Neuroscience Letters最新文献

{"title":"Retraction notice to \"Neuroprotective and memory enhancing effects of auraptene in a rat model of vascular dementia: Experimental study and histopathological evaluation\" [Neurosci. Lett. 623 (2016) 13-21].","authors":"Mustafa Ghanbarabadi, Mehrdad Iranshahi, Sakineh Amoueian, Soghra Mehri, Vahideh Sadat Motamedshariaty, Seyed Ahmad Mohajeri","doi":"10.1016/j.neulet.2024.138002","DOIUrl":"10.1016/j.neulet.2024.138002","url":null,"abstract":"","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":" ","pages":"138002"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytol exerts sedative-like effects and modulates the diazepam and flumazenil’s action, possibly through the GABAA receptor interaction pathway","authors":"Md. Torequl Islam ,&nbsp;Jannatul Ferdous ,&nbsp;Md. Sakib Al Hasan ,&nbsp;Abu Hashem ,&nbsp;Mehedi Hasan Bappi ,&nbsp;Siddique Akber Ansari ,&nbsp;Md. Amirul Islam ,&nbsp;Md. Saifuzzaman","doi":"10.1016/j.neulet.2024.138007","DOIUrl":"10.1016/j.neulet.2024.138007","url":null,"abstract":"<div><div>This study aimed at the evaluation of the sedative effect of phytol (PHY) with possible molecular mechanisms through <em>in vivo</em> and <em>in silico</em> studies. For this, adult male mice were randomly divided into six individual groups, namely control (vehicle), two standards (DZP: diazepam at 2 m/kg, FLU: flumazenil at 0.1 mg/kg), three test groups (PHY at 25, 50, and 75 mg/kg), and three combined groups with the DZP-2 and/or FLU-0.1 with PHY-75 mg/kg. After thirty minutes, each animal was treated with thiopental sodium (TS) at 40 mg/kg to produce sedation and observed for latency and duration of sleep up to 4 h. <em>In silico</em> studies were performed with the 6X3X protein of the GABA_A receptor α1 and β2 subunits. The results demonstrate that PHY dose-dependently enhanced sleep duration in animals. However, it produced an insignificant sleep duration compared to the control and standard groups. It also significantly (p &lt; 0.05) decreased the latency and increased the duration of sleep with DZP-2, while reducing these parameters with FLU-0.1. In <em>in silico</em> studies, DZP and FLU exhibited binding affinities with 6X3X by −6.8 and −6.9 kcal/mol, respectively, while PHY exhibited −6.9 kcal/mol. Taken together, PHY may exert a sedative-<em>like</em> effect in TS-induced sleeping mice and modulate the effects of DZP and FLU, possibly through interacting with the 6X3X protein of the GABA_A receptor. PHY may be one of the good candidates for the management of sleep disturbances, such as insomnia.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"842 ","pages":"Article 138007"},"PeriodicalIF":2.5,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to \"On the early toxic effect of quinolinic acid: Involvement of RAGE\" [Neurosci. Lett. 474(2) (2010) 74-78].","authors":"Elvis Cuevas, Susan Lantz, Glenn Newport, Becky Divine, Qiangen Wu, Merle G Paule, J César Tobón-Velasco, Syed F Ali, Abel Santamaría","doi":"10.1016/j.neulet.2024.138001","DOIUrl":"https://doi.org/10.1016/j.neulet.2024.138001","url":null,"abstract":"","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":" ","pages":"138001"},"PeriodicalIF":2.5,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Task-based modulation of functional connectivity of dorsal attention network in adult-ADHD","authors":"Baris Metin ,&nbsp;Secil Damla Kayaalp ,&nbsp;Shams Farhad ,&nbsp;Elvan Ciftci ,&nbsp;Buse Gocmen Er ,&nbsp;Nevzat Tarhan","doi":"10.1016/j.neulet.2024.137998","DOIUrl":"10.1016/j.neulet.2024.137998","url":null,"abstract":"<div><div>Recent studies have prompted a shift in the understanding of attention deficit hyperactivity disorder (ADHD) from models positing dysfunction of individual brain areas to those that assume alterations in large-scale brain networks. Despite this shift, the underlying neural mechanism of ADHD in the adult population remains uncertain. With functional magnetic resonance imaging (fMRI), this study examined brain connectivity of dorsal and ventral attention networks. Adults with and without