Neuroscience bulletin最新文献_第6页

A New Pathway Mediating Pain Sensitization after Active Sleep Deprivation. 主动睡眠剥夺后介导疼痛敏化的新途径

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-14 DOI: 10.1007/s12264-024-01337-5

Xinyue Zhao, Yanrong Zheng, Zhong Chen

引用次数: 0

Dysregulation of Iron Homeostasis Mediated by FTH Increases Ferroptosis Sensitivity in TP53-Mutant Glioblastoma. FTH介导的铁稳态失调增加tp53突变型胶质母细胞瘤的铁凋亡敏感性。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-12 DOI: 10.1007/s12264-024-01322-y

Xuejie Huan, Jiangang Li, Zhaobin Chu, Hongliang Zhang, Lei Cheng, Peng Lun, Xixun Du, Xi Chen, Qian Jiao, Hong Jiang

{"title":"Dysregulation of Iron Homeostasis Mediated by FTH Increases Ferroptosis Sensitivity in TP53-Mutant Glioblastoma.","authors":"Xuejie Huan, Jiangang Li, Zhaobin Chu, Hongliang Zhang, Lei Cheng, Peng Lun, Xixun Du, Xi Chen, Qian Jiao, Hong Jiang","doi":"10.1007/s12264-024-01322-y","DOIUrl":"https://doi.org/10.1007/s12264-024-01322-y","url":null,"abstract":"Iron metabolism is a critical factor in tumorigenesis and development. Although TP53 mutations are prevalent in glioblastoma (GBM), the mechanisms by which TP53 regulates iron metabolism remain elusive. We reveal an imbalance iron homeostasis in GBM via TCGA database analysis. TP53 mutations disrupted iron homeostasis in GBM, characterized by elevated total iron levels and reduced ferritin (FTH). The gain-of-function effect triggered by TP53 mutations upregulates itchy E3 ubiquitin-protein ligase (ITCH) protein expression in astrocytes, leading to FTH degradation and an increase in free iron levels. TP53-mut astrocytes were more tolerant to the high iron environment induced by exogenous ferric ammonium citrate (FAC), but the increase in intracellular free iron made them more sensitive to Erastin-induced ferroptosis. Interestingly, we found that Erastin combined with FAC treatment significantly increased ferroptosis. These findings provide new insights for drug development and therapeutic modalities for GBM patients with TP53 mutations from iron metabolism perspectives.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Current State and Future Outlook of PET Tracers for AMPA Receptors. AMPA受体PET示踪剂的研究现状及展望。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-11 DOI: 10.1007/s12264-024-01332-w

Ling Li, Shenglin Wen, Ji Dai

引用次数: 0

Reprogramming miR-146b-snphb Signaling Activates Axonal Mitochondrial Transport in the Zebrafish M-cell and Facilitates Axon Regeneration After Injury. 重编程miR-146b-snphb信号激活斑马鱼m细胞轴突线粒体运输并促进损伤后轴突再生

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-08 DOI: 10.1007/s12264-024-01329-5

Xin-Liang Wang, Zong-Yi Wang, Xing-Han Chen, Yuan Cai, Bing Hu

{"title":"Reprogramming miR-146b-snphb Signaling Activates Axonal Mitochondrial Transport in the Zebrafish M-cell and Facilitates Axon Regeneration After Injury.","authors":"Xin-Liang Wang, Zong-Yi Wang, Xing-Han Chen, Yuan Cai, Bing Hu","doi":"10.1007/s12264-024-01329-5","DOIUrl":"https://doi.org/10.1007/s12264-024-01329-5","url":null,"abstract":"Acute mitochondrial damage and the energy crisis following axonal injury highlight mitochondrial transport as an important target for axonal regeneration. Syntaphilin (Snph), known for its potent mitochondrial anchoring action, has emerged as a significant inhibitor of both mitochondrial transport and axonal regeneration. Therefore, investigating the molecular mechanisms that influence the expression levels of the snph gene can provide a viable strategy to regulate mitochondrial trafficking and enhance axonal regeneration. Here, we reveal the inhibitory effect of microRNA-146b (miR-146b) on the expression of the homologous zebrafish gene syntaphilin b (snphb). Through CRISPR/Cas9 and single-cell electroporation, we elucidated the positive regulatory effect of the miR-146b-snphb axis on Mauthner cell (M-cell) axon regeneration at the global and single-cell levels. Through escape response tests, we show that miR-146b-snphb signaling positively regulates functional recovery after M-cell axon injury. In addition, continuous dynamic imaging in vivo showed that reprogramming miR-146b significantly promotes axonal mitochondrial trafficking in the pre-injury and early stages of regeneration. Our study reveals an intrinsic axonal regeneration regulatory axis that promotes axonal regeneration by reprogramming mitochondrial transport and anchoring. This regulation involves noncoding RNA, and mitochondria-associated genes may provide a potential opportunity for the repair of central nervous system injury.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Autophagy in Oligodendrocyte Lineage Cells Controls Oligodendrocyte Numbers and Myelin Integrity in an Age-dependent Manner. 更正：少突胶质细胞系细胞的自噬以年龄依赖的方式控制少突胶质细胞数量和髓磷脂完整性。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-06 DOI: 10.1007/s12264-024-01315-x

