Neuroscience Letters最新文献_第10页

GabaAergic sedative prospection of sclareol-linalool co-treatment: An antagonistic intervention through in vivo and in silico studies 香紫苏-芳樟醇协同处理的加巴镇静前景：通过体内和硅学研究进行拮抗干预。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-23 DOI: 10.1016/j.neulet.2024.138060

Muhammad Torequl Islam , Md.Sakib Al Hasan , Jannatul Ferdous , Emon Mia , Noshin Tasnim Yana , Irfan Aamer Ansari , Siddique Akber Ansari , Md. Amirul Islam , Henrique Douglas Melo Coutinho

{"title":"GabaAergic sedative prospection of sclareol-linalool co-treatment: An antagonistic intervention through in vivo and in silico studies","authors":"Muhammad Torequl Islam , Md.Sakib Al Hasan , Jannatul Ferdous , Emon Mia , Noshin Tasnim Yana , Irfan Aamer Ansari , Siddique Akber Ansari , Md. Amirul Islam , Henrique Douglas Melo Coutinho","doi":"10.1016/j.neulet.2024.138060","DOIUrl":"10.1016/j.neulet.2024.138060","url":null,"abstract":"<div><div>Sleep disturbance causes many health problems in humans worldwide. This study evaluated the effects and possible mechanisms of sclareol (SCL) and/or linalool (LIN) through <em>in vivo</em> and <em>in silico</em> studies. For this, young chicks SCL (5, 10, and 20 mg/kg) and/or LIN (50 mg/kg) were orally administered thirty minutes before to the thiopental sodium (TS)-induced chicks with or without the standard drug diazepam (DZP: 3 mg/kg). Incidence, onset, and duration of sleep were then noted. The results suggest that SCL dose-dependently increased the onset and decreased the duration of sleep in animals. In contrast, LIN50 significantly (p < 0.05) decreased onset and increased sleep duration. SCL20 combined with LIN50 and/or DZP3 modulated the sleep parameters in animals. In combination, LIN50 showed better effects with DZP3, where the percentage decrease in latency and increase in sleep duration were 54.20 and 168.65 %, respectively. SCL20 when combined with LIN50 + DZP3 also modulated the onset and duration of sleep in animals. Further, <em>in silico</em> studies suggest that SCL and LIN have binding affinities with the 6X3X protein of the GABA<sub>A</sub> receptor (α1 and β2 subunits) of −6.9 and −6.8 kcal/mol, respectively. The standard drug DZP showed a binding affinity of −5.0 kcal/mol. Taken together, SCL may exert an angiogenic-<em>like</em> effect and antagonize LIN and/or DZP-mediated sedative effects in TS-induced chicks, possibly through the GABA<sub>A</sub> receptor α1 and β2 subunits interaction pathway.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"845 ","pages":"Article 138060"},"PeriodicalIF":2.5,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antidepressant effects of SY-2476: A caffeine derivative’s role in A1/A2A gene expression modulation in corticosterone-induced depressed rats SY-2476 的抗抑郁作用：咖啡因衍生物在皮质酮诱导的抑郁大鼠体内 A1/A2A 基因表达调节中的作用

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-23 DOI: 10.1016/j.neulet.2024.138059

Irfan Khan , Saif Ullah , Shakir Ullah , Niaz Ali , Zilli Huma , Sedat Yaşar , Siraj Khan , Rizwan Ul Haq , Amjad Khan , Imran Khan

