Neuroscience bulletin最新文献_第5页

Sex-Differential Neural Circuits and Behavioral Responses for Empathy. 移情的性别差异神经回路和行为反应

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-01-01 Epub Date: 2024-10-12 DOI: 10.1007/s12264-024-01303-1

Jingkai Fan, Xinrong Wang, Han Xu

引用次数: 0

Time-Dependent Transcriptional Dynamics of Contextual Fear Memory Retrieval Reveals the Function of Dipeptidyl Peptidase 9 in Reconsolidation. 情境恐惧记忆提取的时间依赖性转录动力学揭示二肽基肽酶9在再巩固中的作用。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-01-01 Epub Date: 2024-12-02 DOI: 10.1007/s12264-024-01324-w

Wen-Ting Guo, Wen-Xing Li, Yu-Chen Liu, Ya-Bo Zhao, Lin Xu, Qi-Xin Zhou

{"title":"Time-Dependent Transcriptional Dynamics of Contextual Fear Memory Retrieval Reveals the Function of Dipeptidyl Peptidase 9 in Reconsolidation.","authors":"Wen-Ting Guo, Wen-Xing Li, Yu-Chen Liu, Ya-Bo Zhao, Lin Xu, Qi-Xin Zhou","doi":"10.1007/s12264-024-01324-w","DOIUrl":"10.1007/s12264-024-01324-w","url":null,"abstract":"Numerous studies on the formation and consolidation of memory have shown that memory processes are characterized by phase-dependent and dynamic regulation. Memory retrieval, as the only representation of memory content and an active form of memory processing that induces memory reconsolidation, has attracted increasing attention in recent years. Although the molecular mechanisms specific to memory retrieval-induced reconsolidation have been gradually revealed, an understanding of the time-dependent regulatory mechanisms of this process is still lacking. In this study, we applied a transcriptome analysis of memory retrieval at different time points in the recent memory stage. Differential expression analysis and Short Time-series Expression Miner (STEM) depicting temporal gene expression patterns indicated that most differential gene expression occurred at 48 h, and the STEM cluster showing the greatest transcriptional upregulation at 48 h demonstrated the most significant difference. We then screened the differentially-expressed genes associated with that met the expression patterns of those cluster-identified genes that have been reported to be involved in learning and memory processes in addition to dipeptidyl peptidase 9 (DPP9). Further quantitative polymerase chain reaction verification and pharmacological intervention suggested that DPP9 is involved in 48-h fear memory retrieval and viral vector-mediated overexpression of DPP9 countered the 48-h retrieval-induced attenuation of fear memory. Taken together, our findings suggest that temporal gene expression patterns are induced by recent memory retrieval and provide hitherto undocumented evidence of the role of DPP9 in the retrieval-induced reconsolidation of fear memory.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"16-32"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The IL-33/ST2 Axis Protects Retinal Ganglion Cells by Modulating the Astrocyte Response After Optic Nerve Injury. IL-33/ST2轴通过调节视神经损伤后星形胶质细胞的反应保护视网膜神经节细胞

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-01-01 Epub Date: 2024-08-27 DOI: 10.1007/s12264-024-01279-y

Zhigang Qian, Mengya Jiao, Na Zhang, Xuhuan Tang, Shiwang Liu, Feng Zhang, Chenchen Wang, Fang Zheng

{"title":"The IL-33/ST2 Axis Protects Retinal Ganglion Cells by Modulating the Astrocyte Response After Optic Nerve Injury.","authors":"Zhigang Qian, Mengya Jiao, Na Zhang, Xuhuan Tang, Shiwang Liu, Feng Zhang, Chenchen Wang, Fang Zheng","doi":"10.1007/s12264-024-01279-y","DOIUrl":"10.1007/s12264-024-01279-y","url":null,"abstract":"IL-33 and its receptor ST2 play crucial roles in tissue repair and homeostasis. However, their involvement in optic neuropathy due to trauma and glaucoma remains unclear. Here, we report that IL-33 and ST2 were highly expressed in the mouse optic nerve and retina. Deletion of IL-33 or ST2 exacerbated retinal ganglion cell (RGC) loss, retinal thinning, and nerve fiber degeneration following optic nerve (ON) injury. This heightened retinal neurodegeneration correlated with increased neurotoxic astrocytes in Il33-/- mice. In vitro, rIL-33 mitigated the neurotoxic astrocyte phenotype and reduced the expression of pro-inflammatory factors, thereby alleviating the RGC death induced by neurotoxic astrocyte-conditioned medium in retinal explants. Exogenous IL-33 treatment improved RGC survival in Il33-/- and WT mice after ON injury, but not in ST2-/- mice. Our findings highlight the role of the IL-33/ST2 axis in modulating reactive astrocyte function and providing neuroprotection for RGCs following ON injury.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"61-76"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Right Frontal Gamma Transcranial Alternating Current Stimulation Modulates Optimism Biases. 右额叶伽马经颅交流电刺激可调节乐观偏差

