Nippon Ishinkin Gakkai Zasshi最新文献_第6页

Itraconazole in the Treatment of Pulmonary Aspergillosis 伊曲康唑治疗肺曲霉病

Nippon Ishinkin Gakkai Zasshi Pub Date : 1996-10-30 DOI: 10.3314/JJMM.37.239

Y. Niki, Takashi Sasaki, K. Yoshida, N. Miyashita, M. Nakajima, T. Matsushima

{"title":"Itraconazole in the Treatment of Pulmonary Aspergillosis","authors":"Y. Niki, Takashi Sasaki, K. Yoshida, N. Miyashita, M. Nakajima, T. Matsushima","doi":"10.3314/JJMM.37.239","DOIUrl":"https://doi.org/10.3314/JJMM.37.239","url":null,"abstract":"トリアゾール系抗真菌薬イトラコナゾール(ITCZ)を,種々の肺アスペルギルス感染症例あるいはその疑いの10例の患者に投与して,それぞれの血中濃度および一部では病巣内の濃度を測定し,また,感染症例ではその臨床効果を検討した.ITCZの血中濃度は用量相関的に高まり,200～400mg/日,8日間以上の投与では1,300ng/mlを上まわる最高血中濃度が得られていた,ただ症例によってはやや血中濃度上昇の不十分なものもみられ,吸収性や代謝の個人差については注意が必要と考えられる.組織内移行については,肺組織へは血中濃度の3/4程度が移行していたが,胸水内濃度はやや低く,1例では測定下限以下であった.また,喀痰中へのITCZ移行も確認できなかった.臨床効果は他の治療法との総合的な評価でみた結果,感染症例9例中2例で治癒,5例で改善の有効率77.8%であったが,血中濃度の高低と必ずしも相関をみなかった.しかしながら,長期間投与でも特に副作用の出現をみたものはなく,慢性経過例や維持療法には好適と考えられた.さらに,比較的大量の初期用量を用いて早期に十分な血中濃度を得ることで,より侵襲型感染も含めた幅広い治療適応も得られるものと考えられた.","PeriodicalId":19301,"journal":{"name":"Nippon Ishinkin Gakkai Zasshi","volume":"22 1","pages":"239-243"},"PeriodicalIF":0.0,"publicationDate":"1996-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75931276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Evaluation of the Efficacy of Antifungal Therapy 抗真菌治疗的临床疗效评价

Nippon Ishinkin Gakkai Zasshi Pub Date : 1996-10-30 DOI: 10.3314/JJMM.37.211

W. Naka

引用次数: 0

Deep-seated Mycosis in Patients with Bone Marrow Transplantation in the United States 美国骨髓移植患者的深部真菌病

Nippon Ishinkin Gakkai Zasshi Pub Date : 1996-10-30 DOI: 10.3314/JJMM.37.229

M. Wakayama, K. Shibuya, T. Ando, Kei Takahashi, S. Naoe, W. Coulson

{"title":"Deep-seated Mycosis in Patients with Bone Marrow Transplantation in the United States","authors":"M. Wakayama, K. Shibuya, T. Ando, Kei Takahashi, S. Naoe, W. Coulson","doi":"10.3314/JJMM.37.229","DOIUrl":"https://doi.org/10.3314/JJMM.37.229","url":null,"abstract":"免疫抑制療法を基盤として発症する日和見真菌感染症の制御は,骨髄移植の成否の鍵を握る重要な要素の一つであろう.今回我々は,米国における骨髄移植剖検例を用い,深在性真菌症の合併頻度や原因菌,侵襲臓器について検討を行った.深在性真菌症は,骨髄移植例の31.5%にみられた.その1/4例は全身性真菌症として認められた.つまり,強力な骨髄抑制が求められる骨髄移植例では,より重篤な全身性真菌症が惹起され易い可能性がある.原因菌の大部分はアスペルギルスとカンジダであった.また,経年的推移をみると,カンジダ症の合併頻度は近年著しく減少しているが,アスペルギルス症は逆に増加傾向にあった.これはカンジダ症が有効な抗真菌剤の開発によって合併頻度の減少が十分期待できるのに対して,アスペルギルス症の治療が困難であることが反映された結果であると考えられた.すなわち,骨髄移植に合併した深在性真菌症を考える上で,アスペルギルス症の予防法や有効かつ安全な治療法の確立が,今後の骨髄移植の成功率を上げる不可欠の要因であると推察された.","PeriodicalId":19301,"journal":{"name":"Nippon Ishinkin Gakkai Zasshi","volume":"20 1","pages":"229-233"},"PeriodicalIF":0.0,"publicationDate":"1996-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74446026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Superficial Hyperkeratotic Candidiasis of Palms Successfully Treated with Itraconazole 伊曲康唑治疗手掌浅表性角化性念珠菌病1例

