Neuroscience Letters最新文献

{"title":"Short-term effects of sertraline against depressive-like behaviors in a rat model of neonatal hypoxic encephalopathy","authors":"Marie-Michèle Serghani ,&nbsp;Sondos Kassem-Moussa ,&nbsp;Rawan Makki ,&nbsp;Abdallah Kurdi ,&nbsp;Marawan Elbaset ,&nbsp;Helene Hajjar ,&nbsp;Reem El Jammal ,&nbsp;Gabriel T. Flath-Everhard ,&nbsp;Ishaan Prasad ,&nbsp;Assaad Eid ,&nbsp;Aida Habib ,&nbsp;Eva Hamade ,&nbsp;Fletcher A. White ,&nbsp;Bassam Badran ,&nbsp;Makram Obeid","doi":"10.1016/j.neulet.2025.138392","DOIUrl":"10.1016/j.neulet.2025.138392","url":null,"abstract":"<div><div>Hypoxic encephalopathy of the newborn is associated with long-term neurodevelopmental behavioral deficits that lack a definitive “optimal” treatment approach. We previously demonstrated that periadolescent depressive-like behaviors occur in a rat model of early-life hypoxia. Here, we investigated the short-term effects of the selective serotonin reuptake inhibitor, sertraline, against later-life behavioral deficits. Rats were exposed to global hypoxia at postnatal day 10 (P10) and then received either sertraline or its vehicle (P24 to P30). Normoxic controls received sertraline or its vehicle. Depressive-like and anxiety-like behaviors were assessed using the forced swim test (FST) and open field test (OFT), respectively. The FST was conducted at P25-26 and the OFT at P27. Rats were sacrificed at P30 to assess hippocampal microRNA (miR) expression and to histologically evaluate hippocampal neuronal densities and synaptophysin (Syp) protein levels. Early-life hypoxic seizures resulted in increased immobility in the FST (p &lt; 0.05) and decreased exploration in the OFT (p &lt; 0.05). Hypoxia also resulted in chronic alterations in the expression of 25 miRs, 22 of which are known to modulate inflammatory responses and synaptic function. Sertraline treatment normalized hypoxia-induced increased immobility and reversed 17 out of 25 alterations in miR expression. However, sertraline potentiated hypoxia-induced exploratory deficits (p &lt; 0.05). The drug treatment also resulted in OFT deficits in controls (p &lt; 0.05) and 13 unique dysregulations in miR expression. Neuronal densities and Syp levels were comparable among all groups. We demonstrate that sertraline reverses hypoxia-induced depressive-like behaviors, possibly by targeting inflammation and synaptic remodeling. Sertraline-induced anxiety-like behaviors may reflect its known transient early side effects and warrant further research on long-term outcomes.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"867 ","pages":"Article 138392"},"PeriodicalIF":2.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145176615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laughing your… brain off. New insights on the adaptive meaning of humour","authors":"Maria Elide Vanutelli ,&nbsp;Mirella Manfredi","doi":"10.1016/j.neulet.2025.138411","DOIUrl":"10.1016/j.neulet.2025.138411","url":null,"abstract":"","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"867 ","pages":"Article 138411"},"PeriodicalIF":2.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tanshinone IIA and hydroxy safflower yellow A reduce cerebral injury via TLR4/NF-κB pathway in rats","authors":"Bin Luo ,&nbsp;Yu Zheng ,&nbsp;Qi Miao ,&nbsp;Yimin Zhang ,&nbsp;Ye Lei ,&nbsp;Qingyun Xu ,&nbsp;Wenwu Li ,&nbsp;Jingao Yu ,&nbsp;Xiao Zhu ,&nbsp;Jianlin Yuan ,&nbsp;Huiyuan Zhu","doi":"10.1016/j.neulet.2025.138390","DOIUrl":"10.1016/j.neulet.2025.138390","url":null,"abstract":"<div><div>Cerebral ischemia–reperfusion injury (CIRI) is a cerebrovascular disorder with high rates of incidence, disability, and death. It has been identified that Salvia miltiorrhiza and safflower have a protective effect in CIRI. However, the mechanisms of which remain to be elucidated. In this study, we investigated the protective mechanisms of the components of Salvia miltiorrhiza and safflower in CIRI, based on the TLR4/NF-κB signaling pathway. Sprague Dawley (SD) rats were used to establish the rat middle cerebral artery occlusion/reperfusion (MACO/R) model by the suture method. Drugs were injected intraperitoneally at 0 and 2 h, followed by once-daily treatment for 3 days. Neurological function and the volume of brain infarction were evaluated, and the pathological changes in brain tissue were examined using HE staining. ELISA kits were used to detect the concentrations of TNF-α and IL-6, while RT-qPCR, Western blot, and immunofluorescence were employed to evaluate the mRNA and protein expression in brain tissue. Following a combination of tanshinone IIA and hydroxy safflower yellow A treatment, our findings indicated that cerebral infarct volume and neurological deficits were reduced. The findings of HE staining revealed an improvement in cerebral histopathological damage in rats with MCAO/R. The levels of TNF-α and IL-6 in serum, as well as the expression of TLR4 and NF-κB in rat brains, were significantly reduced (P &lt; 0.0001). Taken together, these results indicate that the combination of tanshinone ⅡA and hydroxyl safflower yellow A may exhibit a neuroprotective effect on cerebral I/R injury in rats by activating the TLR4/NF-κB signaling pathway.