Neuroscience Letters最新文献_第5页

(−)-Epigallocatechin-3-gallate (EGCG) decreases neuronal network excitability and interictal like activity in mouse brain slices （−）-表没食子儿茶素-3-没食子酸酯（EGCG）降低小鼠脑切片中神经元网络的兴奋性和间期样活动

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-05-26 DOI: 10.1016/j.neulet.2025.138274

Hilal Öztürk , Dilanur Köse , Aslı Beyza Bayrakdar , Hümeyra Ayşe Şimşek , Semanur Yıldırım , Selcen Aydin-Abidin , İsmail Abidin

{"title":"(−)-Epigallocatechin-3-gallate (EGCG) decreases neuronal network excitability and interictal like activity in mouse brain slices","authors":"Hilal Öztürk , Dilanur Köse , Aslı Beyza Bayrakdar , Hümeyra Ayşe Şimşek , Semanur Yıldırım , Selcen Aydin-Abidin , İsmail Abidin","doi":"10.1016/j.neulet.2025.138274","DOIUrl":"10.1016/j.neulet.2025.138274","url":null,"abstract":"<div><div>(−)-Epigallocatechin-3-gallate (EGCG), the main flavonoid in green tea, is best known for its antioxidant and anti-inflammatory effects. EGCG interacts with certain ion channels and modulates ionic currents. However, its acute effect on neuronal activity is not known. In the present study, the effects of acute EGCG application on the excitability of neuronal network and epileptiform discharges were investigated. Acute brain slices were used for electrophysiological recordings. 370 µm thick entorhinal-hippocampal horizontal slices were obtained from 7-8 weeks old C57BL/6 mice. 100 µM 4-Aminopyridine (4AP) was used to induce epileptiform activity. Extracellular recordings of epileptiform activities were evaluated in the entorhinal cortex and hippocampus CA1 region. Additionally, the affinity of EGCG on the GABA-A receptor was evaluated in the central nervous system using the molecular docking method. Bath application of 10 μM and 50 μM EGCG reduced interictal event frequency in both entorhinal cortex and hippocampus. EGCG at 50 μM suppressed the absolute power of neuronal oscillations. To be able to explain these effects, we have analysed docking properties of EGCG to GABA-A receptor. The binding energy between EGCG and the GABA-A receptor was calculated as −7.41 kcal/mol. The affinity of EGCG for the GABA-A receptor is satisfactory compared to the reference molecule Diazepam. Findings showed for the first time that the acute application of EGCG had an inhibitory effect on neuronal excitability and also on synchronized events. EGCG might have a potential as a novel anti-seizure molecule.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"859 ","pages":"Article 138274"},"PeriodicalIF":2.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subregion-specific suppression of dopamine D1 receptor expression prevents L-DOPA-induced dyskinesia in a mouse model of Parkinson’s disease 在帕金森病小鼠模型中，亚区域特异性抑制多巴胺D1受体表达可预防左旋多巴诱导的运动障碍

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-05-25 DOI: 10.1016/j.neulet.2025.138273

Keita Sugiyama , Mahomi Kuroiwa , Takahide Shuto , Sehyeon Hwang , Yong-Seok Oh , Akinori Nishi

{"title":"Subregion-specific suppression of dopamine D1 receptor expression prevents L-DOPA-induced dyskinesia in a mouse model of Parkinson’s disease","authors":"Keita Sugiyama , Mahomi Kuroiwa , Takahide Shuto , Sehyeon Hwang , Yong-Seok Oh , Akinori Nishi","doi":"10.1016/j.neulet.2025.138273","DOIUrl":"10.1016/j.neulet.2025.138273","url":null,"abstract":"<div><div>L-DOPA-induced dyskinesia (LID) is a debilitating motor complication that develops following prolonged L-DOPA therapy in patients with Parkinson’s disease (PD). Aberrant activation of dopamine D1 receptor (DRD1) signaling in D1-type/direct pathway medium spiny neurons (MSNs) of the striatum plays a critical role in the pathophysiology of LID. We previously characterized DRD1 signaling in seven striatal subregions and found that upregulation of DRD1 signaling in the intermediate/caudal part (IC) is associated with LID in a mouse model of PD. Here, we investigated whether DRD1 expression in the IC plays a causal role in LID development. Using an adeno-associated virus (AAV) expressing a short hairpin RNA against <em>Drd1</em> (AAV-sh<em>Drd1</em>), we selectively knocked down DRD1 expression in the IC of male mice. In unilateral 6-hydroxydopamine-lesioned mice, DRD1 knockdown in the IC significantly attenuated LID after acute and chronic L-DOPA treatment. In contrast, knockdown in either the rostral or intermediate/rostral part, previously identified as the LID-unrelated subregion, did not affect LID. These findings highlight the essential role of DRD1 and its signaling in the IC in LID development, providing valuable insights for developing novel therapeutic approaches.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"859 ","pages":"Article 138273"},"PeriodicalIF":2.5,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PCC-hippocampal functional connectivity associated with stress biomarker changes after meditation training for healthy adults 健康成人冥想训练后与应激生物标志物变化相关的pcc -海马功能连通性