ADHD completed a Go/No-Go task inside the scanner and the functional connectivity of attention networks was analysed. The generalized psychophysiological interaction analysis indicated differences involving the dorsal attention network. For the ADHD group, an interaction effect revealed altered dorsal attention-default mode network connectivity modulation, particularly between the right frontal eye field and posterior cingulate gyrus. We conclude that dorsal attention network dysfunction may be involved in sustained attention deficits in adult-ADHD. This study sheds light into network-level alterations contributing to the understanding of adult-ADHD, which may be a potential avenue for future research and clinical interventions.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"842 ","pages":"Article 137998"},"PeriodicalIF":2.5,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered brain function in treatment-resistant depression patients: A resting-state functional magnetic resonance imaging study","authors":"Weijian Han ,&nbsp;Xiaohui Wu ,&nbsp;Ligang Wang ,&nbsp;Chunhui Qu ,&nbsp;Liqiang Dou ,&nbsp;Yiru Fang ,&nbsp;Ping Sun","doi":"10.1016/j.neulet.2024.138004","DOIUrl":"10.1016/j.neulet.2024.138004","url":null,"abstract":"<div><h3>Background</h3><div>It has been established that there are functional changes in the brain of treatment-resistant depression (TRD) patients, but previous studies of functional connectivity (FC) usually involved selection of regions of interest based on accumulated a priori knowledge of the disorder. In this study, we combine amplitude of low-frequency fluctuation (ALFF) and FC; this approach, based on the abnormal ALFF, may provide some insights into the neural basis of the disease in terms of fMRI signals of low-frequency fluctuations.</div></div><div><h3>Methods</h3><div>A total of 16 TRD patients, who visited the Qingdao Mental Health Center, Shandong Province, China between March 2023 and January 2024, along with 16 normal subjects, were enrolled into this study for functional imaging. In this study, we first explored the ALFF changes of TRD patients at a baseline resting state. Second, we selected the regions that were significantly changed in the ALFF as seeds and calculated the regional activity and functional connectivity (FC) of these regions using a seed-based approach. We also calculated correlations between the percent change in the PDQ-5D scores and ALFF values in brain regions with differing activity for TRD patients.</div></div><div><h3>Results</h3><div>During the baseline resting state, by using the ALFF, we found a significantly decreased or increased ALFF in the TRD patients relative to the controls. These regions were located in the left/right postcentral gyrus (PoCG.L/PoCG.R), right cuneus(CUN.R). We found that the ALFF values of the right hippocampus (HIP.R) in the TRD group were negatively correlated with the PDQ-5D score. Then, we selected these brain regions as seeds to investigate the FC changes in brains of TRD patients. We found abnormal functional connectivity in left/right middle frontal gyrus(MFG.L/MFG.R), the right Inferior frontal gyrus, opercular part (IFGoperc.R), the left/right Anterior cingulate and paracingulate gyri (ACC.L/ACC.R), the right supramarginal gyrus (SMG.R), and the right Calcarine fissure and surrounding cortex (CAL.R).</div></div><div><h3>Conclusion</h3><div>We found a larger range of altered brain regions in TRD patients compared to healthy controls, especially in the central executive network (CEN), salience network (SN) and default mode network (DMN).