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"867 ","pages":"Article 138390"},"PeriodicalIF":2.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nicotine exacerbates fear and depression-like behaviors by promoting microglial phagocytosis of synaptic protein in a mouse model of foot shock","authors":"Jiaquan Wang ,&nbsp;Xiao-kang Gong ,&nbsp;Jing Yu ,&nbsp;Liangwei Wu ,&nbsp;Yuheng Zhang ,&nbsp;Pan Li ,&nbsp;Min Qin ,&nbsp;Xiao-chuan Wang ,&nbsp;Xi-ji Shu ,&nbsp;Jian Bao","doi":"10.1016/j.neulet.2025.138394","DOIUrl":"10.1016/j.neulet.2025.138394","url":null,"abstract":"<div><div>Post-traumatic stress disorder (PTSD) is a severe psychiatric disorder characterized by a complex interplay of genetic and environmental influences. Substantial evidence has demonstrated an intricate nexus between nicotine, the principal psychoactive constituent of cigarette smoke, and PTSD neuropathology. Nevertheless, the intricate mechanism underlying the relationship between nicotine consumption and PTSD has not yet been fully understood. Following two weeks of intraperitoneal nicotine administration at two doses (5 mg/kg and 1 mg/kg), we initiated behavioral testing. Our findings reveal that nicotine supplementation exacerbates fear and depression-like behaviors while promoting microglial phagocytosis of synaptic proteins. Moreover, we observed synaptic protein loss and microglial activation in both the hippocampus and cortex in the 5 mg/kg group. CX3CR1-Cre driven Cre recombinase (Cre) is a widely used genetic tool for enabling gene manipulation in microglia. Here, we investigated a genetic ablation method of the CX3CR1 using a Cre-responsive adeno-associated virus (AAV) vector expressing diphtheria toxin subunit-A (DTA). Conversely, microglial ablation via rAAV-EF1a-DIO-DTA-WPRE hGH pA injection in the ventral hippocampus CA1 region of CX3CR1-Cre mice appears to mitigate the pathologies and behavioral abnormalities induced by nicotine. Our results underscore the role of nicotine in the progression of PTSD and demonstrate that microglial depletion mitigates nicotine-induced pathologies and behavioral disturbances. Consequently, our findings suggest that nicotine enhances microglial phagocytosis of synaptic proteins in PTSD, thereby exacerbating fear and depressive symptoms.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"867 ","pages":"Article 138394"},"PeriodicalIF":2.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Membrane fusion deficits of acutely isolated synaptic vesicles from the brains of depression-like mice","authors":"Xuanzhu Zhao ,&nbsp;Pir Tariq Shah ,&nbsp;Lijin Feng ,&nbsp;Siqi Song ,&nbsp;Yazhuo Feng ,&nbsp;Chengjun Wu ,&nbsp;Rong Liu ,&nbsp;Yujun Wang ,&nbsp;Sheng Zhang ,&nbsp;Zhenyong Wu","doi":"10.1016/j.neulet.2025.138366","DOIUrl":"10.1016/j.neulet.2025.138366","url":null,"abstract":"<div><div>Depression is a common and debilitating psychiatric disorder increasingly associated with presynaptic dysfunction, particularly impairments in synaptic vesicle (SV)-mediated neurotransmitter release, yet its underlying neurobiological mechanisms remain largely unresolved. In this study, we investigated SV morphology and fusion capability in a chronic variable stress (CVS)-induced mouse model of depression. To enable this analysis, we established an optimized protocol integrating differential centrifugation, density gradient ultracentrifugation, and size exclusion chromatography to isolate high-purity SVs from mouse brain tissue. Behavioral analyses confirmed the depression-like phenotype in CVS mice, characterized by anhedonia, anxiety-like behavior and behavioral despair. Although SV morphology, as characterized by TEM, appeared largely preserved, reconstituted vesicle fusion assays demonstrated a significant decline in their fusion capacity, suggesting impaired neurotransmitter release. These findings provide direct evidence of functional SV alternations in depression and underscore the key role of presynaptic dysfunction in its pathophysiology. The optimized SV isolation workflow developed in this study offers a valuable tool for investigating presynaptic mechanisms in neuropsychiatric disorders.