Neuroscience Letters最新文献_第10页

Traumatic brain injury, alone or with striatal hemorrhage-like extension, transiently decreases GABA and glutamate levels along motor deficits in the rat striatum: an in vivo study 创伤性脑损伤，单独或纹状体出血样延伸，会短暂降低大鼠纹状体运动缺陷中的GABA和谷氨酸水平：一项体内研究。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-28 DOI: 10.1016/j.neulet.2024.138070

Alberto Avila-Luna , Rodrigo Cruz-Castro , Antonio Verduzco-Mendoza , Adriana Olmos-Hernández , Arturo Gálvez-Rosas , Alfonso Alfaro-Rodríguez , José-Antonio Arias-Montaño , Antonio Bueno-Nava

{"title":"Traumatic brain injury, alone or with striatal hemorrhage-like extension, transiently decreases GABA and glutamate levels along motor deficits in the rat striatum: an in vivo study","authors":"Alberto Avila-Luna , Rodrigo Cruz-Castro , Antonio Verduzco-Mendoza , Adriana Olmos-Hernández , Arturo Gálvez-Rosas , Alfonso Alfaro-Rodríguez , José-Antonio Arias-Montaño , Antonio Bueno-Nava","doi":"10.1016/j.neulet.2024.138070","DOIUrl":"10.1016/j.neulet.2024.138070","url":null,"abstract":"<div><div>The cerebral cortex is connected to the striatum via the axons of the pyramidal glutamatergic neurons, and this pathway is intimately involved in motor function. In the striatum, glutamatergic afferents initiate the activity of GABAergic medium spiny neurons. This study addressed whether traumatic brain injury (TBI) affects GABA and glutamate extracellular levels in the dorsal striatum as an indicator of effects on the cortico-striatal pathway, in rats with motor deficits and recovered animals. Animals were assigned to a sham group, a TBI-alone group, and a TBI + striatal injury group (local injection of a FeCl<sub>2</sub> solution to mimic hemorrhagic lesion). In the TBI-alone and TBI + striatal injury groups, motor deficits were accompanied by decreased extracellular GABA and glutamate levels in the striatum at 3 days post-injury. The TBI + striatal injury group showed higher motor deficits, which lasted 7 days longer, and GABA levels were significantly different compared to the TBI alone group. At 18 days post-injury, in recovered rats from the TBI-alone group GABA and glutamate levels returned to control levels. Alterations in extracellular GABA and glutamate levels indicate damage to the cortico-striatal pathway, underscoring the importance of studying this pathway for treatment and recovery after TBI.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"845 ","pages":"Article 138070"},"PeriodicalIF":2.5,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial and spectral changes in cortical surface potentials during pinching versus thumb and index finger flexion 拇指和食指屈伸时皮层表面电位的空间和频谱变化。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-26 DOI: 10.1016/j.neulet.2024.138062

Panagiotis Kerezoudis , Michael A Jensen , Harvey Huang , Jeffrey G. Ojemann , Bryan T. Klassen , Nuri F. Ince , Dora Hermes , Kai J Miller

{"title":"Spatial and spectral changes in cortical surface potentials during pinching versus thumb and index finger flexion","authors":"Panagiotis Kerezoudis , Michael A Jensen , Harvey Huang , Jeffrey G. Ojemann , Bryan T. Klassen , Nuri F. Ince , Dora Hermes , Kai J Miller","doi":"10.1016/j.neulet.2024.138062","DOIUrl":"10.1016/j.neulet.2024.138062","url":null,"abstract":"<div><div>Electrocorticographic (ECoG) signals provide high-fidelity representations of sensorimotor cortex activation during contralateral hand movements. Understanding the relationship between independent and coordinated finger movements along with their corresponding ECoG signals is crucial for precise brain mapping and neural prosthetic development. We analyzed subdural ECoG signals from three adult epilepsy patients with subdural electrode arrays implanted for seizure foci identification. Patients performed a cue-based task consisting of thumb flexion, index finger flexion or a pinching movement of both fingers together. Broadband power changes were estimated using principal component analysis of the power spectrum. All patients showed significant increases in broadband power during each movement compared to rest. We created topological maps for each movement type on brain renderings and quantified spatial overlap between movement types using a resampling metric. Pinching exhibited the highest spatial overlap with index flexion, followed by superimposed index and thumb flexion, with the least overlap observed for thumb flexion alone. This analysis provides practical insights into the complex overlap of finger representations in the motor cortex during various movement types and may help guide more nuanced approaches to brain-computer interfaces and neural prosthetics.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"845 ","pages":"Article 138062"},"PeriodicalIF":2.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activation of mouse skin mast cells and cutaneous afferent C-fiber subtypes by bee venom 蜂毒对小鼠皮肤肥大细胞和皮肤传入 C 纤维亚型的激活作用

