Neuroscience Letters最新文献_第3页

Soleus H-reflex excitability during standing with stable and unstable light touch 稳定和不稳定轻触站立时比目鱼h反射兴奋性

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-06-02 DOI: 10.1016/j.neulet.2025.138278

John E. Misiaszek , Britt E. Davis , Sisuri G. Hemakumara , Juan Forero

{"title":"Soleus H-reflex excitability during standing with stable and unstable light touch","authors":"John E. Misiaszek , Britt E. Davis , Sisuri G. Hemakumara , Juan Forero","doi":"10.1016/j.neulet.2025.138278","DOIUrl":"10.1016/j.neulet.2025.138278","url":null,"abstract":"<div><div>Light touch reduces sway when participants stand with their eyes closed. Unexpected displacement of the touch reference induces a “false-positive” balance correction in most participants. However, this response is only observed with the first displacement, with subsequent displacements eliciting an arm-extension response. This suggests that the sensorimotor processes involved in stabilizing sway from light touch are rapidly adapted within a single trial. We hypothesized that this change in sensorimotor behaviour would be reflected in changes in the excitability of the soleus H-reflex. Soleus H-reflexes and M-waves, along with background muscle activity, were obtained from ten healthy participants during five standing conditions: 1) eyes open (EO), 2) eyes open with touch (EOT), 3) eyes closed (EC), 4) eyes closed with touch (ECT), and 5) eyes closed touching a reference that has been unexpectedly and repeatedly displaced (ECP). Postural sway was evaluated in each condition, inferred from the motion of the centre of pressure recorded with the use of a force plate. As expected, H-reflexes were suppressed, while sway parameters were increased, during the EC condition, when compared with EO, EOT and ECT. In contrast, H-reflexes during the ECP condition were suppressed comparable to the EC condition, while the sway parameters were not similarly increased. We suggest that the suppression of the H-reflex during the ECP condition reflects an inferred change in the sensorimotor task; specifically switching from utilizing the light touch reference as an external spatial reference, to engaging the touch reference as a target to be maintained.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"859 ","pages":"Article 138278"},"PeriodicalIF":2.5,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Corn Silk Extract on paclitaxel-induced spinal cord and sciatic nerve injuries in rats: Biochemical and histological evaluation 玉米丝提取物对紫杉醇所致大鼠脊髓和坐骨神经损伤的影响：生化和组织学评价

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-06-01 DOI: 10.1016/j.neulet.2025.138282

Nada S. Badr , Sobhy Hassab El-Nabi , Mohamed S.A. El-Gerbed

{"title":"Impact of Corn Silk Extract on paclitaxel-induced spinal cord and sciatic nerve injuries in rats: Biochemical and histological evaluation","authors":"Nada S. Badr , Sobhy Hassab El-Nabi , Mohamed S.A. El-Gerbed","doi":"10.1016/j.neulet.2025.138282","DOIUrl":"10.1016/j.neulet.2025.138282","url":null,"abstract":"<div><h3>Background</h3><div>Overactivation of the Renin-Angiotensin System (RAS) is linked to oxidative stress and inflammation, contributing to the pathogenesis of Paclitaxel-Induced Peripheral Neuropathy (PIPN). Corn Silk Extract (CSE) exhibits neuroprotective activity through its antioxidant, anti-inflammatory, and anti-apoptotic properties. This study aims to evaluate the protective effects of CSE against PIPN through the modulation of oxidative, inflammatory, and RAS-related signals.</div></div><div><h3>Material and methods</h3><div>CSE was analyzed for its phenolic and flavonoid content and its antioxidant activity. The study involved four experimental groups: Control, CSE (400 mg/kg/day), Paclitaxel (PTX) (2 mg/kg, i.p. on days 1st, 3rd, 5th, and 7th), and PTX + CSE. Behavioral tests, biochemical analyses, histological evaluations, and molecular docking were conducted to assess the effects of CSE.</div></div><div><h3>Results</h3><div>PTX-induced hyperalgesia, increased nitric oxide, nuclear factor kappa B (NF-κB), Myeloperoxidase (MPO), Angiotensin-Converting Enzyme (ACE), angiotensin II, aldosterone, high mobility group box 1 protein, and decreased glutathione, total antioxidant capacity, and inhibitor of nuclear factor kappa B alpha. It induced spinal cord and sciatic nerve neuron damage, axonal demyelination, and reduced Schwann cells number. CSE administration with PTX improved behavioral responses, reduced oxidative and inflammatory markers, restored antioxidant and RAS signal balance, and preserved nerve tissue structure. Docking showed strong binding of CSE components with NF-κB, MPO, and ACE, suggesting direct inhibitory interactions.</div></div><div><h3>Conclusion</h3><div>CSE attenuates PINP by reducing oxidative stress, inflammation, and RAS dysregulation while preserving neuronal and nerve structure. In silico results support the effects of CSE components on multiple inflammatory pathways, highlighting its therapeutic potential.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"862 ","pages":"Article 138282"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the effects of pro-myelinating drugs on motor function and myelination in a zebrafish model of genetic leukoencephalopathy 评估促髓鞘形成药物对遗传性白质脑病斑马鱼模型运动功能和髓鞘形成的影响。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-05-31 DOI: 10.1016/j.neulet.2025.138280

