Neuroscience bulletin最新文献_第6页

Pou4f3 Deficiency Obstructs the Subtype Differentiation of Vestibular Hair Cells. Pou4f3缺乏阻碍前庭毛细胞亚型分化。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-24 DOI: 10.1007/s12264-025-01474-5

Qin Zhou, Yikang Huang, Wenli Ni, Mingchuan Feng, Lingjie Wu, Chuijin Lai, Yanping Zhang, Wenyan Li, Yan Chen

引用次数: 0

HSF-1 Regulates Autophagy to Govern Motor Function and Facilitate Toxic Protein Clearance in a C. elegans Model of Amyotrophic Lateral Sclerosis. 在秀丽隐杆线虫肌萎缩性侧索硬化症模型中，HSF-1调节自噬控制运动功能并促进有毒蛋白清除。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-23 DOI: 10.1007/s12264-025-01487-0

Hui Xu, Yaping Shao, Jun Zhang, Yang Ni, Guowang Xu, Cong Liu, Yi Liang, Weidong Le

{"title":"HSF-1 Regulates Autophagy to Govern Motor Function and Facilitate Toxic Protein Clearance in a C. elegans Model of Amyotrophic Lateral Sclerosis.","authors":"Hui Xu, Yaping Shao, Jun Zhang, Yang Ni, Guowang Xu, Cong Liu, Yi Liang, Weidong Le","doi":"10.1007/s12264-025-01487-0","DOIUrl":"https://doi.org/10.1007/s12264-025-01487-0","url":null,"abstract":"Heat shock factor-1 (HSF-1) plays a crucial role in orchestrating stress responses across diverse organisms and disease conditions. Here, we investigate how the HSF-1 signaling pathway influences the degradation of toxic proteins and neuropathological changes in the Caenorhabditis elegans model of amyotrophic lateral sclerosis (ALS). We found that overexpressing HSF-1 improves locomotor ability and increases the survival rate of ALS C. elegans. Moreover, we observed a deceleration of motor neuron degeneration, demonstrating the protective effect of HSF-1 on neurodegenerative processes. Transcriptomic analysis revealed notable changes in genes associated with autophagy and neurodegeneration, underscoring HSF-1's critical involvement in ALS pathology. In addition, metabolomic profiling further highlighted the involvement of this pathway in metabolic reprogramming. Overall, our study underscores the critical role of the HSF-1 signaling pathway in improving survival rate, movement velocity, cellular integrity, and metabolic adaptation, providing new insights into the mechanisms underlying ALS and potential targets for therapeutic intervention.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypothalamic Oxytocin Neuronal Activation Induces Bipolar-Like Mood Changes in Mice in a Sex- and Dosage-Dependent Manner. 下丘脑催产素神经元激活以性别和剂量依赖的方式诱导小鼠双相情感样情绪变化。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-22 DOI: 10.1007/s12264-025-01475-4

Hong Tan, Shizhen Jin, Wenjin Lv, Lingyu Guo, Peiran Jiang, Yongjian Li, Mengjia Shi, Danting Wang, Yongcheng Wang, Aimin Bao

