Neuroscience Letters最新文献_第10页

Cortical beta oscillation in brain slices of hemi parkinsonian mice 半帕金森小鼠脑切片皮层β振荡。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-01-18 DOI: 10.1016/j.neulet.2025.138128

Aidán Ortega , Antonio Laville , Montserrat Padilla-Orozco , Yohana Parrado , Dagoberto Tapia , Miguel Serrano-Reyes , Janintzitzic López-Niño , Héctor A. Vázquez-Vázquez , Elvira Galarraga , José Bargas

{"title":"Cortical beta oscillation in brain slices of hemi parkinsonian mice","authors":"Aidán Ortega , Antonio Laville , Montserrat Padilla-Orozco , Yohana Parrado , Dagoberto Tapia , Miguel Serrano-Reyes , Janintzitzic López-Niño , Héctor A. Vázquez-Vázquez , Elvira Galarraga , José Bargas","doi":"10.1016/j.neulet.2025.138128","DOIUrl":"10.1016/j.neulet.2025.138128","url":null,"abstract":"<div><div>Parkinson’s disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra pars compacta, leading to significant motor and non-motor symptoms. Beta oscillations in cortical areas are a pathognomonic sign. Here we ask whether these oscillations can be recorded in <em>in vitro</em> cortical tissue despite severing the cortico-basal ganglia-thalamo-cortical loop. M1/M2 cortex of hemi parkinsonian mice (6-OHDA) was recorded with multielectrode arrays (MEAs). Spectral decomposition analysis shows a significantly augmented beta band power with respect to controls. The administration of L-DOPA diminished this exacerbated beta rhythm. This result suggests that plastic changes induced by dopamine (DA) depletion remain in isolated cortical tissue even when the complete circuit is no longer present. This finding brings the opportunity to test anti-parkinsonian drugs <em>in vitro</em> by quantifying cortical beta band power.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"849 ","pages":"Article 138128"},"PeriodicalIF":2.5,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Regional specific effect of saturated vs unsaturated fat on leptin receptor signalling in mice brain areas regulating feeding” [Neurosci. Lett. 793 (2023) 136996, 1–5 doi.org/10.1016/j.neulet.2022.136996] 更正："饱和脂肪与不饱和脂肪对小鼠大脑中调节进食的瘦素受体信号的区域特异性影响" [Neurosci. Lett. 793 (2023) 136996, 1-5 doi.org/10.1016/j.neulet.2022.136996]。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-01-18 DOI: 10.1016/j.neulet.2024.138076

Jesús Fernandez-Felipe , Lucía L. López , Victoria Cano , Enrique Sánchez-Hita , A. Belén Sanz , Julie A. Chowen , Nuria Del Olmo , Mariano Ruiz-Gayo , Beatriz Merino

引用次数: 0

The neural ensembles activated by propofol and isoflurane anesthesia across the whole mouse brain 异丙酚和异氟醚麻醉激活整个小鼠大脑的神经系统。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-01-18 DOI: 10.1016/j.neulet.2024.138080

Qian Zhang , Jin Ke , Guangfu Cui , Shen Qian , Weixin Qian , Sun-Wook Moon , Yanyan Sun , Tianwen Huang , Zaisheng Qin

{"title":"The neural ensembles activated by propofol and isoflurane anesthesia across the whole mouse brain","authors":"Qian Zhang , Jin Ke , Guangfu Cui , Shen Qian , Weixin Qian , Sun-Wook Moon , Yanyan Sun , Tianwen Huang , Zaisheng Qin","doi":"10.1016/j.neulet.2024.138080","DOIUrl":"10.1016/j.neulet.2024.138080","url":null,"abstract":"<div><div>General anesthesia has been widely used in surgical procedures. Propofol and isoflurane are the most commonly used injectable and inhaled anesthetics, respectively. The various adverse effects induced by propofol and isoflurane are highly associated with the anesthetic-dependent change of brain activities. In this work, we aim to delineate a brain-wide neuronal activity landscape of injectable versus inhaled anesthetics to understand the neural basis underlying the different physiological effects induced by these two major types of anesthetics. Through detailed scanning of the whole mouse brain subjected to propofol or isoflurane anesthesia, in total, we identified 17 subcortical regions, 3 of which (anterodorsal preoptic nucleus, ADP; lateral habenular, LHb; inferior olivary nucleus, ION) were specifically activated by propofol, and 3 (ventral part of the lateral septum, LSV; the intermediate part of the lateral septum, LSI; the solitary tract nucleus, Sol) were specifically activated by isoflurane, with the remaining 11 were activated by both two anesthetics. Moreover, within the 17 brain regions, ADP, SubCV (subcoeruleus nucleus, ventral part), PCRtA (parvicellular reticular nucleus, alpba part) and ION were newly identified that activated by propofol or isoflurane, respectively. By using Targeted Recombination in Active Populations (TRAP) technique, we further showed that propofol and isoflurane largely activate the same group of neurons in supraoptic nucleus (SON), but activate different groups of neurons in central amygdala (CeA). Our results reveals the neural ensembles activated by injectable and inhaled anesthetics, and provides detailed anatomical references for future studies on general anesthesia.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"846 ","pages":"Article 138080"},"PeriodicalIF":2.5,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of galanin-like peptide on hypothalamic kisspeptin expression in female Zucker fatty rats 甘丙肽样肽对雌性Zucker脂肪大鼠下丘脑kisspeptin表达的影响。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-01-18 DOI: 10.1016/j.neulet.2024.138081

