Neuroscience bulletin最新文献_第5页

Tumor Necrosis Factor Alpha-Mediated Interaction Between Microglia and Müller Cells Exacerbates Retinal Ganglion Cell Damage in Experimental Glaucoma. 实验性青光眼中肿瘤坏死因子α介导的小胶质细胞和<s:1>勒细胞之间的相互作用加剧了视网膜神经节细胞的损伤。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-30 DOI: 10.1007/s12264-025-01478-1

Shu-Ying Li, Hong Zhou, Guoli Zhao, Wen-Wen Ding, Yu Zhang, Yong-Chen Wang, Fang Li, Yanying Miao, Xing-Huai Sun, Zhongfeng Wang

{"title":"Tumor Necrosis Factor Alpha-Mediated Interaction Between Microglia and Müller Cells Exacerbates Retinal Ganglion Cell Damage in Experimental Glaucoma.","authors":"Shu-Ying Li, Hong Zhou, Guoli Zhao, Wen-Wen Ding, Yu Zhang, Yong-Chen Wang, Fang Li, Yanying Miao, Xing-Huai Sun, Zhongfeng Wang","doi":"10.1007/s12264-025-01478-1","DOIUrl":"https://doi.org/10.1007/s12264-025-01478-1","url":null,"abstract":"Interaction between Müller cells and microglia aggravates neuroinflammation, resulting in retinal ganglion cell (RGC) death in glaucoma. Here, we investigated how tumor necrosis factor-alpha (TNF-α) produced by activated microglia mediates the crosstalk between Müller cells and microglia and impacts RGC injury in a chronic ocular hypertension (COH) glaucoma model. In COH retinas, elevated TNF-α induced the activation of Müller cells and microglia, and recruited microglia to the ganglion cell layer. Co-culture with Müller cells enhanced TNF-α-induced microglial activation, migration, and proliferation. Both in vivo and in vitro experiments confirmed that chemokine C-C motif ligand 2 (CCL2), primarily released from Müller cells, mediated the TNF-α-induced effects on microglia in COH retinas. Knockdown of CCL2 attenuated RGC damage and vision loss. Our results demonstrate that TNF-α released from microglia induces the secretion of CCL2 from Müller cells, thus inducing microglial activation and migration, exacerbating retinal neuroinflammation and RGC injury in glaucoma.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitophagy Activation by N-Acetylcysteine Protects against Mic60 Deficiency-Induced Auditory Neuropathy. n -乙酰半胱氨酸激活线粒体可预防Mic60缺乏引起的听神经病变。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-30 DOI: 10.1007/s12264-025-01485-2

Yilin Sun, Chunying Liu, Yakun Liang, An Lv, Wang Nie, Shuyue Bao, Xiaoyi Li, Jing Zhou, Weimin Tong, Yong Tao, Xueling Wang, Tingting Dong

{"title":"Mitophagy Activation by N-Acetylcysteine Protects against Mic60 Deficiency-Induced Auditory Neuropathy.","authors":"Yilin Sun, Chunying Liu, Yakun Liang, An Lv, Wang Nie, Shuyue Bao, Xiaoyi Li, Jing Zhou, Weimin Tong, Yong Tao, Xueling Wang, Tingting Dong","doi":"10.1007/s12264-025-01485-2","DOIUrl":"https://doi.org/10.1007/s12264-025-01485-2","url":null,"abstract":"Auditory neuropathy (AN) is a sensorineural hearing loss that impairs speech perception, but its mechanisms and treatments remain limited. Mic60, essential for the mitochondrial contact site and cristae organizing system, is linked to neurological disorders, yet its role in the auditory system remains unclear. We demonstrate that Mic60+/- mice develop progressive hearing loss from 6 months of age, with reduced auditory brainstem response amplitudes despite preserved outer hair cell function, consistent with AN. Mitochondrial abnormalities in spiral ganglion neurons (SGNs) emerge by 3 months, followed by mitochondrial loss and SGN degeneration, indicating progressive auditory neuron dysfunction. In vitro, Mic60 deficiency disrupts mitochondrial respiration, reversible by N-acetylcysteine (NAC). NAC treatment preserves mitochondrial integrity and rescues hearing by enhancing mitophagy. Our findings establish Mic60+/- mice as an AN animal model, highlight the role of Mic60 in the mitochondria of primary auditory neurons, and identify NAC as a potential AN treatment.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifaceted Role of RIMBP2 in Promoting Hearing in Murine Cochlear Hair Cells. 核糖p2在小鼠耳蜗毛细胞中促进听力的多方面作用。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-29 DOI: 10.1007/s12264-025-01472-7