{"title":"Antidepressant effects of SY-2476: A caffeine derivative’s role in A1/A2A gene expression modulation in corticosterone-induced depressed rats","authors":"Irfan Khan , Saif Ullah , Shakir Ullah , Niaz Ali , Zilli Huma , Sedat Yaşar , Siraj Khan , Rizwan Ul Haq , Amjad Khan , Imran Khan","doi":"10.1016/j.neulet.2024.138059","DOIUrl":"10.1016/j.neulet.2024.138059","url":null,"abstract":"<div><div>Depression is a pervasive mood disorder that continues to challenge researchers and clinicians worldwide. Caffeine and its derivatives have been studied for their neuroprotective and antidepressant effect. Current study aimed to explore the potential antidepressant effect of a caffeine derivative, Sy-2476 [4-(1, 3, 7-trimethyl-2, 6-dioxo-2, 3, 6, 7-tetrahydro-1H-purin-8-yl) benzo nitrile], in corticosterone-induced rat model of depression. Depression-like behaviour in rats was induced by administering 20 mg/kg hydrocortisone s.c for 21 days. Behavioural studies evaluated the potential antidepressant effect of caffeine derivative Sy-2476, its effect on cortisol levels, modulation of A1/A2<sub>A</sub> receptors mRNA expression and antioxidant assays. Treatment of rats with Sy-2476 exhibited robust antidepressant-like effects in corticosterone-exposed rats by increasing sucrose preference (p = 0.0002) while reducing immobility time (p = 0.0118) in the forced swim test. Sy-2476 also reduced lipid peroxidation and increased the level of antioxidant enzymes, including glutathione, catalase, and superoxide dismutase. Moreover, Sy-2476 significantly lowered cortisol levels (p = 0.0019) and up-regulated mRNA expression of A1 (p = 0.0001) and A2<sub>A</sub> receptors (p = 0.0016) compared to the corticosterone-only treated group. In conclusion, Sy-2476 showed an antidepressant effect primarily by suppressing serum cortisol levels, modulating the expression of adenosine receptors, and exhibiting antioxidant properties.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"845 ","pages":"Article 138059"},"PeriodicalIF":2.5,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fentanyl exposure alters rat CB1 receptor expression in the insula, nucleus accumbens and substantia nigra 暴露于芬太尼会改变大鼠脑岛、伏隔核和黑质中 CB1 受体的表达。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-20 DOI: 10.1016/j.neulet.2024.138058

Zuzu Gacso , George Adamson , Joseph Slama , Coco Xie , Emma Burdick , Kirk Persaud , Sharnom Chowdhury , Zaki Sya Ahmed , Emily Vaysman , Arthur Aminov , Robert Ranaldi , Ewa Galaj

{"title":"Fentanyl exposure alters rat CB1 receptor expression in the insula, nucleus accumbens and substantia nigra","authors":"Zuzu Gacso , George Adamson , Joseph Slama , Coco Xie , Emma Burdick , Kirk Persaud , Sharnom Chowdhury , Zaki Sya Ahmed , Emily Vaysman , Arthur Aminov , Robert Ranaldi , Ewa Galaj","doi":"10.1016/j.neulet.2024.138058","DOIUrl":"10.1016/j.neulet.2024.138058","url":null,"abstract":"<div><div>Prolonged periods of opioid use have been shown to cause neuroadaptations in the brain’s reward circuitry, contributing to addictive behaviors and drug dependence. Recently, considerable focus has been placed on the role of the endocannabinoid system (ECS) and its CB receptors in opioid-driven behaviors. However, opioid-induced neuroadaptations to the ECS remain understudied. In this study, we systematically assessed CB1 receptor (CB1R) protein expression within the cortico-mesolimbic-basal ganglia circuit in rats following chronic fentanyl exposure. Male and female Long Evans rats were administered increasing daily doses of fentanyl or saline for 14 days. During naloxone-precipitated withdrawal, fentanyl-treated rats exhibited significantly higher withdrawal symptoms than saline-treated controls. Using Western Blotting, we demonstrated that the fentanyl-treated rats had significantly higher CB1R expression in the insula and significantly lower CB1R expression in the nucleus accumbens and substantia nigra compared to saline-treated rats. No significant differences in CB1R expression were detected between saline and fentanyl-treated rats in the prefrontal cortex, dorsal striatum, medial septum, hypothalamus, amygdala, hippocampus, ventral tegmental area, periaqueductal gray area, pedunculopontine tegmentum, and laterodorsal tegmentum (LDT). These findings suggest that chronic fentanyl exposure leads to region-specific neuroadaptations of CB1R protein expression in motivation- and addiction-associated brain regions.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"844 ","pages":"Article 138058"},"PeriodicalIF":2.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mini-Editorial: Neuroscience Letters - Now Seeking Short Communications! 小社论

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-20 DOI: 10.1016/j.neulet.2024.137999

Pamela E. Knapp PhD (Editor in Chief, Neuroscience Letters)

引用次数: 0

Corrigendum to “Neuroprotective effect of Biochanin a against Bisphenol A-induced prenatal neurotoxicity in zebrafish by modulating oxidative stress and locomotory defects” [Neurosci. Lett. 790 (2022) 136889] 更正："Biochanin a 通过调节氧化应激和运动缺陷对双酚 A 诱导的斑马鱼产前神经毒性的神经保护作用" [Neurosci. Lett. 790 (2022) 136889]。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-20 DOI: 10.1016/j.neulet.2024.138005

B. Haridevamuthu , Ajay Guru , Raghul Murugan , Gokul Sudhakaran , Raman Pachaiappan , Mikhlid H. Almutairi , Bader O. Almutairi , Annie Juliet , Jesu Arockiaraj