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-05-23 DOI: 10.1016/j.neulet.2025.138272

Diane Joss , Gunes Sevinc , John W. Denninger , Sat Bir Singh Khalsa , Elizabeth A. Hoge , Manoj Bhasin , Jeffery A. Dusek , Eric Macklin , Towia A. Libermann , Gregory L. Fricchione , Herbert Benson , Sara W. Lazar

{"title":"PCC-hippocampal functional connectivity associated with stress biomarker changes after meditation training for healthy adults","authors":"Diane Joss , Gunes Sevinc , John W. Denninger , Sat Bir Singh Khalsa , Elizabeth A. Hoge , Manoj Bhasin , Jeffery A. Dusek , Eric Macklin , Towia A. Libermann , Gregory L. Fricchione , Herbert Benson , Sara W. Lazar","doi":"10.1016/j.neulet.2025.138272","DOIUrl":"10.1016/j.neulet.2025.138272","url":null,"abstract":"<div><div>Meditation training has been shown to improve physical and mental health and promote neural plasticity, but more research is needed on the relationships between these effects. This study analyzed the Resting State Functional Connectivity (RSFC) of posterior cingulate cortex (PCC) among 94 chronically stressed but otherwise healthy adults randomized 1:1:1 to receive eight weeks of in-person one-on-one interventions focused either on meditation (n = 32), yoga (n = 31), or stress education (n = 31). We found only in the meditation arm, there was a significant reduction of PCC RSFC with the left hippocampus (<em>p</em> < 0.05, FWE corrected). Post-intervention changes of PCC-hippocampal RSFC were significantly (all <em>p</em> ≤ 0.01) correlated with changes of perceived stress (<em>r</em> = 0.54), allostatic load index (<em>r</em> = 0.58), and NF-κB anti-inflammatory gene expression (<em>r</em> = -0.55), suggesting the neural effects of meditation are closely associated with biomarkers of physical wellness. No significant changes with PCC RSFC were observed within the yoga or stress education arm, suggesting this neurobiological mechanism might be unique to meditation training.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"864 ","pages":"Article 138272"},"PeriodicalIF":2.5,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ventral tegmental area functional connectivity as a marker of resilience to sleep deprivation 腹侧被盖区功能连通性作为睡眠剥夺恢复能力的标志。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-05-20 DOI: 10.1016/j.neulet.2025.138271

Jungwon Cha, Kathryn E.R. Kennedy, David Negelspach, Alisa Huskey, William D.S. Killgore

{"title":"Ventral tegmental area functional connectivity as a marker of resilience to sleep deprivation","authors":"Jungwon Cha, Kathryn E.R. Kennedy, David Negelspach, Alisa Huskey, William D.S. Killgore","doi":"10.1016/j.neulet.2025.138271","DOIUrl":"10.1016/j.neulet.2025.138271","url":null,"abstract":"<div><h3>Objective</h3><div>Sleep deprivation (SD) impairs cognitive functions like attention and reaction speed, though some individuals exhibit a trait-like resilience to these effects. To explore the neurobiological basis of this resilience, we quantified cognitive performance using the Percentage Reaction Speed Change (PRSC) from the psychomotor vigilance test (PVT). We then examined the relationship between PRSC and ventral tegmental area (VTA) functional connectivity during 28 h of SD.</div></div><div><h3>Methods</h3><div>Forty-four healthy adults (21 females; age = 25.4 ± 5.6 years) underwent a resting-state functional MRI (rs-fMRI) to examine whole-brain VTA connectivity. Within the same week, participants completed a 28-hour SD protocol, during which PVT performance was measured. We examined the association between VTA connectivity and PRSC, with a focus on connections to the Primary Visual Cortex (V1) and Supplementary and Cingulate Eye Field (SCEF).</div></div><div><h3>Results</h3><div>Greater VTA connectivity with the V1 and SCEF was associated with higher PRSC, suggesting that stronger VTA connectivity to these visual processing and cognitive control regions supports cognitive resilience to SD.</div></div><div><h3>Conclusion</h3><div>The VTA contributes to cognitive resilience during sleep deprivation through its connectivity with visual and cognitive control regions. These findings provide insight into neural mechanisms that help preserve cognitive performance under SD.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"859 ","pages":"Article 138271"},"PeriodicalIF":2.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in gene expression of D2 and D5 receptors in the thalamus and midbrain caused by a persistent painful stimulus in Parkinsonian rats 持续疼痛刺激对帕金森大鼠丘脑和中脑D2和D5受体基因表达的影响