Menghui Liao, Xin Chen, Ling Lu, Qing Liu, Rongrong Guo, Yuyang Qiu, Yangnan Hu, Yuhua Zhang, Qiaojun Fang, Panpan Zhang, Yige Li, Shuijin He, Mingliang Tang, Huawei Li, Geng-Lin Li, Renjie Chai

{"title":"Multifaceted Role of RIMBP2 in Promoting Hearing in Murine Cochlear Hair Cells.","authors":"Menghui Liao, Xin Chen, Ling Lu, Qing Liu, Rongrong Guo, Yuyang Qiu, Yangnan Hu, Yuhua Zhang, Qiaojun Fang, Panpan Zhang, Yige Li, Shuijin He, Mingliang Tang, Huawei Li, Geng-Lin Li, Renjie Chai","doi":"10.1007/s12264-025-01472-7","DOIUrl":"https://doi.org/10.1007/s12264-025-01472-7","url":null,"abstract":"The mammalian cochlea relies on outer and inner hair cells (OHCs/IHCs) for sound amplification and signal transmission. Rab3-interacting molecular binding protein 2 (RIMBP2), expressed in receptor cells and neurons at synaptic active zones, remains poorly characterized in hearing. We therefore generated a Rimbp2 knockout (KO) mouse model (Rimbp2-/-), which exhibited severe hearing loss with elevated thresholds, prolonged latencies, and reduced amplitudes in auditory brainstem response Wave I. OHC loss via apoptosis was correlated with threshold elevation. In IHCs, patch-clamp recordings revealed reduced exocytosis, including a diminished readily-releasable pool, impaired sustained release, and blocked fast endocytosis. Immunostaining showed unchanged ribbon synapse numbers but positional shifts in the basal pole of KO IHCs. These findings demonstrated RIMBP2's essential role in OHC survival and its broader regulatory functions in IHC synaptic transmission than previously recognized.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sexual Dimorphism of Dendritic Spine Plasticity in the Cortex of Adolescent Mice. 青春期小鼠皮层树突脊柱可塑性的性别二态性。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-29 DOI: 10.1007/s12264-025-01499-w

Fujian Qi, Yanli Ran, Guodong Zhu, Wancong Ding, Xing Gao, Junru Liu, Muhammad Tariq Hafeez, Huatai Xu, Shengxiang Zhang

引用次数: 0

Spatially Resolved Lipid Composition of the Human Brain Cortical Layers. 人脑皮质层的空间分辨脂质组成。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-29 DOI: 10.1007/s12264-025-01486-1

Dmitry Senko, Marina Zavolskova, Olga Efimova, Maria Osetrova, Elena Stekolshchikova, Gleb Vladimirov, Evgeny Nikolaev, Philipp Khaitovich

{"title":"Spatially Resolved Lipid Composition of the Human Brain Cortical Layers.","authors":"Dmitry Senko, Marina Zavolskova, Olga Efimova, Maria Osetrova, Elena Stekolshchikova, Gleb Vladimirov, Evgeny Nikolaev, Philipp Khaitovich","doi":"10.1007/s12264-025-01486-1","DOIUrl":"https://doi.org/10.1007/s12264-025-01486-1","url":null,"abstract":"A better understanding of neocortical architecture provides a means for its functional elucidation. In this study, we focused on the analysis of the lipidome composition in two human neocortical regions using laser-capture microdissection combined with mass spectrometry and mass spectrometry imaging. Among the 312 lipids detected in tissue samples representing discrete neocortical layers (L1, L3, and L5), three-quarters showed significant differences in abundance among layers, forming distinct patterns. Lipid distribution among these patterns depended on both the lipids' biochemical class and their fatty acid residue length and unsaturation. The assignment of lipids to cell types using spatial transcriptomics data suggested biological underpinnings of these patterns. Collected mass spectrometry imaging data further allowed for the reconstruction of lipid spatial distribution patterns across neocortical layers. These results reveal a complex relationship between lipids' biochemical properties and neocortical histological features, laying a foundation for further studies on the lipidome architecture of the human brain.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TRAILblazing Astrocytes: Glioblastoma's Covert Immunosuppressive Agents. 星形胶质细胞：胶质母细胞瘤的隐蔽免疫抑制剂。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-28 DOI: 10.1007/s12264-025-01495-0

Jia-Qi Zhang, Wei Sun, Wei-Lin Jin

引用次数: 0

Restoring Retinoic Acid: Alleviating Autism-Like Behaviors in Sox5-Deficient Mice. 恢复维甲酸：减轻sox5缺陷小鼠的自闭症样行为。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-27 DOI: 10.1007/s12264-025-01494-1

Lanyan Lin, Yongxing Lai, Ainong Mei, Yan Chen, Fan Lin

引用次数: 0

Single-Nucleus RNA-Seq Reveals PTSD-Associated Transcriptional Changes in Dopaminergic Neurons of the Lateral VTA. 单核RNA-Seq揭示外侧VTA多巴胺能神经元与ptsd相关的转录变化。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-25 DOI: 10.1007/s12264-025-01482-5

