Nippon Ishinkin Gakkai Zasshi最新文献

The 50th Anniversary Educational Symposium of the Japanese Society for Medical Mycolgy 日本医学真菌学学会50周年教育研讨会

Nippon Ishinkin Gakkai Zasshi Pub Date : 2007-01-01 DOI: 10.3314/JJMM.48.115

T. Harada, M. Hiruma, K. Nishimoto, Taku Kato, A. Nishikawa, T. Mochizuki, M. Fujihiro

引用次数: 0

Nippon Ishinkin Gakkai Zasshi Pub Date : 2003-10-30 DOI: 10.3314/JJMM.44.307

E. Muroi, Y. Hamasaki, K. Nishimoto, S. Mohri, H. Sagara, Emiko Tanabe, N. Kameda, N. Suzuki, S. Tejima, A. Kurashima, A. Hebisawa

{"title":"Clinico-Pathological Conference","authors":"E. Muroi, Y. Hamasaki, K. Nishimoto, S. Mohri, H. Sagara, Emiko Tanabe, N. Kameda, N. Suzuki, S. Tejima, A. Kurashima, A. Hebisawa","doi":"10.3314/JJMM.44.307","DOIUrl":"https://doi.org/10.3314/JJMM.44.307","url":null,"abstract":"A 53-year-old man was admitted to Keio University Hospital because of serious dyspnea and edema of the lower extremities. Eighteen months previously, the patient had complained of chest discomfort, and was then admitted for the first time to our hospital for evaluation of chest pain. Electrocardiography showed poor R wave progression in leads Vl through V4, and diffuse nonspecific STsegment and T wave abnormalities with low voltage. However, no definitive diagnosis could be made at this initial admission and a calcium-channel blocker was prescribed. Despite this treatment, the patient was readmitted with worsening dyspnea and lower extremity edema. The diagnosis of heart failure and nephritic syndrome was made at the second admission. In addition, immunoelectrophoresis showed a monoclonal IgD (l) M protein and increased plasma cells in the bone marrow, suggesting a diagnosis of multiple myeloma. The patient was thus given dexamethasone (20 mg per day for 4 days) intravenously, but his symptoms did not improve. Two weeks later, the patient deteriorated further with congestive heart failure and renal failure, and subsequently died of cardiac arrest with ventricular fibrillation. On autopsy, IgD (l)-positive plasma cell proliferation was found in the bone marrow, confirming the diagnosis of multiple myeloma. In addition, amyloid deposition was detected in various organs including the heart, kidneys, esophagus, duodenum, ileum, colon, tongue, and lungs. In particular, the weight of the heart was 650 g demonstrating a hypertrophic septum and amyloid deposition in the myocardium and even coronary arteries. In summary, the final diagnosis was IgD (l) multiple myeloma associated with systemic amyloidosis. (Keio J Med 53 (3): 178–191, September 2004)","PeriodicalId":19301,"journal":{"name":"Nippon Ishinkin Gakkai Zasshi","volume":"78 1","pages":"307-319"},"PeriodicalIF":0.0,"publicationDate":"2003-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87088842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mystery of Fermanted-Foods 发酵食品的奥秘

