Neuroscience bulletin最新文献_第7页

Precise Magnetic Stimulation of the Paraventricular Nucleus Improves Sociability in a Mouse Model of ASD. 精确磁刺激室旁核改善ASD小鼠模型的社交能力。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-04 DOI: 10.1007/s12264-025-01444-x

Sha Liu, Quyang Yang, Pengfei Zhu, Xuan Liu, Qingbo Lu, Jie Yang, Jingyao Gao, Hongbin Han, Zhijun Zhang, Ning Gu, Tao Tan, Jianfei Sun

{"title":"Precise Magnetic Stimulation of the Paraventricular Nucleus Improves Sociability in a Mouse Model of ASD.","authors":"Sha Liu, Quyang Yang, Pengfei Zhu, Xuan Liu, Qingbo Lu, Jie Yang, Jingyao Gao, Hongbin Han, Zhijun Zhang, Ning Gu, Tao Tan, Jianfei Sun","doi":"10.1007/s12264-025-01444-x","DOIUrl":"https://doi.org/10.1007/s12264-025-01444-x","url":null,"abstract":"Magnetic stimulation has made significant strides in the treatment of psychiatric disorders. Nonetheless, current magnetic stimulation techniques lack the precision to accurately modulate specific nuclei and cannot realize deep brain magnetic stimulation. To address this, we utilized superparamagnetic iron oxide nanoparticles as mediators to achieve precise targeting and penetration. We investigated the effects of magnetic fields with varying frequencies on neuronal activity and compared the activation effects on neurons using a 10-Hz precise magneto-stimulation system (pMSS) with repetitive transcranial magnetic stimulation in mice. Oxytocin levels, dendritic morphology and density, and mouse behavior were measured before and after pMSS intervention. Our findings suggest that pMSS can activate oxytocinergic neurons, leading to upregulation of oxytocin secretion and neurite outgrowth. As a result, sociability was rapidly improved after a one-week pMSS treatment regimen. These results demonstrate a promising magneto-stimulation method for regulating neuronal activity in deep brain nuclei and provide a promising therapeutic approach for autism spectrum disorder.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ADAM17 Supports Disinhibition of Pre-sympathetic Glutamatergic Neurons Through Microglial Chemotaxis. ADAM17通过小胶质趋化支持前交感谷氨酸能神经元的去抑制。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-04 DOI: 10.1007/s12264-025-01471-8

Jiawei Wang, Zihan Qiu, Yue Han, Hanxue Wu, Miao Yuan, Yan Liu, Huichao Wang, Shenglan Yuan, Dengfeng Gao, Lina Sun, Xingjuan Chen, Eric Lazartigues, Fanni Li, Rui Yang, Jiaxi Xu

{"title":"ADAM17 Supports Disinhibition of Pre-sympathetic Glutamatergic Neurons Through Microglial Chemotaxis.","authors":"Jiawei Wang, Zihan Qiu, Yue Han, Hanxue Wu, Miao Yuan, Yan Liu, Huichao Wang, Shenglan Yuan, Dengfeng Gao, Lina Sun, Xingjuan Chen, Eric Lazartigues, Fanni Li, Rui Yang, Jiaxi Xu","doi":"10.1007/s12264-025-01471-8","DOIUrl":"https://doi.org/10.1007/s12264-025-01471-8","url":null,"abstract":"A disintegrin and metalloprotease 17 (ADAM17) is a membrane-bound enzyme that cleaves cell-surface proteins. Here, we discovered that neuronal ADAM17-mediated signaling supports the reduction of inhibitory presynaptic inputs to the pre-sympathetic glutamatergic neural hub, located in the paraventricular nucleus of the hypothalamus (PVN), upon stimulation by angiotensin II (Ang-II). For Ang-II-induced disinhibition, targeting microglial migration had an effect similar to ADAM17 knockout in glutamatergic neurons. Ang-II promoted neuron-mediated chemotaxis of microglia via neuronal CX3CL1 and ADAM17. Inhibiting microglial chemotaxis by targeting CX3CR1 abolished the Ang-II-induced microglial displacement of GABAergic presynaptic terminals and significantly blunted Ang-II's pressor response. Using conditional and targeted knockout models of ADAM17, an increase in the contact between pre-sympathetic neurons and reactive microglia in the PVN was demonstrated to be neuronal ADAM17-dependent during the developmental stage of salt-sensitive hypertension. Collectively, this study provides evidence that neuronal ADAM17-mediated microglial chemotaxis facilitates the disinhibition of pre-sympathetic glutamatergic tone upon hormonal stimulation.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcranial temporal interference stimulation precisely targets deep brain regions to regulate eye movements. 经颅颞干扰刺激精确地针对大脑深部区域来调节眼球运动。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-01 Epub Date: 2025-04-11 DOI: 10.1007/s12264-025-01387-3