Akiko Sakata , Kinuyo Iwata , Kimihiko Nakao , Yuyu Kunimura , Shunji Suzuki , Hitoshi Ozawa , Hirotaka Ishii

{"title":"Effect of galanin-like peptide on hypothalamic kisspeptin expression in female Zucker fatty rats","authors":"Akiko Sakata , Kinuyo Iwata , Kimihiko Nakao , Yuyu Kunimura , Shunji Suzuki , Hitoshi Ozawa , Hirotaka Ishii","doi":"10.1016/j.neulet.2024.138081","DOIUrl":"10.1016/j.neulet.2024.138081","url":null,"abstract":"<div><div>Kisspeptin and galanin-like peptide (GALP) neurons in the hypothalamic arcuate nucleus (ARC) are involved in gonadotropin-releasing hormone (GnRH) neuron-mediated pulsatile luteinizing hormone (LH) secretion. Zucker fatty (ZF) rats display a leptin receptor gene abnormality and suppressed pulsatile LH secretion. ZF rats reportedly exhibit low hypothalamic GALP and kisspeptin expression, and GALP administration induces LH release in ZF rats. Therefore, we performed a histochemical analysis to determine whether GALP-induced LH release is mediated by kisspeptin neurons in ZF rats. All ZF rats were ovariectomized and subcutaneously implanted with an estradiol tube before the central injection of GALP or vehicle. GALP administration increased the plasma LH concentration. However, no significant difference was observed in the number of <em>Kiss1</em> cells and the proportion of <em>Fos</em>-positive <em>Kiss1</em> cells. The number of c-Fos-positive GnRH neurons significantly increased after GALP administration. Our results suggest that hypothalamic GALP neurons promote LH release by activating GnRH neurons without the activation of kisspeptin neurons in the ARC.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"846 ","pages":"Article 138081"},"PeriodicalIF":2.5,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The diagnostic value and molecular mechanisms of LncRNA ZFAS1 in neuropathic pain LncRNA ZFAS1在神经性疼痛中的诊断价值及分子机制

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-01-18 DOI: 10.1016/j.neulet.2024.138097

Yunchao Chu , Jing Chen , Huaqing Cui , Qiuyi Xie , Shasha Mei

{"title":"The diagnostic value and molecular mechanisms of LncRNA ZFAS1 in neuropathic pain","authors":"Yunchao Chu , Jing Chen , Huaqing Cui , Qiuyi Xie , Shasha Mei","doi":"10.1016/j.neulet.2024.138097","DOIUrl":"10.1016/j.neulet.2024.138097","url":null,"abstract":"<div><h3>Objective</h3><div>Long non-coding RNA (lncRNA) has been playing an increasingly significant role in neuropathic pain (NP). This study aimed to investigate the clinical significance and mechanism of LncRNA ZNFX1 antisense RNA 1 (ZFAS1) in NP.</div></div><div><h3>Methods</h3><div>92 patients with NP and 85 healthy controls were enrolled, and a rat NP model was constructed by chronic constrictive injury (CCI). LPS-induced microglia BV2 cells were used to construct an in vitro cellular model. RT-qPCR analysis of the mRNA levels of ZFAS1, miR-421, and Iba-1 (markers of microglia activation). Paw withdrawal threshold (PWT) and paw withdrawal latency (PWL) were used to assess mechanosensitive and thermal nociceptive allergic responses. ELISA assay for pro-inflammatory factors and anti-inflammatory factors expression. ROC assay for the diagnostic value of ZFAS1. Validation of the targeting between ZFAS1 and miR-421 by dual luciferase reporter assay.</div></div><div><h3>Results</h3><div>ZFAS1 significantly increased while miR-421 significantly decreased in individuals with NP, in a rat model of CCI, and in LPS-induced microglial cells. Functionally, miR-421 directly targeted ZFAS1. ZFAS1 levels could significantly differentiate between NP patients and control (AUC = 0.910). Low expression of ZFAS1 significantly alleviated PWL and PWT in CCI rats. Elevated neuro-proinflammatory factors and decreased anti-inflammatory factors in CCI rats were significantly reversed by low expression of ZFAS1, but this is partially weakened by low expression of miR-421. Moreover, silencing ZFAS1 hindered the upregulation of Iba-1 expression induced by LPS, which was rescued significantly by miR-421.</div></div><div><h3>Conclusion</h3><div>Elevated ZFAS1 is a potential bio-diagnostic marker for NP. Inhibition of ZFAS1 may alleviate NP progression by inhibiting microglia activation and neuro-inflammatory responses.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"846 ","pages":"Article 138097"},"PeriodicalIF":2.5,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Middle-aged females are resistant to LPS-induced learning deficits: Sex comparison 中年女性对lps诱导的学习缺陷有抵抗力：性别比较。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-01-10 DOI: 10.1016/j.neulet.2024.138072

