Neuroscience Letters最新文献_第9页

Effects of visual and auditory cognitive tasks on postural balance in adolescents with intellectual disability: A comparative analysis of trained versus non-trained individuals 视觉和听觉认知任务对智障青少年姿势平衡的影响：受过训练与未受过训练者的比较分析。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-09-03 DOI: 10.1016/j.neulet.2024.137968

Ghada Jouira , Dan Iulian Alexe , Ghazi Rekik , Cristina Ioana Alexe , Denis Čaušević , Edi Setiawan , Sonia Sahli

{"title":"Effects of visual and auditory cognitive tasks on postural balance in adolescents with intellectual disability: A comparative analysis of trained versus non-trained individuals","authors":"Ghada Jouira , Dan Iulian Alexe , Ghazi Rekik , Cristina Ioana Alexe , Denis Čaušević , Edi Setiawan , Sonia Sahli","doi":"10.1016/j.neulet.2024.137968","DOIUrl":"10.1016/j.neulet.2024.137968","url":null,"abstract":"<div><p>This study aimed to investigate the influence of visual and auditory cognitive tasks on postural balance in adolescents with intellectual disabilities (ID). Participants included two groups: a trained group (n = 11) with experience in athletic activities and a sedentary group (n = 14). The experiment used a comparative cross-sectional design, with data collection involving single-task (ST) and Visual dual-task (VDT), and auditory dual-task (ADT) conditions in both firm and foam surface conditions. Cognitive tests included the Working Memory Test (WMT) and the Selective Attention Test (SAT). Results revealed that the trained group demonstrated significantly superior balance performance (p < 0.05). During the SAT, VDT conditions had lower center of pressure (CoP) values than ADT conditions in the sedentary group (p < 0.01), this result was observed in the training group only in the WMT, suggesting greater postural instability during ADT. These findings highlight the complex relationship between cognitive function and motor control in adolescents with ID, highlighting the potential benefits of regular physical activity interventions to improve postural balance abilities in this population.</p></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"842 ","pages":"Article 137968"},"PeriodicalIF":2.5,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The cerebrospinal fluid (CSF)-contacting raphe nucleus (CsfR) in mice 小鼠与脑脊液（CSF）接触的剑突核（CsfR）。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-09-03 DOI: 10.1016/j.neulet.2024.137969

Si-Yuan Song

{"title":"The cerebrospinal fluid (CSF)-contacting raphe nucleus (CsfR) in mice","authors":"Si-Yuan Song","doi":"10.1016/j.neulet.2024.137969","DOIUrl":"10.1016/j.neulet.2024.137969","url":null,"abstract":"<div><p>A unique nucleus, the cerebrospinal fluid-contacting nucleus (CsfR), has been identified in the brain parenchyma. This nucleus features neurons with somas located within the parenchyma and processes extending into the cerebrospinal fluid (CSF). This anatomical configuration suggests that the CsfR may serve as a crucial interface between the nervous and body fluid regulatory systems, potentially playing a significant role in overall physiological modulation. Despite its importance, the precise biological significance of the CsfR remains to be fully elucidated. Previous research has characterized the CsfR, providing detailed information on its position, neighboring structures, neuron distribution, and 3D reconstruction in both rats and non-human primates, with stereotaxic coordinates specifically provided for the rat model. Given the relevance of mice as a model organism, especially the C57BL/6J strain, this study aims to explore the existence and morphology of the CsfR in mice. Our findings confirm the presence of the CsfR, consistently located in the ventral gray area of the lower part of the aqueduct and the upper part of the fourth ventricle floor. It is bilaterally symmetrical and heart-shaped in the coronal plane, which differs slightly from the Y-shape observed in coronal sections of rats. This study provides significant references for researchers investigating this specialized nucleus.</p></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"841 ","pages":"Article 137969"},"PeriodicalIF":2.5,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Auxiliary diagnostic method of Parkinson’s disease based on eye movement analysis in a virtual reality environment 基于虚拟现实环境中眼球运动分析的帕金森病辅助诊断方法。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-09-02 DOI: 10.1016/j.neulet.2024.137956

Maosong Jiang , Yanzhi Liu , Yanlu Cao , Yuzhu Liu , Jiatian Wang , Peixue Li , Shufeng Xia , Yongzhong Lin , Wenlong Liu