Shreya Banerjee, Yasmeen Berry, Emily Fisher, Ryan Thummel

{"title":"Evaluating the effects of pro-myelinating drugs on motor function and myelination in a zebrafish model of genetic leukoencephalopathy","authors":"Shreya Banerjee, Yasmeen Berry, Emily Fisher, Ryan Thummel","doi":"10.1016/j.neulet.2025.138280","DOIUrl":"10.1016/j.neulet.2025.138280","url":null,"abstract":"<div><div>Genetic leukoencephalopathy (gLE) is a white matter disorder affecting the central nervous system, causing hypomyelination, developmental delays, motor deterioration, and cognitive, visual, and hearing impairments. Its clinical variability makes diagnosis challenging. A novel homozygous missense mutation, p.Cys846Gly in <em>VACUOLAR PROTEIN SORTING 11</em> (<em>VPS11</em>), has been linked to infantile-onset gLE in humans. A zebrafish <em>vps11</em> mutant model was developed to replicate gLE-like hypomyelination and sensorimotor deficits. This study investigates the effects of Clemastine, a pro-myelinating drug, on motor function and myelination in zebrafish larvae with mutations in the <em>vps11</em> gene. We exposed zebrafish larvae to this drug during a critical period of early nervous system development, from 2 to 4 days post-fertilization (dpf), and assessed visuomotor responses at 7 dpf. Although Clemastine significantly increased the number of oligodendrocytes, it failed to improve visuomotor function in <em>vps11</em> mutants. These findings imply that increasing oligodendrocyte numbers does not necessarily result in improved behavioral responses in <em>vps11</em> mutants.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"862 ","pages":"Article 138280"},"PeriodicalIF":2.5,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

mGluR5 regulates inflammatory pain and pain aversion of CFA mice by mediating ERK/PI3K signaling pathway mGluR5通过介导ERK/PI3K信号通路调节CFA小鼠炎症性疼痛和疼痛厌恶。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-05-29 DOI: 10.1016/j.neulet.2025.138281

Zhuang Tianxin , Huang Zhongyu , Zhang Weishan , Wang Can , Lin Jiahong , Wang Shuhan , Zhang Runheng , Zhou Chang , Ma Yuxin

{"title":"mGluR5 regulates inflammatory pain and pain aversion of CFA mice by mediating ERK/PI3K signaling pathway","authors":"Zhuang Tianxin , Huang Zhongyu , Zhang Weishan , Wang Can , Lin Jiahong , Wang Shuhan , Zhang Runheng , Zhou Chang , Ma Yuxin","doi":"10.1016/j.neulet.2025.138281","DOIUrl":"10.1016/j.neulet.2025.138281","url":null,"abstract":"<div><div>To investigate whether metabotropic glutamate receptor 5 (mGluR5) in the basolateral amygdala (BLA) regulates inflammatory pain and pain aversion by mediating ERK/PI3K signaling pathway in mice. Two experimental routes were designed. In route 1, 18 male C57BL/6 mice were divided into control, IFA, and CFA groups. In route 2, 18 mice received stereotaxic BLA injections of ACSF, the mGluR5 agonist DHPG, or antagonist MTEP on day 8 following CFA administration. Pain behaviors and aversive emotions were assessed over 14 days. BLA tissues were collected on day 15 for immunofluorescence staining and Western blot analyses of mGluR5, PI3K, p-PI3K, and ERK1/2 expression. The expression levels of p-PI3K, mGluR5 and ERK1/2 in the BLA of CFA mice were significantly increased, suggesting that their activation was associated with inflammatory pain. DHPG increased the expression of p-PI3K and mGluR5 and ERK1/2 in the CFA mouse brain BLA, while MTEP had the opposite effect. Our results show that mGluR5 regulates inflammatory pain and pain aversion of CFA mice by mediating the ERK/PI3K signaling pathway.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"859 ","pages":"Article 138281"},"PeriodicalIF":2.5,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal valproate exposure alters barrel cortex morphology in rats 产前丙戊酸暴露改变大鼠桶皮质形态。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-05-28 DOI: 10.1016/j.neulet.2025.138277

