Neuroscience Letters最新文献_第2页

In ovo exposure to ethynylestradiol demasculinizes the vasotocin system in the medial preoptic nucleus in male Japanese quail 卵细胞暴露于乙炔雌二醇使雄性日本鹌鹑视前核内侧的缩宫素系统失雄。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-07-05 DOI: 10.1016/j.neulet.2025.138310

Maho Suzuki, Shinji Tsukahara

{"title":"In ovo exposure to ethynylestradiol demasculinizes the vasotocin system in the medial preoptic nucleus in male Japanese quail","authors":"Maho Suzuki, Shinji Tsukahara","doi":"10.1016/j.neulet.2025.138310","DOIUrl":"10.1016/j.neulet.2025.138310","url":null,"abstract":"<div><div>Ethynylestradiol (EE<sub>2</sub>) is an estrogen that is used predominantly in oral contraceptives and contaminates the environment. <em>In ovo</em> exposure to EE<sub>2</sub> impairs copulatory behavior in male Japanese quail, although the mechanisms responsible remain undetermined. The medial preoptic nucleus (POM) plays a pivotal role in male copulatory behaviors and is sexually dimorphic, with a higher number of vasotocin (VT) neuronal fibers in males. In this study, the effects of <em>in ovo</em> EE<sub>2</sub> exposure on the VT neuronal fibers of the POM were examined to test the hypothesis that impaired copulatory behaviors caused by EE<sub>2</sub> are due to demasculinization of the POM in male birds. Japanese quail embryos were treated with vehicle or EE<sub>2</sub> by injecting it into the egg yolk. After the male embryos were hatched and sexually matured, the POM in VT-immunostained and Nissl-stained brain sections, as well as the performance of male sexual behaviors, were analyzed to evaluate the effects of EE<sub>2</sub>. The analysis of the POM revealed that EE<sub>2</sub> treatment significantly decreased the number of VT-immunopositive fibers in the POM of adult male quail, but it did not significantly change the volume of the POM. EE<sub>2</sub> dramatically reduced the number and incidence of copulatory behaviors, including neck grabs, mount attempts, mounts, and cloacal contact movements, but it did not affect courtship behaviors, including strutting and crowing. Our results suggest that <em>in ovo</em> EE<sub>2</sub> exposure induces demasculinization of the VT system in the POM. The effect of EE<sub>2</sub> may be responsible for reducing copulatory behaviors in male Japanese quail.</div></div><div><h3>Significant statement</h3><div>Embryonic exposure to ethynylestradiol demasculinizes the vasotocin system in the preoptic area, resulting in reduced copulatory behavior in adult male Japanese quail.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"864 ","pages":"Article 138310"},"PeriodicalIF":2.5,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Absence of a glutamatergic channel arrest mechanisms in hypoxic naked mole-rat cortex 缺氧裸鼹鼠皮质谷氨酸通道阻滞机制的缺失

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-07-04 DOI: 10.1016/j.neulet.2025.138309

George Otell , Liam Eaton , Maria Roy , Matthew E. Pamenter

{"title":"Absence of a glutamatergic channel arrest mechanisms in hypoxic naked mole-rat cortex","authors":"George Otell , Liam Eaton , Maria Roy , Matthew E. Pamenter","doi":"10.1016/j.neulet.2025.138309","DOIUrl":"10.1016/j.neulet.2025.138309","url":null,"abstract":"<div><div>In the brain of hypoxia-intolerant vertebrates, hypoxia induces neuronal depolarization, chronic activation of voltage-gated excitatory glutamatergic receptors, and rapid accumulation of Ca<sup>2+</sup> in the cytosol, which induces downstream activation of cell death pathways. Conversely, deleterious Ca<sup>2+</sup> accumulation and cell death is avoided in the brain of hypoxia-tolerant vertebrates. One neuroprotective adaptation that is present in some of the most hypoxia-tolerant vertebrates is channel arrest, whereby Ca<sup>2+</sup> ion influx through glutamate receptors is reduced in hypoxia, and cytotoxic accumulation of Ca<sup>2+</sup> is avoided. Naked mole-rats are a hypoxia-tolerant mammal and avoid neurotoxic Ca<sup>2+</sup> accumulation during hypoxia; however, the underlying mechanisms are poorly understood. In the present study, we tested the hypothesis that channel arrest of glutamatergic receptors occurs in hypoxic naked mole-rat neurons, which would help to limit Ca<sup>2+</sup> influx during hypoxia. Using the Ca<sup>2+</sup>-sensitive fluorophore Fura-2, we measured Ca<sup>2+</sup> flux through glutamatergic receptors in live brain slices exposed to a normoxic or hypoxic (1 % O<sub>2</sub>) perfusate and following application of either glutamate or NMDA to stimulate glutamatergic receptors. We found no differences in the magnitude of the evoked Ca<sup>2+</sup> transients or the total amount of Ca<sup>2+</sup> movement following ligand stimulus. Our results indicate that channel arrest is not an important strategy to limit deleterious Ca<sup>2+</sup> influx into naked mole-rat neurons during hypoxia. Other mechanisms, such as enhanced mitochondrial buffering of cytosolic Ca<sup>2+</sup>, may play a more important role in hypoxic Ca<sup>2+</sup> homeostasis in this species.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"863 ","pages":"Article 138309"},"PeriodicalIF":2.5,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NMDA current is enhanced by MβCD-induced D1-NMDA receptor perturbation in hippocampal CA1 m β cd诱导海马CA1区D1-NMDA受体的扰动可增强NMDA电流

