Neuroscience Letters最新文献

Analysis of social interaction and proximity preferences in mice exposed to valproic acid prenatally. 胎儿期丙戊酸暴露小鼠的社会互动和邻近偏好分析。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-07-18 DOI: 10.1016/j.neulet.2025.138319

Rei Sugiyama, Munekazu Komada

{"title":"Analysis of social interaction and proximity preferences in mice exposed to valproic acid prenatally.","authors":"Rei Sugiyama, Munekazu Komada","doi":"10.1016/j.neulet.2025.138319","DOIUrl":"https://doi.org/10.1016/j.neulet.2025.138319","url":null,"abstract":"<p><p>It is established that exposure to the antiepileptic drug valproic acid (VPA) during the prenatal period increases the risk of neurodevelopmental disorders, including autism spectrum disorders (ASD). In this study, a multi-animal positioning system (MAPS) was utilized to ICR male mice as control (CT) and prenatal VPA-treated male mice in a shared environment, with the objective of investigating the effects of VPA on social interaction and social proximity. The results of the behavioral analysis indicated that the frequency, duration, and number of contacts were reduced in mice treated with VPA compared to the control group. Additionally, while there was no effect on inter-individual distance, the time spent at a distance was reduced. While no effects were observed on spontaneous locomotion or psychomotor activity, mice treated with VPA demonstrated behavioral abnormalities, characterized by increased social proximity but decreased social interaction. This finding underscores the utility of the MAPS in assessing natural group behavior and highlights the main behavioral differences associated with autism spectrum disorders due to prenatal VPA exposure. The results of this study offer valuable insights into the behavioral consequences of altered neurodevelopment and encourage further research to elucidate the underlying mechanisms.</p>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":" ","pages":"138319"},"PeriodicalIF":2.5,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain biomarker profiles vary with semi-synthetic and grain-based diets in healthy and mTBI mice 在健康小鼠和mTBI小鼠中，大脑生物标志物谱随半合成饮食和谷物饮食而变化。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-07-14 DOI: 10.1016/j.neulet.2025.138318

Erin D. Anderson , Daunel V. Augustin , Anastasia P. Georges , David A. Issadore , David F. Meaney

{"title":"Brain biomarker profiles vary with semi-synthetic and grain-based diets in healthy and mTBI mice","authors":"Erin D. Anderson , Daunel V. Augustin , Anastasia P. Georges , David A. Issadore , David F. Meaney","doi":"10.1016/j.neulet.2025.138318","DOIUrl":"10.1016/j.neulet.2025.138318","url":null,"abstract":"<div><div>Across a range of neurological disorders, there is a growing appreciation for how the gut influences brain health, but few ways of monitoring its effects. Although nutrition influences traumatic brain injury (TBI) recovery, its influence on biomarkers—whether as an intervention or confounder—is poorly understood. Beyond specialized diets, standard rodent diets may also affect brain function. Neuron-derived extracellular vesicles (NDEVs) offer a brain-specific complement to circulating biomarkers, but their sensitivity to diet is unknown. In this study, we isolated miRNAs from NDEVs from the serum of healthy and mild TBI (mTBI) mice fed a semi-synthetic or grain-based diet. NDEV miRNAs encoded dietary differences based on injury condition, suggesting that NDEVs are sensitive to dietary changes and may be able to track diet’s effect on TBI recovery. Additionally, we found that diet influenced injury biomarkers, underscoring diet as a confounding variable for NDEV miRNA biomarkers. Together, these findings highlight NDEVs as a promising tool for monitoring the effects of subtle dietary differences on brain health and the importance of diet reporting to improve study reproducibility.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"864 ","pages":"Article 138318"},"PeriodicalIF":2.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of concern: "Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-κB activation in a rat model of amyloid-beta-induced Alzheimer's disease" [NEUROSCI LETT, Volume 491 (2011) 127-132]. 关注的表达：“富氢盐水通过抑制淀粉样β诱导的阿尔茨海默病大鼠模型中JNK和NF-κB的激活来减少氧化应激和炎症”[神经科学学报，vol . 491(2011) 127-132]。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-07-13 Epub Date: 2025-05-14 DOI: 10.1016/j.neulet.2025.138254