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-01-01 Epub Date: 2024-10-19 DOI: 10.1007/s12264-024-01307-x

Ziqing Yao, Jinwen Wei, Gan Huang, Linling Li, Zhen Liang, Li Zhang, Haiyan Wu, Tifei Yuan, Zhiguo Zhang, Xiaoqing Hu

引用次数: 0

Halting the Progression of Alzheimer's Disease: Is the Goal in Sight? 阻止阿尔茨海默病的进展：目标在眼前吗？

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-27 DOI: 10.1007/s12264-024-01339-3

Yu-Juan Jia, Xuan-Yue Wang, Jie Liu, Yan-Jiang Wang, Colin L Masters, Jun-Hong Guo

引用次数: 0

Psychoactive Substances: Transforming the Paradigm for Treating Mental Health Disorders in the Post-Pandemic Era. 精神活性物质：转变后大流行时代治疗精神健康障碍的范式。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-23 DOI: 10.1007/s12264-024-01341-9

Haojiang Zhai, Yibo Wang, Xiaohui Wang

引用次数: 0

Neuronal Regulation of Feeding and Energy Metabolism: A Focus on the Hypothalamus and Brainstem. 神经元摄食和能量代谢的调控：以下丘脑和脑干为中心。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-20 DOI: 10.1007/s12264-024-01335-7

Jing Chen, Meiting Cai, Cheng Zhan

引用次数: 0

Deciphering the Role of Shank3 in Dendritic Morphology and Synaptic Function Across Postnatal Developmental Stages in the Shank3B KO Mouse. 揭示Shank3B KO小鼠出生后发育阶段树突形态和突触功能中Shank3的作用。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-18 DOI: 10.1007/s12264-024-01330-y

Jing Yang, Guaiguai Ma, Xiaohui Du, Jinyi Xie, Mengmeng Wang, Wenting Wang, Baolin Guo, Shengxi Wu

{"title":"Deciphering the Role of Shank3 in Dendritic Morphology and Synaptic Function Across Postnatal Developmental Stages in the Shank3B KO Mouse.","authors":"Jing Yang, Guaiguai Ma, Xiaohui Du, Jinyi Xie, Mengmeng Wang, Wenting Wang, Baolin Guo, Shengxi Wu","doi":"10.1007/s12264-024-01330-y","DOIUrl":"https://doi.org/10.1007/s12264-024-01330-y","url":null,"abstract":"Autism Spectrum Disorder (ASD) is marked by early-onset neurodevelopmental anomalies, yet the temporal dynamics of genetic contributions to these processes remain insufficiently understood. This study aimed to elucidate the role of the Shank3 gene, known to be associated with monogenic causes of autism, in early developmental processes to inform the timing and mechanisms for potential interventions for ASD. Utilizing the Shank3B knockout (KO) mouse model, we examined Shank3 expression and its impact on neuronal maturation through Golgi staining for dendritic morphology and electrophysiological recordings to measure synaptic function in the anterior cingulate cortex (ACC) across different postnatal stages. Our longitudinal analysis revealed that, while Shank3B KO mice displayed normal neuronal morphology at one week postnatal, significant impairments in dendritic growth and synaptic activity emerged by two to three weeks. These findings highlight the critical developmental window during which Shank3 is essential for neuronal and synaptic maturation in the ACC.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conditional Tnfaip6-Knockout in Inner Ear Hair Cells Does not Alter Auditory Function. 内耳毛细胞条件敲除tnfaip6不会改变听觉功能

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-17 DOI: 10.1007/s12264-024-01326-8

Yue Qiu, Song Gao, Xiaoqiong Ding, Jie Lu, Xinya Ji, Wenli Hao, Siqi Cheng, Haolinag Du, Yajun Gu, Chenjie Yu, Cheng Cheng, Xia Gao

引用次数: 0

Inhibition of the cGAS‑STING Pathway Reduces Cisplatin-Induced Inner Ear Hair Cell Damage. 抑制 cGAS-STING 通路可减轻顺铂诱导的内耳毛细胞损伤

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2024-12-16 DOI: 10.1007/s12264-024-01334-8

Ying Sun, Shengyu Zou, Xiaoxiang Xu, Shan Xu, Haiying Sun, Mingliang Tang, Weijia Kong, Xiong Chen, Zuhong He

引用次数: 0