</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"842 ","pages":"Article 138004"},"PeriodicalIF":2.5,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harmaline attenuates chemotherapy-induced peripheral neuropathy: Modulation of Nrf-2 pathway and NK-1 receptor signaling","authors":"Pankaj Kadyan,&nbsp;Lovedeep Singh","doi":"10.1016/j.neulet.2024.138003","DOIUrl":"10.1016/j.neulet.2024.138003","url":null,"abstract":"<div><div>Peripheral neuropathy, resulting from damage to peripheral nerves, manifests as weakness, numbness, and pain, primarily affecting extremities and significantly impairing quality of life, especially in the elderly. Current treatments often entail severe side effects, necessitating the exploration of alternative therapies. Harmaline, a β-carboline alkaloid derived from <em>Peganum harmala</em>, exhibits promising antioxidant and anti-inflammatory properties. This study aimed to assess the efficacy of harmaline in a vincristine-induced mouse model of peripheral neuropathy. Swiss albino mice received vincristine (0.1 mg/kg, i.p.) for 10 days to induce neuropathy. Harmaline (5 and 10 mg/kg, i.p.) was administered 30 min before vincristine and continued until day 14 to evaluate its protective effects. Behavioral assessments were conducted on days 7 and 14. Vincristine treatment significantly heightened sensitivity to cold, measured by cold plate and acetone drop tests, and to heat, assessed via the hot plate test, while also impairing motor coordination. Biochemical analyses revealed decreased levels of GSH and Nrf-2, alongside elevated TBARS and IL-1β levels in sciatic nerve tissue. Harmaline administration markedly alleviated both behavioral and biochemical alterations induced by vincristine, with the 10 mg/kg dose exhibiting the most pronounced effects. Notably, harmaline treatment elevated GSH and Nrf-2 levels while reducing TBARS and IL-1β. Furthermore, substance-P treatment reversed the protective effects of harmaline, implicating the NK-1 receptor in its mechanism of action. In conclusion, harmaline demonstrates significant potential in mitigating vincristine-induced peripheral neuropathy by reducing oxidative stress through Nrf-2 activation and lowering IL-1β levels, likely via NK-1 receptor inhibition.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"842 ","pages":"Article 138003"},"PeriodicalIF":2.5,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mini-Editorial.","authors":"Pamela E Knapp","doi":"10.1016/j.neulet.2024.137999","DOIUrl":"10.1016/j.neulet.2024.137999","url":null,"abstract":"","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":" ","pages":"137999"},"PeriodicalIF":2.5,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The neural circuit of Superior colliculus to ventral tegmental area modulates visual cue associated with rewarding behavior in optical intracranial Self-Stimulation in mice","authors":"Pei-Yun Li ,&nbsp;Man-Yi Jing ,&nbsp;Xing-Fang Cun ,&nbsp;Ning Wu ,&nbsp;Jin Li ,&nbsp;Rui Song","doi":"10.1016/j.neulet.2024.137997","DOIUrl":"10.1016/j.neulet.2024.137997","url":null,"abstract":"<div><div>Visual system is the most important system of animal to cognize the information in outside world, and reward-related visual cues are the key factors in the consolidation and retrieval of reward memory. However, the neural circuit mechanism is still unclear. Superior Colliculus (SC) receive direct input from the retina and belong to the earliest stages of visual processing. Recent studies identified a specific pathway from SC to ventral tegmental area (VTA) that underlie specific innate behaviors, eg. flight or freezing, approach behaviors and so on. In present research, we investigated that inhibition of SC to VTA circuit with chemogenetics suppressed light cue-associated reward-seeking behaviors, while activation of the SC-VTA circuit with chemogenetic technology triggered the reward-seeking behaviors in optical intracranial self-stimulation for VTA DA neurons (oICSS) in mice. These findings suggest that neural circuit of SC-VTA mediates the retrieval of reward memory associated with visual cues, which will provide a new field for revealing the neural mechanism of pathological memory such as addiction.