Neuroscience Letters最新文献

{"title":"Deletion of β-arrestin 2 in mice affects kappa opioid receptor-mediated behaviors depending on sex, ovariectomy status, and behavioral endpoints","authors":"Peng Huang,&nbsp;Conrad K. Ho,&nbsp;Kathryn Bland,&nbsp;Lee-Yuan Liu-Chen","doi":"10.1016/j.neulet.2025.138154","DOIUrl":"10.1016/j.neulet.2025.138154","url":null,"abstract":"<div><div>We previously demonstrated that in a mouse line expressing a kappa opioid receptor (KOR) mutant with all the four phosphorylation sites mutated to alanines (K4A) the selective KOR agonist U50,488H (U50)-induced anti-scratching tolerance was attenuated in males and conditioned place aversion (CPA) was reduced in females, without affecting acute U50-induced anti-scratching effect and hypo-locomotion (Huang et al, 2022, Neuropharmacology). KOR phosphorylation deficiency in K4A mice would lead to little recruitment of β-arrestin2 (arrb2) and hence greatly reduced arrb2-mediated KOR regulation, downstream signaling and behaviors. Herein we examined effects of arrb2 deletion in mice on KOR-mediated behaviors in arrb2 knockout (arrb2(-/-)) mice vs wildtype (WT) mice. We found that arrb2 deletion enhanced anti-scratching effects produced by acute U50 in males, but not in females. Intriguingly, in ovariectomized (OVX) but not sham-operated females, arrb2 deletion increased U50-induced anti-scratching effect, similar to males. Furthermore, OVX enhanced U50-induced anti-scratching effects specifically in arrb2(-/-) females, but not in WT females. Thus, ovarian hormones-related modulations may obscure the phenotype associated with arrb2(-/-) to promote the KOR-mediated anti-scratching signaling in females, while OVX unmasked it. In contrast, arrb2 deletion did not affect U50-induced CPA and had no effects on anti-scratching tolerance to repeated U50 in either male or female mice. The findings in arrb2(-/-) mice revealed both similarities and differences compared to our previous results in K4A mice. Overall, the effects of arrb2 deletion on KOR-mediated behaviors depended on specific behavioral endpoints, sex, and OVX status.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"850 ","pages":"Article 138154"},"PeriodicalIF":2.5,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-dependent increase in apoptosis is associated with dysregulation of miR-92a/Akt/mTOR and NF-κB signaling pathways in male rats","authors":"Roya Naderi ,&nbsp;Rahil Salimi ,&nbsp;Abbas Jafari ,&nbsp;Nasrin Mehranfard","doi":"10.1016/j.neulet.2025.138115","DOIUrl":"10.1016/j.neulet.2025.138115","url":null,"abstract":"<div><div>Brain aging is the leading risk factor for most neurodegenerative diseases and has been linked with high rates of neuron loss. Thus, identifying molecular mechanisms underlying neuron loss and pharmacological modulation may be of great importance for slowing or preventing age-related diseases. Herein, we investigated the roles of miR-92a, Akt, mTOR, and NF-κB in age-associated apoptosis in the hippocampus (a critical structure involved in brain aging) of male rats alone and in combination with prazosin. Twenty-four male Wistar rats were grouped into young control (3-month-old), aged (18-month-old), and aged + prazosin groups (n = 8 for each). Prazosin (1 mg/kg; i.p.) was administered for 4 weeks to aged rats. Apoptosis was detected by TUNEL staining. Western blot for Akt, mTOR, and NF-κB was conducted. miR-92a gene expression was performed by using RT-PCR. The results indicated a marked enhancement of apoptosis in the aging hippocampus. We also detected substantial up-regulation of NF-κB as well as substantial down-regulation of phosphorylated-Akt and mTOR in the aging hippocampus. Moreover, miR-92a gene expression was markedly reduced in the aging hippocampus. Treatment with prazosin significantly suppressed apoptosis and reversed miR-92a gene expression, as well as Akt, mTOR, and NF-κB protein expressions in the aging hippocampus. Considering the NF-κB regulatory role on miRNAs, our results suggest that NF-κB may be a negative transcriptional regulator of miR-92a, which in turn could regulate the Akt/mTOR signaling. In this regard, NF-κB upregulation may mediate the downregulation of miR-92a/Akt/mTOR axis, and thereby contribute to age-related neurodegeneration. This may provide a novel treatment target for delaying or preventing age-related problems.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"848 ","pages":"Article 138115"},"PeriodicalIF":2.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular baskets in inner hair cells and perineuronal nets in auditory nerves: Changes in noise-induced hearing loss rats","authors":"So Young Kim ,&nbsp;Jong Chan Jeon ,&nbsp;Bohyeon Park ,&nbsp;Do Eun Kim","doi":"10.1016/j.neulet.2025.138147","DOIUrl":"10.1016/j.neulet.2025.138147","url":null,"abstract":"<div><h3>Background</h3><div>The extracellular baskets of cochlear inner hair cell (IhC) ribbon synapses have been suggested to regulate synaptic coupling. This study aimed to investigate the expression of components of the extracellular baskets of the IhCs, chondroitin sulfate proteoglycans (CSPGs) and a hyaluronan and proteoglycan link protein 1 (HAPLN1) in the cochlea and auditory nerve. In addition, changes in CSPGs and HAPLN1 in noise-injured cochleae were examined.