regulating the hyperlocomotion induced by exposure to hyperbaric nitrogen.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"775-789"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large-Scale Sleep Survey and the Impact of Step-Based Exercise. 大规模睡眠调查和基于步数的运动的影响。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2025-04-05 DOI: 10.1007/s12264-025-01392-6

Xinyu Fu, Wanxin Zhang, Xuemei Gao, Zhi-Li Huang

引用次数: 0

A Novel Mouse Model Unveils Protein Deficiency in Truncated CDKL5 Mutations. 一种新的小鼠模型揭示了CDKL5突变缺失中的蛋白质缺陷。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2025-03-05 DOI: 10.1007/s12264-024-01346-4

Xue Feng, Zi-Ai Zhu, Hong-Tao Wang, Hui-Wen Zhou, Ji-Wei Liu, Ya Shen, Yu-Xian Zhang, Zhi-Qi Xiong

引用次数: 0

Activation of Centromedial Amygdala GABAergic Neurons Produces Hypotension in Mice. 激活中央区杏仁核 GABA 能神经元可导致小鼠低血压

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2024-11-25 DOI: 10.1007/s12264-024-01317-9

Xiaoyi Wang, Ziteng Yue, Luo Shi, Wei He, Liuqi Shao, Yuhang Liu, Jinye Zhang, Shangyu Bi, Tianjiao Deng, Fang Yuan, Sheng Wang

{"title":"Activation of Centromedial Amygdala GABAergic Neurons Produces Hypotension in Mice.","authors":"Xiaoyi Wang, Ziteng Yue, Luo Shi, Wei He, Liuqi Shao, Yuhang Liu, Jinye Zhang, Shangyu Bi, Tianjiao Deng, Fang Yuan, Sheng Wang","doi":"10.1007/s12264-024-01317-9","DOIUrl":"10.1007/s12264-024-01317-9","url":null,"abstract":"The central amygdala (CeA) is a crucial modulator of emotional, behavioral, and autonomic functions, including cardiovascular responses. Despite its importance, the specific circuit by which the CeA modulates blood pressure remains insufficiently explored. Our investigations demonstrate that photostimulation of GABAergic neurons in the centromedial amygdala (CeMGABA), as opposed to those in the centrolateral amygdala (CeL), produces a depressor response in both anesthetized and freely-moving mice. In addition, activation of CeMGABA axonal terminals projecting to the nucleus tractus solitarius (NTS) significantly reduces blood pressure. These CeMGABA neurons form synaptic connections with NTS neurons, allowing for the modulation of cardiovascular responses by influencing the caudal or rostral ventrolateral medulla. Furthermore, CeMGABA neurons targeting the NTS receive dense inputs from the CeL. Consequently, stimulation of CeMGABA neurons elicits hypotension through the CeM-NTS circuit, offering deeper insights into the cardiovascular responses associated with emotions and behaviors.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"759-774"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zona Incerta: A Bridge for Infant-Mother Interaction. 空间：母婴互动的桥梁。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2025-02-08 DOI: 10.1007/s12264-025-01361-z

Yawen Huang, Jun Wang, Na Liu, Han Xu

引用次数: 0

Mapping Brain-Wide Neural Activity of Murine Attentional Processing in the Five-Choice Serial Reaction Time Task. 五选择系列反应时间任务中小鼠注意加工的全脑神经活动映射。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2025-03-22 DOI: 10.1007/s12264-025-01380-w

Yin Yue, Youming Tan, Pin Yang, Shu Zhang, Hongzhen Pan, Yiran Lang, Zengqiang Yuan

{"title":"Mapping Brain-Wide Neural Activity of Murine Attentional Processing in the Five-Choice Serial Reaction Time Task.","authors":"Yin Yue, Youming Tan, Pin Yang, Shu Zhang, Hongzhen Pan, Yiran Lang, Zengqiang Yuan","doi":"10.1007/s12264-025-01380-w","DOIUrl":"10.1007/s12264-025-01380-w","url":null,"abstract":"Attention is the cornerstone of effective functioning in a complex and information-rich world. While the neural activity of attention has been extensively studied in the cortex, the brain-wide neural activity patterns are largely unknown. In this study, we conducted a comprehensive analysis of neural activity across the mouse brain during attentional processing using EEG and c-Fos staining, utilizing hierarchical clustering and c-Fos-based functional network analysis to evaluate the c-Fos activation patterns. Our findings reveal that a wide range of brain regions are activated, notably in the high-order cortex, thalamus, and brain stem regions involved in advanced cognition and arousal regulation, with the central lateral nucleus of the thalamus as a strong hub, suggesting the crucial role of the thalamus in attention control. These results provide valuable insights into the neural network mechanisms underlying attention, offering a foundation for formulating functional hypotheses and conducting circuit-level testing.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"741-758"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0