Neuroscience bulletin最新文献_第5页

The Glutamate-gated Chloride Channel Facilitates Sleep by Enhancing the Excitability of Two Pairs of Neurons in the Ventral Nerve Cord of Drosophila. 谷氨酸门控氯离子通道通过增强果蝇腹侧神经索两对神经元的兴奋性来促进睡眠。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-04-30 DOI: 10.1007/s12264-025-01397-1

Yaqian Fan, Yao Tian, Junhai Han

{"title":"The Glutamate-gated Chloride Channel Facilitates Sleep by Enhancing the Excitability of Two Pairs of Neurons in the Ventral Nerve Cord of Drosophila.","authors":"Yaqian Fan, Yao Tian, Junhai Han","doi":"10.1007/s12264-025-01397-1","DOIUrl":"https://doi.org/10.1007/s12264-025-01397-1","url":null,"abstract":"Sleep, an essential and evolutionarily conserved behavior, is regulated by numerous neurotransmitter systems. In mammals, glutamate serves as the wake-promoting signaling agent, whereas in Drosophila, it functions as the sleep-promoting signal. However, the precise molecular and cellular mechanisms through which glutamate promotes sleep remain elusive. Our study reveals that disruption of glutamate signaling significantly diminishes nocturnal sleep, and a neural cell-specific knockdown of the glutamate-gated chloride channel (GluClα) markedly reduces nocturnal sleep. We identified two pairs of neurons in the ventral nerve cord (VNC) that receive glutamate signaling input, and the GluClα derived from these neurons is crucial for sleep promotion. Furthermore, we demonstrated that GluClα mediates the glutamate-gated inhibitory input to these VNC neurons, thereby promoting sleep. Our findings elucidate that GluClα enhances nocturnal sleep by mediating the glutamate-gated inhibitory input to two pairs of VNC neurons, providing insights into the mechanism of sleep promotion in Drosophila.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imaging and Quantifying the Diversity of Native NMDA Receptors. 天然NMDA受体的成像和定量多样性。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-04-30 DOI: 10.1007/s12264-025-01395-3

Sophie Shi, David Stroebel, Laetitia Mony, Pierre Paoletti

引用次数: 0

Upregulation of NR2A in Glutamatergic VTA Neurons Contributes to Chronic Visceral Pain in Male Mice. 谷氨酸能VTA神经元NR2A的上调与雄性小鼠慢性内脏疼痛有关。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-04-28 DOI: 10.1007/s12264-025-01402-7

Meng-Ge Li, Shu-Ting Qu, Yang Yu, Zhenhua Xu, Fu-Chao Zhang, Yong-Chang Li, Rong Gao, Guang-Yin Xu

{"title":"Upregulation of NR2A in Glutamatergic VTA Neurons Contributes to Chronic Visceral Pain in Male Mice.","authors":"Meng-Ge Li, Shu-Ting Qu, Yang Yu, Zhenhua Xu, Fu-Chao Zhang, Yong-Chang Li, Rong Gao, Guang-Yin Xu","doi":"10.1007/s12264-025-01402-7","DOIUrl":"https://doi.org/10.1007/s12264-025-01402-7","url":null,"abstract":"Chronic visceral pain is a persistent and debilitating condition arising from dysfunction or sensitization of the visceral organs and their associated nervous pathways. Increasing evidence suggests that imbalances in central nervous system function play an essential role in the progression of visceral pain, but the exact mechanisms underlying the neural circuitry and molecular targets remain largely unexplored. In the present study, the ventral tegmental area (VTA) was shown to mediate visceral pain in mice. Visceral pain stimulation increased c-Fos expression and Ca2+ activity of glutamatergic VTA neurons, and optogenetic modulation of glutamatergic VTA neurons altered visceral pain. In particular, the upregulation of NMDA receptor 2A (NR2A) subunits within the VTA resulted in visceral pain in mice. Administration of a selective NR2A inhibitor decreased the number of visceral pain-induced c-Fos positive neurons and attenuated visceral pain. Pharmacology combined with chemogenetics further demonstrated that glutamatergic VTA neurons regulated visceral pain behaviors based on NR2A. In summary, our findings demonstrated that the upregulation of NR2A in glutamatergic VTA neurons plays a critical role in visceral pain. These insights provide a foundation for further comprehension of the neural circuits and molecular targets involved in chronic visceral pain and may pave the way for targeted therapies in chronic visceral pain.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancement of Ca²⁺ Signal Strength in Astrocytes in the Lateral Septum Improves Cognitive Disorders in Mice After Hemorrhagic Shock and Resuscitation. 外隔星形胶质细胞Ca2+信号强度的增强改善失血性休克和复苏后小鼠的认知障碍。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-04-25 DOI: 10.1007/s12264-025-01404-5

Wen-Guang Li, Lan-Xin Li, Rong-Xin Song, Xu-Peng Wang, Shi-Yan Jia, Xiao-Yi Ma, Jing-Yu Zhang, Gang-Feng Yin, Xiao-Ming Li, Li-Min Zhang

{"title":"Enhancement of Ca2+ Signal Strength in Astrocytes in the Lateral Septum Improves Cognitive Disorders in Mice After Hemorrhagic Shock and Resuscitation.","authors":"Wen-Guang Li, Lan-Xin Li, Rong-Xin Song, Xu-Peng Wang, Shi-Yan Jia, Xiao-Yi Ma, Jing-Yu Zhang, Gang-Feng Yin, Xiao-Ming Li, Li-Min Zhang","doi":"10.1007/s12264-025-01404-5","DOIUrl":"https://doi.org/10.1007/s12264-025-01404-5","url":null,"abstract":"Hemorrhagic shock is a common clinical emergency that can aggravate cell injury after resuscitation. Astrocytes are crucial for the survival of neurons because they regulate the surrounding ionic microenvironment of neurons. Although hemorrhagic shock and resuscitation (HSR) injury can impair cognition, it remains unclear how this insult directly affects astrocytes. In this study, we established an HSR model by bleeding and re-transfusion in mice. The social interaction test and new object recognition test were applied to evaluate post-operative cognitive changes, and the results suggest that mice experience cognitive impairment following exposure to HSR. In the HSR group, the power spectral density of β and γ oscillations decreased, and the coupling of the θ oscillation phase and γ oscillation amplitude was abnormal, which indicated abnormal neuronal oscillation and cognitive impairment after HSR exposure. In brief, cognitive impairment in mice is strongly correlated with Ca2+ signal strength in lateral septum astrocytes following HSR.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Propofol Promotes Anesthesia Through the Activation of Centrally-Projecting Edinger-Westphal Nucleus Urocortin 1-Positive Neurons. 异丙酚通过激活Edinger-Westphal核尿皮质素1阳性神经元促进麻醉。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-04-24 DOI: 10.1007/s12264-025-01401-8

Jing Huang, Yiwen Hu, Sheng Jing, Fuhai Bai, Zonghong Long, Zhuoxi Wu, Liang Fang, Lei Cao, Youliang Deng, Xiaohang Bao, Hong Li

引用次数: 0

Neural Responses to Hypoxic Injury in a Vascularized Cerebral Organoid Model. 血管化脑类器官模型对缺氧损伤的神经反应。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-04-22 DOI: 10.1007/s12264-025-01396-2

Yang Li, Xin-Yao Sun, Peng-Ming Zeng, Zhen-Ge Luo

引用次数: 0

Targeting Programmed Cell Death in Acquired Sensorineural Hearing Loss: Ferroptosis, Necroptosis, and Pyroptosis. 获得性感音神经性听力损失的靶向程序性细胞死亡：铁下垂、坏死性下垂和焦下垂。