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Link Brain-Wide Projectome to Neuronal Dynamics in the Mouse Brain. 将全脑项目组与小鼠大脑的神经元动力学联系起来
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2024-11-01 Epub Date: 2024-05-31 DOI: 10.1007/s12264-024-01232-z
Xiang Li, Yun Du, Jiang-Feng Huang, Wen-Wei Li, Wei Song, Ruo-Nan Fan, Hua Zhou, Tao Jiang, Chang-Geng Lu, Zhuang Guan, Xiao-Fei Wang, Hui Gong, Xiang-Ning Li, Anan Li, Ling Fu, Yan-Gang Sun
{"title":"Link Brain-Wide Projectome to Neuronal Dynamics in the Mouse Brain.","authors":"Xiang Li, Yun Du, Jiang-Feng Huang, Wen-Wei Li, Wei Song, Ruo-Nan Fan, Hua Zhou, Tao Jiang, Chang-Geng Lu, Zhuang Guan, Xiao-Fei Wang, Hui Gong, Xiang-Ning Li, Anan Li, Ling Fu, Yan-Gang Sun","doi":"10.1007/s12264-024-01232-z","DOIUrl":"10.1007/s12264-024-01232-z","url":null,"abstract":"<p><p>Knowledge about the neuronal dynamics and the projectome are both essential for understanding how the neuronal network functions in concert. However, it remains challenging to obtain the neural activity and the brain-wide projectome for the same neurons, especially for neurons in subcortical brain regions. Here, by combining in vivo microscopy and high-definition fluorescence micro-optical sectioning tomography, we have developed strategies for mapping the brain-wide projectome of functionally relevant neurons in the somatosensory cortex, the dorsal hippocampus, and the substantia nigra pars compacta. More importantly, we also developed a strategy to achieve acquiring the neural dynamic and brain-wide projectome of the molecularly defined neuronal subtype. The strategies developed in this study solved the essential problem of linking brain-wide projectome to neuronal dynamics for neurons in subcortical structures and provided valuable approaches for understanding how the brain is functionally organized via intricate connectivity patterns.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1621-1634"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Special Issue Celebrating the 25th Anniversary of the Institute of Neuroscience, CAS. 庆祝中国科学院神经科学研究所成立 25 周年特刊》。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2024-11-01 Epub Date: 2024-11-13 DOI: 10.1007/s12264-024-01318-8
Ting Lv, Yefei Li, Fei Dong, Shumin Duan
{"title":"Special Issue Celebrating the 25<sup>th</sup> Anniversary of the Institute of Neuroscience, CAS.","authors":"Ting Lv, Yefei Li, Fei Dong, Shumin Duan","doi":"10.1007/s12264-024-01318-8","DOIUrl":"10.1007/s12264-024-01318-8","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1599-1601"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gating of Social Behavior by Inhibitory Inputs from Hippocampal CA1 to Retrosplenial Agranular Cortex. 从海马CA1到后脾上皮层的抑制性输入对社交行为的控制
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2024-11-01 Epub Date: 2024-01-28 DOI: 10.1007/s12264-023-01172-0
Yuhan Shi, Jingjing Yan, Xiaohong Xu, Zilong Qiu
{"title":"Gating of Social Behavior by Inhibitory Inputs from Hippocampal CA1 to Retrosplenial Agranular Cortex.","authors":"Yuhan Shi, Jingjing Yan, Xiaohong Xu, Zilong Qiu","doi":"10.1007/s12264-023-01172-0","DOIUrl":"10.1007/s12264-023-01172-0","url":null,"abstract":"<p><p>The retrosplenial cortex has been implicated in processing sensory information and spatial learning, with abnormal neural activity reported in association with psychedelics and in mouse and non-human primate models of autism spectrum disorders (ASDs). The direct role of the retrosplenial cortex in regulating social behaviors remains unclear. In this work, we reveal that neural activity in the retrosplenial agranular cortex (RSA), a subregion of the retrosplenial cortex, is initially activated, then quickly suppressed upon social contact. This up-down phase of RSA neurons is crucial for normal social behaviors. Parvalbumin-positive GABAergic neurons in the hippocampal CA1 region were found to send inhibitory projections to the RSA. Blocking these CA1-RSA inhibitory inputs significantly impaired social behavior. Notably, enhancing the CA1-RSA inhibitory input rescued the social behavior defects in an ASD mouse model. This work suggests a neural mechanism for the salience processing of social behavior and identifies a potential target for ASD intervention using neural modulation approaches.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1635-1648"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139570893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitative Expression of Latent Disease Factors in Individuals Associated with Psychopathology Dimensions and Treatment Response. 个体中潜在疾病因素的定量表达与精神病理学维度和治疗反应有关。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2024-11-01 Epub Date: 2024-06-06 DOI: 10.1007/s12264-024-01224-z
