Neuroscience Letters最新文献_第10页

Agmatine diminishes behavioral and endocrine alterations in a rat model of post-traumatic stress disorder 胍丁胺在创伤后应激障碍大鼠模型中减少行为和内分泌改变。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-01-10 DOI: 10.1016/j.neulet.2024.138074

Mayur B. Kale , Sandip R. Rahangdale , Trupti A. Banarase , Mohd. Shahnavaj Siddiqui , Brijesh G. Taksande , Manish M. Aglawe , Aman B. Upaganlawar , Spandana Rajendra Kopalli , Sushruta Koppula , Milind J. Umekar , Nitu L. Wankhede

{"title":"Agmatine diminishes behavioral and endocrine alterations in a rat model of post-traumatic stress disorder","authors":"Mayur B. Kale , Sandip R. Rahangdale , Trupti A. Banarase , Mohd. Shahnavaj Siddiqui , Brijesh G. Taksande , Manish M. Aglawe , Aman B. Upaganlawar , Spandana Rajendra Kopalli , Sushruta Koppula , Milind J. Umekar , Nitu L. Wankhede","doi":"10.1016/j.neulet.2024.138074","DOIUrl":"10.1016/j.neulet.2024.138074","url":null,"abstract":"<div><div>Post-traumatic stress disorder (PTSD), is a severe anxiety disorder characterized by associative fear conditioning. Single prolonged stress (SPS) is a widely accepted reliable animal model to stimulate PTSD. Agmatine is an endogenous neuromodulator of stress; however, its effect on PTSD remains to be investigated. This study explored the role of agmatine in conditioned fear response (CFR) in PTSD and highlighted the role of imidazoline receptors in the effect of agmatine. Intra-cerebroventricular (icv) surgery was done in order to facilitate drug administration. Animals were subjected to SPS. Agmatine and the involvement of imidazoline receptors (I<sub>1</sub> and I<sub>2</sub>) were assessed for their effect in fear conditioning apparatus. During weeks 1, 2, and 3, in CFR, agmatine (40 µg/rat, icv) showed significantly decreased freezing time whereas other doses of agmatine (10 and 20 µg/rat, icv). Imidazoline (I<sub>1</sub> and I<sub>2</sub>) receptor agonists Moxonidine (25 µg/rat, icv) and 2-BFI, (10 µg/rat, icv) respectively, at their sub-effective doses, with a submaximal dose of agmatine (20 µg/rat, icv) significantly decreased the altered freezing time during weeks 1, 2 and 3 compared to SPS animals. Moreover, the effective dose of agmatine (40 µg/rat, icv) with imidazoline (I<sub>1</sub> and I<sub>2</sub>) receptor antagonists Efaroxan (10 µg/rat, icv) and Idazoxan (4 µg/rat, icv) respectively does not reversed the effect of agmatine on freezing. Agmatine and its combination with I<sub>1</sub> and I<sub>2</sub> agonists, normalized the altered freezing behavior, corticosterone level, organ coefficient of adrenal gland, neuroinflammatory and neurotrophic factor due to SPS during CFR projecting its strong therapeutic effect in SPS induced PTSD.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"845 ","pages":"Article 138074"},"PeriodicalIF":2.5,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preventive and therapeutic effects of genistein and daidzein on anxiety-like behaviors in ovariectomized rats 染料木素和大豆黄酮对去卵巢大鼠焦虑样行为的防治作用。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-01-10 DOI: 10.1016/j.neulet.2024.138073

Sarinee Kalandakanond-Thongsong , Suwaporn Daendee , Sushawadee Tongta , Boonrit Thongsong , Anan Srikiatkhachorn