{"title":"Auxiliary diagnostic method of Parkinson’s disease based on eye movement analysis in a virtual reality environment","authors":"Maosong Jiang , Yanzhi Liu , Yanlu Cao , Yuzhu Liu , Jiatian Wang , Peixue Li , Shufeng Xia , Yongzhong Lin , Wenlong Liu","doi":"10.1016/j.neulet.2024.137956","DOIUrl":"10.1016/j.neulet.2024.137956","url":null,"abstract":"<div><p>Eye movement dysfunction is one of the non-motor symptoms of Parkinson’s disease (PD). An accurate analysis method for eye movement is an effective way to gain a deeper understanding of the nervous system function of PD patients. However, currently, there are only a few assistive methods available to help physicians conveniently and consistently assess patients suspected of having PD. To solve this problem, we proposed a novel visual behavioral analysis method using eye tracking to evaluate eye movement dysfunction in PD patients automatically. This method first provided a physician task simulation to induce PD-related eye movements in Virtual Reality (VR). Subsequently, we extracted eye movement features from recorded eye videos and applied a machine learning algorithm to establish a PD diagnostic model. Then, we collected eye movement data from 66 participants (including 22 healthy controls and 44 PD patients) in a VR environment for training and testing during visual tasks. Finally, on this relatively small dataset, the results reveal that the Support Vector Machine (SVM) algorithm has better classification potential.</p></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"842 ","pages":"Article 137956"},"PeriodicalIF":2.5,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risperidone suppresses caffeine-induced hyperthermia and hyperactivity in rats 利培酮可抑制咖啡因诱发的大鼠高热和多动现象

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-09-01 DOI: 10.1016/j.neulet.2024.137960

Manabu Takano , Tsuyoshi Okada , Katsutoshi Shioda , Chikara Yonekawa , Shiro Suda

{"title":"Risperidone suppresses caffeine-induced hyperthermia and hyperactivity in rats","authors":"Manabu Takano , Tsuyoshi Okada , Katsutoshi Shioda , Chikara Yonekawa , Shiro Suda","doi":"10.1016/j.neulet.2024.137960","DOIUrl":"10.1016/j.neulet.2024.137960","url":null,"abstract":"<div><p>Caffeine, a methylxanthine alkaloid, works as a nonselective adenosine receptor antagonist. It is the most widely used psychostimulant drug worldwide. However, caffeine overdose can lead to acute intoxication, posing a clinical problem. Hyperthermia and hyperactivity are associated issues with acute caffeine intoxication; however, no definitive treatment exists. This study aimed to assess the ability of risperidone to attenuate caffeine-induced hyperthermia and hyperactivity while elucidating the unknown mechanisms of caffeine intoxication. The rats received intraperitoneal injections of saline, risperidone (0.25 mg/kg, 0.5 mg/kg), WAY-100635, ketanserin, haloperidol, sulpiride, or SCH 23390, 5 min after the administration of caffeine (25 mg/kg). Subcutaneous temperature and activity counts were measured using nano tag ® for up to 90 min. In vivo microdialysis was used to determine the effect of risperidone on caffeine-induced elevation of dopamine (DA), serotonin (5-HT), and noradrenaline (NA) concentrations in the anterior hypothalamus. Rats were injected with caffeine (25 mg/kg), followed by saline or risperidone (0.5 mg/kg) 5 min later. The levels of DA, 5-HT, and noradrenaline were measured every 15 min for up to 90 min after caffeine administration. Risperidone and 5-HT2A receptor antagonist ketanserin attenuated caffeine-induced hyperthermia and hyperactivity. Haloperidol and dopamine D1 antagonist SCH-23390 exacerbated hyperthermia without any effect on the hyperactivity. In the microdialysis study, risperidone treatment further attenuated caffeine-induced 5-HT elevation, but not DA and NA. Our results indicate that risperidone attenuates caffeine-induced hyperthermia and hyperactivity by blocking 5-HT2A receptor activity and may be potentially useful for treating caffeine intoxication.</p></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"840 ","pages":"Article 137960"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tyrosine hydroxylase expression and neuronal loss in the male and female adolescent ventral tegmental area 酪氨酸羟化酶在男性和女性青少年腹侧被盖区的表达和神经元丢失。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-09-01 DOI: 10.1016/j.neulet.2024.137961

