Nippon Ishinkin Gakkai Zasshi最新文献_第7页

Initial Mechanism of Chromomycosis 色霉病的发病机制

Nippon Ishinkin Gakkai Zasshi Pub Date : 1996-07-30 DOI: 10.3314/JJMM.37.143

C. Nishiyama, T. Iida

{"title":"Initial Mechanism of Chromomycosis","authors":"C. Nishiyama, T. Iida","doi":"10.3314/JJMM.37.143","DOIUrl":"https://doi.org/10.3314/JJMM.37.143","url":null,"abstract":"病原性黒色真菌感染の中で最も多くみられる臨床型はクロモミコーシスである.そこで,本稿では,クロモミコーシスの発症機序について述べた.まず,最も頻度の高い原因菌であるFonsecaea pedrosoi(以下F.pedrosoiと略す)によるクロモミコーシスの病理組織所見の特徴を検討した.クロモミコーシスは他のスポロトリコーシスや白癬性肉芽腫のような皮膚の深在性真菌症と異なり,真皮上層～中層に限局して細胞浸潤が認められる.この理由は,腐生的には菌糸形で存在するF.pedrosoiが病変組織内では球状のsclerotic cellの形に変換して認められ,sclerotic cellは真皮の下方には侵入できないことと関連しているようである.またsclerotic cellは真皮上層にとどまって活発に増殖するため,菌要素に向かって遊走する多核白血球や微小膿瘍および組織球,巨細胞,リンパ球などの感染性肉芽腫の像を形成する浸潤細胞も真皮上層～中層に存在することとなり,これらの稠密な浸潤細胞の何らかの働きかけが表皮突起の延長を誘発し,本症に特徴的な経排除現象が引き起こされると考えた.そこで,F.pedrosoiの教室保存株を用いて寒天埋没法を行い,菌糸形菌要素からsclerotic cellに変換する過程を観察したところ,菌糸形からsclerotic cellへの変換は宿主側の多核白血球の遊走が重要な因子であり,またsclerotic cellは菌にとって環境条件が悪いときの耐性形態と考えられた.さらに,赤道部に隔壁を有する球状細胞も認められ,sclerotic cellの増殖する動態も観察された.次いで,腹腔内寒天埋没法と同様の操作を行った寒天ブロックをマウスの背部の表皮下に埋没させ,実験を行った結果,この皮膚寒天埋没法は本症の早期感染組織像の観察と経表皮排除現象の解明に有用な方法と考えられた.最後に皮膚寒天埋没法を用いた経表皮排除現象における免疫担当細胞について若干検討した.Nudeマウスにおいては,正常マウスと同様に菌を含んだ寒天ブロックの経表皮排除を認めたが,NK細胞の欠如しているbeigeマウスではこの現象は起こらなかった.本症の菌の経表皮排除にはNK細胞機能の関与が示唆された.","PeriodicalId":19301,"journal":{"name":"Nippon Ishinkin Gakkai Zasshi","volume":"28 1","pages":"143-146"},"PeriodicalIF":0.0,"publicationDate":"1996-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78012560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of IgG Antibodies Specific for Candida albicans Antigens in Children with Acute Lymphoblastic Leukemia. 急性淋巴细胞白血病儿童白色念珠菌抗原特异性IgG抗体的检测。

Nippon Ishinkin Gakkai Zasshi Pub Date : 1996-07-30 DOI: 10.3314/JJMM.37.167

A. Ishiguro, T. Kanbe, Matsuko Doi, M. Homma, K. Horibe, Kenji Tanaka

{"title":"Detection of IgG Antibodies Specific for Candida albicans Antigens in Children with Acute Lymphoblastic Leukemia.","authors":"A. Ishiguro, T. Kanbe, Matsuko Doi, M. Homma, K. Horibe, Kenji Tanaka","doi":"10.3314/JJMM.37.167","DOIUrl":"https://doi.org/10.3314/JJMM.37.167","url":null,"abstract":"The levels of IgG antibodies specific for enolase, extracellular proteinase (EPR) and common antigens of Candida albicans, namely, the 67, 62, 29 and 25 kDa components in five children with acute lymphoblastic leukemia (ALL) were sequentially monitored by Western blot analysis. The total amounts of immunoglobulins in all sera of patients were below the normal range. Enolase-specific antibodies were detected in four of the five patients and in 38-57% of healthy children. EPR-specific antibody which was not detected in healthy children was shown only in one patient. In contrast, antibodies specific for the 67, 62, 29 and 25 kDa components were frequently detected in patients as well as in healthy children. In most cases in which specific antibodies were detected, the intensities of bands were sequentially decreased during chemotherapy, especially for the 29 and 25 kDa. Candida cells were recovered from four patients with enolase-specific antibodies. These preliminary results justify a large-scale study of quantitative tests of antibodies for enolase, EPR, and 29 and 25 kDa components of C. albicans to clarify their usefulness for monitoring candidal infection and immune status during chemotherapy in patients with ALL.","PeriodicalId":19301,"journal":{"name":"Nippon Ishinkin Gakkai Zasshi","volume":"62 1","pages":"167-173"},"PeriodicalIF":0.0,"publicationDate":"1996-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88129091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Prophylactic Effect of Enterococcus casseliflavus NF-1004 Preparation on the Lethal Infection of Mice with Opportunistic Pathogens casseliflavus肠球菌NF-1004制剂对小鼠条件致病菌致死性感染的预防作用