{"title":"Preventive and therapeutic effects of genistein and daidzein on anxiety-like behaviors in ovariectomized rats","authors":"Sarinee Kalandakanond-Thongsong , Suwaporn Daendee , Sushawadee Tongta , Boonrit Thongsong , Anan Srikiatkhachorn","doi":"10.1016/j.neulet.2024.138073","DOIUrl":"10.1016/j.neulet.2024.138073","url":null,"abstract":"<div><div>Estrogen has demonstrated beneficial effects; however, it can also have unfavorable effects. Phytoestrogens are present in many consumable products and commonly used as supplements. These are of interest as they may have beneficial effects on mood with fewer undesirable effects on reproductive tissues. This study investigated the anxiolytic-like effects of the phytoestrogens genistein and daidzein on ovariectomized (Ovx) rats and their effects on the expression of uterine estrogen receptors (ER) and brain monoamines. In experiment 1, Ovx rats received either vehicle, 17β-estradiol, or 0.25 − 1 mg/kg of genistein or daidzein for 4 weeks before behavioral tests of anxiety. In experiment 2, we assessed the therapeutic effects of genistein and daidzein. The ovariectomies were used to induce anxiety, so the treatments were started 3 weeks post-ovariectomy. The Ovx rats received vehicle, 17β-estradiol, or 0.25 mg/kg of genistein or daidzein daily for 4 weeks before behavioral tests. We found daidzein and genistein comparable to 17β-estradiol in their anxiolytic-like effects. Further, while 17β-estradiol decreased body weight gain, increased uterine weight, and increased the uterine ERα/ERβ ratio, neither genistein nor daidzein had these undesirable effects. The alterations in brain monoamines following genistein or daidzein treatments were somewhat different from those seen after 17β-estradiol treatment. In conclusion, daily daidzein or genistein administration for 4 weeks did not negatively affect body weight, food intake, uterine tissue, uterine ER expressions, or ERα/ERβ ratio but demonstrated anxiolytic-like effects on Ovx rats. We conclude that low-dose (0.25 mg/kg) genistein or daidzein can alleviate anxiety in a female anxious rat model.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"845 ","pages":"Article 138073"},"PeriodicalIF":2.5,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142795051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-01-10 DOI: 10.1016/j.neulet.2024.138071

Yun-Kyung Hahn , Sara R. Nass , William D. Marks , Jason J. Paris , Kurt F. Hauser , Pamela E. Knapp

{"title":"Sex related differences in cognitive deficits: Disrupted Arc/Arg3.1 signaling in an HIV model","authors":"Yun-Kyung Hahn , Sara R. Nass , William D. Marks , Jason J. Paris , Kurt F. Hauser , Pamela E. Knapp","doi":"10.1016/j.neulet.2024.138071","DOIUrl":"10.1016/j.neulet.2024.138071","url":null,"abstract":"<div><div>Combined and highly active anti-retroviral therapies (cART) have transitioned HIV into a more chronic disease. Roughly half of people living with HIV (PLWH) still experience neurocognitive disorders, albeit less severely than in the pre-cART era. Sex-related effects on memory/cognition remain understudied, although the percentage of PLWH that are female has increased. We utilized a transgenic mouse model of HIV that conditionally expresses HIV-1 Tat<sub>1-86</sub> in the CNS to examine cognitive behaviors and the expression of biomarkers related to learning and memory in both sexes. Tat+ males exhibited deficits in spatial learning/memory and object recognition, while Tat+ females showed enhanced fear memory. We investigated the involvement of activity-regulated cytoskeleton-associated protein (Arc), which is induced by novel experience related to learning/memory. We observed hippocampal Arc induction following foot shock in Tat+ females but not Tat+ males. Hippocampal levels of Arc, amyloid β (Aβ) monomers/oligomers and pCREB were altered in a sex-specific manner. CREB activity, which is highly associated with Arc induction, was reduced only in Tat+ males. Tat exposure also decreased Arc expression in cultured human neurons. Thus, HIV-1 Tat effects on CREB/Arc signaling may differ between sexes, contributing to differences in cognitive deficits observed here and in PLWH.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"845 ","pages":"Article 138071"},"PeriodicalIF":2.5,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroplasticity in the motor cortex following the achievement of sufficient motor learning 充分的运动学习后，运动皮层的神经可塑性。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-01-07 DOI: 10.1016/j.neulet.2025.138117