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-07-04 DOI: 10.1016/j.neulet.2025.138311

Ricardo Esquivel-Garcia, Jorge Bravo-Martinez, Karina Bermeo, Isabel Arenas, David E. Garcia

{"title":"NMDA current is enhanced by MβCD-induced D1-NMDA receptor perturbation in hippocampal CA1","authors":"Ricardo Esquivel-Garcia, Jorge Bravo-Martinez, Karina Bermeo, Isabel Arenas, David E. Garcia","doi":"10.1016/j.neulet.2025.138311","DOIUrl":"10.1016/j.neulet.2025.138311","url":null,"abstract":"<div><div>N-methyl-d-aspartate receptors (NMDARs) located in hippocampal CA1 are modulated by D1 receptors (D1Rs). This modulation is thought to be exerted by direct protein-protein interactions. Thus, the nearest spatial and temporal relationship amongst them, immersed in a lipid raft, seems critical in passing the signaling on to each other. However, whether this modulation is affected by disturbing lipid raft conformations is still unknown. Therefore, this work aimed to investigate changes in CA1 synaptic responses resulting from disrupting NMDARs-D1Rs interactions. Experiments were conducted on hippocampal slices obtained from 15-day-old Wistar rats. A selective D1Rs antagonist (SCH23390) was used to reduce NMDA current (NMDAc) activity, suggesting a potential influence of endogenous dopamine (DA). This finding was further supported by depleting DA in experiments including reserpine. Dopaminergic modulation of NMDAc was assessed in slices preincubated with Methyl-β-cyclodextrin (MβCD). Exposure to SCH23390 in MβCD-treated slices significantly enhanced amplitude and τ deactivation of NMDAc compared to slices treated with SCH23390 solely. These alterations were readily correlated with changes in synaptic efficacy. Moreover, CaMKII inhibitory peptide 281–309 significantly counteracted the increased synaptic response observed in SCH23390 + MβCD conditions<sub>.</sub> Together, these results support the notion that lipid rafts perturbation impedes a NMDARs-D1Rs interaction, therefore a modulatory inhibition depending on this interaction.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"864 ","pages":"Article 138311"},"PeriodicalIF":2.5,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144571855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurochemical alterations in monoaminergic systems induced by excessive sucrose consumption from the juvenile period to adolescence in mice 小鼠从幼年期到青春期过量蔗糖摄入引起的单胺能系统的神经化学改变。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-06-30 DOI: 10.1016/j.neulet.2025.138308

