Neuroscience bulletin最新文献_第3页

A Novel Functional Method of Protector Screening for Zebrafish Lateral Line Hair Cells via the Acoustic Escape Response. 利用声逃逸反应筛选斑马鱼侧线毛细胞保护剂的新功能方法

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-06 DOI: 10.1007/s12264-025-01406-3

Ling Zheng, Qiaosen Shen, Tong Zhao, Qingsong Liu, Zihao Huang, Feng Zhao, Mengqian Zhang, Yongdong Song, Daogong Zhang, Dong Liu, Fangyi Chen

{"title":"A Novel Functional Method of Protector Screening for Zebrafish Lateral Line Hair Cells via the Acoustic Escape Response.","authors":"Ling Zheng, Qiaosen Shen, Tong Zhao, Qingsong Liu, Zihao Huang, Feng Zhao, Mengqian Zhang, Yongdong Song, Daogong Zhang, Dong Liu, Fangyi Chen","doi":"10.1007/s12264-025-01406-3","DOIUrl":"https://doi.org/10.1007/s12264-025-01406-3","url":null,"abstract":"Zebrafish larvae are useful for identifying chemicals against lateral line (LL) hair cell (HC) damage and this type of chemical screen mainly focuses on searching for protectors against cell death. To expand the candidate pool of HC protectors, a self-built acoustic escape response (AER)-detecting system was developed to apply both low-frequency near-field sound transmission and AER image acquisition/processing modules. The device quickly confirmed the changed LL HC functions caused by most known ototoxins, protectors, and neural transmission modifiers, or knockdown of LL HC-expressing genes. With ten devices wired in tandem, five 'hit' chemicals were identified from 124 cyclin-dependent kinase inhibitors to partially restore cisplatin-damaged AER in less than a day. AS2863619, ribociclib, and SU9516 among the hits, protected the HCs in the mouse cochlea. Therefore, using free-swimming larval zebrafish, the self-made AER-detecting device can efficiently identify compounds that are protective against HC damage, including cell death and loss-of-function.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endothelial Cell Integrin α6 Regulates Vascular Remodeling Through the PI3K/Akt-eNOS-VEGFA Axis After Stroke. 内皮细胞整合素α6通过PI3K/Akt-eNOS-VEGFA轴调控脑卒中后血管重构

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-02 DOI: 10.1007/s12264-025-01403-6

Bing-Qiao Wang, Yang-Ying Duan, Mao Chen, Yu-Fan Ma, Ru Chen, Cheng Huang, Fei Gao, Rui Xu, Chun-Mei Duan

{"title":"Endothelial Cell Integrin α6 Regulates Vascular Remodeling Through the PI3K/Akt-eNOS-VEGFA Axis After Stroke.","authors":"Bing-Qiao Wang, Yang-Ying Duan, Mao Chen, Yu-Fan Ma, Ru Chen, Cheng Huang, Fei Gao, Rui Xu, Chun-Mei Duan","doi":"10.1007/s12264-025-01403-6","DOIUrl":"https://doi.org/10.1007/s12264-025-01403-6","url":null,"abstract":"The angiogenic response is essential for the repair of ischemic brain tissue. Integrin α6 (Itga6) expression has been shown to increase under hypoxic conditions and is expressed exclusively in vascular structures; however, its role in post-ischemic angiogenesis remains poorly understood. In this study, we demonstrate that mice with endothelial cell-specific knockout of Itga6 exhibit reduced neovascularization, reduced pericyte coverage on microvessels, and accelerated breakdown of microvascular integrity in the peri-infarct area. In vitro, endothelial cells with ITGA6 knockdown display reduced proliferation, migration, and tube-formation. Mechanistically, we demonstrated that ITGA6 regulates post-stroke angiogenesis through the PI3K/Akt-eNOS-VEGFA axis. Importantly, the specific overexpression of Itga6 in endothelial cells significantly enhanced neovascularization and enhanced the integrity of microvessels, leading to improved functional recovery. Our results suggest that endothelial cell Itga6 plays a crucial role in key steps of post-stroke angiogenesis, and may represent a promising therapeutic target for promoting recovery after stroke.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cortical Dysplasia Beyond mTOR: Cellular Senescence Takes a Toll. 超过mTOR的皮质发育不良：细胞衰老造成损失。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2025-02-22 DOI: 10.1007/s12264-025-01365-9