</div></div><div><h3>Methods</h3><div>The expression of CSPGs, including aggrecan (ACAN), brevican (BCAN), neurocan (NCAN), and HAPLN1, was evaluated in the cochleae of 2-month-old Sprague–Dawley (SD) rats. The expression of CSPGs and HAPLN1 in cochleae and auditory nerves was compared to that in 3-month-old noise-exposed SD rats during the developmental period. The cochlear immunohistochemistry (IHC) and cochlear whole mount immunofluorescence studies were conducted for ACAN, BCAN, NCAN, and HAPLN1. To examine the large ganglial cells in auditory nerves, IHC was conducted for parvalbumin (PV), glutamate decarboxylase 67 (GAD67), postsynaptic density protein 95 (PSD95), and glial fibrillary acidic protein (GFAP). In situ hybridization was performed for BCAN.</div></div><div><h3>Results</h3><div>ACAN, BCAN, and HAPLN1 expression was detected in the IhCs and was decreased tendency in noise-injured cochleae. In the spiral ganglial cell (SGC) region, ACAN and NCAN were expressed without the expression of BCAN. In auditory nerves, large ganglionic cells (LGCs) are encased with perineuronal nets (PNNs), which express PV, GAD67, and PSD95. The mRNA expression of BCAN was noted in SGCs and glial cells of auditory nerves.</div></div><div><h3>Conclusions</h3><div>The extracellular baskets of IhCs revealed the expression of CSPGs and HAPLN1, which was attenuated in noise-exposed cochleae. In auditory nerves, PV-positive LGCs with inhibitory synapses presented PNNs. The protein expression of BCAN was restricted to the extracellular baskets of IhC but not to the SGC region. However, the mRNA expression of BCAN in SGCs was not affected.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"850 ","pages":"Article 138147"},"PeriodicalIF":2.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations in iron levels in the locus coeruleus of a transgenic Alzheimer’s disease rat model","authors":"Kayla Aishwarya Bhagaloo ,&nbsp;Lei Yu ,&nbsp;Elizabeth A. West ,&nbsp;Daniel J. Chandler ,&nbsp;Natalia Shcherbik","doi":"10.1016/j.neulet.2025.138151","DOIUrl":"10.1016/j.neulet.2025.138151","url":null,"abstract":"<div><div>Iron is essential for brain function, acting as a cofactor for enzymes involved in neurotransmitter synthesis and metabolism. However, dysregulated iron homeostasis is increasingly linked to neurodegenerative diseases, including Alzheimer’s disease (AD). The locus coeruleus (LC), a norepinephrine-producing brainstem nucleus, is among the earliest regions affected in AD, yet its iron dynamics remain poorly understood. This study presents the first comprehensive analysis of iron content in the LC by combining a transgenic AD rat model, precise anatomical isolation, and Inductively Coupled Plasma Mass Spectrometry for high-sensitivity metal quantification. This approach enabled the profiling of iron and zinc concentrations in the LC, uncovering novel insights into iron dysregulation in AD. We observed a significant genotype-specific increase in LC iron levels in TgF344-AD rats compared to wild-type controls. Notably, our findings reveal distinct iron alterations in TgF344-AD rats, suggesting a previously unrecognized role for iron homeostasis in LC dysfunction. These results provide new perspectives on iron dysregulation in AD pathology and its potential as a therapeutic target.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"850 ","pages":"Article 138151"},"PeriodicalIF":2.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nasal mucosal mesenchymal stem cells promote repair of sciatic nerve injury in rats by modulating the inflammatory microenvironment","authors":"Yushi Tang ,&nbsp;Yilu Li ,&nbsp;Wenhui Yang ,&nbsp;Zhenxing Tao ,&nbsp;Wentao Shi ,&nbsp;Mengyuan Yu ,&nbsp;Bai Xu ,&nbsp;Xiaojie Lu","doi":"10.1016/j.neulet.2024.138112","DOIUrl":"10.1016/j.neulet.2024.138112","url":null,"abstract":"<div><div>Sciatic nerve injury (SNI) represents the most prevalent form of peripheral nerve damage, resulting in the rapid activation of macrophages into the M1 phenotype following injury. This activation induces an inflammatory microenvironment that negatively impacts nerve regeneration. Ectodermal mesenchymal stem cells (EMSCs), isolated from nasal mucosa, possess the capacity for multidirectional differentiation and exhibit immunomodulatory effects. Modulating macrophage polarization to create a favorable environment for nerve repair may represent a potential approach to facilitate nerve recovery. This investigation sought to explore the effects of EMSCs transplantation on macrophage polarization and nerve regeneration in SNI, as well as to identify the underlying mechanisms. An <em>in vivo</em> SNI model was established, and behavioral and histological analyses demonstrated that EMSCs transplantation facilitated nerve function recovery. Furthermore, immunofluorescence and Western blot assays revealed an increase in M2 macrophage presence and the secretion of anti-inflammatory cytokines following EMSCs transplantation, thereby promoting nerve regeneration. <em>In vitro</em>, EMSCs were found to enhance M2 macrophage polarization and the production of anti-inflammatory factors. Additionally, it was confirmed that EMSCs regulate macrophage polarization through the PI3K/AKT/NF-κB signaling pathway, thereby fostering an optimal inflammatory environment for nerve regeneration.