Mo Wang, Sixian Song, Dan Li, Guangchao Zhao, Yu Luo, Yi Tian, Jiajia Zhang, Quanying Liu, Pengfei Wei

引用次数: 0

GPR37L1 in Spinal Astrocytes: A Potential Target for Neuropathic Pain Management. 脊髓星形胶质细胞中的GPR37L1：神经性疼痛治疗的潜在靶点。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-01 Epub Date: 2025-07-04 DOI: 10.1007/s12264-025-01447-8

Jingyang Xu, Yufeng Chen, Lerong Chen, Boyi Liu

引用次数: 0

The Role of Prefrontal and Posterior Parietal Cortex in Generating Multiple Step Saccades. 前额叶和后顶叶皮层在产生多步扫视中的作用。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-01 Epub Date: 2025-03-11 DOI: 10.1007/s12264-025-01377-5

Wenbo Ma, Zhaohuan Ding, Leixiao Feng, Xiaoli Li, Mingsha Zhang

引用次数: 0

Histopathological Insights into Demyelination and Remyelination After Spinal Cord Injury in Non-human Primates. 非人灵长类动物脊髓损伤后脱髓鞘和再髓鞘的组织病理学观察。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-01 Epub Date: 2025-04-05 DOI: 10.1007/s12264-025-01388-2

Junhao Liu, Zucheng Huang, Kinon Chen, Rong Li, Zhiping Huang, Junyu Lin, Hui Jiang, Jie Liu, Qingan Zhu

{"title":"Histopathological Insights into Demyelination and Remyelination After Spinal Cord Injury in Non-human Primates.","authors":"Junhao Liu, Zucheng Huang, Kinon Chen, Rong Li, Zhiping Huang, Junyu Lin, Hui Jiang, Jie Liu, Qingan Zhu","doi":"10.1007/s12264-025-01388-2","DOIUrl":"10.1007/s12264-025-01388-2","url":null,"abstract":"Demyelination and remyelination play key roles in spinal cord injury (SCI), affecting the recovery of motor and sensory functions. Research in rodent models is extensive, but the study of these processes in non-human primates is limited. Therefore, our goal was to thoroughly study the histological features of demyelination and remyelination after contusion injury of the cervical spinal cord in Macaca fascicularis. In a previous study, we created an SCI model in M. fascicularis by controlling the contusion displacement. We used Eriochrome Cyanine staining, immunohistochemical analysis, and toluidine blue staining to evaluate demyelination and remyelination. The results showed demyelination ipsilateral to the injury epicenter both rostrally and caudally, the former mainly impacting sensory pathways, while the latter primarily affected motor pathways. Toluidine blue staining showed myelin loss and axonal distension at the injury site. Schwann cell-derived myelin sheaths were only found at the center, while thinner myelin sheaths from oligodendrocytes were seen at the center and surrounding areas. Our study showed that long-lasting demyelination occurs in the spinal cord of M. fascicularis after SCI, with oligodendrocytes and Schwann cells playing a significant role in myelin sheath formation at the injury site.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1429-1447"},"PeriodicalIF":5.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancement of Ca²⁺ Signal Strength in Astrocytes in the Lateral Septum Improves Cognitive Disorders in Mice After Hemorrhagic Shock and Resuscitation. 外隔星形胶质细胞Ca2+信号强度的增强改善失血性休克和复苏后小鼠的认知障碍。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-01 Epub Date: 2025-04-25 DOI: 10.1007/s12264-025-01404-5

Wen-Guang Li, Lan-Xin Li, Rong-Xin Song, Xu-Peng Wang, Shi-Yan Jia, Xiao-Yi Ma, Jing-Yu Zhang, Gang-Feng Yin, Xiao-Ming Li, Li-Min Zhang