Lauren G. Singleton , Kelsey F. Thompson , Jordyn Carroll , Rachel A. Kohman

{"title":"Middle-aged females are resistant to LPS-induced learning deficits: Sex comparison","authors":"Lauren G. Singleton , Kelsey F. Thompson , Jordyn Carroll , Rachel A. Kohman","doi":"10.1016/j.neulet.2024.138072","DOIUrl":"10.1016/j.neulet.2024.138072","url":null,"abstract":"<div><div>Preclinical data have repeatedly shown learning and memory disruption following administration of the bacterial endotoxin lipopolysaccharide (LPS). Normal aging is reported to enhance vulnerability to LPS-induced cognitive impairments. However, a limitation is the primary use of male subjects. Recent evidence indicates sex-related differences in vulnerability to LPS-induced cognitive deficits <span><span>[1]</span></span>, <span><span>[2]</span></span>, with young females showing resilience. Whether middle-aged females are susceptible to LPS-induced cognitive impairment is unknown. The current experiment compared associative learning in young and middle-aged male and female C57BL/6J mice following a systemic LPS challenge. While LPS impaired acquisition of the two-way active avoidance conditioning task in adult and middle-aged males, females’ learning was unaffected. The sex difference in LPS-induced cognitive impairments appears unrelated to responsivity to LPS, as males and females mount a comparable sickness-like response. Additionally, relative to males, females produce higher brain levels of interleukin-6 (IL-6) and comparable splenic IL-6 levels following LPS. These data demonstrate that female resilience to LPS-induced learning deficits persists into middle age, whereas males are vulnerable as both young and middle-aged adults. Our findings confirm the importance of considering sex as a biological variable and extend the existing literature by evaluating sex-related responsivity to LPS in middle-aged males and females.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"845 ","pages":"Article 138072"},"PeriodicalIF":2.5,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the antinociceptive effect of taraxasterol in mice: Possible mechanisms 探索他腊杉醇对小鼠的抗伤害感受作用：可能的机制。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-01-10 DOI: 10.1016/j.neulet.2024.138075

Cagil Onal Sis , Yagmur Okcay , Kemal Gokhan Ulusoy , Ismail Mert Vural , Oguzhan Yıldız