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"848 ","pages":"Article 138112"},"PeriodicalIF":2.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Augmentation of neural stem cell proliferation and enhanced differentiation toward neural and oligodendroglia lineages through sonic hedgehog pathway: Cross-activation of Notch1 and SOX10","authors":"Arsalan Azizi ,&nbsp;Nahid Azarmehr ,&nbsp;Maryam Hashemi Shahraki ,&nbsp;Roya Aryanpour ,&nbsp;Elham Enanat ,&nbsp;Parisa Danaee fard ,&nbsp;Mehrzad Jafari Barmak ,&nbsp;Amir Ghanbari","doi":"10.1016/j.neulet.2024.138098","DOIUrl":"10.1016/j.neulet.2024.138098","url":null,"abstract":"<div><div>The study aimed to understand the impact of the sonic-hedge signal pathway (SHH) on mouse neural stem cells. We manipulated the pathway using purmorphamine (Pur) and Gant 61 and observed the effects on cell viability, neurosphere formation, and gene expression. We found that activating the SHH pathway with Pur increased cell viability, neurosphere formation, and the expression of specific genes, promoting the differentiation of neural stem cells into mature cells. Conversely, inhibiting the SHH pathway with Gant61 decreased cell viability and neurosphere formation and suppressed differentiation. This suggests that the SHH pathway plays a crucial role in determining the fate of neural stem cells.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"848 ","pages":"Article 138098"},"PeriodicalIF":2.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolactin levels increased by physical exercise correlate with platelet monoamine oxidase activity: Evidence linking platelet MAO with serotonin release capacity","authors":"Jaanus Harro ,&nbsp;Diva Eensoo ,&nbsp;Silva Suvi ,&nbsp;Saima Timpmann ,&nbsp;Vahur Ööpik","doi":"10.1016/j.neulet.2025.138116","DOIUrl":"10.1016/j.neulet.2025.138116","url":null,"abstract":"<div><h3>Objective</h3><div>Lower platelet monoamine oxidase (MAO) activity has consistently been associated with excessive risk-taking and general psychiatric vulnerability. How this peripheral measure can represent presumably centrally regulated complex behaviours is not clear but platelet MAO activity has been suggested to reflect the capacity of serotonin release in the brain. Secretion of prolactin is in part under serotonergic control and indicates serotonin release capacity.</div></div><div><h3>Methods</h3><div>We have assessed release of prolactin and other exercise-induced hormones in response to strenuous physical exercise in twenty male subjects and examined its association with platelet MAO activity as measured radioenzymatically.</div></div><div><h3>Results</h3><div>Increase in prolactin levels was positively correlated with platelet MAO activity. Levels of cortisol, growth hormone and aldosterone were also raised by exercise, but these increases were not associated with platelet MAO activity. Unexpectedly, aldosterone levels before exercise were also in a positive correlation with platelet MAO activity.</div></div><div><h3>Conclusion</h3><div>The finding that exercise-induced prolactin release is associated with MAO activity in platelets indirectly supports the notion that platelet MAO activity is a marker of central serotonin release capacity.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"848 ","pages":"Article 138116"},"PeriodicalIF":2.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential effects of statins on the anti-dyskinetic activity of sub-anesthetic ketamine","authors":"Mitchell J. Bartlett ,&nbsp;Carolyn J. Stopera ,&nbsp;Stephen L. Cowen ,&nbsp;Scott J. Sherman ,&nbsp;Torsten Falk","doi":"10.1016/j.neulet.2025.138114","DOIUrl":"10.1016/j.neulet.2025.138114","url":null,"abstract":"<div><div>Sub-anesthetic ketamine has been demonstrated to reduce abnormal involuntary movements (AIMs) in preclinical models of L-DOPA-induced dyskinesia (LID) and retrospective Parkinson’s disease (PD) case reports. In this study, we examined the effects on LID of two different statins alone and in combination with ketamine in unilateral 6-hydroxydopamine-lesioned male rats, the standard model for preclinical LID studies. Ketamine attenuated the development of AIMs, while the non-polar lovastatin only showed anti-dyskinetic activity early in the priming period but did not prevent the development of LID, and the polar pravastatin showed no anti-dyskinetic activity. Furthermore, our main result is that pravastatin blocked the long-term neuroplastic anti-dyskinetic effects of ketamine, while lovastatin did not. This study shows two different statins affect LID and the anti-dyskinetic activity of ketamine differentially, pointing to an important drug interaction. The results further inform and support ongoing clinical testing of sub-anesthetic ketamine to treat LID in individuals with PD.