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-05-19 DOI: 10.1016/j.neulet.2025.138270

José Luis Cortes-Altamirano , Alfonso Alfaro-Rodríguez , Abril Morraz-Varela , Samuel Reyes-Long

{"title":"Changes in gene expression of D2 and D5 receptors in the thalamus and midbrain caused by a persistent painful stimulus in Parkinsonian rats","authors":"José Luis Cortes-Altamirano , Alfonso Alfaro-Rodríguez , Abril Morraz-Varela , Samuel Reyes-Long","doi":"10.1016/j.neulet.2025.138270","DOIUrl":"10.1016/j.neulet.2025.138270","url":null,"abstract":"<div><div>Pain is the most common and underdiagnosed non-motor symptom in Parkinson’s disease. Dopaminergic receptors D2 and D5 have been implicated in pain modulation. In this study, the expression of D2 and D5 receptors in the midbrain and thalamus in response to a painful stimulus was evaluated. The animals were assigned to a 6-OHDA group, a Sham group and a Control group. 6-OHDA was administered to the experimental group and 2 μl of 1 % ascorbic acid to the Sham group in the substantia nigra pars compacta. The midbrain and thalamus were dissected for RT-qPCR. In the formalin test, phase 1 showed significant differences between the Sham, 6-OHDA and Control groups, while in phase 2 the 6-OHDA group presented a greater nociceptive response. In the cylinder test, the 6-OHDA group showed a reduction in the use of the left limb and both limbs. In the open-field test, the 6-OHDA group spent more time in corners and showed less exploration in the periphery and center. An increasing trend for D5 was observed in the midbrain of the 6-OHDA group and in the thalamus of the Sham group. Dopaminergic injury induced by 6-OHDA as part of the parkinsonian model alters motor function, increases anxiety, and increases nociceptive response in the persistent phase of the formalin model. In addition, a non-significant increase in D5 receptor expression in the midbrain and thalamus may suggest an adaptive response of dopaminergic signaling to persistent pain.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"859 ","pages":"Article 138270"},"PeriodicalIF":2.5,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The leptin/BDNF/TrkB signaling pathway improves corticosteroid combined with chronic restraint stress-induced depressive-like behavior in mice 瘦素/BDNF/TrkB信号通路改善皮质类固醇联合慢性约束应激诱导的小鼠抑郁样行为。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-05-17 DOI: 10.1016/j.neulet.2025.138268