Diego Méndez , Natalia Uriarte , Marcela Espino , Mauricio Ramos , Federico Lecumberry , Javier Nogueira

{"title":"Prenatal valproate exposure alters barrel cortex morphology in rats","authors":"Diego Méndez , Natalia Uriarte , Marcela Espino , Mauricio Ramos , Federico Lecumberry , Javier Nogueira","doi":"10.1016/j.neulet.2025.138277","DOIUrl":"10.1016/j.neulet.2025.138277","url":null,"abstract":"<div><div>Autism Spectrum Disorder (ASD) is a neurodevelopmental condition influenced by genetic and environmental factors. Prenatal exposure to valproic acid (VPA) has been linked to morphological and behavioral abnormalities resembling ASD symptoms in humans. The whisker somatosensory system in rodents serves as an optimal model for studying ASD-related sensory alterations due to its well-defined modular and somatotopic organization. In this study, we analyzed whisker cortical maps in VPA-exposed rats using cytochrome oxidase histochemistry. Our results revealed significant alterations in the primary somatosensory cortex, including a reduction in total whisker map area and poorly defined cortical barrels. Additionally, some adjacent barrels exhibited fusion, and barrel row curvature was significantly reduced, suggesting disrupted somatotopic organization. These findings align with previous studies in genetic ASD models, such as Mecp2-knockout mice, which show reduced thalamocortical connectivity and structural changes in layer IV neurons. Moreover, recent research suggests that sensory deficits in ASD may also involve dysfunctions in the peripheral nervous system. Our study highlights the relevance of somatosensory cortical map alterations in environmentally induced ASD models. Further investigations into both central and peripheral nervous system contributions could provide valuable insights into the sensory deficits underlying ASD.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"859 ","pages":"Article 138277"},"PeriodicalIF":2.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ferulic acid methylester improves the comorbidity of insomnia and anxiety in a rat model of PCPA-induced sleep disorder by activating DRN 5-HT neurons 阿威酸甲基酯通过激活DRN 5-HT神经元改善pppa诱导的睡眠障碍大鼠模型中失眠和焦虑的共病。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-05-27 DOI: 10.1016/j.neulet.2025.138276

Quntao Li , Jingwen Zhai , Tongyu Du , Junjie He , Jingbin Zhang , Yuhe Tian , Ketao Ma , Junqiang Si , Jiangwen Yin , Yan Li