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"866 ","pages":"Article 138366"},"PeriodicalIF":2.0,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left-right asymmetry in the thoracic spinal cord","authors":"Peter A. Kirkwood","doi":"10.1016/j.neulet.2025.138370","DOIUrl":"10.1016/j.neulet.2025.138370","url":null,"abstract":"<div><div>Evidence of left–right asymmetry in the spinal cord has been accumulating for some time. This report adds an anatomical example. For thoracic segments in the cat, the dorsal root entries of a given segment, at least for T5 to T9, were shown to have a tendency to be located more rostrally on the right than on the left. Measurements of the root positions have been brought together from notes in experimental protocols over nine years (36 animals). The rostral-most root of a segment on the right was found to lie up to 4.5 mm more rostrally than that on the left (mean 0.93 ± 1.05 mm, n = 86), while the caudal-most root was similarly asymmetric by up to 5.5 mm (mean 0.98 ± 1.72 mm, n = 30). These results are supported by very similar measurements made from the undamaged regions of spinal cords in a further 36 animals that had spinal cord lesions. Implications of the asymmetry are discussed.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"866 ","pages":"Article 138370"},"PeriodicalIF":2.0,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Directional flow of brain connections and neurodevelopmental outcomes in healthy full-term newborns","authors":"Venkata Chaitanya Chirumamilla ,&nbsp;Sarah B. Mulkey ,&nbsp;Tayyba Anwar ,&nbsp;Robin Baker ,&nbsp;G.Larry Maxwell ,&nbsp;Josepheen De Asis-Cruz ,&nbsp;Kushal Kapse ,&nbsp;Catherine Limperopoulos ,&nbsp;Adre du Plessis ,&nbsp;R.B. Govindan","doi":"10.1016/j.neulet.2025.138371","DOIUrl":"10.1016/j.neulet.2025.138371","url":null,"abstract":"<div><h3>Objective</h3><div>We examined whether directional flow among brain hubs in healthy-term infants is associated with neurodevelopmental outcomes at two years of age.</div></div><div><h3>Methods</h3><div>High-density electroencephalography (EEG) was collected within 72 h after birth. Neurodevelopmental outcomes (cognitive, language, and motor scores) were measured using Bayley Scales of Infant Development-III (BSID-III) at two years. Source signals were extracted from the hubs, and directed information flow from hub was calculated using partial directed coherence method in delta band. The relationship between information flow and BSID-III scores was assessed using stepwise regression.</div></div><div><h3>Results</h3><div>Forty-seven newborns had EEG and BSID-III scores. Efferent flow from the left amygdala (t-statistic = -2.97, p = 0.027), right amygdala (t-statistic = -2.15, p = 0.03), and right caudate nucleus (t-statistic = -2.16, p = 0.036) were negatively associated, while the left pallidum (t-statistic = 2.72, p = 0.02) was positively associated with cognitive scores. The efferent flow from the right amygdala (t-statistic = -2.34, p = 0.03) was negatively associated with language scores, while efferent flow from the brainstem (t-statistic = 2.38, p = 0.03) was positively associated with motor scores.</div></div><div><h3>Conclusions</h3><div>Efferent output from specific hubs at birth is associated with neurodevelopmental outcomes at two years of age.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"866 ","pages":"Article 138371"},"PeriodicalIF":2.0,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1, 2, 4-trimethoxybenzene alleviates pain and related psychiatric disorders by inhibiting NLRP3 inflammasome activation","authors":"Xiangxi Kong ,&nbsp;Zhijie Fan ,&nbsp;Tang Rui ,&nbsp;Yuxuan Qi ,&nbsp;Xuening Wang ,&nbsp;Anran Zhang ,&nbsp;Xin Chen ,&nbsp;Yajin Liao ,&nbsp;Jun Ma","doi":"10.1016/j.neulet.2025.138375","DOIUrl":"10.1016/j.neulet.2025.138375","url":null,"abstract":"<div><div>Pain and pain-related psychiatric diseases affect approximately one-third of the global population, and effective treatment remains a lack of options. NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome is regarded as a potential therapeutic target for managing pain and related psychiatric diseases. Our previous research reported that 1,2,4-trimethoxybenzene (1,2,4-TTB) effectively inhibited NLRP3 inflammasome activity. Therefore, we further investigated the role of 1,2,4-TTB in the treatment of pain and its associated psychiatric disorders. In this study, we evaluated the effects of 1,2,4-TTB (200 <span><span>mg.kg</span><svg><path></path></svg></span>⁻¹) by intragastric administration on mechanical pain, anxiety and depression-like behaviors using Complete Freund’s Adjuvant (CFA) induced acute and chronic inflammatory pain mouse models. Furthermore, NLRP3 inflammasome activation was assessed through western blotting. Immunofluorescence was employed to observe the number of macrophages and microglia. Results indicated that 1,2,4-TTB markedly relieved mechanical pain in acute and chronic pain mouse models. 