{"title":"Hypothalamic Oxytocin Neuronal Activation Induces Bipolar-Like Mood Changes in Mice in a Sex- and Dosage-Dependent Manner.","authors":"Hong Tan, Shizhen Jin, Wenjin Lv, Lingyu Guo, Peiran Jiang, Yongjian Li, Mengjia Shi, Danting Wang, Yongcheng Wang, Aimin Bao","doi":"10.1007/s12264-025-01475-4","DOIUrl":"https://doi.org/10.1007/s12264-025-01475-4","url":null,"abstract":"Clinical studies have suggested that increased plasma oxytocin (OT) levels are a promising biomarker for bipolar disorder (BD), and our earlier post-mortem study found increased OT activity in the hypothalamic paraventricular nucleus (OTPVN) in BD. However, the potential contribution of the supraoptic nucleus (SON, OTSON), a major part of the central OT system, to BD remains unknown. We therefore systematically performed independent acute or chronic chemogenetic activation of OTPVN, OTSON, or OTPVN+SON experiments in OT-cre mice. We found that acute activation of OTPVN+SON neurons led to slight mania-like (anti-depression-like) behaviors both in male and female mice, while chronic activation of OTPVN or OTPVN+SON led to sex-dependent behavioural changes from depression/anxiety-like to mania-like, accompanied by stress-related molecular changes in a sex- dependent manner in the medial prefrontal cortex. Our findings imply that OT may be involved in bipolar-like mood changes in a sex- and dosage-dependent manner.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Bed Nucleus of the Stria Terminalis-Paraventricular Nucleus of the Hypothalamus Neural Circuit Regulates Neuropathic Pain Through the Brain-Spleen Axis. 下丘脑神经回路终纹床核-室旁核通过脑-脾轴调控神经性疼痛。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-20 DOI: 10.1007/s12264-025-01454-9

Shoumeng Han, Xin Chen, Li Ma, Xin Zeng, Ying Wang, Tingting Xie, Fancan Wu, Kun Song, Kenji Hashimoto, Hanbing Wang, Long Wang

{"title":"The Bed Nucleus of the Stria Terminalis-Paraventricular Nucleus of the Hypothalamus Neural Circuit Regulates Neuropathic Pain Through the Brain-Spleen Axis.","authors":"Shoumeng Han, Xin Chen, Li Ma, Xin Zeng, Ying Wang, Tingting Xie, Fancan Wu, Kun Song, Kenji Hashimoto, Hanbing Wang, Long Wang","doi":"10.1007/s12264-025-01454-9","DOIUrl":"https://doi.org/10.1007/s12264-025-01454-9","url":null,"abstract":"Neuropathic pain is a chronic condition caused by damage or dysfunction in the nervous system. While the spleen may influence neuropathic pain, its role has been poorly understood. This study demonstrates that the spleen plays a crucial role in regulating neuropathic pain through the bed nucleus of the stria terminalis (BNST) - paraventricular nucleus of the hypothalamus (PVN) neural circuit in a chronic constriction injury (CCI) mouse model. Splenectomy, splenic denervation, or splenic sympathectomy significantly increased the mechanical withdrawal threshold (MWT) and reduced macrophage infiltration in the dorsal root ganglia (DRG) of CCI mice. Pseudorabies virus injections into the spleen revealed connections to the BNST and PVN in the brain. Chemogenetic inhibition of the BNST-PVN circuit increased macrophage infiltration in the DRG and decreased the MWT; these effects were reversed by splenectomy, splenic denervation, or sympathectomy. These findings underscore the critical role of the spleen, regulated by the BNST-PVN circuit, in neuropathic pain.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Potential of MgH₂ in Mitigating Cisplatin-Induced Hearing Loss. MgH2在减轻顺铂性听力损失中的治疗潜力。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-11 DOI: 10.1007/s12264-025-01477-2

Yibing Hu, Yihuan Zhang, Shufen Li, Yuan Yu, Jingjing Wang, Zihan Lou, Boya Zhang, Yazhi Xing, Zhengnong Chen