Won-Hui Choe, Ye-Jin Kim, Kyung-A Lee, Young-A Lee

{"title":"Neurochemical alterations in monoaminergic systems induced by excessive sucrose consumption from the juvenile period to adolescence in mice","authors":"Won-Hui Choe, Ye-Jin Kim, Kyung-A Lee, Young-A Lee","doi":"10.1016/j.neulet.2025.138308","DOIUrl":"10.1016/j.neulet.2025.138308","url":null,"abstract":"<div><div>Postweaning to early adulthood is a critical period for neural maturation, with dopamine (DA) and serotonin (5-HT) systems undergoing significant changes. Excessive sucrose (SUC) intake during this period is associated with metabolic and neuropsychiatric disorders; however, its effects on neurodevelopment remain unclear, especially in comparison to noncaloric sweeteners like saccharin (SAC). Therefore, we aimed to investigate the impact of chronic SUC and SAC consumption from postweaning to early adulthood on DA and 5-HT metabolism in the mesocorticolimbic system. Male mice of the Institute of Cancer Research strain received 20 % SUC or 0.2 % SAC ad libitum from postnatal days 21–56. Response to amphetamine (AMP) treatment was determined using the open-field test. The levels of DA, 5-HT, and their metabolites in the mesocorticolimbic system were assessed using high-performance liquid chromatography. Unlike SAC, SUC increased locomotor activity and attenuated the AMP response. SUC and SAC reduced DA levels in the prefrontal cortex (PFC). SUC altered DA turnover in the dorsal striatum and hippocampus, whereas SAC affected the PFC. Differences in the 5-HT/DA ratio further highlighted distinct neurobiological effects. Excessive SUC and SAC consumption during the critical developmental window induces region-specific alterations in DA and 5-HT metabolism, suggesting distinct neural effects of caloric vs. noncaloric sweeteners. These findings emphasize the need for further research on their long-term neurodevelopmental consequences.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"864 ","pages":"Article 138308"},"PeriodicalIF":2.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144554035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-specific cell death mechanisms in rodent sub-acute and chronic stroke 啮齿类动物亚急性和慢性中风的性别特异性细胞死亡机制

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-06-25 DOI: 10.1016/j.neulet.2025.138307

Alexandra J White , Latavya Chintada , Hugh H Chan , Brittany MD Fisher , Nymisha Mandava , Olivia Hogue , Andre G Machado , Kenneth B Baker

{"title":"Sex-specific cell death mechanisms in rodent sub-acute and chronic stroke","authors":"Alexandra J White , Latavya Chintada , Hugh H Chan , Brittany MD Fisher , Nymisha Mandava , Olivia Hogue , Andre G Machado , Kenneth B Baker","doi":"10.1016/j.neulet.2025.138307","DOIUrl":"10.1016/j.neulet.2025.138307","url":null,"abstract":"<div><div>To characterize subacute and chronic effects of sex as a biological variable in the severity and pathophysiology of stroke, ten male and ten female animals (>230 g and 2–4 months old) underwent photothrombotic infarction at the sensorimotor cortex. Lesion volume was calculated two- and four-weeks post-stroke (5 animals/sex/timepoint). The perilesional area was stained for active caspase-8, apoptosis-inducing factor (AIF), and Iba-1 expression at each timepoint. Males demonstrated significantly larger lesion volume than females at both two- (male: 11.2 mm<sup>3</sup> vs female: 7.3 mm<sup>3</sup>, p = 0.02) and four-week (male: 9.3 mm<sup>3</sup> vs female: 4.7 mm<sup>3</sup>, p = 0.008). The median caspase-8/AIF ratio was significantly higher in females as compared to males at two weeks (male: 0.59 vs female: 2.1, p = 0.02), however this difference was no longer present at the four-week (male: 6.0 vs female: 6.2, p = 0.56). At two weeks post-stroke, Iba1 signal in males was significantly greater than in females (male: 13.7 % vs female: 3.2 %, p = 0.0008). Although expression decreased in males at four weeks (p = 0.008), there was still a trend towards greater Iba-1 signal in comparison to females (male: 5.2 vs female: 2.8, p = 0.06). In the subacute stage, males showed a pattern consistent with parthanatos and higher neuroinflammation, while females showed a pattern consistent with caspase-8-mediated apoptosis. In the chronic stage, both sexes exhibit reduction in neuroinflammation and caspase-predominant cell death. These exploratory findings highlight potential sex-based differences in neuronal death patterns that may be influenced by microglial activity and may warrant consideration in future treatment-related studies.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"863 ","pages":"Article 138307"},"PeriodicalIF":2.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-06-22 DOI: 10.1016/j.neulet.2025.138306

Sofia C. Valladão , Cátia R. Lopes , João Pedro Lopes , Madalena Piteira , Pablo Pandolfo , Alexandre Santos-Rodrigues , Paula Agostinho , Ângelo R. Tomé , Rodrigo A. Cunha , Samira G. Ferreira