Shaoling Zhao, Qian Lv, Ge Zhang, Jiangtao Zhang, Heqiu Wang, Jianmin Zhang, Meiyun Wang, Zheng Wang
{"title":"Quantitative Expression of Latent Disease Factors in Individuals Associated with Psychopathology Dimensions and Treatment Response.","authors":"Shaoling Zhao, Qian Lv, Ge Zhang, Jiangtao Zhang, Heqiu Wang, Jianmin Zhang, Meiyun Wang, Zheng Wang","doi":"10.1007/s12264-024-01224-z","DOIUrl":"10.1007/s12264-024-01224-z","url":null,"abstract":"<p><p>Psychiatric comorbidity is common in symptom-based diagnoses like autism spectrum disorder (ASD), attention/deficit hyper-activity disorder (ADHD), and obsessive-compulsive disorder (OCD). However, these co-occurring symptoms mediated by shared and/or distinct neural mechanisms are difficult to profile at the individual level. Capitalizing on unsupervised machine learning with a hierarchical Bayesian framework, we derived latent disease factors from resting-state functional connectivity data in a hybrid cohort of ASD and ADHD and delineated individual associations with dimensional symptoms based on canonical correlation analysis. Models based on the same factors generalized to previously unseen individuals in a subclinical cohort and one local OCD database with a subset of patients undergoing neurosurgical intervention. Four factors, identified as variably co-expressed in each patient, were significantly correlated with distinct symptom domains (r = -0.26-0.53, P < 0.05): behavioral regulation (Factor-1), communication (Factor-2), anxiety (Factor-3), adaptive behaviors (Factor-4). Moreover, we demonstrated Factor-1 expressed in patients with OCD and Factor-3 expressed in participants with anxiety, at the degree to which factor expression was significantly predictive of individual symptom scores (r = 0.18-0.5, P < 0.01). Importantly, peri-intervention changes in Factor-1 of OCD were associated with variable treatment outcomes (r = 0.39, P < 0.05). Our results indicate that these data-derived latent disease factors quantify individual factor expression to inform dimensional symptom and treatment outcomes across cohorts, which may promote quantitative psychiatric diagnosis and personalized intervention.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1667-1680"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141262548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Loss of TET Activity in the Postnatal Mouse Brain Perturbs Synaptic Gene Expression and Impairs Cognitive Function. 出生后小鼠大脑中 TET 活性的丧失会干扰突触基因表达并损害认知功能
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2024-11-01 Epub Date: 2024-10-12 DOI: 10.1007/s12264-024-01302-2
Ji-Wei Liu, Ze-Qiang Zhang, Zhi-Chuan Zhu, Kui Li, Qiwu Xu, Jing Zhang, Xue-Wen Cheng, Han Li, Ying Sun, Ji-Jun Wang, Lu-Lu Hu, Zhi-Qi Xiong, Yongchuan Zhu
{"title":"Loss of TET Activity in the Postnatal Mouse Brain Perturbs Synaptic Gene Expression and Impairs Cognitive Function.","authors":"Ji-Wei Liu, Ze-Qiang Zhang, Zhi-Chuan Zhu, Kui Li, Qiwu Xu, Jing Zhang, Xue-Wen Cheng, Han Li, Ying Sun, Ji-Jun Wang, Lu-Lu Hu, Zhi-Qi Xiong, Yongchuan Zhu","doi":"10.1007/s12264-024-01302-2","DOIUrl":"10.1007/s12264-024-01302-2","url":null,"abstract":"<p><p>Conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) by ten-eleven translocation (TET) family proteins leads to the accumulation of 5hmC in the central nervous system; however, the role of 5hmC in the postnatal brain and how its levels and target genes are regulated by TETs remain elusive. We have generated mice that lack all three Tet genes specifically in postnatal excitatory neurons. These mice exhibit significantly reduced 5hmC levels, altered dendritic spine morphology within brain regions crucial for cognition, and substantially impaired spatial and associative memories. Transcriptome profiling combined with epigenetic mapping reveals that a subset of genes, which display changes in both 5hmC/5mC levels and expression patterns, are involved in synapse-related functions. Our findings provide insight into the role of postnatally accumulated 5hmC in the mouse brain and underscore the impact of 5hmC modification on the expression of genes essential for synapse development and function.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1699-1712"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Insular Cortex: An Interface Between Sensation, Emotion and Cognition. 岛叶皮层:感觉、情感和认知之间的界面