Victoria R. Riesgo , Theador Zumaski , Jari Willing

{"title":"Tyrosine hydroxylase expression and neuronal loss in the male and female adolescent ventral tegmental area","authors":"Victoria R. Riesgo , Theador Zumaski , Jari Willing","doi":"10.1016/j.neulet.2024.137961","DOIUrl":"10.1016/j.neulet.2024.137961","url":null,"abstract":"<div><p>Adolescence is a critical period of development characterized by numerous behavioral and neuroanatomical changes. While studies of adolescent neurodevelopment typically compare adolescent age groups with young adults, there are fewer studies that assess developmental trajectories within the adolescent period. In the adolescent prefrontal cortex, some maturational changes take place linearly/chronologically, while others are associated specifically with pubertal onset. The adolescent ventral tegmental area (VTA), a primary source of forebrain dopamine, is relatively understudied during this period. In the present study, dopamine neuron number, total neuron number and tyrosine hydroxylase expression are assessed in the male and female rat VTA at three timepoints: postnatal day(P) 30 (pre-pubertal), P40 (post-pubertal for females, pre-pubertal for males) and P60 (post-pubertal). There was a non-significant trend for a reduction in total VTA neuron number between P30 and P60, but there was a significant reduction in dopamine neuron number across age. The expression of tyrosine hydroxylase did not change with age. However, in a second cohort of subjects, brain tissue was collected pre-pubertal, from recently post-pubertal males and females, and young adults. In this cohort, there was a sex-specific and transient decrease in tyrosine hydroxylase expression in recently post-pubertal males. These results suggest a selective pruning of VTA dopamine cells between early adolescence and young adulthood, while pubertal onset may coincide with a rapid maturation of these neurons. These findings may have implications for psychiatric disorders associated with dopamine dysfunction that tend to manifest during adolescence.</p></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"841 ","pages":"Article 137961"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0304394024003392/pdfft?md5=8881747b670c781101bf51e58aea2830&pid=1-s2.0-S0304394024003392-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vivo spectrally unmixed multi-photon imaging of longitudinal axon-glia changes in injured spinal white matter 损伤脊髓白质纵向轴突-胶质细胞变化的活体光谱非混合多光子成像。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-08-31 DOI: 10.1016/j.neulet.2024.137959

Payam Dibaj , Sam Safavi-Abbasi , Ebrahim Asadollahi

{"title":"In vivo spectrally unmixed multi-photon imaging of longitudinal axon-glia changes in injured spinal white matter","authors":"Payam Dibaj , Sam Safavi-Abbasi , Ebrahim Asadollahi","doi":"10.1016/j.neulet.2024.137959","DOIUrl":"10.1016/j.neulet.2024.137959","url":null,"abstract":"<div><p>Understanding the sequence of cellular responses and their contributions to pathomorphogical changes in spinal white matter injuries is a prerequisite for developing efficient therapeutic strategies for spinal cord injury (SCI) as well as neurodegenerative and inflammatory diseases of the spinal cord such as amyotrophic lateral sclerosis and multiple sclerosis. We have developed several types of surgical procedures suitable for acute one-time and chronic recurrent <em>in vivo</em> multiphoton microscopy of spinal white matter [1]. Sophisticated surgical procedures were combined with transgenic mouse technology to image spinal tissue labeled with up to four fluorescent proteins (FPs) in axons, astrocytes, microglia, and blood vessels. To clearly separate the simultaneously excited FPs, spectral unmixing including iterative procedures was performed after imaging the diversely labeled spinal white matter with a custom-made 4-channel two-photon laser-scanning microscope. In our longitudinal multicellular studies of injured spinal white matter, we imaged axonal dynamics and invasion of microglia and astrocytes for a time course of over 200 days after SCI. Our methods offer ideal platforms for investigating acute and chronic cellular dynamics, cell–cell interactions, and metabolite fluctuations in health and disease as well as pharmacological manipulations <em>in vivo.</em></p></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"841 ","pages":"Article 137959"},"PeriodicalIF":2.5,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0304394024003379/pdfft?md5=d38c17852951453b52f308487df3b019&pid=1-s2.0-S0304394024003379-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The epigenetic changes are affected by sex and valproic acid treatment in a rat model of post-traumatic stress disorder 在创伤后应激障碍大鼠模型中，表观遗传学变化受性别和丙戊酸治疗的影响。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-08-31 DOI: 10.1016/j.neulet.2024.137957

Gökçe Akpınar , Sema Ketenci , Gökçe E. Sarıdoğan , Banu Aydın , Nurdan Tekin , Hülya Cabadak , M. Zafer Gören

