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Imaging and Quantifying the Diversity of Native NMDA Receptors. 天然NMDA受体的成像和定量多样性。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-04-30 DOI: 10.1007/s12264-025-01395-3
Sophie Shi, David Stroebel, Laetitia Mony, Pierre Paoletti
{"title":"Imaging and Quantifying the Diversity of Native NMDA Receptors.","authors":"Sophie Shi, David Stroebel, Laetitia Mony, Pierre Paoletti","doi":"10.1007/s12264-025-01395-3","DOIUrl":"https://doi.org/10.1007/s12264-025-01395-3","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upregulation of NR2A in Glutamatergic VTA Neurons Contributes to Chronic Visceral Pain in Male Mice. 谷氨酸能VTA神经元NR2A的上调与雄性小鼠慢性内脏疼痛有关。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-04-28 DOI: 10.1007/s12264-025-01402-7
Meng-Ge Li, Shu-Ting Qu, Yang Yu, Zhenhua Xu, Fu-Chao Zhang, Yong-Chang Li, Rong Gao, Guang-Yin Xu
{"title":"Upregulation of NR2A in Glutamatergic VTA Neurons Contributes to Chronic Visceral Pain in Male Mice.","authors":"Meng-Ge Li, Shu-Ting Qu, Yang Yu, Zhenhua Xu, Fu-Chao Zhang, Yong-Chang Li, Rong Gao, Guang-Yin Xu","doi":"10.1007/s12264-025-01402-7","DOIUrl":"https://doi.org/10.1007/s12264-025-01402-7","url":null,"abstract":"<p><p>Chronic visceral pain is a persistent and debilitating condition arising from dysfunction or sensitization of the visceral organs and their associated nervous pathways. Increasing evidence suggests that imbalances in central nervous system function play an essential role in the progression of visceral pain, but the exact mechanisms underlying the neural circuitry and molecular targets remain largely unexplored. In the present study, the ventral tegmental area (VTA) was shown to mediate visceral pain in mice. Visceral pain stimulation increased c-Fos expression and Ca<sup>2+</sup> activity of glutamatergic VTA neurons, and optogenetic modulation of glutamatergic VTA neurons altered visceral pain. In particular, the upregulation of NMDA receptor 2A (NR2A) subunits within the VTA resulted in visceral pain in mice. Administration of a selective NR2A inhibitor decreased the number of visceral pain-induced c-Fos positive neurons and attenuated visceral pain. Pharmacology combined with chemogenetics further demonstrated that glutamatergic VTA neurons regulated visceral pain behaviors based on NR2A. In summary, our findings demonstrated that the upregulation of NR2A in glutamatergic VTA neurons plays a critical role in visceral pain. These insights provide a foundation for further comprehension of the neural circuits and molecular targets involved in chronic visceral pain and may pave the way for targeted therapies in chronic visceral pain.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancement of Ca2+ Signal Strength in Astrocytes in the Lateral Septum Improves Cognitive Disorders in Mice After Hemorrhagic Shock and Resuscitation. 外隔星形胶质细胞Ca2+信号强度的增强改善失血性休克和复苏后小鼠的认知障碍。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-04-25 DOI: 10.1007/s12264-025-01404-5
Wen-Guang Li, Lan-Xin Li, Rong-Xin Song, Xu-Peng Wang, Shi-Yan Jia, Xiao-Yi Ma, Jing-Yu Zhang, Gang-Feng Yin, Xiao-Ming Li, Li-Min Zhang
{"title":"Enhancement of Ca<sup>2+</sup> Signal Strength in Astrocytes in the Lateral Septum Improves Cognitive Disorders in Mice After Hemorrhagic Shock and Resuscitation.","authors":"Wen-Guang Li, Lan-Xin Li, Rong-Xin Song, Xu-Peng Wang, Shi-Yan Jia, Xiao-Yi Ma, Jing-Yu Zhang, Gang-Feng Yin, Xiao-Ming Li, Li-Min Zhang","doi":"10.1007/s12264-025-01404-5","DOIUrl":"https://doi.org/10.1007/s12264-025-01404-5","url":null,"abstract":"<p><p>Hemorrhagic shock is a common clinical emergency that can aggravate cell injury after resuscitation. Astrocytes are crucial for the survival of neurons because they regulate the surrounding ionic microenvironment of neurons. Although hemorrhagic shock and resuscitation (HSR) injury can impair cognition, it remains unclear how this insult directly affects astrocytes. In this study, we established an HSR model by bleeding and re-transfusion