Neuroscience bulletin最新文献_第6页

Targeting Programmed Cell Death in Acquired Sensorineural Hearing Loss: Ferroptosis, Necroptosis, and Pyroptosis. 获得性感音神经性听力损失的靶向程序性细胞死亡：铁下垂、坏死性下垂和焦下垂。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-06-01 Epub Date: 2025-04-22 DOI: 10.1007/s12264-025-01370-y

Shasha Zhang, Hairong Xiao, Yanqin Lin, Xujun Tang, Wei Tong, Buwei Shao, He Li, Lei Xu, Xiaoqiong Ding, Renjie Chai

引用次数: 0

Stress-Induced Endogenous Cannabinoid Signaling Contributes to Fear Generalization. 应激诱导的内源性大麻素信号有助于恐惧泛化。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-06-01 Epub Date: 2025-04-15 DOI: 10.1007/s12264-025-01391-7

Yanan Yue, Xia Zhang, Yuan Dong

引用次数: 0

Engineered Extracellular Vesicles Loaded with MiR-100-5p Antagonist Selectively Target the Lesioned Region to Promote Recovery from Brain Damage. 负载MiR-100-5p拮抗剂的工程细胞外囊泡选择性靶向损伤区域以促进脑损伤的恢复。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-06-01 Epub Date: 2025-04-01 DOI: 10.1007/s12264-025-01376-6

Yahong Cheng, Chengcheng Gai, Yijing Zhao, Tingting Li, Yan Song, Qian Luo, Danqing Xin, Zige Jiang, Wenqiang Chen, Dexiang Liu, Zhen Wang

{"title":"Engineered Extracellular Vesicles Loaded with MiR-100-5p Antagonist Selectively Target the Lesioned Region to Promote Recovery from Brain Damage.","authors":"Yahong Cheng, Chengcheng Gai, Yijing Zhao, Tingting Li, Yan Song, Qian Luo, Danqing Xin, Zige Jiang, Wenqiang Chen, Dexiang Liu, Zhen Wang","doi":"10.1007/s12264-025-01376-6","DOIUrl":"10.1007/s12264-025-01376-6","url":null,"abstract":"Hypoxic-ischemic (HI) brain damage poses a high risk of death or lifelong disability, yet effective treatments remain elusive. Here, we demonstrated that miR-100-5p levels in the lesioned cortex increased after HI insult in neonatal mice. Knockdown of miR-100-5p expression in the brain attenuated brain injury and promoted functional recovery, through inhibiting the cleaved-caspase-3 level, microglia activation, and the release of proinflammation cytokines following HI injury. Engineered extracellular vesicles (EVs) containing neuron-targeting rabies virus glycoprotein (RVG) and miR-100-5p antagonists (RVG-EVs-Antagomir) selectively targeted brain lesions and reduced miR-100-5p levels after intranasal delivery. Both pre- and post-HI administration showed therapeutic benefits. Mechanistically, we identified protein phosphatase 3 catalytic subunit alpha (Ppp3ca) as a novel candidate target gene of miR-100-5p, inhibiting c-Fos expression and neuronal apoptosis following HI insult. In conclusion, our non-invasive method using engineered EVs to deliver miR-100-5p antagomirs to the brain significantly improves functional recovery after HI injury by targeting Ppp3ca to suppress neuronal apoptosis.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1021-1040"},"PeriodicalIF":5.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Potentially Shared Neural Basis Linking Rapid Saccades and Avoidance Initiation in the Superior Colliculus Driven by Visual Threats. 视觉威胁驱动下上丘快速扫视和回避启动的潜在共享神经基础。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-06-01 Epub Date: 2025-03-29 DOI: 10.1007/s12264-025-01389-1

Zhou Sun, Yu Gu

引用次数: 0

Sexually Dimorphic Cellular Architecture and Neural Circuity of ovBNST Proenkephalin Neurons. ovBNST前脑啡肽神经元的两性二态细胞结构和神经回路。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-30 DOI: 10.1007/s12264-025-01428-x

Limei Song, Yuqing Zhang, Mengqi Feng, Wenwen Su, Riming Zhu, Bin Zhang, Xia Zhang, Jie Li