Yixin Zhan, Jiping Zhou, Guoqing Zheng, Yang Zheng

引用次数: 0

The Supplementary Motor Area as a Flexible Hub Mediating Behavioral and Neuroplastic Changes in Motor Sequence Learning: A TMS and TMS-EEG Study. 辅助运动区作为灵活的枢纽，介导运动序列学习中的行为和神经可塑性变化：TMS和TMS-EEG研究。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2025-03-13 DOI: 10.1007/s12264-025-01375-7

Jing Chen, Yanzi Fan, Xize Jia, Fengmei Fan, Jinhui Wang, Qihong Zou, Bing Chen, Xianwei Che, Yating Lv

{"title":"The Supplementary Motor Area as a Flexible Hub Mediating Behavioral and Neuroplastic Changes in Motor Sequence Learning: A TMS and TMS-EEG Study.","authors":"Jing Chen, Yanzi Fan, Xize Jia, Fengmei Fan, Jinhui Wang, Qihong Zou, Bing Chen, Xianwei Che, Yating Lv","doi":"10.1007/s12264-025-01375-7","DOIUrl":"10.1007/s12264-025-01375-7","url":null,"abstract":"Attempts have been made to modulate motor sequence learning (MSL) through repetitive transcranial magnetic stimulation, targeting different sites within the sensorimotor network. However, the target with the optimum modulatory effect on neural plasticity associated with MSL remains unclarified. This study was therefore designed to compare the role of the left primary motor cortex and the left supplementary motor area proper (SMAp) in modulating MSL across different complexity levels and for both hands, as well as the associated neuroplasticity by applying intermittent theta burst stimulation together with the electroencephalogram and concurrent transcranial magnetic stimulation. Our data demonstrated the role of SMAp stimulation in modulating neural communication to support MSL, which is achieved by facilitating regional activation and orchestrating neural coupling across distributed brain regions, particularly in interhemispheric connections. These findings may have important clinical implications, particularly for motor rehabilitation in populations such as post-stroke patients.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"837-852"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2025-02-09 DOI: 10.1007/s12264-025-01362-y

Minzhu Li, Li Cheng

引用次数: 0

A Novel Model of Traumatic Optic Neuropathy Under Direct Vision Through the Anterior Orbital Approach in Non-human Primates. 非人类灵长类动物经眶前入路直接视觉下创伤性视神经病变的新模型。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2025-03-10 DOI: 10.1007/s12264-025-01372-w

Zhi-Qiang Xiao, Xiu Han, Xin Ren, Zeng-Qiang Wang, Si-Qi Chen, Qiao-Feng Zhu, Hai-Yang Cheng, Yin-Tian Li, Dan Liang, Xuan-Wei Liang, Ying Xu, Hui Yang

引用次数: 0

The Role of Neuroinflammation and Network Anomalies in Drug-Resistant Epilepsy. 神经炎症和网络异常在耐药癫痫中的作用。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2025-02-24 DOI: 10.1007/s12264-025-01348-w

Jianwei Shi, Jing Xie, Zesheng Li, Xiaosong He, Penghu Wei, Josemir W Sander, Guoguang Zhao

{"title":"The Role of Neuroinflammation and Network Anomalies in Drug-Resistant Epilepsy.","authors":"Jianwei Shi, Jing Xie, Zesheng Li, Xiaosong He, Penghu Wei, Josemir W Sander, Guoguang Zhao","doi":"10.1007/s12264-025-01348-w","DOIUrl":"10.1007/s12264-025-01348-w","url":null,"abstract":"Epilepsy affects over 50 million people worldwide. Drug-resistant epilepsy (DRE) accounts for up to a third of these cases, and neuro-inflammation is thought to play a role in such cases. Despite being a long-debated issue in the field of DRE, the mechanisms underlying neuroinflammation have yet to be fully elucidated. The pro-inflammatory microenvironment within the brain tissue of people with DRE has been probed using single-cell multimodal transcriptomics. Evidence suggests that inflammatory cells and pro-inflammatory cytokines in the nervous system can lead to extensive biochemical changes, such as connexin hemichannel excitability and disruption of neurotransmitter homeostasis. The presence of inflammation may give rise to neuronal network abnormalities that suppress endogenous antiepileptic systems. We focus on the role of neuroinflammation and brain network anomalies in DRE from multiple perspectives to identify critical points for clinical application. We hope to provide an insightful overview to advance the quest for better DRE treatments.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"881-905"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triple-Target Inhibition of Cholinesterase, Amyloid Aggregation, and GSK3β to Ameliorate Cognitive Deficits and Neuropathology in the Triple-Transgenic Mouse Model of Alzheimer's Disease. 三靶点抑制胆碱酯酶、淀粉样蛋白聚集和GSK3β改善阿尔茨海默病小鼠模型的认知缺陷和神经病理学