{"title":"Exploring the antinociceptive effect of taraxasterol in mice: Possible mechanisms","authors":"Cagil Onal Sis , Yagmur Okcay , Kemal Gokhan Ulusoy , Ismail Mert Vural , Oguzhan Yıldız","doi":"10.1016/j.neulet.2024.138075","DOIUrl":"10.1016/j.neulet.2024.138075","url":null,"abstract":"<div><h3>Objectives</h3><div>Taraxasterol is the active ingredient of <em>Taraxacum officinale</em> which has been used in traditional medicine for its several therapeutic effects. This study aims first to evaluate the potential spinal/supraspinal and peripheral/visceral antinociceptive effect of taraxasterol and then to investigate the contribution of GABAergic, opioidergic systems, and K<sub>ATP</sub> channels to its antinociceptive effect.</div></div><div><h3>Methods</h3><div>The antinociceptive activity of taraxasterol (2.5, 5, and 10 mg/kg i.p.) was investigated with hot-plate, tail-immersion, and acetic acid-induced abdominal writhing tests (for supraspinal, spinal, peripheral/visceral pain evaluation, respectively) in BALB/c male mice, and percentage of possible maximum effect (MPE%) values were calculated. Mechanism of action studies were performed by pre-administering bicuculline, naloxone, and glibenclamide.</div></div><div><h3>Results</h3><div>Taraxasterol increased the MPE% values in hot-plate and tail-immersion tests at 2.5, 5, and 10 mg/kg doses (<em>P</em> < 0.001) and decreased the mean number of writhes at 10 mg/kg in the abdominal writhing test (<em>P</em> < 0.05). Naloxone and bicuculline pre-administration reversed the antinociceptive effect of taraxasterol in hot-plate and tail-immersion tests and it had no effect in the abdominal writhing test. Pre-administration of glibenclamide reversed the antinociceptive effect of taraxasterol in all tests.</div></div><div><h3>Conclusion</h3><div>Our study is the first to show the involvement of GABAergic and opioidergic systems in the antinociceptive effect of taraxasterol in supraspinal and spinal pain tests, and K<sub>ATP</sub> channels in tests evaluating supraspinal, spinal, and peripheral pain pathways. Taraxasterol is a potential new herbal medicine that can be used for pain control.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"845 ","pages":"Article 138075"},"PeriodicalIF":2.5,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-panic effect of fluoxetine during late diestrus in female rats is mediated through GABAergic mechanisms in the dorsal periaqueductal gray 氟西汀在雌性大鼠晚期死亡期间的抗恐慌作用是通过输导灰质背侧gaba能机制介导的。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-01-10 DOI: 10.1016/j.neulet.2024.138078

Matheus F. Batistela , Paloma M. Hernandes , Alana T. Frias , Thelma A. Lovick , Helio Zangrossi Jr

{"title":"Anti-panic effect of fluoxetine during late diestrus in female rats is mediated through GABAergic mechanisms in the dorsal periaqueductal gray","authors":"Matheus F. Batistela , Paloma M. Hernandes , Alana T. Frias , Thelma A. Lovick , Helio Zangrossi Jr","doi":"10.1016/j.neulet.2024.138078","DOIUrl":"10.1016/j.neulet.2024.138078","url":null,"abstract":"<div><div>Panic disorder is more frequent in women than in men. In women, vulnerability to panic is enhanced during the late luteal phase of the menstrual cycle. At this time secretion of progesterone and its neuroactive metabolite allopregnanolone (ALLO), which acts as a positive allosteric modulator of the actions of GABA at GABA<sub>A</sub> receptors, decline sharply. In female rats, responsiveness to a hypoxic panicogenic challenge increases during the late diestrus (LD) phase as ALLO concentration in the brain falls. During LD, short-term treatment with fluoxetine at a low dose (1.75 mg/kg i.p.) blocked panic-related escape behavior in response to hypoxia. At this dose fluoxetine increases brain concentration of ALLO without affecting 5-HT levels, thereby stabilizing brain ALLO concentration. We here report that the panicolytic-like effect of fluoxetine during LD is prevented by microinjection of the GABA<sub>A</sub> receptor antagonist bicuculline (5 pmol) into the dorsal periaqueductal gray (dPAG), a key panic-related area. This result suggests that fluoxetine’s effect is indirectly mediated via a GABAergic mechanism in the dPAG and highlights the important role of changes in GABAergic tone in regulating neuronal excitability in the panic circuitry during the estrous cycle. It also points to the potential for using short-term, low dose fluoxetine as an anti-panic medication in women.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"845 ","pages":"Article 138078"},"PeriodicalIF":2.5,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Agmatine diminishes behavioral and endocrine alterations in a rat model of post-traumatic stress disorder 胍丁胺在创伤后应激障碍大鼠模型中减少行为和内分泌改变。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-01-10 DOI: 10.1016/j.neulet.2024.138074

Mayur B. Kale , Sandip R. Rahangdale , Trupti A. Banarase , Mohd. Shahnavaj Siddiqui , Brijesh G. Taksande , Manish M. Aglawe , Aman B. Upaganlawar , Spandana Rajendra Kopalli , Sushruta Koppula , Milind J. Umekar , Nitu L. Wankhede