{"title":"Ferulic acid methylester improves the comorbidity of insomnia and anxiety in a rat model of PCPA-induced sleep disorder by activating DRN 5-HT neurons","authors":"Quntao Li , Jingwen Zhai , Tongyu Du , Junjie He , Jingbin Zhang , Yuhe Tian , Ketao Ma , Junqiang Si , Jiangwen Yin , Yan Li","doi":"10.1016/j.neulet.2025.138276","DOIUrl":"10.1016/j.neulet.2025.138276","url":null,"abstract":"<div><h3>Objective</h3><div>Previous studies have indicated that ferulic acid possesses sedative and hypnotic functions. As a derivative of ferulic acid, ferulic acid methylester (FAM) exhibits stronger activity and lower toxicity than ferulic acid. This study is intended to establish a rat model of insomnia induced by PCPA, with the aim of exploring the improvement effect of FAM on the comorbidity of anxiety and insomnia in PCPA-induced insomnia model rats and its underlying mechanisms.</div></div><div><h3>Methods</h3><div>Insomnia models were established by intraperitoneal injection of 400 mg/kg p-chlorophenylalanine (PCPA) in SD rats. FAM was administered at three doses: 10, 20, and 40 mg/kg. Anxiety levels were assessed using the elevated plus maze and open field tests. Sleep status was evaluated through 24-hour in vivo EEG monitoring. Immunofluorescence staining was used to observe changes in DRN 5-HT neuron activity. Chemogenetic techniques were employed to inhibit DRN 5-HT neurons to elucidate the underlying mechanism.</div></div><div><h3>Results</h3><div>Behavioral tests revealed that FAM at 20 mg/kg significantly reduced anxiety levels <em>(P</em> < 0.001) and increased total sleep time (<em>P</em> < 0.001). EEG recordings showed improved sleep structure, with increased NREM and REM sleep times. Immunofluorescence staining indicated increased activity of DRN 5-HT neurons following FAM treatment. Chemogenetic inhibition of DRN 5-HT neurons reversed the beneficial effects of FAM on anxiety and sleep, thereby confirming the involvement of these neurons in the mechanism of action of FAM.</div></div><div><h3>Conclusions</h3><div>Ferulic acid methylester improves comorbidity of anxiety and insomnia in PCPA-induced insomnia model rats by activating DRN 5-HT neurons.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"859 ","pages":"Article 138276"},"PeriodicalIF":2.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visual mismatch negativity to change of Japanese phonetic script type 视觉错配对日语音标类型变化的消极性

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-05-27 DOI: 10.1016/j.neulet.2025.138279

Kota Suzuki

引用次数: 0

(−)-Epigallocatechin-3-gallate (EGCG) decreases neuronal network excitability and interictal like activity in mouse brain slices （−）-表没食子儿茶素-3-没食子酸酯（EGCG）降低小鼠脑切片中神经元网络的兴奋性和间期样活动

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-05-26 DOI: 10.1016/j.neulet.2025.138274

Hilal Öztürk , Dilanur Köse , Aslı Beyza Bayrakdar , Hümeyra Ayşe Şimşek , Semanur Yıldırım , Selcen Aydin-Abidin , İsmail Abidin

{"title":"(−)-Epigallocatechin-3-gallate (EGCG) decreases neuronal network excitability and interictal like activity in mouse brain slices","authors":"Hilal Öztürk , Dilanur Köse , Aslı Beyza Bayrakdar , Hümeyra Ayşe Şimşek , Semanur Yıldırım , Selcen Aydin-Abidin , İsmail Abidin","doi":"10.1016/j.neulet.2025.138274","DOIUrl":"10.1016/j.neulet.2025.138274","url":null,"abstract":"<div><div>(−)-Epigallocatechin-3-gallate (EGCG), the main flavonoid in green tea, is best known for its antioxidant and anti-inflammatory effects. EGCG interacts with certain ion channels and modulates ionic currents. However, its acute effect on neuronal activity is not known. In the present study, the effects of acute EGCG application on the excitability of neuronal network and epileptiform discharges were investigated. Acute brain slices were used for electrophysiological recordings. 370 µm thick entorhinal-hippocampal horizontal slices were obtained from 7-8 weeks old C57BL/6 mice. 100 µM 4-Aminopyridine (4AP) was used to induce epileptiform activity. Extracellular recordings of epileptiform activities were evaluated in the entorhinal cortex and hippocampus CA1 region. Additionally, the affinity of EGCG on the GABA-A receptor was evaluated in the central nervous system using the molecular docking method. Bath application of 10 μM and 50 μM EGCG reduced interictal event frequency in both entorhinal cortex and hippocampus. EGCG at 50 μM suppressed the absolute power of neuronal oscillations. To be able to explain these effects, we have analysed docking properties of EGCG to GABA-A receptor. The binding energy between EGCG and the GABA-A receptor was calculated as −7.41 kcal/mol. The affinity of EGCG for the GABA-A receptor is satisfactory compared to the reference molecule Diazepam. Findings showed for the first time that the acute application of EGCG had an inhibitory effect on neuronal excitability and also on synchronized events. EGCG might have a potential as a novel anti-seizure molecule.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"859 ","pages":"Article 138274"},"PeriodicalIF":2.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subregion-specific suppression of dopamine D1 receptor expression prevents L-DOPA-induced dyskinesia in a mouse model of Parkinson’s disease 在帕金森病小鼠模型中，亚区域特异性抑制多巴胺D1受体表达可预防左旋多巴诱导的运动障碍