Cai Wang, Jian Li, Qiang Liu, Rui Yang, John H Zhang, Yun-Peng Cao, Xue-Jun Sun

引用次数: 0

Expression of concern: "Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model" [NEUROSCI LETT, Volume 441 (2008) 167-172]. 关注的表达：“氢疗法减少新生儿缺氧缺血大鼠模型的细胞凋亡”[神经科学杂志，vol . 441(2008) 167-172]。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-07-13 Epub Date: 2025-05-14 DOI: 10.1016/j.neulet.2025.138255

Jianmei Cai, Zhimin Kang, Wen Wu Liu, Xu Luo, Sun Qiang, John H Zhang, Shigeo Ohta, Xuejun Sun, Weigang Xu, Hengyi Tao, Runping Li

引用次数: 0

Neuro-compensatory changes in face recognition in older adults: evidence from evoked and oscillatory responses of event-related potentials 老年人面部识别的神经代偿性变化：来自事件相关电位诱发和振荡反应的证据。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-07-13 DOI: 10.1016/j.neulet.2025.138317

Kanako Matsufuji , Emi Yamada , Hisato Nakazono , Shozo Tobimatsu

{"title":"Neuro-compensatory changes in face recognition in older adults: evidence from evoked and oscillatory responses of event-related potentials","authors":"Kanako Matsufuji , Emi Yamada , Hisato Nakazono , Shozo Tobimatsu","doi":"10.1016/j.neulet.2025.138317","DOIUrl":"10.1016/j.neulet.2025.138317","url":null,"abstract":"<div><div>Although face recognition is an essential function for human social interaction, face identification, memory retention, and processing speed decline with age. Recent event-related potential studies suggest that aging effects occur at relatively early perceptual stages; age-related increases in amplitude and latency and reduced hemispheric lateralization of the N170 component have been noted. However, studies into the P100 component have been sparse and yielded inconsistent findings. Here, we measured event-related potentials during face stimulus presentation in young (<em>n</em> = 22) and older (<em>n</em> = 22) adults. We focused on neuronal transients (P100 and N170) that are phase-locked to the stimulus, thereby reflecting changes in neuronal input. We also analyzed the oscillatory activities of P100 and N170, whose latencies fluctuate from trial to trial; this signaled the coupling mechanisms of each trial. We observed significant age-related differences in both P100 and N170. Notably, although older adults did not exhibit the characteristic right hemispheric predominance observed in young adults, they still demonstrated the preserved face inversion effect. Intertrial phase coherence analysis revealed lower phase synchronization in the older adults than in the young adults. Our findings suggest that age-related functional changes in the primary visual cortex influence the P100 component, and that the reduced right hemispheric predominance of N170 may be attributed to neural compensation. Thus, neural specificity for face recognition appears to be preserved in older adults, counterbalancing the aging effect. Moreover, intertrial phase coherence measurements indicate that the age-related decline in face recognition may be explained by asynchronous phase-locking neural activity in the face-specific area.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"864 ","pages":"Article 138317"},"PeriodicalIF":2.5,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effects of empagliflozin against NMDA-induced excitotoxicity in the rat retina 恩格列净对nmda诱导大鼠视网膜兴奋性毒性的保护作用。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-07-08 DOI: 10.1016/j.neulet.2025.138315