{"title":"The epigenetic changes are affected by sex and valproic acid treatment in a rat model of post-traumatic stress disorder","authors":"Gökçe Akpınar , Sema Ketenci , Gökçe E. Sarıdoğan , Banu Aydın , Nurdan Tekin , Hülya Cabadak , M. Zafer Gören","doi":"10.1016/j.neulet.2024.137957","DOIUrl":"10.1016/j.neulet.2024.137957","url":null,"abstract":"<div><p>Post-traumatic stress disorder (PTSD) presents distinct sex-specific differences in both symptom expression and treatment outcomes, with the underlying biological mechanisms still remain unclear. Epigenetic modifications, particularly histone acetylation, have been increasingly recognized as critical factors in the pathophysiology of PTSD. Valproic acid (VPA), a potent histone deacetylase (HDAC) inhibitor, has shown promise in modulating epigenetic responses and improving therapeutic outcomes is PTSD, though its effect may differ between sexes.</p><p>This study aimed to explore the sex-specific epigenetic changes in response to trauma and the impact of VPA treatment in a rat model of PTSD induced by predator scent stress. Sprague-Dawley rats of both sexes were randomly assigned to stressed and non-stressed groups and treated with either VPA (100 mg/kg) or vehicle. Anxiety levels were assessed using the elevated plus maze, followed by analysis of histone H3 and H4 acetylation, HDAC activity, and c-fos expression in the hippocampus.</p><p>Our findings revealed that traumatic stress led to increased freezing time and anxiety levels, with more pronounced effects observed in females. Additionally, we have identified sex-specific differences in hippocampal epigenetic modifications; stressed females exhibited higher H3 acetylation, and VPA-treated stressed males showed increased H4 acetylation.</p><p>These results highlight the importance of considering sex differences in the epigenetic mechanism underlying PTSD and suggest that personalized therapeutic approaches may be necessary to address these complexities.</p></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"839 ","pages":"Article 137957"},"PeriodicalIF":2.5,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improvement of olfactory function in AD mice mediated by immune responses under 40 Hz light flickering 在 40 Hz 灯光闪烁下，通过免疫反应改善注意力缺失症小鼠的嗅觉功能。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-08-30 DOI: 10.1016/j.neulet.2024.137958

Jiaying Hu , Xukai Liu , Jintao Wang , Qi Yang , Weiyun Li , Jing Yang , Wei Zhang , Linghui Zeng , Shanshan Li

{"title":"Improvement of olfactory function in AD mice mediated by immune responses under 40 Hz light flickering","authors":"Jiaying Hu , Xukai Liu , Jintao Wang , Qi Yang , Weiyun Li , Jing Yang , Wei Zhang , Linghui Zeng , Shanshan Li","doi":"10.1016/j.neulet.2024.137958","DOIUrl":"10.1016/j.neulet.2024.137958","url":null,"abstract":"<div><h3>Background</h3><p>40 Hz light flickering has shown promise as a non-invasive therapeutic approach for alleviating both pathological features and cognitive impairments in Alzheimer’s disease (AD) model mice and AD patients. Additionally, vision may influence olfactory function through cross-modal sensory interactions.</p></div><div><h3>Objective</h3><p>To investigate the impact of 40 Hz light flickering on olfactory behavior in AD model mice and to explore the underlying mechanisms of this intervention.</p></div><div><h3>Methods</h3><p>We used immunofluorescence techniques to observe the activation of the olfactory bulb (OB) in C57BL/6J mice under 40 Hz light flickering. A buried food test was conducted to evaluate olfactory behavior in AD mice. Additionally, RNA sequencing technology was employed to detect transcriptional alterations in the OBs of AD mice following light stimulation.</p></div><div><h3>Results</h3><p>40 Hz light flickering was found to effectively activate the OB. This stimulation led to enhanced olfactory behavior and did not alter P-tau protein mRNA levels within the OBs of AD mice. RNA sequencing revealed significant transcriptional changes in the OBs under flickering, particularly related to immune responses.</p></div><div><h3>Conclusion</h3><p>Vision can influence olfactory function through cross-modal sensory interactions in rodent models. 40 Hz light stimulation improved olfactory performance in AD mice. However, the improvement in olfaction in AD mice is not related to changes in P-tau mRNA levels. Instead, it may be associated with an altered immune response, providing a scientific basis for the clinical treatment of olfactory disorders in Alzheimer’s disease.</p></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"842 ","pages":"Article 137958"},"PeriodicalIF":2.5,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Impact of anxiety profiles in trait anxiety on visual discrimination performance in Wistar rats” [Neurosci. Lett. 838 (2024) 137920] 特质焦虑中的焦虑特征对 Wistar 大鼠视觉辨别能力的影响》[Neurosci. Lett. 838 (2024) 137920]的更正。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-08-29 DOI: 10.1016/j.neulet.2024.137947

Yifan Guo , Xianglei Li , Kai Gao , Xiuping Sun

引用次数: 0

Macrophage Scavenger Receptor 1 attenuates ischemic white matter injury via HRH1-mediated microglial phagocytosis 巨噬细胞清道夫受体 1 通过 HRH1 介导的小胶质细胞吞噬作用减轻缺血性白质损伤

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-08-28 DOI: 10.1016/j.neulet.2024.137952

Cunsheng Wei , Tianming Wang , Rongfen Shi , Xiaorong Yu , Junying Jiang , Yuan Chen , Meng Cao , Xuemei Chen

引用次数: 0