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2024-11-01 Epub Date: 2024-05-09 DOI: 10.1007/s12264-024-01211-4
Ruohan Zhang, Hanfei Deng, Xiong Xiao
{"title":"The Insular Cortex: An Interface Between Sensation, Emotion and Cognition.","authors":"Ruohan Zhang, Hanfei Deng, Xiong Xiao","doi":"10.1007/s12264-024-01211-4","DOIUrl":"10.1007/s12264-024-01211-4","url":null,"abstract":"<p><p>The insula is a complex brain region central to the orchestration of taste perception, interoception, emotion, and decision-making. Recent research has shed light on the intricate connections between the insula and other brain regions, revealing the crucial role of this area in integrating sensory, emotional, and cognitive information. The unique anatomical position and extensive connectivity allow the insula to serve as a critical hub in the functional network of the brain. We summarize its role in interoceptive and exteroceptive sensory processing, illustrating insular function as a bridge connecting internal and external experiences. Drawing on recent research, we delineate the insular involvement in emotional processes, highlighting its implications in psychiatric conditions, such as anxiety, depression, and addiction. We further discuss the insular contributions to cognition, focusing on its significant roles in time perception and decision-making. Collectively, the evidence underscores the insular function as a dynamic interface that synthesizes diverse inputs into coherent subjective experiences and decision-making processes. Through this review, we hope to highlight the importance of the insula as an interface between sensation, emotion, and cognition, and to inspire further research into this fascinating brain region.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1763-1773"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140899020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Specific and Plastic: Chandelier Cell-to-Axon Initial Segment Connections in Shaping Functional Cortical Network. 特异性和可塑性:塑造皮层功能网络中的吊灯细胞与轴突起始节段连接
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2024-11-01 Epub Date: 2024-07-30 DOI: 10.1007/s12264-024-01266-3
Yanqing Qi, Rui Zhao, Jifeng Tian, Jiangteng Lu, Miao He, Yilin Tai
{"title":"Specific and Plastic: Chandelier Cell-to-Axon Initial Segment Connections in Shaping Functional Cortical Network.","authors":"Yanqing Qi, Rui Zhao, Jifeng Tian, Jiangteng Lu, Miao He, Yilin Tai","doi":"10.1007/s12264-024-01266-3","DOIUrl":"10.1007/s12264-024-01266-3","url":null,"abstract":"<p><p>Axon initial segment (AIS) is the most excitable subcellular domain of a neuron for action potential initiation. AISs of cortical projection neurons (PNs) receive GABAergic synaptic inputs primarily from chandelier cells (ChCs), which are believed to regulate action potential generation and modulate neuronal excitability. As individual ChCs often innervate hundreds of PNs, they may alter the activity of PN ensembles and even impact the entire neural network. During postnatal development or in response to changes in network activity, the AISs and axo-axonic synapses undergo dynamic structural and functional changes that underlie the wiring, refinement, and adaptation of cortical microcircuits. Here we briefly introduce the history of ChCs and review recent research advances employing modern genetic and molecular tools. Special attention will be attributed to the plasticity of the AIS and the ChC-PN connections, which play a pivotal role in shaping the dynamic network under both physiological and pathological conditions.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1774-1788"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Axonopathy Underlying Amyotrophic Lateral Sclerosis: Unraveling Complex Pathways and Therapeutic Insights. 肌萎缩侧索硬化症的轴突病变:揭示复杂的治疗途径和治疗见解。