{"title":"Therapeutic Potential of MgH2 in Mitigating Cisplatin-Induced Hearing Loss.","authors":"Yibing Hu, Yihuan Zhang, Shufen Li, Yuan Yu, Jingjing Wang, Zihan Lou, Boya Zhang, Yazhi Xing, Zhengnong Chen","doi":"10.1007/s12264-025-01477-2","DOIUrl":"https://doi.org/10.1007/s12264-025-01477-2","url":null,"abstract":"Cisplatin is a widely-used chemotherapeutic agent, but its dose-limiting ototoxicity often results in irreversible hearing loss. The pathogenesis involves oxidative stress, apoptosis, DNA damage, and inflammatory responses, yet effective preventive strategies remain limited. Here, we demonstrate that magnesium hydride (MgH2), a hydrogen-releasing compound, provides robust protection against cisplatin-induced hearing loss. Our results showed that MgH2 protected auditory function and preserved cochlear hair cells in vivo. Furthermore, it significantly attenuated cisplatin-induced oxidative stress and apoptosis in cultured HEI-OC1 (House Ear Institute-Organ of Corti 1) cells and cochlear explants. Notably, MgH2 suppressed NOD-like receptor family pyrin domain containing 3 (NLRP3)-mediated inflammatory cascades, thereby limiting downstream inflammatory damage. These findings revealed that MgH2 alleviated cisplatin-induced hearing loss through integrated antioxidant, anti-inflammatory, and anti-apoptotic pathways, with NLRP3 identified as a critical regulatory molecule. Collectively, our study provides compelling evidence for MgH2 as a potential therapeutic candidate for the prevention of cisplatin-induced hearing loss.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Model-Dependent Attenuation of Seizures by Cinnabar. 朱砂对癫痫发作的模型依赖性减弱。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-10 DOI: 10.1007/s12264-025-01480-7

Yuang Gu, Yu Yao, Qiuwen Lou, Xinyan Zhu, Ju Lan, Chenshu Gao, Shuangshuang Wu, Jingjia Liang, Cenglin Xu, Yi Wang, Heming Cheng, Zhong Chen

{"title":"Model-Dependent Attenuation of Seizures by Cinnabar.","authors":"Yuang Gu, Yu Yao, Qiuwen Lou, Xinyan Zhu, Ju Lan, Chenshu Gao, Shuangshuang Wu, Jingjia Liang, Cenglin Xu, Yi Wang, Heming Cheng, Zhong Chen","doi":"10.1007/s12264-025-01480-7","DOIUrl":"https://doi.org/10.1007/s12264-025-01480-7","url":null,"abstract":"Epilepsy is one of the most prevalent and severe neurological disorders, and it is inadequately controlled with currently available medications. While cinnabar (mercury(II) sulfide)-a traditional Chinese medicine-has historical application in epilepsy treatment, its therapeutic efficacy and underlying mechanisms are unclear. In this study, we find that cinnabar exerts model-dependent antiseizure efficacy in mice. Specifically, it significantly attenuates acute seizures, enhances the termination of diazepam-resistant status epilepticus, and reduces spontaneous seizures in the kainic acid (KA)-induced seizure model. Conversely, no therapeutic effect was found in the maximal electroshock-, pentylenetetrazole-, or kindling-induced seizure model. Fiber photometry revealed that cinnabar normalizes KA-induced hippocampal neurotransmission imbalances by simultaneously decreasing glutamate hyperactivity and γ-aminobutyric acid hypoactivity. Furthermore, cinnabar has neuroprotective effects and alleviates comorbid anxiety-like behaviors, while showing no alterations in motor function. Our findings suggest cinnabar's potential as a therapeutic agent for seizure management, via a mechanism associated with the reversal of the hippocampal excitatory/inhibitory imbalance.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporoparietal Junction Selectively Mediates Social Projection in Mentalizing. 颞顶连接选择性地调节心理化中的社会投射。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-10 DOI: 10.1007/s12264-025-01483-4