{"title":"Agmatine diminishes behavioral and endocrine alterations in a rat model of post-traumatic stress disorder","authors":"Mayur B. Kale , Sandip R. Rahangdale , Trupti A. Banarase , Mohd. Shahnavaj Siddiqui , Brijesh G. Taksande , Manish M. Aglawe , Aman B. Upaganlawar , Spandana Rajendra Kopalli , Sushruta Koppula , Milind J. Umekar , Nitu L. Wankhede","doi":"10.1016/j.neulet.2024.138074","DOIUrl":"10.1016/j.neulet.2024.138074","url":null,"abstract":"<div><div>Post-traumatic stress disorder (PTSD), is a severe anxiety disorder characterized by associative fear conditioning. Single prolonged stress (SPS) is a widely accepted reliable animal model to stimulate PTSD. Agmatine is an endogenous neuromodulator of stress; however, its effect on PTSD remains to be investigated. This study explored the role of agmatine in conditioned fear response (CFR) in PTSD and highlighted the role of imidazoline receptors in the effect of agmatine. Intra-cerebroventricular (icv) surgery was done in order to facilitate drug administration. Animals were subjected to SPS. Agmatine and the involvement of imidazoline receptors (I<sub>1</sub> and I<sub>2</sub>) were assessed for their effect in fear conditioning apparatus. During weeks 1, 2, and 3, in CFR, agmatine (40 µg/rat, icv) showed significantly decreased freezing time whereas other doses of agmatine (10 and 20 µg/rat, icv). Imidazoline (I<sub>1</sub> and I<sub>2</sub>) receptor agonists Moxonidine (25 µg/rat, icv) and 2-BFI, (10 µg/rat, icv) respectively, at their sub-effective doses, with a submaximal dose of agmatine (20 µg/rat, icv) significantly decreased the altered freezing time during weeks 1, 2 and 3 compared to SPS animals. Moreover, the effective dose of agmatine (40 µg/rat, icv) with imidazoline (I<sub>1</sub> and I<sub>2</sub>) receptor antagonists Efaroxan (10 µg/rat, icv) and Idazoxan (4 µg/rat, icv) respectively does not reversed the effect of agmatine on freezing. Agmatine and its combination with I<sub>1</sub> and I<sub>2</sub> agonists, normalized the altered freezing behavior, corticosterone level, organ coefficient of adrenal gland, neuroinflammatory and neurotrophic factor due to SPS during CFR projecting its strong therapeutic effect in SPS induced PTSD.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"845 ","pages":"Article 138074"},"PeriodicalIF":2.5,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preventive and therapeutic effects of genistein and daidzein on anxiety-like behaviors in ovariectomized rats 染料木素和大豆黄酮对去卵巢大鼠焦虑样行为的防治作用。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-01-10 DOI: 10.1016/j.neulet.2024.138073

Sarinee Kalandakanond-Thongsong , Suwaporn Daendee , Sushawadee Tongta , Boonrit Thongsong , Anan Srikiatkhachorn

{"title":"Preventive and therapeutic effects of genistein and daidzein on anxiety-like behaviors in ovariectomized rats","authors":"Sarinee Kalandakanond-Thongsong , Suwaporn Daendee , Sushawadee Tongta , Boonrit Thongsong , Anan Srikiatkhachorn","doi":"10.1016/j.neulet.2024.138073","DOIUrl":"10.1016/j.neulet.2024.138073","url":null,"abstract":"<div><div>Estrogen has demonstrated beneficial effects; however, it can also have unfavorable effects. Phytoestrogens are present in many consumable products and commonly used as supplements. These are of interest as they may have beneficial effects on mood with fewer undesirable effects on reproductive tissues. This study investigated the anxiolytic-like effects of the phytoestrogens genistein and daidzein on ovariectomized (Ovx) rats and their effects on the expression of uterine estrogen receptors (ER) and brain monoamines. In experiment 1, Ovx rats received either vehicle, 17β-estradiol, or 0.25 − 1 mg/kg of genistein or daidzein for 4 weeks before behavioral tests of anxiety. In experiment 2, we assessed the therapeutic effects of genistein and daidzein. The ovariectomies were used to induce anxiety, so the treatments were started 3 weeks post-ovariectomy. The Ovx rats received vehicle, 17β-estradiol, or 0.25 mg/kg of genistein or daidzein daily for 4 weeks before behavioral tests. We found daidzein and genistein comparable to 17β-estradiol in their anxiolytic-like effects. Further, while 17β-estradiol decreased body weight gain, increased uterine weight, and increased the uterine ERα/ERβ ratio, neither genistein nor daidzein had these undesirable effects. The alterations in brain monoamines following genistein or daidzein treatments were somewhat different from those seen after 17β-estradiol treatment. In conclusion, daily daidzein or genistein administration for 4 weeks did not negatively affect body weight, food intake, uterine tissue, uterine ER expressions, or ERα/ERβ ratio but demonstrated anxiolytic-like effects on Ovx rats. We conclude that low-dose (0.25 mg/kg) genistein or daidzein can alleviate anxiety in a female anxious rat model.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"845 ","pages":"Article 138073"},"PeriodicalIF":2.5,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142795051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0