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2024-11-01 Epub Date: 2024-08-04 DOI: 10.1007/s12264-024-01267-2
Tongshu Luan, Qing Li, Zhi Huang, Yu Feng, Duo Xu, Yujie Zhou, Yiqing Hu, Tong Wang
{"title":"Axonopathy Underlying Amyotrophic Lateral Sclerosis: Unraveling Complex Pathways and Therapeutic Insights.","authors":"Tongshu Luan, Qing Li, Zhi Huang, Yu Feng, Duo Xu, Yujie Zhou, Yiqing Hu, Tong Wang","doi":"10.1007/s12264-024-01267-2","DOIUrl":"10.1007/s12264-024-01267-2","url":null,"abstract":"<p><p>Amyotrophic Lateral Sclerosis (ALS) is a complex neurodegenerative disorder characterized by progressive axonopathy, jointly leading to the dying back of the motor neuron, disrupting both nerve signaling and motor control. In this review, we highlight the roles of axonopathy in ALS progression, driven by the interplay of multiple factors including defective trafficking machinery, protein aggregation, and mitochondrial dysfunction. Dysfunctional intracellular transport, caused by disruptions in microtubules, molecular motors, and adaptors, has been identified as a key contributor to disease progression. Aberrant protein aggregation involving TDP-43, FUS, SOD1, and dipeptide repeat proteins further amplifies neuronal toxicity. Mitochondrial defects lead to ATP depletion, oxidative stress, and Ca<sup>2+</sup> imbalance, which are regarded as key factors underlying the loss of neuromuscular junctions and axonopathy. Mitigating these defects through interventions including neurotrophic treatments offers therapeutic potential. Collaborative research efforts aim to unravel ALS complexities, opening avenues for holistic interventions that target diverse pathological mechanisms.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1789-1810"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sonic Hedgehog Mediates High Frequency-Dependent Deep Brain Stimulation for the Correction of Motor Deficits in a Parkinson's Disease Model. 音速刺猬介导高频依赖性深部脑刺激以纠正帕金森病模型的运动障碍
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2024-11-01 Epub Date: 2024-11-06 DOI: 10.1007/s12264-024-01306-y
Hui Zhang, Yujuan Su, Zhongwei Qu, Chunkui Zhang, Shaorong Ma, Xia Li, Yizheng Wang
{"title":"Sonic Hedgehog Mediates High Frequency-Dependent Deep Brain Stimulation for the Correction of Motor Deficits in a Parkinson's Disease Model.","authors":"Hui Zhang, Yujuan Su, Zhongwei Qu, Chunkui Zhang, Shaorong Ma, Xia Li, Yizheng Wang","doi":"10.1007/s12264-024-01306-y","DOIUrl":"10.1007/s12264-024-01306-y","url":null,"abstract":"","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"1732-1738"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurodegenerative Diseases: What Can Be Learned from Toothed Whales? 神经退行性疾病:从齿鲸身上能学到什么?
IF 5.9 2区 医学
Neuroscience bulletin Pub Date : 2024-11-01 DOI: 10.1007/s12264-024-01310-2
Simona Sacchini
{"title":"Neurodegenerative Diseases: What Can Be Learned from Toothed Whales?","authors":"Simona Sacchini","doi":"10.1007/s12264-024-01310-2","DOIUrl":"https://doi.org/10.1007/s12264-024-01310-2","url":null,"abstract":"<p><p>Neurodegeneration involves a wide range of neuropathological alterations affecting the integrity, physiology, and architecture of neural cells. Many studies have demonstrated neurodegeneration in different animals. In the case of Alzheimer's disease (AD), spontaneous animal models should display two neurohistopathological hallmarks: the deposition of β-amyloid and the arrangement of neurofibrillary tangles. However, no natural animal models that fulfill these conditions have been reported and most research into AD has been performed using transgenic rodents. Recent studies have also demonstrated that toothed whales - homeothermic, long-lived, top predatory marine mammals - show neuropathological signs of AD-like pathology. The neuropathological hallmarks in these cetaceans could help to better understand their endangered health as well as neurodegenerative diseases in humans. This systematic review analyzes all the literature published to date on this trending topic and the proposed causes for neurodegeneration in these iconic marine mammals are approached in the context of One Health/Planetary Health and translational medicine.</p>","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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