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"842 ","pages":"Article 137997"},"PeriodicalIF":2.5,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated adult zebrafish as a model for Parkinson’s Disease","authors":"Emmeline Bagwell ,&nbsp;Minhyun Shin ,&nbsp;Nicole Henkel ,&nbsp;Doris Migliaccio ,&nbsp;Congyue Peng ,&nbsp;Jessica Larsen","doi":"10.1016/j.neulet.2024.137991","DOIUrl":"10.1016/j.neulet.2024.137991","url":null,"abstract":"<div><div>Dopamine (DA) is a catecholamine neurotransmitter that works to regulate cognitive functions. Patients affected by Parkinson’s Disease (PD) experience a loss of dopaminergic neurons and downregulated neural DA production. This leads to cognitive and physical decline that is the hallmark of PD for which no cure currently exists. <em>Danio rerio</em>, or zebrafish, have become an increasingly popular disease model used in PD pharmaceutical development. This model still requires extensive development to better characterize which PD features are adequately represented. Furthermore, the great majority of PD zebrafish models have been performed in embryos, which may not be relevant towards age-related human PD. As an improvement, mature <em>D. rerio</em> were treated with neurotoxic prodrug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) through intraperitoneal injection to induce parkinsonism. Behavioral analysis confirmed disparities in movement between saline-injected control and the MPTP-injected experimental group, with swim distance and speed significantly lowered seven days after MPTP injection. Simultaneously, cognitive decline was apparent in MPTP-injected zebrafish, demonstrated by decreased alternation in a y-maze. RT-qPCR confirmed trends consistent with downregulation in Parkinsonian genetic markers, specifically DA transporter (DAT), MAO-B, PINK1. In summary, mature zebrafish injected with MPTP present with similar movement and cognitive decline as compared to human disease. Despite its benefits, this model does not appear to recapitulate pathophysiology of the disease with the full profile of expected gene downregulation. Because of this, it is important that researchers looking for pharmacological interventions for PD only use this zebrafish model when targeting the human-relevant PD symptoms and causes that are represented.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"842 ","pages":"Article 137991"},"PeriodicalIF":2.5,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142323320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships between neuroimaging biomarkers and glymphatic-system activity in dementia with Lewy bodies","authors":"Miho Ota ,&nbsp;Hiroyuki Maki ,&nbsp;Yuji Takahashi ,&nbsp;Yoko Shigemoto ,&nbsp;Yukio Kimura ,&nbsp;Hiroshi Matsuda ,&nbsp;Noriko Sato","doi":"10.1016/j.neulet.2024.137995","DOIUrl":"10.1016/j.neulet.2024.137995","url":null,"abstract":"<div><div>Alpha-synuclein deposits in the brain have been suspected to cause Parkinson’s disease and dementia with Lewy bodies (DLB). It was recently revealed that the glymphatic system is largely responsible for the removal of alpha-synuclein. We investigated changes in the glymphatic system’s activity by determining the DTI‑ALPS (diffusion tensor image analysis along the perivascular space) index in DLB patients. Twenty-six patients with DLB and 43 healthy subjects underwent diffusion tensor imaging (DTI) scanning at our hospital during the period April 2013 to March 2023. We retrospectively computed each subject’s DTI‑ALPS index to evaluate his/her glymphatic-system activity and then analyzed the relationships between the subjects’ DTI‑ALPS index data and their DLB neuroimaging biomarker values. A significant reduction of the DTI‑ALPS index was observed in the patients with DLB compared to the healthy subjects. Significant positive correlations were also detected in the DLB group between the DTI‑ALPS index and the regional gray matter volume in the left insula and between the index and the specific binding ratio of ¹²³I–N-ω-fluoropropyl-2β-carboxymethoxy-3β-(4-iodophenyl)nortropane ([¹²³I]-FP-CIT). These results indicate that (<em>i</em>) the DTI‑ALPS index is a good biomarker of the progression of DLB, and (<em>ii</em>) this index might be effective to distinguish DLB from other neurocognitive disorders.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"842 ","pages":"Article 137995"},"PeriodicalIF":2.5,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}