Momoka Ota, Akane Morita, Toshihide Kashihara, Tsutomu Nakahara

{"title":"Protective effects of empagliflozin against NMDA-induced excitotoxicity in the rat retina","authors":"Momoka Ota, Akane Morita, Toshihide Kashihara, Tsutomu Nakahara","doi":"10.1016/j.neulet.2025.138315","DOIUrl":"10.1016/j.neulet.2025.138315","url":null,"abstract":"<div><div>Empagliflozin (EMPA), a sodium-glucose cotransporter 2 inhibitor used in patients with type 2 diabetes, exerts various beneficial effects, including anti-inflammatory and antioxidant properties, in addition to its glucose-lowering effect. In this study, we examined whether EMPA protects against <em>N</em>-methyl-<span>d</span>-aspartic acid (NMDA)-induced retinal excitotoxicity and the mechanisms underlying its protective effects. Male Sprague-Dawley rats (7–8 weeks old) were used in this study. The number of cells in the ganglion cell layer (GCL) decreased 7 days after intravitreal injection of NMDA (50 nmol). Simultaneous intravitreal injection of EMPA (50 and 100 nmol) and NMDA reduced NMDA-induced cell loss in a dose-dependent manner. The protective effect of EMPA was significantly attenuated by the AMP-activated protein kinase (AMPK) inhibitor, compound C (10 nmol). NMDA increased the number of terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL)-positive cells in the GCL 6 h after injection, and the response was significantly, but not completely, attenuated by EMPA. These results suggest that EMPA protects against NMDA-induced retinal excitotoxicity in rats. The protective effect of EMPA may be partly attributed to the activation of the AMPK pathway and inhibition of neuronal cell apoptosis.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"864 ","pages":"Article 138315"},"PeriodicalIF":2.5,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences between coherence and phase locking value during the Stroop task in athletes 运动员Stroop任务中相干性和锁相值的差异

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-07-08 DOI: 10.1016/j.neulet.2025.138316

Hasan Batuhan Dirik

引用次数: 0

Degree centrality alterations in different frequency bands in chronic insomnia: A resting-state fMRI study 慢性失眠症不同频带的度中心性改变：静息状态fMRI研究

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-07-06 DOI: 10.1016/j.neulet.2025.138313

Jurong Ding , Pan Yang , Zhiyuan Xu , Mengjie Yu , Mei Yang , Lihong Li , Bo Hua , Wei Zeng , Xin Ding

{"title":"Degree centrality alterations in different frequency bands in chronic insomnia: A resting-state fMRI study","authors":"Jurong Ding , Pan Yang , Zhiyuan Xu , Mengjie Yu , Mei Yang , Lihong Li , Bo Hua , Wei Zeng , Xin Ding","doi":"10.1016/j.neulet.2025.138313","DOIUrl":"10.1016/j.neulet.2025.138313","url":null,"abstract":"<div><h3>Purpose</h3><div>Abnormal spontaneous neural activity in chronic insomnia (CI) has been identified in previous neuroimaging studies. However, whether the spontaneous neural activity is frequency-specific in CI is largely unknown.</div></div><div><h3>Methods</h3><div>We used resting-state functional magnetic resonance imaging (rs-fMRI) and degree centrality (DC) analysis to examine spontaneous neural activity in 37 CI patients and 20 healthy controls (HCs) across four frequency bands: slow-5 (0.012–0.031 Hz), slow-4 (0.031–0.081 Hz), slow-3 (0.081–0.224 Hz), and slow-2 (0.224–0.25 Hz). Partial correlation analysis was used to explore the relationship between abnormal DC values and clinical scales.</div></div><div><h3>Results</h3><div>In the slow-5 band, CI patients showed reduced DC in the occipital cortex compared with HCs. In the slow-4 band, CI patients displayed lower DC in the left middle temporal gyrus. In the slow-3 and slow-2 bands, decreased DC was primarily located in the frontal cortex. Moreover, CI patients showed higher DC in the right middle frontal gyrus and dorsolateral part of the superior frontal gyrus at the slow-4, slow-3, and slow-2 bands. Increased DC was also observed in the right median cingulate and paracingulate gyri at the slow-3 band. Furthermore, DC values in the right MFG at the slow-4 band were positively correlated with Mini-Mental State Examination scores.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that CI patients exhibit widespread, frequency-specific alterations in brain activity, offering insights into the neurobiological mechanisms of CI.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"864 ","pages":"Article 138313"},"PeriodicalIF":2.5,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term cannabinoid therapy can ameliorate chronic sleep deprivation-induced behavioral and neuroinflammatory changes in mice 长期大麻素治疗可以改善小鼠慢性睡眠剥夺引起的行为和神经炎症变化

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-07-06 DOI: 10.1016/j.neulet.2025.138314

