Neuroscience bulletin最新文献_第3页

Exploring the Therapeutic Potential of Psychedelics in Chronic Pain Management: A New Frontier in Medicine. 探索致幻剂在慢性疼痛管理中的治疗潜力：医学的新前沿。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-01-20 DOI: 10.1007/s12264-025-01351-1

Cong Lin, Xue Wang, Xiaohui Wang

引用次数: 0

Genetic Etiology Link to Brain Function Underlying ADHD Symptoms and its Interaction with Sleep Disturbance: An ABCD Study. ADHD症状与脑功能相关的遗传病因及其与睡眠障碍的相互作用：一项ABCD研究。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-01-19 DOI: 10.1007/s12264-025-01349-9

Aichen Feng, Dongmei Zhi, Zening Fu, Shan Yu, Na Luo, Vince Calhoun, Jing Sui

{"title":"Genetic Etiology Link to Brain Function Underlying ADHD Symptoms and its Interaction with Sleep Disturbance: An ABCD Study.","authors":"Aichen Feng, Dongmei Zhi, Zening Fu, Shan Yu, Na Luo, Vince Calhoun, Jing Sui","doi":"10.1007/s12264-025-01349-9","DOIUrl":"https://doi.org/10.1007/s12264-025-01349-9","url":null,"abstract":"Attention deficit hyperactivity disorder (ADHD), a prevalent neurodevelopmental disorder influenced by both genetic and environmental factors, remains poorly understood regarding how its polygenic risk score (PRS) impacts functional networks and symptomology. This study capitalized on data from 11,430 children in the Adolescent Brain Cognitive Development study to explore the interplay between PRSADHD, brain function, and behavioral problems, along with their interactive effects. The results showed that children with a higher PRSADHD exhibited more severe attention deficits and rule-breaking problems, and experienced sleep disturbances, particularly in initiating and maintaining sleep. We also identified the central executive network, default mode network, and sensory-motor network as the functional networks most associated with PRS and symptoms in ADHD cases, with potential mediating roles. Particularly, the impact of PRSADHD was enhanced in children experiencing heightened sleep disturbances, emphasizing the need for early intervention in sleep issues to potentially mitigate subsequent ADHD symptoms.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role and Mechanisms of Ubiquitin-Proteasome System-Mediated Ferroptosis in Neurological Disorders. 泛素-蛋白酶体系统介导的铁下垂在神经系统疾病中的作用和机制。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-01-07 DOI: 10.1007/s12264-024-01343-7

Xin Liu, Wei Wang, Qiucheng Nie, Xinjing Liu, Lili Sun, Qiang Ma, Jie Zhang, Yiju Wei

引用次数: 0

Type 2 Diabetes Mellitus Exacerbates Pathological Processes of Parkinson's Disease: Insights from Signaling Pathways Mediated by Insulin Receptors. 2型糖尿病加剧帕金森病的病理过程：胰岛素受体介导的信号通路的见解

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-01-04 DOI: 10.1007/s12264-024-01342-8

Shufen Liu, Tingting Liu, Jingwen Li, Jun Hong, Ali A Moosavi-Movahedi, Jianshe Wei

引用次数: 0

To Attack or Not: A Neural Circuit Coding Sexually Dimorphic Aggression. 攻击与否：编码两性二态攻击的神经回路。

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-01-03 DOI: 10.1007/s12264-024-01345-5

Qiuhong Xin, Hailan Hu

引用次数: 0

Pseudogene Lamr1-ps1 Aggravates Early Spatial Learning Memory Deficits in Alzheimer's Disease Model Mice. 假基因Lamr1-ps1加重阿尔茨海默病模型小鼠早期空间学习记忆缺陷

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-01-02 DOI: 10.1007/s12264-024-01336-6

Zhuoze Wu, Xiaojie Liu, Yuntai Wang, Zimeng Zeng, Wei Chen, Hao Li

{"title":"Pseudogene Lamr1-ps1 Aggravates Early Spatial Learning Memory Deficits in Alzheimer's Disease Model Mice.","authors":"Zhuoze Wu, Xiaojie Liu, Yuntai Wang, Zimeng Zeng, Wei Chen, Hao Li","doi":"10.1007/s12264-024-01336-6","DOIUrl":"https://doi.org/10.1007/s12264-024-01336-6","url":null,"abstract":"Alzheimer's disease (AD), a neurodegenerative disorder with complex etiologies, manifests through a cascade of pathological changes before clinical symptoms become apparent. Among these early changes, alterations in the expression of non-coding RNAs (ncRNAs) have emerged as pivotal events. In this study, we focused on the aberrant expression of ncRNAs and revealed that Lamr1-ps1, a pseudogene of the laminin receptor, significantly exacerbates early spatial learning and memory deficits in APP/PS1 mice. Through a combination of bioinformatics prediction and experimental validation, we identified the miR-29c/Bace1 pathway as a potential regulatory mechanism by which Lamr1-ps1 influences AD pathology. Importantly, augmenting the miR-29c-3p levels in mice ameliorated memory deficits, underscoring the therapeutic potential of targeting miR-29c-3p in early AD intervention. This study not only provides new insights into the role of pseudogenes in AD but also consolidates a foundational basis for considering miR-29c as a viable therapeutic target, offering a novel avenue for AD research and treatment strategies.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crosstalk Between the Nervous System and Colorectal Cancer. 神经系统与结直肠癌之间的相互影响

