鼻内胰岛素给药在早期APP/PS1阿尔茨海默病小鼠中显示有限的tau靶向效应。

IF 2 4区医学 Q3 NEUROSCIENCES

Neuroscience Letters Pub Date : 2025-10-14 Epub Date: 2025-08-05 DOI:10.1016/j.neulet.2025.138337

Yan Fang Mao, Liang Chen, Jun Yu Liu, Zhang Yu Guo, Pei Lin Lu, Yan Xing Chen

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引用次数: 0

摘要

脑胰岛素信号缺陷有助于阿尔茨海默病（AD）的多种病理特征。鼻内胰岛素已显示出治疗潜力，但其潜在机制尚不清楚。本研究探讨了鼻内胰岛素是否调节早期APPswe/PS1dE9 （APP/PS1）小鼠的tau病理。治疗六周后，未观察到总tau或磷酸化tau水平的显著变化。然而，与tau激酶相关的失调信号通路有改善的趋势。这些发现表明，鼻腔胰岛素对早期AD的保护作用可能不是主要针对tau相关的神经毒性。

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Intranasal insulin administration shows limited tau-targeted effects in early-stage APP/PS1 Alzheimer's mice.

Brain insulin signaling deficits contribute to multiple pathologicalfeatures of Alzheimer's disease (AD).Intranasal insulin has demonstrated therapeutic potential, but its underlying mechanisms remain unclear. This study investigated whether intranasal insulinmodulates tau pathology in early-stage APPswe/PS1dE9 (APP/PS1) mice.After six weeks of treatment, no significant changes in total or phosphorylated tau levels were observed. However, there was a trend toward improvement in dysregulated signaling pathways associated with tau kinases. These findings suggest that the protective effect of nasal insulin in early AD may not primarily be against tau-related neurotoxicity.

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来源期刊

Neuroscience Letters 医学-神经科学

CiteScore

5.20

自引率

0.00%

发文量

408

审稿时长

50 days

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