{"title":"Similar adenosine neuromodulation in male and female hippocampal and prefrontocortical synapses of young and aged mice","authors":"Sofia C. Valladão , Cátia R. Lopes , João Pedro Lopes , Madalena Piteira , Pablo Pandolfo , Alexandre Santos-Rodrigues , Paula Agostinho , Ângelo R. Tomé , Rodrigo A. Cunha , Samira G. Ferreira","doi":"10.1016/j.neulet.2025.138306","DOIUrl":"10.1016/j.neulet.2025.138306","url":null,"abstract":"<div><div>Caffeine is the most widely consumed psychoactive drug worldwide, acting through adenosine receptors at non-toxic doses. Epidemiological studies have reported a different impact of caffeine in men and women, namely in the incidence of brain stroke and neurodegenerative diseases. This prompts the tentative hypothesis that adenosine neuromodulation might be different in males and females, which we now tested. In hippocampal slices from adult mice, the potency and efficacy of 2-chloroadenosine to inhibit synaptic transmission and the disinhibitory effect resulting from selective blockade of adenosine A<sub>1</sub> receptors, were superimposable in males and females. Likewise, a similar adenosine neuromodulation was observed in synapses of the hippocampus and prefrontal cortex of aged male and female mice. This excludes the possibility that differences in A<sub>1</sub> receptor function contribute to the sex-specific central effects of caffeine, which may arise from variations in metabolism, interactions with sex hormones, or differences in brain connectivity—factors that remain to be investigated.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"863 ","pages":"Article 138306"},"PeriodicalIF":2.5,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

C1ql3 promotes cognitive flexibility behavior in mice C1ql3促进小鼠的认知灵活性行为。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-06-18 DOI: 10.1016/j.neulet.2025.138305

Keaven Caro , Trevor Religa , Shahnawaz Alam , Mark H. Cristino , Maya Preibisz-Kamat , James R. Rybczyk , Hiu W. Cheung , Maksym V. Ugrak , Timothy Spellman , David C. Martinelli

引用次数: 0

Inhibition of the nucleus accumbens core with DREADDs after acute and repeated exposure to oxycodone reduces locomotor activity in female but not male Rattus norvegicus 急性和反复暴露于氧可酮后，对雌性褐家鼠伏隔核的抑制可降低雌性褐家鼠的运动活性，但对雄性褐家鼠没有作用

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-06-18 DOI: 10.1016/j.neulet.2025.138304

Lenah C. Midani , Julie S. Jesurum , Megan G. Bachant, Fair M. Vassoler

{"title":"Inhibition of the nucleus accumbens core with DREADDs after acute and repeated exposure to oxycodone reduces locomotor activity in female but not male Rattus norvegicus","authors":"Lenah C. Midani , Julie S. Jesurum , Megan G. Bachant, Fair M. Vassoler","doi":"10.1016/j.neulet.2025.138304","DOIUrl":"10.1016/j.neulet.2025.138304","url":null,"abstract":"<div><div>Opioid use disorder affects both men and women, but significant sex differences exist in addiction vulnerability and progression. The nucleus accumbens (NAc) plays a critical role in drug reward and motor outputs, yet its sex-specific functions in opioid response remain poorly understood. We investigated the role of the NAc in acute and repeated oxycodone response using chemogenetics in male and female Sprague Dawley rats. Inhibitory DREADDs (hM4D(Gi)) or control vectors were injected into the NAc core. Rats received oxycodone (1 mg/kg, i.p.) or saline for 5 consecutive days with locomotor activity monitoring. Following a 7-day drug-free period, all rats received oxycodone challenge (1 mg/kg, i.p.) with clozapine-N-oxide (CNO, 3 mg/kg) to activate DREADD-mediated inhibition. Results revealed sex differences in both baseline and drug-induced locomotor activity, with females showing consistently higher activity in response to oxycodone than males across all sessions. Chemogenetic inhibition of the NAc significantly reduced locomotor activity in females but not males during challenge conditions, indicating sex-specific NAc involvement in the opioid response at this dose. These findings reveal sex differences in NAc involvement in acute and chronic oxycodone induced locomotor activity. Our results underscore the need for sex-specific considerations in addiction research.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"863 ","pages":"Article 138304"},"PeriodicalIF":2.5,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cocaine conditioning promotes persistent inhibition of GABAergic transmission in the mouse ventral hippocampal CA1 region 可卡因调节促进小鼠海马腹侧CA1区gaba能传递的持续抑制