Nippon Ishinkin Gakkai Zasshi Pub Date : 1996-10-30 DOI: 10.3314/JJMM.37.235

S. Ishizaki, Haruo Ito, Rie Kurimura, T. Harada

引用次数: 0

Pre-clinical Studies of Antifungal Agents for Deep-seated Mycoses 深部真菌病抗真菌药物的临床前研究

Nippon Ishinkin Gakkai Zasshi Pub Date : 1996-10-30 DOI: 10.3314/JJMM.37.207

Y. Niki

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引用次数: 0

Augmentation of Anti-Candida Activity of Lanoconazole by Lysozyme 溶菌酶增强兰诺康唑抗念珠菌活性的研究

Nippon Ishinkin Gakkai Zasshi Pub Date : 1996-10-30 DOI: 10.3314/JJMM.37.245

S. Tansho, T. Tansho, T. Ikeda, S. Abe, H. Yamaguchi, P. Perera

引用次数: 3

Inflammatory Infiltrating Cells in Sporotrichosis 孢子菌病中的炎性浸润细胞

Nippon Ishinkin Gakkai Zasshi Pub Date : 1996-07-30 DOI: 10.3314/JJMM.37.153

Y. Iizumi

引用次数: 0

Ultrastructure of Fungal Conidial and Spore Walls as Revealed by Freeze-Fracturing a Basis to Show Phylogenical Difference Between Pathogenic and Saprobic Cladosporium Species 冻裂法揭示真菌分生孢子和孢子壁的超微结构——病原和腐坏枝孢子种系统发育差异的基础

Nippon Ishinkin Gakkai Zasshi Pub Date : 1996-07-30 DOI: 10.3314/JJMM.37.123

K. Takeo, K. Nishimura, M. Miyaji

引用次数: 0

Effects of Itraconazole on Cell Membrane of Murine Macrophages 伊曲康唑对小鼠巨噬细胞细胞膜的影响

Nippon Ishinkin Gakkai Zasshi Pub Date : 1996-07-30 DOI: 10.3314/JJMM.37.161

Y. Hinohara, H. Ochi, S. Ishijima, M. Osumi, S. Abe, H. Yamaguchi

引用次数: 2

Studies on Phaeohyphomycosis and Its Causative Agents in China 中国褐丝酵母菌病及其病原的研究

Nippon Ishinkin Gakkai Zasshi Pub Date : 1996-07-30 DOI: 10.3314/JJMM.37.135

Ruoyu Li, Duanli Wang

{"title":"Studies on Phaeohyphomycosis and Its Causative Agents in China","authors":"Ruoyu Li, Duanli Wang","doi":"10.3314/JJMM.37.135","DOIUrl":"https://doi.org/10.3314/JJMM.37.135","url":null,"abstract":"Until now, 10 cases of phaeohyphomycosis have been reported in China. Their causative agents were as follows: Exophiala dermatitidis (4 cases), E. spinifera (3), E. jeanselmei (1), Alternaria alternata (1) and Veronaea botryosa (1). The clinical data will be reviewed in this paper.The pathogenic dematiaceous fungi isolated from the phaeohyphomycosis patients were identified carefully and the conidiogenesis of these organisms was studied by using a scanning electron microscope. Besides of these, physiological and other studies were also carried out to aid the correct classification and identification. RAPD-PCR technique was applied to the genomic DNA assay of pathogenic ‘black yeasts’ and reveled highly polymorphisms in their genomic fingerprints.The ecological studies were carried out and seven species were isolated from the soil and rotting plant materials. Phialophora verrucosa was the most dominant species in nature in Shandong, China, followed by Exophiala spinifera and Veronaea botryosa. The pathogenicity of Veronaea botryosa and Exophiala spinifera were studied by using both normal and precompromised mice. The results show that both natural and clinical strains of V. botryosa have potential pathogenicity. E. spinifera is neurotropic and its pathogenicity is specially potential in immunodeficient hosts.","PeriodicalId":19301,"journal":{"name":"Nippon Ishinkin Gakkai Zasshi","volume":"11 1","pages":"135-141"},"PeriodicalIF":0.0,"publicationDate":"1996-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80789503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13