激活中央区杏仁核 GABA 能神经元可导致小鼠低血压

IF 5.9 2区 医学 Q1 NEUROSCIENCES
Xiaoyi Wang, Ziteng Yue, Luo Shi, Wei He, Liuqi Shao, Yuhang Liu, Jinye Zhang, Shangyu Bi, Tianjiao Deng, Fang Yuan, Sheng Wang
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引用次数: 0

摘要

中央杏仁核(CeA)是情绪、行为和自律神经功能(包括心血管反应)的重要调节器。尽管杏仁核非常重要,但人们对杏仁核调节血压的具体回路仍然缺乏足够的研究。我们的研究表明,与杏仁核中央外侧(CeL)的 GABA 能神经元相比,光刺激杏仁核中央内侧(CeMGABA)的 GABA 能神经元会在麻醉和自由活动的小鼠体内产生降压反应。此外,激活投射到脊髓束核(NTS)的 CeMGABA 轴突末梢可显著降低血压。这些 CeMGABA 神经元与 NTS 神经元形成突触连接,可通过影响尾侧或喙侧腹外侧延髓来调节心血管反应。此外,以 NTS 为靶点的 CeMGABA 神经元会接受来自 CeL 的密集输入。因此,刺激 CeMGABA 神经元可通过 CeM-NTS 回路引起低血压,从而更深入地了解与情绪和行为相关的心血管反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Activation of Centromedial Amygdala GABAergic Neurons Produces Hypotension in Mice.

The central amygdala (CeA) is a crucial modulator of emotional, behavioral, and autonomic functions, including cardiovascular responses. Despite its importance, the specific circuit by which the CeA modulates blood pressure remains insufficiently explored. Our investigations demonstrate that photostimulation of GABAergic neurons in the centromedial amygdala (CeMGABA), as opposed to those in the centrolateral amygdala (CeL), produces a depressor response in both anesthetized and freely-moving mice. In addition, activation of CeMGABA axonal terminals projecting to the nucleus tractus solitarius (NTS) significantly reduces blood pressure. These CeMGABA neurons form synaptic connections with NTS neurons, allowing for the modulation of cardiovascular responses by influencing the caudal or rostral ventrolateral medulla. Furthermore, CeMGABA neurons targeting the NTS receive dense inputs from the CeL. Consequently, stimulation of CeMGABA neurons elicits hypotension through the CeM-NTS circuit, offering deeper insights into the cardiovascular responses associated with emotions and behaviors.

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来源期刊
Neuroscience bulletin
Neuroscience bulletin NEUROSCIENCES-
CiteScore
7.20
自引率
16.10%
发文量
163
审稿时长
6-12 weeks
期刊介绍: Neuroscience Bulletin (NB), the official journal of the Chinese Neuroscience Society, is published monthly by Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) and Springer. NB aims to publish research advances in the field of neuroscience and promote exchange of scientific ideas within the community. The journal publishes original papers on various topics in neuroscience and focuses on potential disease implications on the nervous system. NB welcomes research contributions on molecular, cellular, or developmental neuroscience using multidisciplinary approaches and functional strategies. We feature full-length original articles, reviews, methods, letters to the editor, insights, and research highlights. As the official journal of the Chinese Neuroscience Society, which currently has more than 12,000 members in China, NB is devoted to facilitating communications between Chinese neuroscientists and their international colleagues. The journal is recognized as the most influential publication in neuroscience research in China.
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