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-06-17 DOI: 10.1016/j.neulet.2025.138301

Kyle A. Brown , John J. Wagner

{"title":"Cocaine conditioning promotes persistent inhibition of GABAergic transmission in the mouse ventral hippocampal CA1 region","authors":"Kyle A. Brown , John J. Wagner","doi":"10.1016/j.neulet.2025.138301","DOIUrl":"10.1016/j.neulet.2025.138301","url":null,"abstract":"<div><div>Millions of individuals globally meet the current diagnostic criteria for cocaine use disorder (CUD), and cocaine misuse contributes to thousands of overdose deaths every year in the United States. Current hypotheses suggest that cocaine misuse imparts a diminished ability for synaptic plasticity (i.e., drug-induced metaplasticity). This metaplasticity impairs adaptive learning, which has been proposed to contribute to the likelihood of cocaine relapse. Delineating plasticity processes that mediate drug-seeking behavior can facilitate the development of therapeutic interventions for CUD. We used behavioral pharmacology and <em>ex vivo</em> patch-clamp electrophysiology to test the hypothesis that escalating cocaine doses elicit long-lasting, drug-seeking behavior that is correlated with a persisting decrease of GABAergic transmission in the mouse ventral hippocampus (vH) CA1 region. We found that noncontingent cocaine conditioning reduced the amplitude of evoked inhibitory postsynaptic currents measured from vH CA1 pyramidal cells 4–5 weeks after the last dose, suggesting sustained synaptic disinhibition. The magnitude of drug-seeking behavior observed 4 weeks, but not 1 day, after cocaine abstinence predicted the extent of synaptic disinhibition. Persisting inhibition of GABAergic transmission occurred in the absence of altered IPSC kinetics. We conclude that cocaine conditioning evokes a progressive metaplasticity that persistently shifts the GABAergic tone of the vH CA1 region, and these synaptic actions are correlated with long-lasting drug-seeking behavior in mice. Our results suggest that targeting metaplastic processes that modulate vH neuronal excitability represents a promising therapeutic strategy for relieving symptoms associated with CUD.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"863 ","pages":"Article 138301"},"PeriodicalIF":2.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144320780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anodal transcranial direct current stimulation of cerebellum relieves motion sickness by reducing the release of acetylcholine 经颅阳极直流电刺激小脑通过减少乙酰胆碱的释放来缓解晕动病。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-06-14 DOI: 10.1016/j.neulet.2025.138303

Niu Deng , Yihong Long , Cong Li , Yu Chen , Xiaoyu Zhang , Wei Li

{"title":"Anodal transcranial direct current stimulation of cerebellum relieves motion sickness by reducing the release of acetylcholine","authors":"Niu Deng , Yihong Long , Cong Li , Yu Chen , Xiaoyu Zhang , Wei Li","doi":"10.1016/j.neulet.2025.138303","DOIUrl":"10.1016/j.neulet.2025.138303","url":null,"abstract":"<div><div>Motion sickness (MS) is a condition caused by conflicts between motion sensors and past visual or motion memories, leading to discomfort with symptoms like hypolocomotion, low body temperature, poor appetite, and nausea. Previous studies have shown that the cerebellum is closely related to the occurrence of MS. In the present study, we aimed to evaluate the potential therapeutic effects of transcranial direct current stimulation (tDCS) of cerebellum on MS. The motion sickness index and the rotarod motor performance test were used to assess the motion sickness symptoms and motor learning in mice. Our results showed that tDCS was effective in reducing the motion sickness index in rotation-induced MS mice, as well as in reversing the rotation-induced impairment in rotarod motor learning. To understand the potential underlying mechanism, we used two-photon microimaging to monitor the release of acetylcholine in the cerebellum. Our results showed a significant increase in acetylcholine release in the cerebellum after rotation. Furthermore, anodal tDCS (a-tDCS) not only counteracted rotation-induced increase of acetylcholine in MS mice but also reduced the level of acetylcholine in static control mice. Together, these findings indicate that anodal transcranial direct current stimulation alleviates symptoms associated with motion sickness, which may be related to the reduction of acetylcholine release in the cerebellum.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"863 ","pages":"Article 138303"},"PeriodicalIF":2.5,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0