Yunqian Ke, Yiming Wang, Yongxue Hu

{"title":"The leptin/BDNF/TrkB signaling pathway improves corticosteroid combined with chronic restraint stress-induced depressive-like behavior in mice","authors":"Yunqian Ke, Yiming Wang, Yongxue Hu","doi":"10.1016/j.neulet.2025.138268","DOIUrl":"10.1016/j.neulet.2025.138268","url":null,"abstract":"<div><div>This study explored the effect and mechanism of leptin on depressive-like behavior induced by chronic corticosterone injections combined with chronic restraint stress (CORT-CRS) in mice. Differentially expressed genes (DEGs) were extracted using the Gene Expression Omnibus database and Sangerbox tool. Construct protein–protein interaction networks of target DEGs using Cytoscape software, and hub genes brain-derived neurotrophic factor (<em>BDNF</em>) were identified. A mouse model of depression was established using CORT-CRS. Behavioral changes were detected in the mice using the tail suspension, forced swimming, sugar water preference (SPT), and open field tests (OFT). Serum inflammatory factors were measured by Enzyme-linked immunosorbent assay (ELISA). Western blotting was used to detect the protein expression levels of BDNF and tyrosine kinase receptor B (TrkB). Immunofluorescence was used to detect hippocampal neurogenesis in each mouse group. Compared with the control group, mice in the CORT-CRS group presented with marked depression-like behavior and a higher interleukin (IL) -6, IL-1 β, tumor necrosis factor alpha (TNF – α) concentration. Different doses of leptin reversed depressive-like behavior in the CORT-CRS model mice, with significantly increased levels of BDNF, TrkB protein expression (<em>P</em> < 0.01).</div><div>Furthermore, leptin promoted hippocampal neurogenesis in CORT-CRS-treated mice in vivo. Consequently, leptin alleviates CORT-CRS-induced depression-like behavior in mice by stimulating hippocampal neurogenesis. One possible mechanism could be related to the activation of the BDNF/TrkB signaling pathway, which could pave way for novel therapeutic targets that can be explored to prevent and treat depression.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"859 ","pages":"Article 138268"},"PeriodicalIF":2.5,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The expression of connexin 36 and 43 in animal models of trait and state anxiety 连接蛋白36和43在特质性和状态性焦虑动物模型中的表达。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-05-17 DOI: 10.1016/j.neulet.2025.138269

Mohammadreza Alizadeh , Sahel Motaghi , Mahya Moradi Sirchi , Mehdi Abbasnejad , Saeed Esmaili-Mahani

{"title":"The expression of connexin 36 and 43 in animal models of trait and state anxiety","authors":"Mohammadreza Alizadeh , Sahel Motaghi , Mahya Moradi Sirchi , Mehdi Abbasnejad , Saeed Esmaili-Mahani","doi":"10.1016/j.neulet.2025.138269","DOIUrl":"10.1016/j.neulet.2025.138269","url":null,"abstract":"<div><div>Few studies have investigated the role of gap junctions in anxiety. Gap junctions (GJs) are intercellular channels, and their subunit are connexins (CXs). The specific isoforms of connexins for neurons and astrocytes are CX36, and CX43 respectively. Neuronal CX36 and astrocytic CX43 are critical for brain synchrony and homeostasis. Elevated plus maze (EPM) was used for animal models of trait and state anxiety. The gene expression was assessed by Real-time PCR technique in the ventral hippocampus (v Hip), basolateral amygdala (BLA), and medial prefrontal cortex (m PC). The rats were grouped as follows (n = 6): control, trait anxiety, in which the rats were placed in the EPM apparatus, state anxiety, in which the animals were placed in the EPM apparatus after tolerating 120 min of isolation. The data showed that the anxiety of the animals in the state anxiety group was significantly greater than the trait anxiety group (<em>p < 0.05</em>). In the state anxiety animals, the gene expression of CX36 was lower in the m PC and BLA regions than the control and trait anxiety groups (<em>p < 0.01</em>). CX43 expression in the BLA, and v Hip structures was also lower than in the control and trait anxiety groups. These findings suggest that downregulation of CX36 and CX43 contributes to state anxiety pathophysiology, highlighting GJs as potential therapeutic targets.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"859 ","pages":"Article 138269"},"PeriodicalIF":2.5,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic administration of 1,3-di-o-tolylguanidyne induces catalepsy and reduces immobility responses by clamping and grasping in Wistar rat, evaluation in vivo and in silico 长期给药1,3-二-邻多聚胍通过Wistar大鼠夹紧和抓握诱导猝倒和减少不动反应，体内和计算机评价

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-05-16 DOI: 10.1016/j.neulet.2025.138267

Dulce E. Nicolás-Álvarez , José Luna-Muñoz , Vicente Sandoval-Herrera , Martha A. Estrada-Silva , Javier Cruz-Rodríguez , Nabil I. Luna-Viramontes , Brenda Granados-Rivas , Gabriela Silva-Luna , Jimena Natalia Torres-Mendoza , Hiram Tendilla-Beltrán , Gonzalo Flores , Linda Garcés-Ramírez , Fidel de la Cruz-López