1,2,4-TTB also improved anxiety and depression-like behaviors in pain mouse models. Additionally, NLRP3 inflammasome activation was dramatically suppressed by 1,2,4-TTB in pain mouse models. The macrophage and microglia activation were also inhibited by 1,2,4-TTB. Our research shows that 1,2,4-TTB attenuates both acute and chronic inflammatory pain as well as anxiety and depression-like behaviors. These findings suggest that 1,2,4-TTB is a promising therapeutic option for managing various types of pain, anxiety, and depression.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"866 ","pages":"Article 138375"},"PeriodicalIF":2.0,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lethal yellow mutation in the Raly-Agouti locus reduces the energy expenditure in male mice","authors":"Nikita V. Khotskin,&nbsp;Arseniy E. Izyurov,&nbsp;Alexander V. Kulikov","doi":"10.1016/j.neulet.2025.138374","DOIUrl":"10.1016/j.neulet.2025.138374","url":null,"abstract":"<div><div>The <em>lethal yellow (A^Y)</em> mutation in the <em>Raly-Agouti</em> locus leads to ectopic expression of the agouti protein in the brain where it inhibits melanocortin receptors, causes obesity as well as alters some traits of adaptive behavior. In the present study we used the Phenomaster calorimetric module tool to compare the travel distance, food and O₂ consumption as well as CO₂ excretion in 12 weeks old males of C57BL/6- A^Y and C57BL/6 mice. The <em>A^Y</em> mutation did not affect travelled distance and food consumption. At the same time, this mutation significantly reduced O₂ consumption and CO₂ excretion which are the main indices of indirect calorimetry. This result suggests that the reduced energy expenditure is a cause of obesity in C57BL/6- A^Y mice. These mutant mice seem to use energy received with food in a more economical way compared to C57BL/6 mice. The results of the present study increase the impact of C57BL/6- A^Y mice as a convenient model of neural and molecular mechanisms of economical expenditure of energy resources.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"866 ","pages":"Article 138374"},"PeriodicalIF":2.0,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Region-specific modulation and predictive potential of the oscillatory dynamics in an ex vivo model of ictogenesis in the CA1, CA3 and dentate gyrus","authors":"Lida-Evmorfia Vagiaki ,&nbsp;Dionysios Xydias ,&nbsp;Mary Kefalogianni ,&nbsp;Sotiris Psilodimitrakopoulos ,&nbsp;Emmanuel Stratakis ,&nbsp;Kyriaki Sidiropoulou","doi":"10.1016/j.neulet.2025.138367","DOIUrl":"10.1016/j.neulet.2025.138367","url":null,"abstract":"<div><div>The hippocampus, including the cornu ammonis (CA) and dentate gyrus (DG) subregions, is a brain area highly susceptible to seizure-like activity (SLA). Most studies conducted in vivo have been performed in a single hippocampal subregion. In our study, we used the high [K⁺] (HK⁺) model of SLA to investigate the role of oscillatory activity in predicting SLA and in its modulation by anti-epileptic drugs in the three hippocampal subregions (CA1, CA3 and DG). For this, we recorded spontaneous local field potentials (LFPs) in CA1, CA3 and DG subregions from mouse hippocampal slices. We find that the oscillatory activity in the 20 s pre-ictal period is significantly different compared to the oscillatory activity in the absence of SLA or to a more distant period from the ictal event. A classification algorithm revealed that the oscillatory dynamics, particularly in the CA1 subregion, can predict the emergence of an ictal event with high accuracy. Furthermore, oscillatory activity is differentially modulated by anti-epileptic drugs in the different hippocampal subregions. We found that diazepam and carbamazepine modulated the oscillatory activity significantly greater in the CA3 and DG subregions, compared to CA1. Imaging of neuronal activation in the <em>ex vivo</em> model of seizure-like activity, using the Fos protein as an activity marker, revealed a similar subregion-dependent differential modulation following diazepam and carbamazepine perfusion. Therefore, while oscillatory activity in the pre-ictal period in the CA1 subregion can better predict the emergence of ictal events, anti-convulsant drugs have a stronger effect in oscillatory activity in the CA3 and DG subregions.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"866 ","pages":"Article 138367"},"PeriodicalIF":2.0,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}