Akira Mitani, Tomoko Shimizu, Jun Terai, Koji Maeda, Kohei Suzuki, Kazumi Kioka

{"title":"Neuroplasticity in the motor cortex following the achievement of sufficient motor learning","authors":"Akira Mitani, Tomoko Shimizu, Jun Terai, Koji Maeda, Kohei Suzuki, Kazumi Kioka","doi":"10.1016/j.neulet.2025.138117","DOIUrl":"10.1016/j.neulet.2025.138117","url":null,"abstract":"<div><div>Skilled motor training causes the cortical representation of the trained body parts to expand into regions of the motor cortex related to other body parts. However, the effect of neuroplastic changes on the neurons originally existing within the expanded area is not well understood. In this study, the extent of the neuroplastic changes after achieving sufficient motor learning and the impact of the expansion on the neurons related to movements of other body parts were investigated. Rats were trained to perform a single-pellet retrieval reaching task, and intracortical microstimulation in the motor cortex was used to assess neuroplastic changes. After 54 to 73 days of training, the trained rats achieved sufficient motor learning. In the motor cortex, the occurrence rate of evoked wrist movements increased to approximately double that of the control group in the expanded area. This finding suggests that the extent of neuroplastic changes in the occurrence rate of evoked movements in the motor cortex achieved through sufficient motor learning is approximately double. Additionally, stimulation in the expanded area predominantly evoked vibrissae movements in the control group; however, the occurrence rate and threshold of evoked vibrissae movements were not significantly changed in the expanded areas in the trained group. This observation may suggest that the expansion of cortical areas corresponding to the trained body parts does not disrupt the original function of movements of other parts in the expanded area.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"849 ","pages":"Article 138117"},"PeriodicalIF":2.5,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traumatic brain injury, alone or with striatal hemorrhage-like extension, transiently decreases GABA and glutamate levels along motor deficits in the rat striatum: an in vivo study 创伤性脑损伤，单独或纹状体出血样延伸，会短暂降低大鼠纹状体运动缺陷中的GABA和谷氨酸水平：一项体内研究。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-28 DOI: 10.1016/j.neulet.2024.138070

Alberto Avila-Luna , Rodrigo Cruz-Castro , Antonio Verduzco-Mendoza , Adriana Olmos-Hernández , Arturo Gálvez-Rosas , Alfonso Alfaro-Rodríguez , José-Antonio Arias-Montaño , Antonio Bueno-Nava

{"title":"Traumatic brain injury, alone or with striatal hemorrhage-like extension, transiently decreases GABA and glutamate levels along motor deficits in the rat striatum: an in vivo study","authors":"Alberto Avila-Luna , Rodrigo Cruz-Castro , Antonio Verduzco-Mendoza , Adriana Olmos-Hernández , Arturo Gálvez-Rosas , Alfonso Alfaro-Rodríguez , José-Antonio Arias-Montaño , Antonio Bueno-Nava","doi":"10.1016/j.neulet.2024.138070","DOIUrl":"10.1016/j.neulet.2024.138070","url":null,"abstract":"<div><div>The cerebral cortex is connected to the striatum via the axons of the pyramidal glutamatergic neurons, and this pathway is intimately involved in motor function. In the striatum, glutamatergic afferents initiate the activity of GABAergic medium spiny neurons. This study addressed whether traumatic brain injury (TBI) affects GABA and glutamate extracellular levels in the dorsal striatum as an indicator of effects on the cortico-striatal pathway, in rats with motor deficits and recovered animals. Animals were assigned to a sham group, a TBI-alone group, and a TBI + striatal injury group (local injection of a FeCl<sub>2</sub> solution to mimic hemorrhagic lesion). In the TBI-alone and TBI + striatal injury groups, motor deficits were accompanied by decreased extracellular GABA and glutamate levels in the striatum at 3 days post-injury. The TBI + striatal injury group showed higher motor deficits, which lasted 7 days longer, and GABA levels were significantly different compared to the TBI alone group. At 18 days post-injury, in recovered rats from the TBI-alone group GABA and glutamate levels returned to control levels. Alterations in extracellular GABA and glutamate levels indicate damage to the cortico-striatal pathway, underscoring the importance of studying this pathway for treatment and recovery after TBI.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"845 ","pages":"Article 138070"},"PeriodicalIF":2.5,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial and spectral changes in cortical surface potentials during pinching versus thumb and index finger flexion 拇指和食指屈伸时皮层表面电位的空间和频谱变化。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-26 DOI: 10.1016/j.neulet.2024.138062

Panagiotis Kerezoudis , Michael A Jensen , Harvey Huang , Jeffrey G. Ojemann , Bryan T. Klassen , Nuri F. Ince , Dora Hermes , Kai J Miller