Shaohan Jiang, Sidong Wang, Xiaohong Wan

{"title":"Temporoparietal Junction Selectively Mediates Social Projection in Mentalizing.","authors":"Shaohan Jiang, Sidong Wang, Xiaohong Wan","doi":"10.1007/s12264-025-01483-4","DOIUrl":"https://doi.org/10.1007/s12264-025-01483-4","url":null,"abstract":"Mentalizing, the cognitive process of inferring others' mental states from limited social information, is often facilitated by social projection, a \"self-as-proxy\" strategy that engenders self-other mergence (SOM). While SOM overlaps conceptually with the simulation or theory-driven processes, its neural basis remains unresolved. Using fMRI during a dyadic task where participants estimated both their own confidence (metacognition) and a partner's confidence (mentalizing), we found that SOM critically depended on self-confidence encoded in the dorsal anterior cingulate cortex (dACC) during metacognition. The temporoparietal junction (TPJ) tracked SOM magnitude via effective connectivity with the dACC, while the partner's confidence was distinctly represented in the dorsomedial prefrontal cortex. Further, disrupting TPJ activity via transcranial magnetic stimulation causally attenuated the SOM effect. These findings disentangle social projection from competing frameworks and suggest that the TPJ plays a pivotal role in mediating social projection during mentalizing, advancing the mechanistic understanding of how the self scaffolds social cognition.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction Note: Fluoxetine is Neuroprotective in Early Brain Injury via its Anti-inflammatory and Anti-apoptotic Effects in a Rat Experimental Subarachnoid Hemorrhage Model. 注：氟西汀在实验性大鼠蛛网膜下腔出血模型中通过抗炎和抗凋亡作用对早期脑损伤具有神经保护作用。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-09 DOI: 10.1007/s12264-025-01484-3

Hui-Min Hu, Bin Li, Xiao-Dong Wang, Yun-Shan Guo, Hua Hui, Hai-Ping Zhang, Biao Wang, Da-Geng Huang, Ding-Jun Hao

引用次数: 0

Sex Differences in Pain Contagion Determined by the Balance of Oxytocin and Corticosterone in the Anterior Cingulate Cortex in Rodents. 啮齿动物前扣带皮层催产素和皮质酮平衡决定疼痛传染的性别差异。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-06 DOI: 10.1007/s12264-025-01473-6

Zhiyuan Xie, Wenxi Yuan, Lingbo Zhou, Jie Xiao, Huabao Liao, Jiang-Jian Hu, Xue-Jun Song

引用次数: 0

Modulation of Ryanodine Receptors on Microglial Ramification, Migration, and Phagocytosis in an Alzheimer's Disease Mouse Model. 在阿尔茨海默病小鼠模型中Ryanodine受体对小胶质细胞分支、迁移和吞噬的调节。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-06 DOI: 10.1007/s12264-025-01469-2

Yulin Ouyang, Zihao Chen, Qiang Huang, Hai Zhang, Haolin Song, Xinnian Wang, Wenxiu Dong, Yong Tang, Najeebullah Shah, Shimin Shuai, Yang Zhan

{"title":"Modulation of Ryanodine Receptors on Microglial Ramification, Migration, and Phagocytosis in an Alzheimer's Disease Mouse Model.","authors":"Yulin Ouyang, Zihao Chen, Qiang Huang, Hai Zhang, Haolin Song, Xinnian Wang, Wenxiu Dong, Yong Tang, Najeebullah Shah, Shimin Shuai, Yang Zhan","doi":"10.1007/s12264-025-01469-2","DOIUrl":"https://doi.org/10.1007/s12264-025-01469-2","url":null,"abstract":"Microglial functions are linked to Ca2+ signaling, with endoplasmic reticulum (ER) calcium stores playing a crucial role. Microglial abnormality is a hallmark of Alzheimer's disease (AD), but how ER Ca2+ receptors regulate microglial functions under physiological and AD conditions remains unclear. We found reduced ryanodine receptor 2 (Ryr2) expression in microglia from an AD mouse model. Modulation of RyR2 using S107, a RyR-Calstabin stabilizer, blunted spontaneous Ca2+ transients in controls and normalized Ca2+ transients in AD mice. S107 enhanced ATP-induced migration and phagocytosis while reducing ramification in control microglia; however, these effects were absent in AD microglia. Our findings indicate that RyR2 stabilization promotes an activation state shift in control microglia, a mechanism impaired in AD. These results highlight the role of ER Ca2+ receptors in both homeostatic and AD microglia, providing insights into microglial Ca2+ malfunctions in AD.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0