引用次数: 0

Retraction notice to “On the early toxic effect of quinolinic acid: Involvement of RAGE” [Neurosci. Lett. 474(2) (2010) 74–78] 关于喹啉酸早期毒性作用的撤稿通知：474(2) (2010) 74-78] 的撤稿通知。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-20 DOI: 10.1016/j.neulet.2024.138001

Elvis Cuevas , Susan Lantz , Glenn Newport , Becky Divine , Qiangen Wu , Merle G. Paule , J. César Tobón-Velasco , Syed F. Ali , Abel Santamaría

引用次数: 0

Retraction notice to “Neuroprotective and memory enhancing effects of auraptene in a rat model of vascular dementia: Experimental study and histopathological evaluation” [Neurosci. Lett. 623 (2016) 13–21] 金合欢烯对血管性痴呆大鼠模型的神经保护和记忆增强作用：实验研究和组织病理学评估》[Neurosci. Lett. 623 (2016) 13-21]。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-20 DOI: 10.1016/j.neulet.2024.138002

Mustafa Ghanbarabadi , Mehrdad Iranshahi , Sakineh Amoueian , Soghra Mehri , Vahideh Sadat Motamedshariaty , Seyed Ahmad Mohajeri

引用次数: 0

Retraction notice to “The endoplasmic reticulum is the main site for caspase-3 activation following aluminum-induced neurotoxicity in rabbit hippocampus” [Neurosci. Lett. 324 (2002) 217–221] 内质网是铝诱导兔海马神经毒性后 Caspase-3 激活的主要部位"[Neurosci. Lett.

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-20 DOI: 10.1016/j.neulet.2024.138000

Othman Ghribi , Mary M. Herman , John Savory

引用次数: 0

Causal brain network analysis of driving fatigue based on generalized orthogonalized partially directed coherence 基于广义正交部分定向相干性的驾驶疲劳因果脑网络分析。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-19 DOI: 10.1016/j.neulet.2024.138057

Daping Chen , Xin Zhou , Wanchao Yao , Fuwang Wang

引用次数: 0

Central administration of galanin-like peptide (GALP) causes short-term orexigenic effects in broilers: Mediatory role of NPY1 and D1 receptors 加拉宁样肽（GALP）的中枢给药会导致肉鸡产生短期促矿物质效应：NPY1 和 D1 受体的中介作用。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-17 DOI: 10.1016/j.neulet.2024.138042

Elham Sanadgol , Morteza Zendehdel , Bita Vazir , Ali Rassouli , Hadi Haghbinnazarpak

{"title":"Central administration of galanin-like peptide (GALP) causes short-term orexigenic effects in broilers: Mediatory role of NPY1 and D1 receptors","authors":"Elham Sanadgol , Morteza Zendehdel , Bita Vazir , Ali Rassouli , Hadi Haghbinnazarpak","doi":"10.1016/j.neulet.2024.138042","DOIUrl":"10.1016/j.neulet.2024.138042","url":null,"abstract":"<div><div>Studies conducted on mammalian models have indicated the role of galanin-like peptide (GALP) in appetite regulation. For the first time, the present study examines the effects of this peptide on feed consumption and behavioral changes, as well as its interaction with dopaminergic and neuropeptide Y (NPY) systems in broilers. In experiment 1, broilers were injected with GALP (0.5, 1, and 2 μg) and saline. In experiment 2, saline, NPY1 receptor antagonist (BIBO-3304), GALP (2 μg), and BIBO-3304 + GALP were administrated. Experiments 3–6 were identical to experiment 2, except that NPY2 receptor antagonist (BIIE 0246), NPY5 receptor antagonist (CGP 71683A), D1 receptor antagonist (SCH39166), and D2 receptor antagonist (L-741,626) were injected instead of BIBO-3304. After that, cumulative meal consumption was recorded for 2 h. Also, behavioral changes in the broilers receiving GALP (0.5, 1, and 2 μg) were monitored for thirty minutes after infusion. Following the administration of GALP (1 and 2 μg), food intake and the number of feeding and exploratory pecks of chicks increased (P < 0.05), while other behaviors did not change significantly (P ≥ 0.05). Co-infusion of BIBO-3304 + GALP suppressed the orexigenic effect of GALP (P < 0.05). Infusion of BIIE 0246, CGP 71683A, and L-741,626 with GALP, had no significant effect on GALP-induced hyperphagia (P ≥ 0.05). However, the orexigenic effects of GALP were stimulated following the co-administration of SCH39166A + GALP (P < 0.05). These findings indicate that NPY1 and D1 receptors can mediate GALP-induced hyperphagia in broilers.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"844 ","pages":"Article 138042"},"PeriodicalIF":2.5,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0