{"title":"Spatial and spectral changes in cortical surface potentials during pinching versus thumb and index finger flexion","authors":"Panagiotis Kerezoudis , Michael A Jensen , Harvey Huang , Jeffrey G. Ojemann , Bryan T. Klassen , Nuri F. Ince , Dora Hermes , Kai J Miller","doi":"10.1016/j.neulet.2024.138062","DOIUrl":"10.1016/j.neulet.2024.138062","url":null,"abstract":"<div><div>Electrocorticographic (ECoG) signals provide high-fidelity representations of sensorimotor cortex activation during contralateral hand movements. Understanding the relationship between independent and coordinated finger movements along with their corresponding ECoG signals is crucial for precise brain mapping and neural prosthetic development. We analyzed subdural ECoG signals from three adult epilepsy patients with subdural electrode arrays implanted for seizure foci identification. Patients performed a cue-based task consisting of thumb flexion, index finger flexion or a pinching movement of both fingers together. Broadband power changes were estimated using principal component analysis of the power spectrum. All patients showed significant increases in broadband power during each movement compared to rest. We created topological maps for each movement type on brain renderings and quantified spatial overlap between movement types using a resampling metric. Pinching exhibited the highest spatial overlap with index flexion, followed by superimposed index and thumb flexion, with the least overlap observed for thumb flexion alone. This analysis provides practical insights into the complex overlap of finger representations in the motor cortex during various movement types and may help guide more nuanced approaches to brain-computer interfaces and neural prosthetics.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"845 ","pages":"Article 138062"},"PeriodicalIF":2.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activation of mouse skin mast cells and cutaneous afferent C-fiber subtypes by bee venom 蜂毒对小鼠皮肤肥大细胞和皮肤传入 C 纤维亚型的激活作用

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-25 DOI: 10.1016/j.neulet.2024.138061

Danica Jurcakova , Fei Ru , Renata Pecova , Bradley J Undem

{"title":"Activation of mouse skin mast cells and cutaneous afferent C-fiber subtypes by bee venom","authors":"Danica Jurcakova , Fei Ru , Renata Pecova , Bradley J Undem","doi":"10.1016/j.neulet.2024.138061","DOIUrl":"10.1016/j.neulet.2024.138061","url":null,"abstract":"<div><div>In mammals, many Hymenopteran stings are characterized by pain, redness, and swelling − three manifestations consistent with nociceptive nerve fiber activation. The effect of a Western honeybee <em>(Apis mellifera)</em> venom on the activation of sensory C-fibers in mouse skin was studied using an innervated isolated mouse skin preparation that allows for intra-arterial delivery of chemicals to the nerve terminals in the skin. Our data show that honeybee venom stimulated mouse cutaneous nociceptive-like C-fibers, with an intensity (action potential discharge frequency) similar to that seen with a maximally-effective concentration of capsaicin. The venom had a stronger effect on chloroquine-sensitive C-fibers compared to chloroquine-insensitive C-fibers, an effect that was recapitulated with a wasp <em>(Vespula</em> spp.<em>)</em> venom. Blocking TRPV1 and TRPA1 channels did not influence the honeybee venom-induced C-fiber activation. The effect of the venoms on chloroquine-sensitive and −insensitive subpopulation of C-fiber terminals was mimicked by melittin but not apamin; two of peptide venom components. Chloroquine-sensitive C-fibers are stimulated as a consequence of mast cell activation. Melittin degranulated mast cells in mouse skin by a non-IgE and non-MrgprB2 mechanism, and this may explain the stronger activation of the chloroquine-sensitive C-fibers.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"845 ","pages":"Article 138061"},"PeriodicalIF":2.5,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GabaAergic sedative prospection of sclareol-linalool co-treatment: An antagonistic intervention through in vivo and in silico studies 香紫苏-芳樟醇协同处理的加巴镇静前景：通过体内和硅学研究进行拮抗干预。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-23 DOI: 10.1016/j.neulet.2024.138060

Muhammad Torequl Islam , Md.Sakib Al Hasan , Jannatul Ferdous , Emon Mia , Noshin Tasnim Yana , Irfan Aamer Ansari , Siddique Akber Ansari , Md. Amirul Islam , Henrique Douglas Melo Coutinho