Nippon Ishinkin Gakkai Zasshi Pub Date : 2001-01-30 DOI: 10.3314/JJMM.42.1

T. Koizumi

引用次数: 2

1996 Epidemiological Survey of Dermatophytoses in Japan. 1996年日本皮肤病流行病学调查。

Nippon Ishinkin Gakkai Zasshi Pub Date : 2000-01-01 DOI: 10.3314/JJMM.41.187

Epidemiological Investigation Commi

{"title":"1996 Epidemiological Survey of Dermatophytoses in Japan.","authors":"Epidemiological Investigation Commi","doi":"10.3314/JJMM.41.187","DOIUrl":"https://doi.org/10.3314/JJMM.41.187","url":null,"abstract":"日本医真菌学会疫学調査委員会の継続的疫学調査の一環として,1996年次の全国15施設における皮膚真菌症例を集計し,前回1991,1992両年の集計結果と比較検討した.皮膚真菌症総例数は8,402例で,新来患者の13.1%に相当.うち白癬患者は7,395例と皮膚真菌例の88%を占める.白癬の病型別では足白癬が4,764例(64.4%)と3分の2弱を占め,次いで爪白癬1,487例(20.1%),体部白癬558例(7.5%),股部白癬369例(5.0%),手白癬195例(2.6%),頭部浅在性白癬11例,ケルスス禿瘡7例,白癬菌性毛瘡1例,汎発性白癬1例,その他2例であった.白癬の原因菌種別分離頻度は培養陽性の2,615株中T.rubrum1,828株(69.9%),T.mentagrophytes743株(28.4%),E.floccosum20株(0.8%),M.canis13株(0.5%),M.gypseum5株,T.violaceum2株.T.r/T.m比2.46.爪白癬は増加傾向を,股部白癬は減少傾向を示し,全体に罹患年齢分布が高年齢側に増加.M.canis分離頻度も引き続き減少.15歳未満の小児の白癬は113例(全白癬の1.3%)と前回調査より著しく減少.病型別には成人に比して体部白癬,頭部白癬の比が高く,足白癬の比が低く,手・爪白癬も少ない.カンジダ症は総計722例(皮膚真菌症の8.6%),病型別には,間擦疹299例(41.4%),指趾間びらん95例(13.2%),乳児紅斑89例(12.3%),口腔カンジダ症63例(8.7%),爪囲爪炎56例(7.8%),外陰カンジダ症56例(7.8%),爪カンジダ症24例,CMCC1例,上記以外の非定型カンジダ症39例であった.癜風は265例(真菌症例の3.2%),マラセチア毛包炎15例(同じく0.2%).深在性真菌症はスポロトリコーシス3例,黒色真菌症1例,原発性膿皮症様アスペルギルス症1例であった.","PeriodicalId":19301,"journal":{"name":"Nippon Ishinkin Gakkai Zasshi","volume":"24 1","pages":"187-196"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84409363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Molecular Biological Approach to Morphological Differentiation in Candida albicans 白色念珠菌形态分化的分子生物学研究

Nippon Ishinkin Gakkai Zasshi Pub Date : 1997-10-30 DOI: 10.3314/JJMM.38.285

T. Cho, H. Hamatake, Takeshi Hirota, H. Kaminishi, Y. Hagihara, Kenji Watanabe

{"title":"Molecular Biological Approach to Morphological Differentiation in Candida albicans","authors":"T. Cho, H. Hamatake, Takeshi Hirota, H. Kaminishi, Y. Hagihara, Kenji Watanabe","doi":"10.3314/JJMM.38.285","DOIUrl":"https://doi.org/10.3314/JJMM.38.285","url":null,"abstract":"Candida albicansの二形性発現のメカニズムを解明する目的で,規則正しい細胞周期を繰返しながら対数増殖を行っている酵母形発育菌から,germ tube形成を誘導する培地を2種類作製した.1つは,グルコース培地で,この培地で高いgerm tube形成率を得るには,対数期の菌を飢餓処理後用いなければならなかった.他方は,N-アセチルグルコサミン培地で,この場合には菌の前処理は必須ではなかった.この2種類の培地における飢餓処理と形態発現の関係を考察する上で,次のような仮説を立てた.飢餓処理のような増殖停止状態では,酵母形発育遺伝子は抑制される.更に,N-アセチルグルコサミン培地においても,一時的に同様の状況が出現する.以上の仮説を証明するために,増殖停止およびN-アセチルグルコサミン培地接種直後の菌に共通して出現するmRNAをDifferential Display法で検索したところ,電気泳動ゲル上に興味のあるバンドが数種得られた.現在これらのバンドのクローニングおよびシークエンスを行っている.","PeriodicalId":19301,"journal":{"name":"Nippon Ishinkin Gakkai Zasshi","volume":"90 1","pages":"285-290"},"PeriodicalIF":0.0,"publicationDate":"1997-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76331772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dermatophyte Flora at the Department of Dermatology of Asahikawa Medical College During a Period of 1990 to 1995 1990年至1995年期间，旭川医学院皮肤科的皮肤菌群