Peiling Zhou, Hongwei Yan, Jingtong Wu, Qinghui Lan, Xue-Min Wang, Jin-Jun Ding, Hai-Tao Wu, Changzheng Zhang

引用次数: 0

Temporal Features of Gamma Activity of Hyper-direct Pathway Regulated by Dopamine Receptors in the Dyskinetic Rat. 运动障碍大鼠多巴胺受体调节超直接通路γ活性的时间特征。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-25 DOI: 10.1007/s12264-025-01470-9

Pengfei Wang, Weina Dai, Hongmin Li, Weijie Li, Yang Wang, Yichang Liu, Le Wang, Fanglei Ye, Yuming Xu

{"title":"Temporal Features of Gamma Activity of Hyper-direct Pathway Regulated by Dopamine Receptors in the Dyskinetic Rat.","authors":"Pengfei Wang, Weina Dai, Hongmin Li, Weijie Li, Yang Wang, Yichang Liu, Le Wang, Fanglei Ye, Yuming Xu","doi":"10.1007/s12264-025-01470-9","DOIUrl":"https://doi.org/10.1007/s12264-025-01470-9","url":null,"abstract":"Cortico-thalamic projections (the hyper-direct pathway) are implicated in levodopa-induced dyskinesia (LID), a challenging complication in the advanced stages of Parkinson's disease (PD). Excessive beta and gamma activity in PD and LID has frequently been reported in recent cross-sectional studies. We aimed to investigate the temporal features of beta and gamma activity in the hyper-direct pathway during the development of PD and LID in rats, as well as the regulatory role of the dopamine receptors DI (D1Rs) and DIII (D3Rs) in these disorders. We recorded motor behavior and electrophysiological data during the development of PD and LID, and after interventions with D1R and D3R antagonists and agonists. We demonstrated exaggerated beta-band activity in the PD state and excessive gamma-band activity during on-state dyskinesia. Subsequently, process-dependent increased beta activity correlated with bradykinesia during PD modeling, while process-dependent increased gamma activity correlated with dyskinesia under the cumulative effects of levodopa during on-state dyskinesia. Finally, both D1Rs and D3Rs were found to be involved in regulating dyskinesia and gamma activity. Dynamic oscillations are closely associated with motor behavior, and mapping dynamic oscillations may be associated with optimizing deep brain stimulation parameters and developing personalized neurotherapeutic targeting. Moreover, D1Rs and D3Rs may ameliorate dyskinesia by mediating gamma oscillations.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glutamatergic Periaqueductal Gray Projections to the Locus Coeruleus Orchestrate Adaptive Arousal States in Threatening Contexts. 在威胁环境下，对蓝斑的谷氨酸能灰色投射协调适应性唤醒状态。

IF 5.8 2区医学

Neuroscience bulletin Pub Date : 2025-08-25 DOI: 10.1007/s12264-025-01491-4

Siyu Wang, Yiwen Yang, Sijia Hao, Yanhui Sun, Hao Wang

{"title":"Glutamatergic Periaqueductal Gray Projections to the Locus Coeruleus Orchestrate Adaptive Arousal States in Threatening Contexts.","authors":"Siyu Wang, Yiwen Yang, Sijia Hao, Yanhui Sun, Hao Wang","doi":"10.1007/s12264-025-01491-4","DOIUrl":"https://doi.org/10.1007/s12264-025-01491-4","url":null,"abstract":"The locus coeruleus (LC), a norepinephrine nucleus governing arousal states through tonic activity, requires precise regulatory mechanisms to maintain its dynamic activation levels. However, the neural circuitry underlying LC activity maintenance remains unclear. Here, we identify a glutamatergic projection from the ventrolateral periaqueductal gray (vlPAG) to the LC in mice as a critical regulator of arousal dynamics. Fiber photometry recordings revealed stress-induced Ca2+ dynamics in vlPAGCaMKIIα-LC axon terminals across diverse threat paradigms. Slice electrophysiology demonstrated that this pathway mediates LC-norepinephrine (LC-NE) neuronal activity via glutamatergic transmission. Low-frequency pathway activation (1 Hz) mainly induced anxiety-like behaviors, whereas high-frequency stimulation (10 Hz) evoked more panic-like hyperlocomotion, establishing a frequency-dependent continuum of arousal states. Conversely, pathway inhibition reduced pupil size, a reliable biomarker for arousal, concurrently suppressing threat avoidance behaviors and alleviating anxiety-related behaviors without altering environmental preference. These findings reveal that the vlPAGCaMKIIα-LC pathway maintains baseline arousal while dynamically scaling threat-induced hyperarousal.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0