{"title":"GabaAergic sedative prospection of sclareol-linalool co-treatment: An antagonistic intervention through in vivo and in silico studies","authors":"Muhammad Torequl Islam , Md.Sakib Al Hasan , Jannatul Ferdous , Emon Mia , Noshin Tasnim Yana , Irfan Aamer Ansari , Siddique Akber Ansari , Md. Amirul Islam , Henrique Douglas Melo Coutinho","doi":"10.1016/j.neulet.2024.138060","DOIUrl":"10.1016/j.neulet.2024.138060","url":null,"abstract":"<div><div>Sleep disturbance causes many health problems in humans worldwide. This study evaluated the effects and possible mechanisms of sclareol (SCL) and/or linalool (LIN) through <em>in vivo</em> and <em>in silico</em> studies. For this, young chicks SCL (5, 10, and 20 mg/kg) and/or LIN (50 mg/kg) were orally administered thirty minutes before to the thiopental sodium (TS)-induced chicks with or without the standard drug diazepam (DZP: 3 mg/kg). Incidence, onset, and duration of sleep were then noted. The results suggest that SCL dose-dependently increased the onset and decreased the duration of sleep in animals. In contrast, LIN50 significantly (p < 0.05) decreased onset and increased sleep duration. SCL20 combined with LIN50 and/or DZP3 modulated the sleep parameters in animals. In combination, LIN50 showed better effects with DZP3, where the percentage decrease in latency and increase in sleep duration were 54.20 and 168.65 %, respectively. SCL20 when combined with LIN50 + DZP3 also modulated the onset and duration of sleep in animals. Further, <em>in silico</em> studies suggest that SCL and LIN have binding affinities with the 6X3X protein of the GABA<sub>A</sub> receptor (α1 and β2 subunits) of −6.9 and −6.8 kcal/mol, respectively. The standard drug DZP showed a binding affinity of −5.0 kcal/mol. Taken together, SCL may exert an angiogenic-<em>like</em> effect and antagonize LIN and/or DZP-mediated sedative effects in TS-induced chicks, possibly through the GABA<sub>A</sub> receptor α1 and β2 subunits interaction pathway.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"845 ","pages":"Article 138060"},"PeriodicalIF":2.5,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antidepressant effects of SY-2476: A caffeine derivative’s role in A1/A2A gene expression modulation in corticosterone-induced depressed rats SY-2476 的抗抑郁作用：咖啡因衍生物在皮质酮诱导的抑郁大鼠体内 A1/A2A 基因表达调节中的作用

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-23 DOI: 10.1016/j.neulet.2024.138059

Irfan Khan , Saif Ullah , Shakir Ullah , Niaz Ali , Zilli Huma , Sedat Yaşar , Siraj Khan , Rizwan Ul Haq , Amjad Khan , Imran Khan

{"title":"Antidepressant effects of SY-2476: A caffeine derivative’s role in A1/A2A gene expression modulation in corticosterone-induced depressed rats","authors":"Irfan Khan , Saif Ullah , Shakir Ullah , Niaz Ali , Zilli Huma , Sedat Yaşar , Siraj Khan , Rizwan Ul Haq , Amjad Khan , Imran Khan","doi":"10.1016/j.neulet.2024.138059","DOIUrl":"10.1016/j.neulet.2024.138059","url":null,"abstract":"<div><div>Depression is a pervasive mood disorder that continues to challenge researchers and clinicians worldwide. Caffeine and its derivatives have been studied for their neuroprotective and antidepressant effect. Current study aimed to explore the potential antidepressant effect of a caffeine derivative, Sy-2476 [4-(1, 3, 7-trimethyl-2, 6-dioxo-2, 3, 6, 7-tetrahydro-1H-purin-8-yl) benzo nitrile], in corticosterone-induced rat model of depression. Depression-like behaviour in rats was induced by administering 20 mg/kg hydrocortisone s.c for 21 days. Behavioural studies evaluated the potential antidepressant effect of caffeine derivative Sy-2476, its effect on cortisol levels, modulation of A1/A2<sub>A</sub> receptors mRNA expression and antioxidant assays. Treatment of rats with Sy-2476 exhibited robust antidepressant-like effects in corticosterone-exposed rats by increasing sucrose preference (p = 0.0002) while reducing immobility time (p = 0.0118) in the forced swim test. Sy-2476 also reduced lipid peroxidation and increased the level of antioxidant enzymes, including glutathione, catalase, and superoxide dismutase. Moreover, Sy-2476 significantly lowered cortisol levels (p = 0.0019) and up-regulated mRNA expression of A1 (p = 0.0001) and A2<sub>A</sub> receptors (p = 0.0016) compared to the corticosterone-only treated group. In conclusion, Sy-2476 showed an antidepressant effect primarily by suppressing serum cortisol levels, modulating the expression of adenosine receptors, and exhibiting antioxidant properties.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"845 ","pages":"Article 138059"},"PeriodicalIF":2.5,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fentanyl exposure alters rat CB1 receptor expression in the insula, nucleus accumbens and substantia nigra 暴露于芬太尼会改变大鼠脑岛、伏隔核和黑质中 CB1 受体的表达。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-20 DOI: 10.1016/j.neulet.2024.138058

Zuzu Gacso , George Adamson , Joseph Slama , Coco Xie , Emma Burdick , Kirk Persaud , Sharnom Chowdhury , Zaki Sya Ahmed , Emily Vaysman , Arthur Aminov , Robert Ranaldi , Ewa Galaj

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