Neuroscience bulletin最新文献_第6页

Acute Recruitment of VTA Dopamine Neurons by mPOA Esr1+ Neurons to Facilitate Consummatory Male Mating Actions. mPOA Esr1+神经元急性招募VTA多巴胺神经元促进雄性交配行为的完成

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-11-01 Epub Date: 2024-09-07 DOI: 10.1007/s12264-024-01288-x

Zhuo-Lei Jiao, Min Zhang, Ya-Nan Wu, Shuai-Shuai Li, Meng-Tong Gao, Wen Zhang, Xiao-Hong Xu

引用次数: 0

Nucleus Accumbens Corticotropin-Releasing Hormone Neurons Projecting to the Bed Nucleus of the Stria Terminalis Promote Wakefulness and Positive Affective State. 投射到椎体末端床核的大脑皮质促肾上腺皮质激素释放激素神经元促进清醒和积极情绪状态

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-11-01 Epub Date: 2024-07-09 DOI: 10.1007/s12264-024-01233-y

Gaojie Pan, Bing Zhao, Mutian Zhang, Yanan Guo, Yuhua Yan, Dan Dai, Xiaoxi Zhang, Hui Yang, Jinfei Ni, Zhili Huang, Xia Li, Shumin Duan

{"title":"Nucleus Accumbens Corticotropin-Releasing Hormone Neurons Projecting to the Bed Nucleus of the Stria Terminalis Promote Wakefulness and Positive Affective State.","authors":"Gaojie Pan, Bing Zhao, Mutian Zhang, Yanan Guo, Yuhua Yan, Dan Dai, Xiaoxi Zhang, Hui Yang, Jinfei Ni, Zhili Huang, Xia Li, Shumin Duan","doi":"10.1007/s12264-024-01233-y","DOIUrl":"10.1007/s12264-024-01233-y","url":null,"abstract":"The nucleus accumbens (NAc) plays an important role in various emotional and motivational behaviors that rely on heightened wakefulness. However, the neural mechanisms underlying the relationship between arousal and emotion regulation in NAc remain unclear. Here, we investigated the roles of a specific subset of inhibitory corticotropin-releasing hormone neurons in the NAc (NAcCRH) in regulating arousal and emotional behaviors in mice. We found an increased activity of NAcCRH neurons during wakefulness and rewarding stimulation. Activation of NAcCRH neurons converts NREM or REM sleep to wakefulness, while inhibition of these neurons attenuates wakefulness. Remarkably, activation of NAcCRH neurons induces a place preference response (PPR) and decreased basal anxiety level, whereas their inactivation induces a place aversion response and anxious state. NAcCRH neurons are identified as the major NAc projection neurons to the bed nucleus of the stria terminalis (BNST). Furthermore, activation of the NAcCRH-BNST pathway similarly induced wakefulness and positive emotional behaviors. Taken together, we identified a basal forebrain CRH pathway that promotes the arousal associated with positive affective states.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1602-1620"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Molecular Taxonomics of Neuron in Cingulate Cortex of Rhesus Monkey and Mouse via Single-Nucleus RNA Sequencing. 通过单核 RNA 测序比较猕猴和小鼠扣带回皮层神经元的分子分类学。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-11-01 Epub Date: 2024-05-23 DOI: 10.1007/s12264-024-01209-y

Lei Zhang, Yanyong Cheng, Zhenyu Xue, Shihao Wu, Zilong Qiu, Hong Jiang

引用次数: 0

Glutamatergic Circuits in the Pedunculopontine Nucleus Modulate Multiple Motor Functions. 脊髓前核中的谷氨酸能回路调节多种运动功能

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-11-01 Epub Date: 2024-11-11 DOI: 10.1007/s12264-024-01314-y

Yanwang Huang, Shangyi Wang, Qingxiu Wang, Chaowen Zheng, Feng Yang, Lei Wei, Xintong Zhou, Zuoren Wang