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-01-01 Epub Date: 2024-06-16 DOI: 10.1007/s12264-024-01238-7

Xi Li, Chunshui Ye, Min Wang, Patrick Kwan, Xin Tian, Yanke Zhang

引用次数: 0

Cortical Morphological Networks Differ Between Gyri and Sulci. 神经节和脑室的皮层形态网络存在差异

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-01-01 Epub Date: 2024-07-23 DOI: 10.1007/s12264-024-01262-7

Qingchun Lin, Suhui Jin, Guole Yin, Junle Li, Umer Asgher, Shijun Qiu, Jinhui Wang

{"title":"Cortical Morphological Networks Differ Between Gyri and Sulci.","authors":"Qingchun Lin, Suhui Jin, Guole Yin, Junle Li, Umer Asgher, Shijun Qiu, Jinhui Wang","doi":"10.1007/s12264-024-01262-7","DOIUrl":"10.1007/s12264-024-01262-7","url":null,"abstract":"This study explored how the human cortical folding pattern composed of convex gyri and concave sulci affected single-subject morphological brain networks, which are becoming an important method for studying the human brain connectome. We found that gyri-gyri networks exhibited higher morphological similarity, lower small-world parameters, and lower long-term test-retest reliability than sulci-sulci networks for cortical thickness- and gyrification index-based networks, while opposite patterns were observed for fractal dimension-based networks. Further behavioral association analysis revealed that gyri-gyri networks and connections between gyral and sulcal regions significantly explained inter-individual variance in Cognition and Motor domains for fractal dimension- and sulcal depth-based networks. Finally, the clinical application showed that only sulci-sulci networks exhibited morphological similarity reductions in major depressive disorder for cortical thickness-, fractal dimension-, and gyrification index-based networks. Taken together, these findings provide novel insights into the constraint of the cortical folding pattern to the network organization of the human brain.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"46-60"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141752274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Medial Prefrontal Cortex-Basolateral Amygdala Circuit Mediates Anxiety in Shank3 InsG3680 Knock-in Mice. 内侧前额叶皮层-基底外侧杏仁核环路介导 Shank3 InsG3680 基因敲入小鼠的焦虑情绪

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-01-01 Epub Date: 2024-08-29 DOI: 10.1007/s12264-024-01280-5

Jiabin Feng, Xiaojun Wang, Meidie Pan, Chen-Xi Li, Zhe Zhang, Meng Sun, Tailin Liao, Ziyi Wang, Jianhong Luo, Lei Shi, Yu-Jing Chen, Hai-Feng Li, Junyu Xu

{"title":"The Medial Prefrontal Cortex-Basolateral Amygdala Circuit Mediates Anxiety in Shank3 InsG3680 Knock-in Mice.","authors":"Jiabin Feng, Xiaojun Wang, Meidie Pan, Chen-Xi Li, Zhe Zhang, Meng Sun, Tailin Liao, Ziyi Wang, Jianhong Luo, Lei Shi, Yu-Jing Chen, Hai-Feng Li, Junyu Xu","doi":"10.1007/s12264-024-01280-5","DOIUrl":"10.1007/s12264-024-01280-5","url":null,"abstract":"Anxiety disorder is a major symptom of autism spectrum disorder (ASD) with a comorbidity rate of ~40%. However, the neural mechanisms of the emergence of anxiety in ASD remain unclear. In our study, we found that hyperactivity of basolateral amygdala (BLA) pyramidal neurons (PNs) in Shank3 InsG3680 knock-in (InsG3680+/+) mice is involved in the development of anxiety. Electrophysiological results also showed increased excitatory input and decreased inhibitory input in BLA PNs. Chemogenetic inhibition of the excitability of PNs in the BLA rescued the anxiety phenotype of InsG3680+/+ mice. Further study found that the diminished control of the BLA by medial prefrontal cortex (mPFC) and optogenetic activation of the mPFC-BLA pathway also had a rescue effect, which increased the feedforward inhibition of the BLA. Taken together, our results suggest that hyperactivity of the BLA and alteration of the mPFC-BLA circuitry are involved in anxiety in InsG3680+/+ mice.","PeriodicalId":19314,"journal":{"name":"Neuroscience bulletin","volume":" ","pages":"77-92"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SARS-CoV-2 Inhibits Exo-Endocytosis and Enhances Short-Term Depression at a Central Synapse. SARS-CoV-2抑制中枢突触的外吞作用并增强其短期抑制作用

IF 5.9 2区医学

Neuroscience bulletin Pub Date : 2025-01-01 Epub Date: 2024-08-31 DOI: 10.1007/s12264-024-01293-0

Jiawei Hu, Yuhan Zhang, Qingzhuo Liu, Jiaqi Hu, Yichen Ru, Lu Zhang, Lixin Xie, Lei Xue

引用次数: 0