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Pseudogene Lamr1-ps1 Aggravates Early Spatial Learning Memory Deficits in Alzheimer's Disease Model Mice. 假基因Lamr1-ps1加重阿尔茨海默病模型小鼠早期空间学习记忆缺陷
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-04-01 Epub Date: 2025-01-02 DOI: 10.1007/s12264-024-01336-6
Zhuoze Wu, Xiaojie Liu, Yuntai Wang, Zimeng Zeng, Wei Chen, Hao Li
{"title":"Pseudogene Lamr1-ps1 Aggravates Early Spatial Learning Memory Deficits in Alzheimer's Disease Model Mice.","authors":"Zhuoze Wu, Xiaojie Liu, Yuntai Wang, Zimeng Zeng, Wei Chen, Hao Li","doi":"10.1007/s12264-024-01336-6","DOIUrl":"10.1007/s12264-024-01336-6","url":null,"abstract":"<p><p>Alzheimer's disease (AD), a neurodegenerative disorder with complex etiologies, manifests through a cascade of pathological changes before clinical symptoms become apparent. Among these early changes, alterations in the expression of non-coding RNAs (ncRNAs) have emerged as pivotal events. In this study, we focused on the aberrant expression of ncRNAs and revealed that Lamr1-ps1, a pseudogene of the laminin receptor, significantly exacerbates early spatial learning and memory deficits in APP/PS1 mice. Through a combination of bioinformatics prediction and experimental validation, we identified the miR-29c/Bace1 pathway as a potential regulatory mechanism by which Lamr1-ps1 influences AD pathology. Importantly, augmenting the miR-29c-3p levels in mice ameliorated memory deficits, underscoring the therapeutic potential of targeting miR-29c-3p in early AD intervention. This study not only provides new insights into the role of pseudogenes in AD but also consolidates a foundational basis for considering miR-29c as a viable therapeutic target, offering a novel avenue for AD research and treatment strategies.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"600-614"},"PeriodicalIF":5.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11979086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associative Learning-Induced Synaptic Potentiation at the Two Major Hippocampal CA1 Inputs for Cued Memory Acquisition. 联想学习诱导海马 CA1 两大输入端突触电位增强，促进诱导记忆的获得
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-04-01 Epub Date: 2024-11-27 DOI: 10.1007/s12264-024-01327-7
Bing-Ying Wang, Bo Wang, Bo Cao, Ling-Ling Gu, Jiayu Chen, Hua He, Zheng Zhao, Fujun Chen, Zhiru Wang
{"title":"Associative Learning-Induced Synaptic Potentiation at the Two Major Hippocampal CA1 Inputs for Cued Memory Acquisition.","authors":"Bing-Ying Wang, Bo Wang, Bo Cao, Ling-Ling Gu, Jiayu Chen, Hua He, Zheng Zhao, Fujun Chen, Zhiru Wang","doi":"10.1007/s12264-024-01327-7","DOIUrl":"10.1007/s12264-024-01327-7","url":null,"abstract":"<p><p>Learning-associated functional plasticity at hippocampal synapses remains largely unexplored. Here, in a single session of reward-based trace conditioning, we examine learning-induced synaptic plasticity in the dorsal CA1 hippocampus (dCA1). Local field-potential recording combined with selective optogenetic inhibition first revealed an increase of dCA1 synaptic responses to the conditioned stimulus (CS) induced during conditioning at both Schaffer collaterals to the stratum radiatum (Rad) and temporoammonic input to the lacunosum moleculare (LMol). At these dCA1 inputs, synaptic potentiation of CS-responding excitatory synapses was further demonstrated by locally blocking NMDA receptors during conditioning and whole-cell recording sensory-evoked synaptic responses in dCA1 neurons from naive animals. An overall similar time course of the induction of synaptic potentiation was found in the Rad and LMol by multiple-site recording; this emerged later and saturated earlier than conditioned behavioral responses. Our experiments demonstrate a cued memory-associated dCA1 synaptic plasticity induced at both Schaffer collaterals and temporoammonic pathways.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"649-664"},"PeriodicalIF":5.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11979062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuronal Regulation of Feeding and Energy Metabolism: A Focus on the Hypothalamus and Brainstem. 神经元摄食和能量代谢的调控：以下丘脑和脑干为中心。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-04-01 Epub Date: 2024-12-20 DOI: 10.1007/s12264-024-01335-7
Jing Chen, Meiting Cai, Cheng Zhan