Nippon Ishinkin Gakkai Zasshi Pub Date : 1996-07-30 DOI: 10.3314/JJMM.37.175

T. Nohmi, S. Abe, T. Ikeda, Tetsurou Yamamoto, H. Yamaguchi

引用次数: 1

A Case of Chromomycosis Successfully Treated with Topical Heat Therapy 局部热疗成功治疗色霉病1例

Nippon Ishinkin Gakkai Zasshi Pub Date : 1996-07-30 DOI: 10.3314/JJMM.37.181

K. Kudoh, Yasushi Tomita, H. Tagami

引用次数: 1

Treatment of Chromomycosis 色霉病的治疗

Nippon Ishinkin Gakkai Zasshi Pub Date : 1996-07-30 DOI: 10.3314/JJMM.37.147

W. Naka

{"title":"Treatment of Chromomycosis","authors":"W. Naka","doi":"10.3314/JJMM.37.147","DOIUrl":"https://doi.org/10.3314/JJMM.37.147","url":null,"abstract":"従来は外科的治療,5-fluorocytosine(5-FC)の内服(もしくはamphotericin Bの局注との併用),局所温熱療法が黒色真菌感染症の主な治療法であったが,いずれも確定的ではない.感染症である本症には,術後の醜形が予想されるような外科的切除はできるだけ避けるべきであろう.局所温熱療法は長時間の圧抵を要するとともに,年齢や部位によっては施行困難である点,また5-FCの内服は耐性菌が生じやすいという点で問題がある.最近itraconazole, fluconazole, terbinafineといった新しい内用抗真菌剤が本症に用いられるようになり,その有効例が報告されている.しかし,これら新しい薬剤の本症に対する有効率をみると,itraconazoleが60%,terbinafineは67%と従来の治療法とさほど変わらない.これらの薬剤の用量や使用例数を増やすことにより,有効率が上がる可能性はあるが,今後は外科的治療,温熱療法や5-FCとの併用など,これら新しい薬剤と従来の治療法を症例により上手に組み合わせて用いることも必要と思われる.しかし,未だ難治例も多く,今後の新しい抗真菌剤の開発や免疫療法の可能性の追求が望まれる.","PeriodicalId":19301,"journal":{"name":"Nippon Ishinkin Gakkai Zasshi","volume":"64 1","pages":"147-151"},"PeriodicalIF":0.0,"publicationDate":"1996-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80893042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Typing and Molecular Epidemiology of Some Black Fungi Based on Analysis of the Restriction Fragment Length Polymorphism in the Mitochondrial DNA 基于线粒体DNA限制性内切片段多态性分析的几种黑真菌分型及分子流行病学

Nippon Ishinkin Gakkai Zasshi Pub Date : 1996-07-30 DOI: 10.3314/JJMM.37.129

M. Kawasaki

{"title":"Typing and Molecular Epidemiology of Some Black Fungi Based on Analysis of the Restriction Fragment Length Polymorphism in the Mitochondrial DNA","authors":"M. Kawasaki","doi":"10.3314/JJMM.37.129","DOIUrl":"https://doi.org/10.3314/JJMM.37.129","url":null,"abstract":"mtDNAのRFLP (restriction fragment length polymorphism)分析によりE. dermatitidis, E. jeanselmei (var. jeanselmei), E. jeanselmei var. heteromorpha, E. jeanselmei var. lecaniicorni, E. spinifera, F. pedrosoi, P. verrucosa, C. carrionii, H. werneckiiは明確に区別され同定が可能である事が示された.またE.dermatitidisが極めて均一な種である事,E.jeanselmei,E.spinifera,E.moniliaeが複合種である事が示唆され,F.pedrosoi,P.verrucosa,C.carrionii,H.werneckiiでは種内変異はあるものの遺伝的にまとまりのある単一種である事が明らかにされた.更にF.pedrosoiとF.compacta及びP.verrucosaとP.americanaがそれぞれ同一種である事が遺伝的に示され,F.pedrosoiは6,P.verrucosaは10,C.carrioniiは4,H.werneckiiは9のタイプに分けられた.前3種において各タイプは地域特異的な分布を示し,後の一種では地域特異性は見られない事よりH.werneckiiが他の3種とは異なる分布の広げ方をしている事が推測された.また系統的に遠い関係にある,即ち共通の祖先から早い時期に分かれたと推定されるタイプがいずれも南米において分離されている事から,これらの菌種が北米及びアジアに比べ,より古くから南米に存在していた事が推測された.","PeriodicalId":19301,"journal":{"name":"Nippon Ishinkin Gakkai Zasshi","volume":"55 26 1","pages":"129-133"},"PeriodicalIF":0.0,"publicationDate":"1996-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87840344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Candida albicans: Morphogenesis and Pathogenesis 白色念珠菌:形态发生和发病机制