{"title":"Glutamatergic Circuits in the Pedunculopontine Nucleus Modulate Multiple Motor Functions.","authors":"Yanwang Huang, Shangyi Wang, Qingxiu Wang, Chaowen Zheng, Feng Yang, Lei Wei, Xintong Zhou, Zuoren Wang","doi":"10.1007/s12264-024-01314-y","DOIUrl":"10.1007/s12264-024-01314-y","url":null,"abstract":"The functional role of glutamatergic (vGluT2) neurons in the pedunculopontine nucleus (PPN) in modulating motor activity remains controversial. Here, we demonstrated that the activity of vGluT2 neurons in the rostral PPN is correlated with locomotion and ipsilateral head-turning. Beyond these motor functions, we found that these rostral PPN-vGluT2 neurons remarkably respond to salient stimuli. Furthermore, we systematically traced the upstream and downstream projections of these neurons and identified two downstream projections from these neurons to the caudal pontine reticular nucleus/anterior gigantocellular reticular nucleus (PnC/GiA) and the zona incerta (ZI). Our findings indicate that the projections to the PnC/GiA inhibit movement, consistent with 'pause-and-play' behavior, whereas those to the ZI promote locomotion, and others respond to a new 'pause-switch-play' pattern. Collectively, these findings elucidate the multifaceted influence of the PPN on motor functions and provide a robust theoretical framework for understanding its physiological and potential therapeutic implications.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1713-1731"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Whole-brain Mapping of Inputs and Outputs of Specific Orbitofrontal Cortical Neurons in Mice. 小鼠特定轨道额叶皮层神经元输入和输出的全脑图谱。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-11-01 Epub Date: 2024-05-27 DOI: 10.1007/s12264-024-01229-8

Yijie Zhang, Wen Zhang, Lizhao Wang, Dechen Liu, Taorong Xie, Ziwei Le, Xiangning Li, Hui Gong, Xiao-Hong Xu, Min Xu, Haishan Yao

{"title":"Whole-brain Mapping of Inputs and Outputs of Specific Orbitofrontal Cortical Neurons in Mice.","authors":"Yijie Zhang, Wen Zhang, Lizhao Wang, Dechen Liu, Taorong Xie, Ziwei Le, Xiangning Li, Hui Gong, Xiao-Hong Xu, Min Xu, Haishan Yao","doi":"10.1007/s12264-024-01229-8","DOIUrl":"10.1007/s12264-024-01229-8","url":null,"abstract":"The orbitofrontal cortex (ORB), a region crucial for stimulus-reward association, decision-making, and flexible behaviors, extensively connects with other brain areas. However, brain-wide inputs to projection-defined ORB neurons and the distribution of inhibitory neurons postsynaptic to neurons in specific ORB subregions remain poorly characterized. Here we mapped the inputs of five types of projection-specific ORB neurons and ORB outputs to two types of inhibitory neurons. We found that different projection-defined ORB neurons received inputs from similar cortical and thalamic regions, albeit with quantitative variations, particularly in somatomotor areas and medial groups of the dorsal thalamus. By counting parvalbumin (PV) or somatostatin (SST) interneurons innervated by neurons in specific ORB subregions, we found a higher fraction of PV neurons in sensory cortices and a higher fraction of SST neurons in subcortical regions targeted by medial ORB neurons. These results provide insights into understanding and investigating the function of specific ORB neurons.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1681-1698"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Chemokine CCL2 Promotes Excitatory Synaptic Transmission in Hippocampal Neurons via GluA1 Subunit Trafficking. 趋化因子 CCL2 通过 GluA1 亚基运输促进海马神经元的兴奋性突触传递

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-11-01 Epub Date: 2024-07-02 DOI: 10.1007/s12264-024-01236-9

En Ji, Yuanyuan Zhang, Zhiqiang Li, Lai Wei, Zhaofa Wu, Yulong Li, Xiang Yu, Tian-Jia Song