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-25 DOI: 10.1016/j.neulet.2024.138061

Danica Jurcakova , Fei Ru , Renata Pecova , Bradley J Undem

{"title":"Activation of mouse skin mast cells and cutaneous afferent C-fiber subtypes by bee venom","authors":"Danica Jurcakova , Fei Ru , Renata Pecova , Bradley J Undem","doi":"10.1016/j.neulet.2024.138061","DOIUrl":"10.1016/j.neulet.2024.138061","url":null,"abstract":"<div><div>In mammals, many Hymenopteran stings are characterized by pain, redness, and swelling − three manifestations consistent with nociceptive nerve fiber activation. The effect of a Western honeybee <em>(Apis mellifera)</em> venom on the activation of sensory C-fibers in mouse skin was studied using an innervated isolated mouse skin preparation that allows for intra-arterial delivery of chemicals to the nerve terminals in the skin. Our data show that honeybee venom stimulated mouse cutaneous nociceptive-like C-fibers, with an intensity (action potential discharge frequency) similar to that seen with a maximally-effective concentration of capsaicin. The venom had a stronger effect on chloroquine-sensitive C-fibers compared to chloroquine-insensitive C-fibers, an effect that was recapitulated with a wasp <em>(Vespula</em> spp.<em>)</em> venom. Blocking TRPV1 and TRPA1 channels did not influence the honeybee venom-induced C-fiber activation. The effect of the venoms on chloroquine-sensitive and −insensitive subpopulation of C-fiber terminals was mimicked by melittin but not apamin; two of peptide venom components. Chloroquine-sensitive C-fibers are stimulated as a consequence of mast cell activation. Melittin degranulated mast cells in mouse skin by a non-IgE and non-MrgprB2 mechanism, and this may explain the stronger activation of the chloroquine-sensitive C-fibers.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"845 ","pages":"Article 138061"},"PeriodicalIF":2.5,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GabaAergic sedative prospection of sclareol-linalool co-treatment: An antagonistic intervention through in vivo and in silico studies 香紫苏-芳樟醇协同处理的加巴镇静前景：通过体内和硅学研究进行拮抗干预。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-23 DOI: 10.1016/j.neulet.2024.138060

Muhammad Torequl Islam , Md.Sakib Al Hasan , Jannatul Ferdous , Emon Mia , Noshin Tasnim Yana , Irfan Aamer Ansari , Siddique Akber Ansari , Md. Amirul Islam , Henrique Douglas Melo Coutinho