in mice. The social interaction test and new object recognition test were applied to evaluate post-operative cognitive changes, and the results suggest that mice experience cognitive impairment following exposure to HSR. In the HSR group, the power spectral density of β and γ oscillations decreased, and the coupling of the θ oscillation phase and γ oscillation amplitude was abnormal, which indicated abnormal neuronal oscillation and cognitive impairment after HSR exposure. In brief, cognitive impairment in mice is strongly correlated with Ca<sup>2+</sup> signal strength in lateral septum astrocytes following HSR.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Propofol Promotes Anesthesia Through the Activation of Centrally-Projecting Edinger-Westphal Nucleus Urocortin 1-Positive Neurons. 异丙酚通过激活Edinger-Westphal核尿皮质素1阳性神经元促进麻醉。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-04-24 DOI: 10.1007/s12264-025-01401-8
Jing Huang, Yiwen Hu, Sheng Jing, Fuhai Bai, Zonghong Long, Zhuoxi Wu, Liang Fang, Lei Cao, Youliang Deng, Xiaohang Bao, Hong Li
{"title":"Propofol Promotes Anesthesia Through the Activation of Centrally-Projecting Edinger-Westphal Nucleus Urocortin 1-Positive Neurons.","authors":"Jing Huang, Yiwen Hu, Sheng Jing, Fuhai Bai, Zonghong Long, Zhuoxi Wu, Liang Fang, Lei Cao, Youliang Deng, Xiaohang Bao, Hong Li","doi":"10.1007/s12264-025-01401-8","DOIUrl":"https://doi.org/10.1007/s12264-025-01401-8","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural Responses to Hypoxic Injury in a Vascularized Cerebral Organoid Model. 血管化脑类器官模型对缺氧损伤的神经反应。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-04-22 DOI: 10.1007/s12264-025-01396-2
Yang Li, Xin-Yao Sun, Peng-Ming Zeng, Zhen-Ge Luo
{"title":"Neural Responses to Hypoxic Injury in a Vascularized Cerebral Organoid Model.","authors":"Yang Li, Xin-Yao Sun, Peng-Ming Zeng, Zhen-Ge Luo","doi":"10.1007/s12264-025-01396-2","DOIUrl":"https://doi.org/10.1007/s12264-025-01396-2","url":null,"abstract":"<p><p>Hypoxic injury (HI) in the prenatal period often causes neonatal neurological disabilities. Due to the difficulty in obtaining clinical samples, the molecular and cellular mechanisms remain unclear. Here we use vascularized cerebral organoids to investigate the hypoxic injury phenotype and explore the intercellular interactions between vascular and neural tissues under hypoxic conditions. Our results indicate that fused vascularized cerebral organoids exhibit broader hypoxic responses and larger decreases in panels of neural development-related genes when exposed to low oxygen levels compared to single cerebral organoids. Interestingly, vessels also exhibit neural protective effects on T-box brain protein 2<sup>+</sup> intermediate progenitors (IPs), which are markedly lost in HI cerebral organoids. Furthermore, we identify the role of bone morphogenic protein signaling in protecting IPs. Thus, this study has established an in vitro organoid system that can be used to study the contribution of vessels to brain injury under hypoxic conditions and provides a strategy for the identification of intervention targets.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting Programmed Cell Death in Acquired Sensorineural Hearing Loss: Ferroptosis, Necroptosis, and Pyroptosis. 获得性感音神经性听力损失的靶向程序性细胞死亡:铁下垂、坏死性下垂和焦下垂。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-04-22 DOI: 10.1007/s12264-025-01370-y
Shasha Zhang, Hairong Xiao, Yanqin Lin, Xujun Tang, Wei Tong, Buwei Shao, He Li, Lei Xu, Xiaoqiong Ding, Renjie Chai