Nippon Ishinkin Gakkai Zasshi Pub Date : 1997-10-30 DOI: 10.3314/JJMM.38.303

K. Asano, T. Tamura, H. Iizuka, H. Kubo, H. Shibaki

引用次数: 0

Multidrug Resistance Genes in Candida albicans 白色念珠菌多药耐药基因

Nippon Ishinkin Gakkai Zasshi Pub Date : 1997-10-30 DOI: 10.3314/JJMM.38.297

M. Niimi, M. Arisawa, R. Cannon

{"title":"Multidrug Resistance Genes in Candida albicans","authors":"M. Niimi, M. Arisawa, R. Cannon","doi":"10.3314/JJMM.38.297","DOIUrl":"https://doi.org/10.3314/JJMM.38.297","url":null,"abstract":"日和見カンジダ症の予防あるいは治療の目的で,フルコナゾールなどアゾール系抗真菌剤の長期投与が行なわれているが,フルコナゾール耐性あるいはアゾール剤に交差耐性のCandida albicansが分離される報告が相次ぎ,臨床上重要な問題となっている.近年,ヒトの多剤耐性遺伝子MDR (Multidrug resistance)のコードするP糖タンパク質が抗癌剤を細胞内から細胞外に汲み出すポンプの役割を担っていることが分かり,このようなポンプによる薬剤排出が耐性獲得に寄与していることが認識されてきた.C.albicansにおいても薬剤排出遺伝子の存在が明らかになり,ポンプを介したアゾール剤耐性の仕組みの解明が始まっている.本稿では,C.albicansのフルコナゾールの取り込みと排出,薬剤排出遺伝子のクローニング,感受性株と耐性株の間の薬剤耐性遺伝子の発現の比較,ポンプ機能を担う遺伝子の導入によるアゾール剤感受性の変化などについてしらべた結果を紹介する.C.albicansの薬剤排出系はアゾール剤耐性に重要な役割を果していると考えられる.","PeriodicalId":19301,"journal":{"name":"Nippon Ishinkin Gakkai Zasshi","volume":"11 1","pages":"297-302"},"PeriodicalIF":0.0,"publicationDate":"1997-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87802381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Genome Information and the Repetitive Sequences in Candida albicans 白色念珠菌基因组信息与重复序列

Nippon Ishinkin Gakkai Zasshi Pub Date : 1997-10-30 DOI: 10.3314/JJMM.38.279

Y. Nakagawa

{"title":"Genome Information and the Repetitive Sequences in Candida albicans","authors":"Y. Nakagawa","doi":"10.3314/JJMM.38.279","DOIUrl":"https://doi.org/10.3314/JJMM.38.279","url":null,"abstract":"Candida albicansで頻繁に観察される染色体サイズの多型現象の研究が発端となって,反復配列RPSが発見された.RPSはゲノム内に60-80コピー存在し,いくつかの染色体では複数のRPSが直列に配置している.多数のRPSをゲノムDNAよりクローン化し,塩基配列を決定したところ,多くの興味ある事実が得られた.RPSには172bpからなる内部反復配列altが存在し,この配列の繰り返しの多様性がRPSのサイズ,塩基配列の多様性を生み出していることが明らかになった.RPSの解析を進める過程で,RPSに隣接した領域が,RPS同様に各染色体に存在していることがわかってきた.ノーザン分析の結果より,この領域がRNAに転写されていることがわかった.そこで,cDNAライブラリよりクローン化して配列決定を行ったところ,機能すると予想されるORFが存在しなかったことから,この領域がRNA分子として働いていることが想像された.最近になって,RPSに隣接する新規反復配列を発見し,これらの反復配列群がまとまって染色体の構成や機能に必須の役割を果たしていると考えている.C.albicansをめぐる以上のようなゲノム,遺伝子に関する情報は,インターネット上に蓄積され,研究者が共有できる情報としてますます充実しつつある.","PeriodicalId":19301,"journal":{"name":"Nippon Ishinkin Gakkai Zasshi","volume":"55 1","pages":"279-283"},"PeriodicalIF":0.0,"publicationDate":"1997-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89482205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Cloning of Candida albicans Genes by Differential Display 利用差异显示技术克隆白色念珠菌基因

Nippon Ishinkin Gakkai Zasshi Pub Date : 1997-10-30 DOI: 10.3314/JJMM.38.291

S. Nakashima, Y. Kitajima, Y. Nozawa, F. Mirbod

引用次数: 0

Aspartic Proteinases Secreted by Pathogenic Candida Species 致病性念珠菌分泌的天冬氨酸蛋白酶

Nippon Ishinkin Gakkai Zasshi Pub Date : 1997-10-30 DOI: 10.3314/JJMM.38.273

S. Murayama, H. Yamaguchi

引用次数: 0