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"848 ","pages":"Article 138114"},"PeriodicalIF":2.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142962199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive response to energy variations in Non-Contact tactile sensations interface using Laser-Induced plasma","authors":"Kyu-Beom Kim ,&nbsp;Min-Kyun Lee ,&nbsp;Yong-Bin Jeong ,&nbsp;Jeong-Min Kim ,&nbsp;Mi-Hyun Choi ,&nbsp;Hyung-Sik Kim ,&nbsp;Byung-Chan Min ,&nbsp;Soon-Cheol Chung","doi":"10.1016/j.neulet.2025.138119","DOIUrl":"10.1016/j.neulet.2025.138119","url":null,"abstract":"<div><div>Laser-induced plasma technology provides a novel method for generating tactile sensations without physical contact, offering precise and controlled stimulation. However, the impact of varying energy levels on human cognitive and perceptual responses is not yet fully understood. This study aimed to present tactile sensations using laser-induced plasma in a non-contact manner and investigate the cognitive characteristics linked to changes in the plasma’s energy parameters, specifically Pulse Width (PW) and Set Current (SC). The experiment was conducted with 35 right-handed male and female adults in their 20 s. Tactile stimuli were presented under two conditions: Condition 1 fixed SC and varied PW, while Condition 2 fixed PW and varied SC, with each condition adjusted to produce three energy levels. Subjective evaluations included assessments of tactile intensity and vocabulary using a 5-point scale. Sixteen terms related to tactile sensations were evaluated. A two-way repeated measures analysis of variance was used to compare scores across both factors (Condition and Energy). The results showed that as the energy level increased, the perceived intensity also rose. In the vocabulary evaluation, sensations such as “Tapping” and “Rapping” were predominant, with higher scores at increased energy levels. No significant differences were observed between the two conditions for either tactile intensity or vocabulary evaluations. In conclusion, varying the energy magnitude of laser-induced plasma can produce tactile sensations of different intensities, and the parameters used in this study successfully evoked specific sensations like slow vibration.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"848 ","pages":"Article 138119"},"PeriodicalIF":2.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ivabradine reduces neuropathic pain after spinal cord injury by inhibiting excitatory synaptic transmission in the spinal dorsal horn","authors":"Nobuko Ohashi ,&nbsp;Masayuki Ohashi ,&nbsp;Rintaro Hoshino ,&nbsp;Hiroyuki Deguchi ,&nbsp;Hiroshi Baba","doi":"10.1016/j.neulet.2025.138113","DOIUrl":"10.1016/j.neulet.2025.138113","url":null,"abstract":"<div><div>Spinal cord injuries (SCIs) can lead to severe neuropathic pain and increased risk of myocardial infarction and heart failure; therefore, the use of analgesics against SCI-induced pain should be minimized because of their adverse effects on the cardiovascular system. Ivabradine, a blocker of hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels, is used as a bradycardic agent, but recent studies focused on it as an analgesic agent for peripheral neuropathic pain. However, the analgesic effects of ivabradine on central neuropathic pain, such as SCI-induced pain, have not been examined. The aim of this study was to investigate the spinal analgesic effects of ivabradine on central neuropathic pain induced by SCI. Ivabradine induced analgesia in both spontaneous pain-related behavior and mechanical allodynia in SCI-induced pain (6–7 rats/group; <em>p</em> &lt; 0.01). In immunohistochemical staining analyses, ivabradine suppressed phosphorylation of extracellular signal-regulated kinases activated by SCI-induced pain in the superficial spinal dorsal horn (6 rats/group; <em>p</em> &lt; 0.01). In <em>in vitro</em> whole-cell patch-clamp analysis, ivabradine decreased the frequency of miniature excitatory postsynaptic currents in substantia gelatinosa neurons (11–12 rats/group; <em>p</em> &lt; 0.01). We concluded that ivabradine reduces SCI-induced pain by inhibiting excitatory synaptic transmission in the spinal dorsal horn.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"848 ","pages":"Article 138113"},"PeriodicalIF":2.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142962203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}