{"title":"Neuronal Regulation of Feeding and Energy Metabolism: A Focus on the Hypothalamus and Brainstem.","authors":"Jing Chen, Meiting Cai, Cheng Zhan","doi":"10.1007/s12264-024-01335-7","DOIUrl":"10.1007/s12264-024-01335-7","url":null,"abstract":"<p><p>In the face of constantly changing environments, the central nervous system (CNS) rapidly and accurately calculates the body's needs, regulates feeding behavior, and maintains energy homeostasis. The arcuate nucleus of the hypothalamus (ARC) plays a key role in this process, serving as a critical brain region for detecting nutrition-related hormones and regulating appetite and energy homeostasis. Agouti-related protein (AgRP)/neuropeptide Y (NPY) neurons in the ARC are core elements that interact with other brain regions through a complex appetite-regulating network to comprehensively control energy homeostasis. In this review, we explore the discovery and research progress of AgRP neurons in regulating feeding and energy metabolism. In addition, recent advances in terms of feeding behavior and energy homeostasis, along with the redundant neural mechanisms involved in energy metabolism, are discussed. Finally, the challenges and opportunities in the field of neural regulation of feeding and energy metabolism are briefly discussed.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"665-675"},"PeriodicalIF":5.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11978587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role and Mechanisms of Ubiquitin-Proteasome System-Mediated Ferroptosis in Neurological Disorders. 泛素-蛋白酶体系统介导的铁下垂在神经系统疾病中的作用和机制。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-04-01 Epub Date: 2025-01-07 DOI: 10.1007/s12264-024-01343-7
Xin Liu, Wei Wang, Qiucheng Nie, Xinjing Liu, Lili Sun, Qiang Ma, Jie Zhang, Yiju Wei
{"title":"The Role and Mechanisms of Ubiquitin-Proteasome System-Mediated Ferroptosis in Neurological Disorders.","authors":"Xin Liu, Wei Wang, Qiucheng Nie, Xinjing Liu, Lili Sun, Qiang Ma, Jie Zhang, Yiju Wei","doi":"10.1007/s12264-024-01343-7","DOIUrl":"10.1007/s12264-024-01343-7","url":null,"abstract":"<p><p>Ferroptosis is a form of cell death elicited by an imbalance in intracellular iron concentrations, leading to enhanced lipid peroxidation. In neurological disorders, both oxidative stress and mitochondrial damage can contribute to ferroptosis, resulting in nerve cell dysfunction and death. The ubiquitin-proteasome system (UPS) refers to a cellular pathway in which specific proteins are tagged with ubiquitin for recognition and degradation by the proteasome. In neurological conditions, the UPS plays a significant role in regulating ferroptosis. In this review, we outline how the UPS regulates iron metabolism, ferroptosis, and their interplay in neurological diseases. In addition, we discuss the future application of small-molecule inhibitors and identify potential drug targets. Further investigation into the mechanisms of UPS-mediated ferroptosis will provide novel insights and strategies for therapeutic interventions and clinical applications in neurological diseases.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"691-706"},"PeriodicalIF":5.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11979074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Type 2 Diabetes Mellitus Exacerbates Pathological Processes of Parkinson's Disease: Insights from Signaling Pathways Mediated by Insulin Receptors. 2型糖尿病加剧帕金森病的病理过程：胰岛素受体介导的信号通路的见解
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-04-01 Epub Date: 2025-01-04 DOI: 10.1007/s12264-024-01342-8
Shufen Liu, Tingting Liu, Jingwen Li, Jun Hong, Ali A Moosavi-Movahedi, Jianshe Wei
{"title":"Type 2 Diabetes Mellitus Exacerbates Pathological Processes of Parkinson's Disease: Insights from Signaling Pathways Mediated by Insulin Receptors.","authors":"Shufen Liu, Tingting Liu, Jingwen Li, Jun Hong, Ali A Moosavi-Movahedi, Jianshe Wei","doi":"10.1007/s12264-024-01342-8","DOIUrl":"10.1007/s12264-024-01342-8","url":null,"abstract":"<p><p>Parkinson's disease (PD), a chronic and common neurodegenerative disease, is characterized by the progressive loss of dopaminergic neurons in the dense part of the substantia nigra and abnormal aggregation of alpha-synuclein. Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by chronic insulin resistance and deficiency in insulin secretion. Extensive evidence has confirmed shared pathogenic mechanisms underlying PD and T2DM, such as oxidative stress caused by insulin resistance, mitochondrial dysfunction, inflammation, and disorders of energy metabolism. Conventional drugs for treating T2DM, such as metformin and glucagon-like peptide-1 receptor agonists, affect nerve repair. Even drugs for treating PD, such as levodopa, can affect insulin secretion. This review summarizes the relationship between PD and T2DM and related therapeutic drugs from the perspective of insulin signaling pathways in the brain.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"676-690"},"PeriodicalIF":5.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11978575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histamine H1 Receptor in Medial Septum Cholinergic Circuit: New Hope for Fear-related Disorders? 中隔胆碱能回路中的组胺H1受体：治疗恐惧相关疾病的新希望？
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-04-01 Epub Date: 2025-02-01 DOI: 10.1007/s12264-025-01357-9
Kang Liu
{"title":"Histamine H<sub>1</sub> Receptor in Medial Septum Cholinergic Circuit: New Hope for Fear-related Disorders?","authors":"Kang Liu","doi":"10.1007/s12264-025-01357-9","DOIUrl":"10.1007/s12264-025-01357-9","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"737-740"},"PeriodicalIF":5.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11979059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Therapeutic Potential of Psychedelics in Chronic Pain Management: A New Frontier in Medicine. 探索致幻剂在慢性疼痛管理中的治疗潜力：医学的新前沿。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-04-01 Epub Date: 2025-01-20 DOI: 10.1007/s12264-025-01351-1
Cong Lin, Xue Wang, Xiaohui Wang
{"title":"Exploring the Therapeutic Potential of Psychedelics in Chronic Pain Management: A New Frontier in Medicine.","authors":"Cong Lin, Xue Wang, Xiaohui Wang","doi":"10.1007/s12264-025-01351-1","DOIUrl":"10.1007/s12264-025-01351-1","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"719-722"},"PeriodicalIF":5.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11979092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
To Attack or Not: A Neural Circuit Coding Sexually Dimorphic Aggression. 攻击与否：编码两性二态攻击的神经回路。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-04-01 Epub Date: 2025-01-03 DOI: 10.1007/s12264-024-01345-5
Qiuhong Xin, Hailan Hu
{"title":"To Attack or Not: A Neural Circuit Coding Sexually Dimorphic Aggression.","authors":"Qiuhong Xin, Hailan Hu","doi":"10.1007/s12264-024-01345-5","DOIUrl":"10.1007/s12264-024-01345-5","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"728-730"},"PeriodicalIF":5.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11979018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Direct Hippocampal and Thalamic Inputs to Layer 3 Pyramidal Cells in the Medial Entorhinal Cortex Revealed by Monosynaptic Rabies Tracing. 单突触狂犬病追踪揭示海马和丘脑对内嗅皮层第3层锥体细胞的直接输入。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-04-01 Epub Date: 2025-03-10 DOI: 10.1007/s12264-025-01363-x
Ze Chen, Dietmar Schmitz, John J Tukker
{"title":"Direct Hippocampal and Thalamic Inputs to Layer 3 Pyramidal Cells in the Medial Entorhinal Cortex Revealed by Monosynaptic Rabies Tracing.","authors":"Ze Chen, Dietmar Schmitz, John J Tukker","doi":"10.1007/s12264-025-01363-x","DOIUrl":"10.1007/s12264-025-01363-x","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"707-712"},"PeriodicalIF":5.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11979043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Halting the Progression of Alzheimer's Disease: Is the Goal in Sight? 阻止阿尔茨海默病的进展：目标在眼前吗？
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-04-01 Epub Date: 2024-12-27 DOI: 10.1007/s12264-024-01339-3
Yu-Juan Jia, Xuan-Yue Wang, Jie Liu, Yan-Jiang Wang, Colin L Masters, Jun-Hong Guo
{"title":"Halting the Progression of Alzheimer's Disease: Is the Goal in Sight?","authors":"Yu-Juan Jia, Xuan-Yue Wang, Jie Liu, Yan-Jiang Wang, Colin L Masters, Jun-Hong Guo","doi":"10.1007/s12264-024-01339-3","DOIUrl":"10.1007/s12264-024-01339-3","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"723-727"},"PeriodicalIF":5.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11979006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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