{"title":"The Chemokine CCL2 Promotes Excitatory Synaptic Transmission in Hippocampal Neurons via GluA1 Subunit Trafficking.","authors":"En Ji, Yuanyuan Zhang, Zhiqiang Li, Lai Wei, Zhaofa Wu, Yulong Li, Xiang Yu, Tian-Jia Song","doi":"10.1007/s12264-024-01236-9","DOIUrl":"10.1007/s12264-024-01236-9","url":null,"abstract":"The CC chemokine ligand 2 (CCL2, also known as MCP-1) and its cognate receptor CCR2 have well-characterized roles in chemotaxis. CCL2 has been previously shown to promote excitatory synaptic transmission and neuronal excitability. However, the detailed molecular mechanism underlying this process remains largely unclear. In cultured hippocampal neurons, CCL2 application rapidly upregulated surface expression of GluA1, in a CCR2-dependent manner, assayed using SEP-GluA1 live imaging, surface GluA1 antibody staining, and electrophysiology. Using pharmacology and reporter assays, we further showed that CCL2 upregulated surface GluA1 expression primarily via Gαq- and CaMKII-dependent signaling. Consistently, using i.p. injection of lipopolysaccharide to induce neuroinflammation, we found upregulated phosphorylation of S831 and S845 sites on AMPA receptor subunit GluA1 in the hippocampus, an effect blocked in Ccr2-/- mice. Together, these results provide a mechanism through which CCL2, and other secreted molecules that signal through G-protein coupled receptors, can directly regulate synaptic transmission.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1649-1666"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tracing from Periphery to Cortex: Application of Herpes Simplex Virus to Somatosensory Neural Networks. 从外周追踪到皮层：单纯疱疹病毒在体感神经网络中的应用。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-11-01 Epub Date: 2024-10-16 DOI: 10.1007/s12264-024-01309-9

Yan Chen, Qin Chen, Yuran Song, Huadong Wang, Xinyu Hu, Kaikai Wang, Xuanyuan Wu, Fuqiang Xu, Lan Bao, Xu Zhang

引用次数: 0

Functional Connectivity Encodes Sound Locations by Lateralization Angles. 功能连接通过侧化角度编码声音位置

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-10-29 DOI: 10.1007/s12264-024-01312-0

Renjie Tong, Shaoyi Su, Ying Liang, Chunlin Li, Liwei Sun, Xu Zhang

{"title":"Functional Connectivity Encodes Sound Locations by Lateralization Angles.","authors":"Renjie Tong, Shaoyi Su, Ying Liang, Chunlin Li, Liwei Sun, Xu Zhang","doi":"10.1007/s12264-024-01312-0","DOIUrl":"https://doi.org/10.1007/s12264-024-01312-0","url":null,"abstract":"The ability to localize sound sources rapidly allows human beings to efficiently understand the surrounding environment. Previous studies have suggested that there is an auditory \"where\" pathway in the cortex for processing sound locations. The neural activation in regions along this pathway encodes sound locations by opponent hemifield coding, in which each unilateral region is activated by sounds coming from the contralateral hemifield. However, it is still unclear how these regions interact with each other to form a unified representation of the auditory space. In the present study, we investigated whether functional connectivity in the auditory \"where\" pathway encoded sound locations during passive listening. Participants underwent functional magnetic resonance imaging while passively listening to sounds from five distinct horizontal locations (-90°, -45°, 0°, 45°, 90°). We were able to decode sound locations from the functional connectivity patterns of the \"where\" pathway. Furthermore, we found that such neural representation of sound locations was primarily based on the coding of sound lateralization angles to the frontal midline. In addition, whole-brain analysis indicated that functional connectivity between occipital regions and the primary auditory cortex also encoded sound locations by lateralization angles. Overall, our results reveal a lateralization-angle-based representation of sound locations encoded by functional connectivity patterns, which could add on the activation-based opponent hemifield coding to provide a more precise representation of the auditory space.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

VTA is the Key to Pain Resilience in Empathic Behavior. VTA是移情行为中疼痛复原力的关键

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-10-28 DOI: 10.1007/s12264-024-01313-z

Xue-Qing Wu, Yi-La Ding, Yu Du, Zhong Chen, Bei Tan

引用次数: 0

Early Postnatal Pharmacological Intervention Rescues the Disruption of Developmental Connectivity in MAO-A KO Mice. 产后早期药物干预可挽救 MAO-A KO 小鼠发育连通性的破坏

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-10-24 DOI: 10.1007/s12264-024-01304-0

Qian Xue, Hanpeng Xu, Muye Zhu, Bin Qian, Lei Gao, Lin Gou, Houri Hintiryan, Jean C Shih, Hong-Wei Dong

引用次数: 0