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2025-02-05 DOI: 10.1007/s12264-025-01354-y

Junqiu He, Shan Sun, Hongfeng Wang, Zheng Ying, Kin Yip Tam

{"title":"Triple-Target Inhibition of Cholinesterase, Amyloid Aggregation, and GSK3β to Ameliorate Cognitive Deficits and Neuropathology in the Triple-Transgenic Mouse Model of Alzheimer's Disease.","authors":"Junqiu He, Shan Sun, Hongfeng Wang, Zheng Ying, Kin Yip Tam","doi":"10.1007/s12264-025-01354-y","DOIUrl":"10.1007/s12264-025-01354-y","url":null,"abstract":"Alzheimer's disease (AD) poses one of the most urgent medical challenges in the 21st century as it affects millions of people. Unfortunately, the etiopathogenesis of AD is not yet fully understood and the current pharmacotherapy options are somewhat limited. Here, we report a novel inhibitor, Compound 44, for targeting cholinesterases, amyloid-β (Aβ) aggregation, and glycogen synthase kinase 3β (GSK-3β) simultaneously with the aim of achieving symptomatic relief and disease modification in AD therapy. We found that Compound 44 had good inhibitory effects on all intended targets with IC50s of submicromolar or better, significant neuroprotective effects in cell models, and beneficial improvement of cognitive deficits in the triple transgenic AD (3 × Tg AD) mouse model. Moreover, we showed that Compound 44 acts as an autophagy regulator by inducing nuclear translocation of transcription factor EB through GSK-3β inhibition, enhancing the biogenesis of lysosomes and elevating autophagic flux, thus ameliorating the amyloid burden and tauopathy, as well as mitigating the disease phenotype. Our results suggest that triple-target inhibition via Compound 44 could be a promising strategy that may lead to the development of effective therapeutic approaches for AD.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"821-836"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large-Scale Sleep Survey and the Impact of Step-Based Exercise. 大规模睡眠调查和基于步数的运动的影响。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2025-04-05 DOI: 10.1007/s12264-025-01392-6

Xinyu Fu, Wanxin Zhang, Xuemei Gao, Zhi-Li Huang

引用次数: 0

Anterior Cingulate Cortex Contributes to the Hyperlocomotion under Nitrogen Narcosis. 前扣带回皮层有助于氮麻醉下的过度运动

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-05-01 Epub Date: 2024-08-19 DOI: 10.1007/s12264-024-01278-z

Bin Peng, Xiao-Bo Wu, Zhi-Jun Zhang, De-Li Cao, Lin-Xia Zhao, Hao Wu, Yong-Jing Gao

{"title":"Anterior Cingulate Cortex Contributes to the Hyperlocomotion under Nitrogen Narcosis.","authors":"Bin Peng, Xiao-Bo Wu, Zhi-Jun Zhang, De-Li Cao, Lin-Xia Zhao, Hao Wu, Yong-Jing Gao","doi":"10.1007/s12264-024-01278-z","DOIUrl":"10.1007/s12264-024-01278-z","url":null,"abstract":"Nitrogen narcosis is a neurological syndrome that manifests when humans or animals encounter hyperbaric nitrogen, resulting in a range of motor, emotional, and cognitive abnormalities. The anterior cingulate cortex (ACC) is known for its significant involvement in regulating motivation, cognition, and action. However, its specific contribution to nitrogen narcosis-induced hyperlocomotion and the underlying mechanisms remain poorly understood. Here we report that exposure to hyperbaric nitrogen notably increased the locomotor activity of mice in a pressure-dependent manner. Concurrently, this exposure induced heightened activation among neurons in both the ACC and dorsal medial striatum (DMS). Notably, chemogenetic inhibition of ACC neurons effectively suppressed hyperlocomotion. Conversely, chemogenetic excitation lowered the hyperbaric pressure threshold required to induce hyperlocomotion. Moreover, both chemogenetic inhibition and genetic ablation of activity-dependent neurons within the ACC reduced the hyperlocomotion. Further investigation revealed that ACC neurons project to the DMS, and chemogenetic inhibition of ACC-DMS projections resulted in a reduction in hyperlocomotion. Finally, nitrogen narcosis led to an increase in local field potentials in the theta frequency band and a decrease in the alpha frequency band in both the ACC and DMS. These results collectively suggest that excitatory neurons within the ACC, along with their projections to the DMS, play a pivotal role in regulating the hyperlocomotion induced by exposure to hyperbaric nitrogen.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"775-789"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0