Nippon Ishinkin Gakkai Zasshi Pub Date : 1996-04-30 DOI: 10.3314/JJMM.37.49

N. Gow

{"title":"Candida albicans: Morphogenesis and Pathogenesis","authors":"N. Gow","doi":"10.3314/JJMM.37.49","DOIUrl":"https://doi.org/10.3314/JJMM.37.49","url":null,"abstract":"Germ tube production of Candida albicans is favoured by, and is adapted to, conditions of nutrient deprivation, particularly low nitrogen. Hyphal development in media containing low serum concentrations is characterised by the formation of sparsely branched hyphae in which uninucleated, highly vacuolated intercalary compartments are arrested in the cell cycle, probably in G1. Re-entry into the cell cycle is accelerated by enrichment of the medium for nutrients and is preceded by reduction of the vacuolar space and concomitant increase in the size of the cytoplasmic volume. Hyphae exhibit contact guidance (thigmotropism) which may facilitate the invasion of tissues through local wounds, invaginations or sites of weakened surface integrity. Thus hyphal growth is adapted for nutrient scavenging and penetration of irregular surfaces.The genetics of dimorphism and virulence has been investigated through studies of differential gene expression, and by specific manipulation of gene expression by overexpression and the creation of null mutants. The expression of many genes is regulated during dimorphism however few of these play active roles in the regulation of morphogenesis. Disruption of genes encoding certain secreted aspartyl proteinases (SAP2) and a key step in the assembly of O-linked mannosylation (MNT1) led to attenuation of virulence. Manipulation of the expression of a hyphal specific gene HYR1 did not affect germ tube growth while overexpression of a constitutively expressed Candida gene HST7 stimulated pseudohyphal growth in Saccharomyces. Therefore, analysis and manipulation of the normal temporal pattern of gene expression is yielding valuable information regarding the regulation of morphogenesis and pathogenesis in this fungus.","PeriodicalId":19301,"journal":{"name":"Nippon Ishinkin Gakkai Zasshi","volume":"1 1","pages":"49-58"},"PeriodicalIF":0.0,"publicationDate":"1996-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72757919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Tumor Necrosis Facter and Gamma Interferon in Murine Candidiasis 小鼠念珠菌病的肿瘤坏死因子和γ干扰素

Nippon Ishinkin Gakkai Zasshi Pub Date : 1996-04-30 DOI: 10.3314/JJMM.37.91

T. Miyazaki, Yoshiyuki Yamamoto, K. Yanagihara, H. Kakeya, T. Noda, S. Kohno

{"title":"Tumor Necrosis Facter and Gamma Interferon in Murine Candidiasis","authors":"T. Miyazaki, Yoshiyuki Yamamoto, K. Yanagihara, H. Kakeya, T. Noda, S. Kohno","doi":"10.3314/JJMM.37.91","DOIUrl":"https://doi.org/10.3314/JJMM.37.91","url":null,"abstract":"BALB/cマウスにC. albicans 7N株1.0×106CFUを静注した場合,無処置群は2ヶ月間全例生存したが,抗TNFα抗体投与群では生存率の低下が認められた.これに対し,抗γIFN抗体投与群では全例が生存し,生存率に差を認めなかった.C. albicans 7N株1.5×106CFUを静注した場合,無処置群は5日までに,全例が死亡した.抗γIFN抗体投与群では明らかに生存率の改善が認められたが,抗TNFα抗体投与群ではさらに生存率が低下した.C. albicans 7N浮遊液を飲水させ,腸管内に定着していることを確認したSCIDマウスに抗TNFα抗体,抗γIFN抗体,cyclophosphamide(5mg 2回)を静注したが,いずれでも全身性のカンジダ症への進展は病理学的にも,菌学的にも認められなかった.1.0×106CFUを投与した全身性カンジダ感染症モデルに,IL-12 0.1μgを腹腔内に連日2週間投与したが,生存率の変化は認められなかった.1.5×106CFUを感染させた致死的全身性カンジダ感染症モデルでは,無処理群が4日目までしか生存しなかったのに対して,予防的に感染前日にIL-12 0.1μgを1回のみ腹腔内投与した群では,6日まで生存した.","PeriodicalId":19301,"journal":{"name":"Nippon Ishinkin Gakkai Zasshi","volume":"72 1","pages":"91-95"},"PeriodicalIF":0.0,"publicationDate":"1996-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90582493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antireceptor Yeast Killer Toxin-like Antibiobodies 抗受体酵母杀手毒素样抗菌素体

Nippon Ishinkin Gakkai Zasshi Pub Date : 1996-04-30 DOI: 10.3314/JJMM.37.63

S. Conti, W. Magliani, M. Gerloni, P. Fisicaro, C. Cantelli, P. Mozzoni, D. Bertolotti, L. Polonelli

引用次数: 0

Deep Mycoses and Fungemia 深部真菌病和真菌病

Nippon Ishinkin Gakkai Zasshi Pub Date : 1996-04-30 DOI: 10.3314/JJMM.37.81

K. Wada

引用次数: 0