{"title":"Sexually Dimorphic Cellular Architecture and Neural Circuity of ovBNST Proenkephalin Neurons.","authors":"Limei Song, Yuqing Zhang, Mengqi Feng, Wenwen Su, Riming Zhu, Bin Zhang, Xia Zhang, Jie Li","doi":"10.1007/s12264-025-01428-x","DOIUrl":"https://doi.org/10.1007/s12264-025-01428-x","url":null,"abstract":"Sexual dimorphism in the brain underlies behavioral differences between sexes. The bed nucleus of the stria terminalis (BNST) is a complex nucleus that differs between males and females, but the sexual dimorphism in cytoarchitecture and the connectome of its oval subdivision (ovBNST) remains largely unexplored. By combining snRNA-seq and transgenic labeling, we found a higher density of ovBNST proenkephalin (ovBNSTPENK) neurons in male than female mice. Anatomically, we virally mapped the efferents and afferents of ovBNSTPENK neurons, finding reciprocally dimorphic connections with the hypothalamus and striatum. Gene enrichment analysis suggests that ovBNSTPENK neurons are modulated by the upstream dopamine pathway. Functionally, by applying caspase-3-mediated depletion of ovBNSTPENK neurons, we found that loss of these neurons enhanced locomotor activity in male but not female mice, without altering the anxiety-like phenotypes in either sex. Our study may pave the way for a better understanding of the anatomical and functional profiles of ovBNSTPENK neurons from a sexually dimorphic perspective.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Piezo1 Mediates Ultrasound-Stimulated Dopaminergic Neuron Protection via Synaptic Vesicle Recycling and Ferroptosis Inhibition. 压电1通过突触囊泡循环和铁下垂抑制介导超声刺激的多巴胺能神经元保护。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-29 DOI: 10.1007/s12264-025-01420-5

Tian Xu, Li Zhang, Xiaoxiao Lu, Wei Ji, Kaidong Chen

{"title":"Piezo1 Mediates Ultrasound-Stimulated Dopaminergic Neuron Protection via Synaptic Vesicle Recycling and Ferroptosis Inhibition.","authors":"Tian Xu, Li Zhang, Xiaoxiao Lu, Wei Ji, Kaidong Chen","doi":"10.1007/s12264-025-01420-5","DOIUrl":"https://doi.org/10.1007/s12264-025-01420-5","url":null,"abstract":"Parkinson's disease (PD) is a neurodegenerative disorder characterized by the aggregation of α-synuclein (α-syn) and dysregulated synaptic vesicle (SV) recycling. Emerging evidence suggests that ferroptosis is the target of PD therapy. However, the identification of effective anti-ferroptosis treatments remains elusive. This study explores the therapeutic potential of low-intensity ultrasound (US) in modulating SV recycling and anti-ferroptosis in cellular and animal models of PD. We demonstrate that optimized US stimulation (610 kHz, 0.2 W/cm2) activates Piezo1 channel-mediated fast endophilin-mediated endocytosis, which promotes SV recycling and synaptic function, presenting with increased frequency and amplitude of both spontaneous excitatory synaptic currents and miniature excitatory postsynaptic currents. Repaired SV recycling in turn reduces the accumulation of α-syn expression and ferroptotic cell death. These findings support the potential of noninvasive ultrasonic neuromodulation as a therapeutic strategy for PD and lead to meaningful health outcomes for the aging population.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vitro and Animal Studies of Human Natural Killer Cell-Derived Exosomes for the Treatment of Otitis Media. 人自然杀伤细胞衍生外泌体治疗中耳炎的体外和动物研究。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-27 DOI: 10.1007/s12264-025-01423-2

Zirui Zhao, Liqin Wang, Zhen Guo, Kanglun Jiang, Jianghong Xu, Yilai Shu, Christina Y Xu, Jianning Zhang, Yunfeng Wang, Geng-Lin Li

引用次数: 0

WNK1 Alleviates Chloride Efflux-Induced NLRP3 Inflammasome Activation and Subsequent Neuroinflammation in Early Brain Injury Following Subarachnoid Hemorrhage. WNK1减轻氯化物外排诱导的NLRP3炎性体激活和蛛网膜下腔出血后早期脑损伤的后续神经炎症

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-27 DOI: 10.1007/s12264-025-01414-3

Panpan Zhao, Huimiao Feng, Xinyu Zhou, Jingyuan Zhou, Fangbo Hu, Taotao Hu, Yong Sun