{"title":"GabaAergic sedative prospection of sclareol-linalool co-treatment: An antagonistic intervention through in vivo and in silico studies","authors":"Muhammad Torequl Islam , Md.Sakib Al Hasan , Jannatul Ferdous , Emon Mia , Noshin Tasnim Yana , Irfan Aamer Ansari , Siddique Akber Ansari , Md. Amirul Islam , Henrique Douglas Melo Coutinho","doi":"10.1016/j.neulet.2024.138060","DOIUrl":"10.1016/j.neulet.2024.138060","url":null,"abstract":"<div><div>Sleep disturbance causes many health problems in humans worldwide. This study evaluated the effects and possible mechanisms of sclareol (SCL) and/or linalool (LIN) through <em>in vivo</em> and <em>in silico</em> studies. For this, young chicks SCL (5, 10, and 20 mg/kg) and/or LIN (50 mg/kg) were orally administered thirty minutes before to the thiopental sodium (TS)-induced chicks with or without the standard drug diazepam (DZP: 3 mg/kg). Incidence, onset, and duration of sleep were then noted. The results suggest that SCL dose-dependently increased the onset and decreased the duration of sleep in animals. In contrast, LIN50 significantly (p < 0.05) decreased onset and increased sleep duration. SCL20 combined with LIN50 and/or DZP3 modulated the sleep parameters in animals. In combination, LIN50 showed better effects with DZP3, where the percentage decrease in latency and increase in sleep duration were 54.20 and 168.65 %, respectively. SCL20 when combined with LIN50 + DZP3 also modulated the onset and duration of sleep in animals. Further, <em>in silico</em> studies suggest that SCL and LIN have binding affinities with the 6X3X protein of the GABA<sub>A</sub> receptor (α1 and β2 subunits) of −6.9 and −6.8 kcal/mol, respectively. The standard drug DZP showed a binding affinity of −5.0 kcal/mol. Taken together, SCL may exert an angiogenic-<em>like</em> effect and antagonize LIN and/or DZP-mediated sedative effects in TS-induced chicks, possibly through the GABA<sub>A</sub> receptor α1 and β2 subunits interaction pathway.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"845 ","pages":"Article 138060"},"PeriodicalIF":2.5,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antidepressant effects of SY-2476: A caffeine derivative’s role in A1/A2A gene expression modulation in corticosterone-induced depressed rats SY-2476 的抗抑郁作用：咖啡因衍生物在皮质酮诱导的抑郁大鼠体内 A1/A2A 基因表达调节中的作用

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-23 DOI: 10.1016/j.neulet.2024.138059

Irfan Khan , Saif Ullah , Shakir Ullah , Niaz Ali , Zilli Huma , Sedat Yaşar , Siraj Khan , Rizwan Ul Haq , Amjad Khan , Imran Khan

{"title":"Antidepressant effects of SY-2476: A caffeine derivative’s role in A1/A2A gene expression modulation in corticosterone-induced depressed rats","authors":"Irfan Khan , Saif Ullah , Shakir Ullah , Niaz Ali , Zilli Huma , Sedat Yaşar , Siraj Khan , Rizwan Ul Haq , Amjad Khan , Imran Khan","doi":"10.1016/j.neulet.2024.138059","DOIUrl":"10.1016/j.neulet.2024.138059","url":null,"abstract":"<div><div>Depression is a pervasive mood disorder that continues to challenge researchers and clinicians worldwide. Caffeine and its derivatives have been studied for their neuroprotective and antidepressant effect. Current study aimed to explore the potential antidepressant effect of a caffeine derivative, Sy-2476 [4-(1, 3, 7-trimethyl-2, 6-dioxo-2, 3, 6, 7-tetrahydro-1H-purin-8-yl) benzo nitrile], in corticosterone-induced rat model of depression. Depression-like behaviour in rats was induced by administering 20 mg/kg hydrocortisone s.c for 21 days. Behavioural studies evaluated the potential antidepressant effect of caffeine derivative Sy-2476, its effect on cortisol levels, modulation of A1/A2<sub>A</sub> receptors mRNA expression and antioxidant assays. Treatment of rats with Sy-2476 exhibited robust antidepressant-like effects in corticosterone-exposed rats by increasing sucrose preference (p = 0.0002) while reducing immobility time (p = 0.0118) in the forced swim test. Sy-2476 also reduced lipid peroxidation and increased the level of antioxidant enzymes, including glutathione, catalase, and superoxide dismutase. Moreover, Sy-2476 significantly lowered cortisol levels (p = 0.0019) and up-regulated mRNA expression of A1 (p = 0.0001) and A2<sub>A</sub> receptors (p = 0.0016) compared to the corticosterone-only treated group. In conclusion, Sy-2476 showed an antidepressant effect primarily by suppressing serum cortisol levels, modulating the expression of adenosine receptors, and exhibiting antioxidant properties.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"845 ","pages":"Article 138059"},"PeriodicalIF":2.5,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fentanyl exposure alters rat CB1 receptor expression in the insula, nucleus accumbens and substantia nigra 暴露于芬太尼会改变大鼠脑岛、伏隔核和黑质中 CB1 受体的表达。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-20 DOI: 10.1016/j.neulet.2024.138058

Zuzu Gacso , George Adamson , Joseph Slama , Coco Xie , Emma Burdick , Kirk Persaud , Sharnom Chowdhury , Zaki Sya Ahmed , Emily Vaysman , Arthur Aminov , Robert Ranaldi , Ewa Galaj