Nasar Ullah Khan Niazi , Rabia Parveen

{"title":"Long-term cannabinoid therapy can ameliorate chronic sleep deprivation-induced behavioral and neuroinflammatory changes in mice","authors":"Nasar Ullah Khan Niazi , Rabia Parveen","doi":"10.1016/j.neulet.2025.138314","DOIUrl":"10.1016/j.neulet.2025.138314","url":null,"abstract":"<div><div>Endocannabinoid system is an important contributor to body’s immune responses which are significantly impaired by chronic sleep deprivation (cSD). Although cannabinoids can modulate the endocannabinoid system, but most are understudied, especially regarding cSD. To investigate the therapeutic potential of CBD, CBG, CBC and their combinations, current study analyzed cSD-induced memory impairment, depression, microglial responses, cytokine profile and therapeutic effects of cannabinoid treatments using behavioral test and ELISA. Furthermore, molecular docking of these cannabinoids was performed to deduce the binding affinity with cannabinoid receptors and possible entrouge effects. The results showed that memory impairment and depression were more evident in cSD groups. Moreover, microglial activation and pro-inflammatory polarization was also more evident and was supported by increased pro-inflammatory cytokine concentrations in cSD groups. These changes were significantly reversed the cannabinoid groups but the combination of CBD + CBC was more effective than other treatments in reversing these cSD-induced behavioral and neuroinflammatory changes. Whereas, the molecular docking results also corroborated with the neuroimmunological changes observed in the current study, pointing towards the possible therapeutic role.</div></div><div><h3>Significance statement</h3><div>Chronic SD employs microglial activation/polarization, to exert behavioral impairments and neuroinflammation. This study signifies the therapeutic potential of proper sleep and cannabinoid intake.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"864 ","pages":"Article 138314"},"PeriodicalIF":2.5,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spinal activation of TRPV1-mediated attenuation of a chemoreflex: Potential mechanism of action linking TRPV1 activation with modulation of CaV2.2 channels TRPV1激活介导的化学反射衰减：TRPV1激活与CaV2.2通道调节的潜在作用机制

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-07-05 DOI: 10.1016/j.neulet.2025.138312

Laura Anselmi , Marc P. Kaufman , Victor Ruiz-Velasco

{"title":"Spinal activation of TRPV1-mediated attenuation of a chemoreflex: Potential mechanism of action linking TRPV1 activation with modulation of CaV2.2 channels","authors":"Laura Anselmi , Marc P. Kaufman , Victor Ruiz-Velasco","doi":"10.1016/j.neulet.2025.138312","DOIUrl":"10.1016/j.neulet.2025.138312","url":null,"abstract":"<div><div>The objective of the present study was to examine the effect of intrathecal injection of the transient receptor potential vanilloid 1 (TRPV1) channel agonist, capsaicin, on the spinal transmission of the pressure reflex induced by intra-arterial administration of capsaicin (chemoreflex). In decerebrated rats, we found that intrathecal injection of capsaicin attenuated significantly the increase in arterial pressure evoked by intra-arterial capsaicin when compared to intrathecal injection of saline. Afterwards, whole-cell patch-clamp technique was employed to determine if TRPV1 activation was involved in the modulation of voltage-gated Ca<sup>2+</sup> channels (Ca<sub>V</sub>2.2) in DiI-labeled sensory neurons innervating the triceps surae muscle. This channel subtype was previously shown to play a key role in the exercise pressor reflex, and is also the major Ca<sup>2+</sup> ion carrier in sensory neurons innervating the triceps surae muscle. Our results showed that either TRPV1 agonists, capsaicin or olvanil, inhibited Ca<sub>V</sub>2.2 currents. The agonist-mediated Ca<sub>V</sub>2.2 inhibition was sensitive to the TRPV1 blocker, AMG 517, and absent in sensory neurons isolated from TRPV1 knockout rats. Moreover, in ‘rescue’ experiments, after transfecting sensory neurons from TRPV1 knockout rats with TRPV1 cDNA, application of capsaicin led to Ca<sub>V</sub>2.2 inhibition as observed with neurons isolated from wild-type rats. These data suggest that the decrease of the pressor response following intrathecal capsaicin-mediated stimulation appears to involve a mechanism of action linking TRPV1 activation with Ca<sub>V</sub>2.2 current inhibition.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"864 ","pages":"Article 138312"},"PeriodicalIF":2.5,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0