Hong Chen, Gang Yang, De-En Xu, Yu-Tong Du, Chao Zhu, Hua Hu, Li Luo, Lei Feng, Wenhui Huang, Yan-Yun Sun, Quan-Hong Ma

引用次数: 0

NG2 Glia: The Guardians Against Prion-induced Neurotoxicity Through Prostaglandin E2 Blockade. NG2胶质细胞：通过阻断前列腺素E2抵抗朊病毒诱导的神经毒性的守护者。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-05 DOI: 10.1007/s12264-024-01333-9

Shu Feng, Emily Parker, Timon Cheng-Yi Liu, Luodan Yang

引用次数: 0

Histaminergic Innervation of the Ventral Anterior Thalamic Nucleus Alleviates Motor Deficits in a 6-OHDA-Induced Rat Model of Parkinson's Disease. 丘脑腹侧前核的组胺能神经支配减轻6-羟多巴胺诱导的帕金森病大鼠模型的运动缺陷。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-02 DOI: 10.1007/s12264-024-01320-0

Han-Ting Xu, Xiao-Ya Xi, Shuang Zhou, Yun-Yong Xie, Zhi-San Cui, Bei-Bei Zhang, Shu-Tao Xie, Hong-Zhao Li, Qi-Peng Zhang, Yang Pan, Xiao-Yang Zhang, Jing-Ning Zhu

{"title":"Histaminergic Innervation of the Ventral Anterior Thalamic Nucleus Alleviates Motor Deficits in a 6-OHDA-Induced Rat Model of Parkinson's Disease.","authors":"Han-Ting Xu, Xiao-Ya Xi, Shuang Zhou, Yun-Yong Xie, Zhi-San Cui, Bei-Bei Zhang, Shu-Tao Xie, Hong-Zhao Li, Qi-Peng Zhang, Yang Pan, Xiao-Yang Zhang, Jing-Ning Zhu","doi":"10.1007/s12264-024-01320-0","DOIUrl":"https://doi.org/10.1007/s12264-024-01320-0","url":null,"abstract":"The ventral anterior (VA) nucleus of the thalamus is a major target of the basal ganglia and is closely associated with the pathogenesis of Parkinson's disease (PD). Notably, the VA receives direct innervation from the hypothalamic histaminergic system. However, its role in PD remains unknown. Here, we assessed the contribution of histamine to VA neuronal activity and PD motor deficits. Functional magnetic resonance imaging showed reduced VA activity in PD patients. Optogenetic activation of VA neurons or histaminergic afferents significantly alleviated motor deficits in 6-OHDA-induced PD rats. Furthermore, histamine excited VA neurons via H1 and H2 receptors and their coupled hyperpolarization-activated cyclic nucleotide-gated channels, inward-rectifier K+ channels, or Ca2+-activated K+ channels. These results demonstrate that histaminergic afferents actively compensate for Parkinsonian motor deficits by biasing VA activity. These findings suggest that targeting VA histamine receptors and downstream ion channels may be a potential therapeutic strategy for PD motor dysfunction.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Method to Extract Task-Related EEG Feature Based on Lightweight Convolutional Neural Network. 基于轻量级卷积神经网络的任务相关脑电图特征提取方法

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-01 Epub Date: 2024-07-02 DOI: 10.1007/s12264-024-01247-6

Qi Huang, Jing Ding, Xin Wang

{"title":"A Method to Extract Task-Related EEG Feature Based on Lightweight Convolutional Neural Network.","authors":"Qi Huang, Jing Ding, Xin Wang","doi":"10.1007/s12264-024-01247-6","DOIUrl":"10.1007/s12264-024-01247-6","url":null,"abstract":"Unlocking task-related EEG spectra is crucial for neuroscience. Traditional convolutional neural networks (CNNs) effectively extract these features but face limitations like overfitting due to small datasets. To address this issue, we propose a lightweight CNN and assess its interpretability through the fully connected layer (FCL). Initially tested with two tasks (Task 1: open vs closed eyes, Task 2: interictal vs ictal stage), the CNN demonstrated enhanced spectral features in the alpha band for Task 1 and the theta band for Task 2, aligning with established neurophysiological characteristics. Subsequent experiments on two brain-computer interface tasks revealed a correlation between delta activity (around 1.55 Hz) and hand movement, with consistent results across pericentral electroencephalogram (EEG) channels. Compared to recent research, our method stands out by delivering task-related spectral features through FCL, resulting in significantly fewer trainable parameters while maintaining comparable interpretability. This indicates its potential suitability for a wider array of EEG decoding scenarios.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1915-1930"},"PeriodicalIF":5.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurotransmitter Switching: A Novel Mechanism for Fear Generalization. 神经递质转换：恐惧泛化的新机制

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-01 Epub Date: 2024-07-29 DOI: 10.1007/s12264-024-01264-5

Jiayuan Zheng, Zhanzhuang Tian

引用次数: 0

CGRP: Does A Novel Neuroimmune Modulator Facilitate Tissue Repair? CGRP：一种新型神经免疫调节剂是否能促进组织修复？

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-01 Epub Date: 2024-08-03 DOI: 10.1007/s12264-024-01275-2

Xiang Cui, Xinyan Gao, Bing Zhu

引用次数: 0