{"title":"WNK1 Alleviates Chloride Efflux-Induced NLRP3 Inflammasome Activation and Subsequent Neuroinflammation in Early Brain Injury Following Subarachnoid Hemorrhage.","authors":"Panpan Zhao, Huimiao Feng, Xinyu Zhou, Jingyuan Zhou, Fangbo Hu, Taotao Hu, Yong Sun","doi":"10.1007/s12264-025-01414-3","DOIUrl":"https://doi.org/10.1007/s12264-025-01414-3","url":null,"abstract":"The nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome plays a crucial role in the prognosis of subarachnoid hemorrhage (SAH). WNK1 kinase negatively regulates NLRP3 in various inflammatory conditions, but its role in early brain injury (EBI) after SAH remains unclear. In this study, we used an in vivo SAH model in rats/mice and AAV-WNK1 intraventricular injection to investigate its neuroprotective mechanisms. WNK1 expression was significantly reduced in SAH patient blood and SAH model brain tissue, correlating negatively with microglial activation. AAV-WNK1 alleviated brain edema, neuronal necrosis, behavioral deficits, and inflammation by inhibiting NLRP3 inflammasome activation. In hemin-stimulated BV-2 cells, WNK1 overexpression reduced NLRP3 activation and inflammatory cytokines. Chloride counteracted WNK1's inhibitory effects, and WNK1 suppressed P2X7R-induced NLRP3 activation. Mechanistically, WNK1 functioned via the OXSR1/STK39 pathway. These findings highlight WNK1 as a key regulator of intracellular chloride balance and neuroinflammation, presenting a potential therapeutic target for SAH treatment.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intrinsic Functional Connectivity Associated with γ‑Aminobutyric Acid and Glutamate/Glutamine in the Lateral Prefrontal Cortex and Internalizing Psychopathology in Adolescents. 青少年前额叶外侧皮层γ -氨基丁酸和谷氨酸/谷氨酰胺相关的内在功能连接与内化精神病理。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-26 DOI: 10.1007/s12264-025-01408-1

Kai Wang, Harry R Smolker, Mark S Brown, Hannah R Snyder, Yu Cheng, Benjamin L Hankin, Marie T Banich

{"title":"Intrinsic Functional Connectivity Associated with γ‑Aminobutyric Acid and Glutamate/Glutamine in the Lateral Prefrontal Cortex and Internalizing Psychopathology in Adolescents.","authors":"Kai Wang, Harry R Smolker, Mark S Brown, Hannah R Snyder, Yu Cheng, Benjamin L Hankin, Marie T Banich","doi":"10.1007/s12264-025-01408-1","DOIUrl":"https://doi.org/10.1007/s12264-025-01408-1","url":null,"abstract":"In this study, we systematically tested the hypothesis that during the critical developmental period of adolescence, on a macro scale, the concentrations of major excitatory and inhibitory neurotransmitters (glutamate/glutamine and γ‑aminobutyric acid [GABA]) in the dorsal and ventral lateral prefrontal cortex are associated with the brain's functional connectivity and an individual's psychopathology. Neurotransmitters were measured via magnetic resonance spectroscopy while functional connectivity was measured with resting-state fMRI (n = 121). Seed-based and network-based analyses revealed associations of neurotransmitter concentrations and functional connectivities between regions/networks that are connected to prefrontal cortices via structural connections that are thought to be under dynamic development during adolescence. These regions tend to be boundary areas between functional networks. Furthermore, several connectivities were found to be associated with individual's levels of internalizing psychopathology. These findings provide insights into specific neurochemical mechanisms underlying the brain's macroscale functional organization, its development during adolescence, and its potential associations with symptoms associated with internalizing psychopathology.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OGT-Mediated O-GlcNAcylation of ATF2 Protects Against Sepsis-Associated Encephalopathy by Inhibiting Microglial Pyroptosis. ogt介导的o - glcn酰化ATF2通过抑制小胶质细胞焦亡来预防败血症相关脑病。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-24 DOI: 10.1007/s12264-025-01418-z

Huan Yao, Caixia Liang, Xueting Wang, Chengwei Duan, Xiao Song, Yanxing Shang, Mingyang Zhang, Yiyun Peng, Dongmei Zhang

引用次数: 0