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-05-25 DOI: 10.1016/j.neulet.2025.138273

Keita Sugiyama , Mahomi Kuroiwa , Takahide Shuto , Sehyeon Hwang , Yong-Seok Oh , Akinori Nishi

{"title":"Subregion-specific suppression of dopamine D1 receptor expression prevents L-DOPA-induced dyskinesia in a mouse model of Parkinson’s disease","authors":"Keita Sugiyama , Mahomi Kuroiwa , Takahide Shuto , Sehyeon Hwang , Yong-Seok Oh , Akinori Nishi","doi":"10.1016/j.neulet.2025.138273","DOIUrl":"10.1016/j.neulet.2025.138273","url":null,"abstract":"<div><div>L-DOPA-induced dyskinesia (LID) is a debilitating motor complication that develops following prolonged L-DOPA therapy in patients with Parkinson’s disease (PD). Aberrant activation of dopamine D1 receptor (DRD1) signaling in D1-type/direct pathway medium spiny neurons (MSNs) of the striatum plays a critical role in the pathophysiology of LID. We previously characterized DRD1 signaling in seven striatal subregions and found that upregulation of DRD1 signaling in the intermediate/caudal part (IC) is associated with LID in a mouse model of PD. Here, we investigated whether DRD1 expression in the IC plays a causal role in LID development. Using an adeno-associated virus (AAV) expressing a short hairpin RNA against <em>Drd1</em> (AAV-sh<em>Drd1</em>), we selectively knocked down DRD1 expression in the IC of male mice. In unilateral 6-hydroxydopamine-lesioned mice, DRD1 knockdown in the IC significantly attenuated LID after acute and chronic L-DOPA treatment. In contrast, knockdown in either the rostral or intermediate/rostral part, previously identified as the LID-unrelated subregion, did not affect LID. These findings highlight the essential role of DRD1 and its signaling in the IC in LID development, providing valuable insights for developing novel therapeutic approaches.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"859 ","pages":"Article 138273"},"PeriodicalIF":2.5,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PCC-hippocampal functional connectivity associated with stress biomarker changes after meditation training for healthy adults. 健康成人冥想训练后与应激生物标志物变化相关的pcc -海马功能连通性

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2025-05-23 DOI: 10.1016/j.neulet.2025.138272

Diane Joss, Gunes Sevinc, John W Denninger, Sat Bir Singh Khalsa, Elizabeth A Hoge, Manoj Bhasin, Jeffery A Dusek, Eric Macklin, Towia A Libermann, Gregory L Fricchione, Herbert Benson, Sara W Lazar

{"title":"PCC-hippocampal functional connectivity associated with stress biomarker changes after meditation training for healthy adults.","authors":"Diane Joss, Gunes Sevinc, John W Denninger, Sat Bir Singh Khalsa, Elizabeth A Hoge, Manoj Bhasin, Jeffery A Dusek, Eric Macklin, Towia A Libermann, Gregory L Fricchione, Herbert Benson, Sara W Lazar","doi":"10.1016/j.neulet.2025.138272","DOIUrl":"https://doi.org/10.1016/j.neulet.2025.138272","url":null,"abstract":"<p><p>Meditation training has been shown to improve physical and mental health and promote neural plasticity, but more research is needed on the relationships between these effects. This study analyzed the Resting State Functional Connectivity (RSFC) of posterior cingulate cortex (PCC) among 94 chronically stressed but otherwise healthy adults randomized 1:1:1 to receive eight weeks of in-person one-on-one interventions focused either on meditation (n = 32), yoga (n = 31), or stress education (n = 31). We found only in the meditation arm, there was a significant reduction of PCC RSFC with the left hippocampus (p < 0.05, FWE corrected). Post-intervention changes of PCC-hippocampal RSFC were significantly (all p ≤ 0.01) correlated with changes of perceived stress (r = 0.54), allostatic load index (r = 0.58), and NF-κB anti-inflammatory gene expression (r = -0.55), suggesting the neural effects of meditation are closely associated with biomarkers of physical wellness. No significant changes with PCC RSFC were observed within the yoga or stress education arm, suggesting this neurobiological mechanism might be unique to meditation training.</p>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":" ","pages":"138272"},"PeriodicalIF":2.5,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0