{"title":"Chronic administration of 1,3-di-o-tolylguanidyne induces catalepsy and reduces immobility responses by clamping and grasping in Wistar rat, evaluation in vivo and in silico","authors":"Dulce E. Nicolás-Álvarez , José Luna-Muñoz , Vicente Sandoval-Herrera , Martha A. Estrada-Silva , Javier Cruz-Rodríguez , Nabil I. Luna-Viramontes , Brenda Granados-Rivas , Gabriela Silva-Luna , Jimena Natalia Torres-Mendoza , Hiram Tendilla-Beltrán , Gonzalo Flores , Linda Garcés-Ramírez , Fidel de la Cruz-López","doi":"10.1016/j.neulet.2025.138267","DOIUrl":"10.1016/j.neulet.2025.138267","url":null,"abstract":"<div><div>Catalepsy, used to assess antipsychotic effects in animal models, involves sustained abnormal postures and resistance to displacement through balance reflexes. In contrast, immobility is a passive, stimulus-induced state marked by reduced movement and responsiveness, it can be triggered by a variety of stimuli. We found that a single administration of 1,3-di-o-tolylguanidine (DTG) had no effect on catalepsy, whereas daily administration induced cataleptic behavior by day 21. DTG reduced dorsal (grasping) and clamping immobility from the first day of administration, and this reduction persisted through day 21. Our findings support the potential use of sigma receptors as targets for antipsychotic drug development. Molecular dynamics studies indicate that DTG exhibits high stability and binding affinity for sigma-1 and dopamine D2 receptors, which may underlie its behavioral effects. Given the well-documented cataleptic properties of haloperidol, we compared and discussed both the molecular dynamics and previously reported behavioral effects of DTG in relation to haloperidol.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"859 ","pages":"Article 138267"},"PeriodicalIF":2.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tyrosol ameliorates depressive-like behavior and hippocampal damage in perimenopausal depression rats by inhibiting oxidative stress and thyroid dysfunction Tyrosol通过抑制氧化应激和甲状腺功能障碍改善围绝经期抑郁症大鼠的抑郁样行为和海马损伤。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-05-16 DOI: 10.1016/j.neulet.2025.138266

Xiaolong Sun , Meng Zhao , Xu Wang , Yinuo Sun , Jing Li , Yan Zhang , Youzhi Zhang , Xiaoling Feng

{"title":"Tyrosol ameliorates depressive-like behavior and hippocampal damage in perimenopausal depression rats by inhibiting oxidative stress and thyroid dysfunction","authors":"Xiaolong Sun , Meng Zhao , Xu Wang , Yinuo Sun , Jing Li , Yan Zhang , Youzhi Zhang , Xiaoling Feng","doi":"10.1016/j.neulet.2025.138266","DOIUrl":"10.1016/j.neulet.2025.138266","url":null,"abstract":"<div><div>Perimenopausal depression (PMD) is a common condition during the female perimenopausal period. Tyrosol represents a promising neuroprotective agent. This study aims to determine if tyrosol alleviate PMD progression. A rat model of PMD was established using bilateral ovariectomy and chronic unpredictable mild stress. Behavioral tests showed that tyrosol alleviated the depressive-like behavior in PMD rats. Tyrosol increased sucrose preference in SPT and residence time in the central region of OFT, and reduced immobility time in FST of PMD rats. Apoptosis of neurons in the hippocampus of PMD rats was inhibited by tyrosol treatment, as evidenced by an increase in the protein expression of Bcl-2 and a decrease in the expression of Bax and cleaved caspase-3 in hippocampal tissue. Tyrosol treatment effectively reduced thyroid-stimulating hormone levels and elevated the levels of free triiodothyronine and free thyroxine in the serum of PMD rats. The levels of ROS and MDA were decreased, and the levels of GPX and SOD were increased in the hippocampal tissue of PMD rats by tyrosol treatment. In addition, tyrosol treatment promoted the levels of brain-derived neurotrophic factor (BDNF) and monoamine neurotransmitters (5-HT, DA, and NA) in the hippocampal tissue. In summary, tyrosol might ameliorate depression-like behavior in PMD rats by inhibiting hippocampal oxidative stress and damage and promoting monoamine neurotransmitter release, and restoration of thyroid function may also be involved.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"859 ","pages":"Article 138266"},"PeriodicalIF":2.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tripterygium-derived celastrol inhibits 5-HT3A receptors via key residue interactions: A comparative electrophysiological and docking study 雷公藤衍生的雷公藤红素通过关键残基相互作用抑制5-HT3A受体：比较电生理和对接研究

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-05-15 DOI: 10.1016/j.neulet.2025.138265

Hye Duck Yeom , Jihwon Yun , Chaewon Seo , Mee-Hyun Lee , Gihyun Lee , Junho H Lee

引用次数: 0