{"title":"Enhancement of Ca2+ Signal Strength in Astrocytes in the Lateral Septum Improves Cognitive Disorders in Mice After Hemorrhagic Shock and Resuscitation.","authors":"Wen-Guang Li, Lan-Xin Li, Rong-Xin Song, Xu-Peng Wang, Shi-Yan Jia, Xiao-Yi Ma, Jing-Yu Zhang, Gang-Feng Yin, Xiao-Ming Li, Li-Min Zhang","doi":"10.1007/s12264-025-01404-5","DOIUrl":"10.1007/s12264-025-01404-5","url":null,"abstract":"Hemorrhagic shock is a common clinical emergency that can aggravate cell injury after resuscitation. Astrocytes are crucial for the survival of neurons because they regulate the surrounding ionic microenvironment of neurons. Although hemorrhagic shock and resuscitation (HSR) injury can impair cognition, it remains unclear how this insult directly affects astrocytes. In this study, we established an HSR model by bleeding and re-transfusion in mice. The social interaction test and new object recognition test were applied to evaluate post-operative cognitive changes, and the results suggest that mice experience cognitive impairment following exposure to HSR. In the HSR group, the power spectral density of β and γ oscillations decreased, and the coupling of the θ oscillation phase and γ oscillation amplitude was abnormal, which indicated abnormal neuronal oscillation and cognitive impairment after HSR exposure. In brief, cognitive impairment in mice is strongly correlated with Ca2+ signal strength in lateral septum astrocytes following HSR.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1403-1417"},"PeriodicalIF":5.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Correlation to Causation: Understanding Episodic Memory Networks. 从相关性到因果关系：理解情景记忆网络。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-01 Epub Date: 2025-06-24 DOI: 10.1007/s12264-025-01407-2

Ahsan Khan, Jing Liu, Maité Crespo-García, Kai Yuan, Cheng-Peng Hu, Ziyin Ren, Chun-Hang Eden Ti, Desmond J Oathes, Raymond Kai-Yu Tong

{"title":"From Correlation to Causation: Understanding Episodic Memory Networks.","authors":"Ahsan Khan, Jing Liu, Maité Crespo-García, Kai Yuan, Cheng-Peng Hu, Ziyin Ren, Chun-Hang Eden Ti, Desmond J Oathes, Raymond Kai-Yu Tong","doi":"10.1007/s12264-025-01407-2","DOIUrl":"10.1007/s12264-025-01407-2","url":null,"abstract":"Episodic memory, our ability to recall past experiences, is supported by structures in the medial temporal lobe (MTL) particularly the hippocampus, and its interactions with fronto-parietal brain regions. Understanding how these brain regions coordinate to encode, consolidate, and retrieve episodic memories remains a fundamental question in cognitive neuroscience. Non-invasive brain stimulation (NIBS) methods, especially transcranial magnetic stimulation (TMS), have advanced episodic memory research beyond traditional lesion studies and neuroimaging by enabling causal investigations through targeted magnetic stimulation to specific brain regions. This review begins by delineating the evolving understanding of episodic memory from both psychological and neurobiological perspectives and discusses the brain networks supporting episodic memory processes. Then, we review studies that employed TMS to modulate episodic memory, with the aim of identifying potential cortical regions that could be used as stimulation sites to modulate episodic memory networks. We conclude with the implications and prospects of using NIBS to understand episodic memory mechanisms.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1463-1486"},"PeriodicalIF":5.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Eyes are The Windows To The Soul: Pupillary Changes Reflect The Consolidation of New and Old Memories During Sleep. 眼睛是心灵的窗户：瞳孔的变化反映了睡眠中新旧记忆的巩固。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-01 Epub Date: 2025-05-11 DOI: 10.1007/s12264-025-01410-7

Wei-Kun Su, Yan-Jia Luo, Fangyuan Li, Hong Jiang, Jing Wang, Ya-Dong Li

引用次数: 0

Interoceptive Dysfunction in Psychiatric Disorders and Non-invasive Neuromodulation for Improving Interoception. 精神疾病的内感受功能障碍和改善内感受的非侵入性神经调节。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-01 Epub Date: 2025-06-19 DOI: 10.1007/s12264-025-01432-1

Huiru Cui, Jijun Wang, Chunbo Li

引用次数: 0