{"title":"Fentanyl exposure alters rat CB1 receptor expression in the insula, nucleus accumbens and substantia nigra","authors":"Zuzu Gacso , George Adamson , Joseph Slama , Coco Xie , Emma Burdick , Kirk Persaud , Sharnom Chowdhury , Zaki Sya Ahmed , Emily Vaysman , Arthur Aminov , Robert Ranaldi , Ewa Galaj","doi":"10.1016/j.neulet.2024.138058","DOIUrl":"10.1016/j.neulet.2024.138058","url":null,"abstract":"<div><div>Prolonged periods of opioid use have been shown to cause neuroadaptations in the brain’s reward circuitry, contributing to addictive behaviors and drug dependence. Recently, considerable focus has been placed on the role of the endocannabinoid system (ECS) and its CB receptors in opioid-driven behaviors. However, opioid-induced neuroadaptations to the ECS remain understudied. In this study, we systematically assessed CB1 receptor (CB1R) protein expression within the cortico-mesolimbic-basal ganglia circuit in rats following chronic fentanyl exposure. Male and female Long Evans rats were administered increasing daily doses of fentanyl or saline for 14 days. During naloxone-precipitated withdrawal, fentanyl-treated rats exhibited significantly higher withdrawal symptoms than saline-treated controls. Using Western Blotting, we demonstrated that the fentanyl-treated rats had significantly higher CB1R expression in the insula and significantly lower CB1R expression in the nucleus accumbens and substantia nigra compared to saline-treated rats. No significant differences in CB1R expression were detected between saline and fentanyl-treated rats in the prefrontal cortex, dorsal striatum, medial septum, hypothalamus, amygdala, hippocampus, ventral tegmental area, periaqueductal gray area, pedunculopontine tegmentum, and laterodorsal tegmentum (LDT). These findings suggest that chronic fentanyl exposure leads to region-specific neuroadaptations of CB1R protein expression in motivation- and addiction-associated brain regions.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"844 ","pages":"Article 138058"},"PeriodicalIF":2.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mini-Editorial: Neuroscience Letters - Now Seeking Short Communications! 小社论

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-20 DOI: 10.1016/j.neulet.2024.137999

Pamela E. Knapp PhD (Editor in Chief, Neuroscience Letters)

引用次数: 0

Corrigendum to “Neuroprotective effect of Biochanin a against Bisphenol A-induced prenatal neurotoxicity in zebrafish by modulating oxidative stress and locomotory defects” [Neurosci. Lett. 790 (2022) 136889] 更正："Biochanin a 通过调节氧化应激和运动缺陷对双酚 A 诱导的斑马鱼产前神经毒性的神经保护作用" [Neurosci. Lett. 790 (2022) 136889]。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-20 DOI: 10.1016/j.neulet.2024.138005

B. Haridevamuthu , Ajay Guru , Raghul Murugan , Gokul Sudhakaran , Raman Pachaiappan , Mikhlid H. Almutairi , Bader O. Almutairi , Annie Juliet , Jesu Arockiaraj

引用次数: 0

Retraction notice to “On the early toxic effect of quinolinic acid: Involvement of RAGE” [Neurosci. Lett. 474(2) (2010) 74–78] 关于喹啉酸早期毒性作用的撤稿通知：474(2) (2010) 74-78] 的撤稿通知。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-20 DOI: 10.1016/j.neulet.2024.138001

Elvis Cuevas , Susan Lantz , Glenn Newport , Becky Divine , Qiangen Wu , Merle G. Paule , J. César Tobón-Velasco , Syed F. Ali , Abel Santamaría

引用次数: 0

Retraction notice to “Neuroprotective and memory enhancing effects of auraptene in a rat model of vascular dementia: Experimental study and histopathological evaluation” [Neurosci. Lett. 623 (2016) 13–21] 金合欢烯对血管性痴呆大鼠模型的神经保护和记忆增强作用：实验研究和组织病理学评估》[Neurosci. Lett. 623 (2016) 13-21]。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-20 DOI: 10.1016/j.neulet.2024.138002

Mustafa Ghanbarabadi , Mehrdad Iranshahi , Sakineh Amoueian , Soghra Mehri , Vahideh Sadat Motamedshariaty , Seyed Ahmad Mohajeri

引用次数: 0