{"title":"Targeting Programmed Cell Death in Acquired Sensorineural Hearing Loss: Ferroptosis, Necroptosis, and Pyroptosis.","authors":"Shasha Zhang, Hairong Xiao, Yanqin Lin, Xujun Tang, Wei Tong, Buwei Shao, He Li, Lei Xu, Xiaoqiong Ding, Renjie Chai","doi":"10.1007/s12264-025-01370-y","DOIUrl":"https://doi.org/10.1007/s12264-025-01370-y","url":null,"abstract":"<p><p>Sensorineural hearing loss (SNHL), the most commonly-occurring form of hearing loss, is caused mainly by injury to or the loss of hair cells and spiral ganglion neurons in the cochlea. Numerous environmental and physiological factors have been shown to cause acquired SNHL, such as ototoxic drugs, noise exposure, aging, infections, and diseases. Several programmed cell death (PCD) pathways have been reported to be involved in SNHL, especially some novel PCD pathways that have only recently been reported, such as ferroptosis, necroptosis, and pyroptosis. Here we summarize these PCD pathways and their roles and mechanisms in SNHL, aiming to provide new insights and potential therapeutic strategies for SNHL by targeting these PCD pathways.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel Strategies for Cognitive Enhancement via Noninvasive Neuromodulation. 通过无创神经调节增强认知的新策略。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-04-21 DOI: 10.1007/s12264-025-01394-4
Hongwei Li, Kun Zhao, Yong Liu
{"title":"Novel Strategies for Cognitive Enhancement via Noninvasive Neuromodulation.","authors":"Hongwei Li, Kun Zhao, Yong Liu","doi":"10.1007/s12264-025-01394-4","DOIUrl":"https://doi.org/10.1007/s12264-025-01394-4","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What Information do Systemic Pathological Changes Bring to the Diagnosis and Treatment of Alzheimer's Disease? 全身病理变化对阿尔茨海默病的诊断和治疗有哪些启示?
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-04-21 DOI: 10.1007/s12264-025-01399-z
Jinyue Zhou, Xiaoli Sun, Keren Wang, Min Shen, Jingbo Yu, Qi Yao, Hang Hong, Chunlan Tang, Qinwen Wang
{"title":"What Information do Systemic Pathological Changes Bring to the Diagnosis and Treatment of Alzheimer's Disease?","authors":"Jinyue Zhou, Xiaoli Sun, Keren Wang, Min Shen, Jingbo Yu, Qi Yao, Hang Hong, Chunlan Tang, Qinwen Wang","doi":"10.1007/s12264-025-01399-z","DOIUrl":"https://doi.org/10.1007/s12264-025-01399-z","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is regarded as a neurodegenerative disease, and it has been proposed that AD may be a systemic disease. Studies have reported associations between non-neurological diseases and AD. The correlations between AD pathology and systemic (non-neurological) pathological changes are intricate, and the mechanisms underlying these correlations and their causality are unclear. In this article, we review the association between AD and disorders of other systems. In addition, we summarize the possible mechanisms associated with AD and disorders of other systems, mainly from the perspective of AD pathology. Regarding the relationship between AD and systemic pathological changes, we aim to provide a new outlook on the early warning signs and treatment of AD, such as establishing a diagnostic and screening system based on more accessible peripheral samples.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perifornical UCN3 Neurons Regulate Overeating-Induced Weight Gain. 皮层周围UCN3神经元调节暴饮暴食引起的体重增加。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-04-19 DOI: 10.1007/s12264-025-01400-9
Shanshan Lu, Xinran Zhang, Wanqi Chen, Baofang Zhang, Haiyang Jing, Yunlong Xu, Fengling Li, Chenyu Jiang, Gaowei Chen, Xiaofei Deng, Yingjie Zhu
{"title":"Perifornical UCN3 Neurons Regulate Overeating-Induced Weight Gain.","authors":"Shanshan Lu, Xinran Zhang, Wanqi Chen, Baofang Zhang, Haiyang Jing, Yunlong Xu, Fengling Li, Chenyu Jiang, Gaowei Chen, Xiaofei Deng, Yingjie Zhu","doi":"10.1007/s12264-025-01400-9","DOIUrl":"https://doi.org/10.1007/s12264-025-01400-9","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stress-Induced Endogenous Cannabinoid Signaling Contributes to Fear Generalization. 应激诱导的内源性大麻素信号有助于恐惧泛化。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2025-04-15 DOI: 10.1007/s12264-025-01391-7
Yanan Yue, Xia Zhang, Yuan Dong
{"title":"Stress-Induced Endogenous Cannabinoid Signaling Contributes to Fear Generalization.","authors":"Yanan Yue, Xia Zhang, Yuan Dong","doi":"10.1007/s12264-025-01391-7","DOIUrl":"https://doi.org/10.1007/s12264-025-01391-7","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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