Neuroscience Letters最新文献_第4页

Retraction notice to “On the early toxic effect of quinolinic acid: Involvement of RAGE” [Neurosci. Lett. 474(2) (2010) 74–78] 关于喹啉酸早期毒性作用的撤稿通知：474(2) (2010) 74-78] 的撤稿通知。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-20 DOI: 10.1016/j.neulet.2024.138001

Elvis Cuevas , Susan Lantz , Glenn Newport , Becky Divine , Qiangen Wu , Merle G. Paule , J. César Tobón-Velasco , Syed F. Ali , Abel Santamaría

引用次数: 0

Retraction notice to “Neuroprotective and memory enhancing effects of auraptene in a rat model of vascular dementia: Experimental study and histopathological evaluation” [Neurosci. Lett. 623 (2016) 13–21] 金合欢烯对血管性痴呆大鼠模型的神经保护和记忆增强作用：实验研究和组织病理学评估》[Neurosci. Lett. 623 (2016) 13-21]。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-20 DOI: 10.1016/j.neulet.2024.138002

Mustafa Ghanbarabadi , Mehrdad Iranshahi , Sakineh Amoueian , Soghra Mehri , Vahideh Sadat Motamedshariaty , Seyed Ahmad Mohajeri

引用次数: 0

Retraction notice to “The endoplasmic reticulum is the main site for caspase-3 activation following aluminum-induced neurotoxicity in rabbit hippocampus” [Neurosci. Lett. 324 (2002) 217–221] 内质网是铝诱导兔海马神经毒性后 Caspase-3 激活的主要部位"[Neurosci. Lett.

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-20 DOI: 10.1016/j.neulet.2024.138000

Othman Ghribi , Mary M. Herman , John Savory

引用次数: 0

Causal brain network analysis of driving fatigue based on generalized orthogonalized partially directed coherence 基于广义正交部分定向相干性的驾驶疲劳因果脑网络分析。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-19 DOI: 10.1016/j.neulet.2024.138057

Daping Chen , Xin Zhou , Wanchao Yao , Fuwang Wang

引用次数: 0

Central administration of galanin-like peptide (GALP) causes short-term orexigenic effects in broilers: Mediatory role of NPY1 and D1 receptors 加拉宁样肽（GALP）的中枢给药会导致肉鸡产生短期促矿物质效应：NPY1 和 D1 受体的中介作用。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-17 DOI: 10.1016/j.neulet.2024.138042

Elham Sanadgol , Morteza Zendehdel , Bita Vazir , Ali Rassouli , Hadi Haghbinnazarpak

{"title":"Central administration of galanin-like peptide (GALP) causes short-term orexigenic effects in broilers: Mediatory role of NPY1 and D1 receptors","authors":"Elham Sanadgol , Morteza Zendehdel , Bita Vazir , Ali Rassouli , Hadi Haghbinnazarpak","doi":"10.1016/j.neulet.2024.138042","DOIUrl":"10.1016/j.neulet.2024.138042","url":null,"abstract":"<div><div>Studies conducted on mammalian models have indicated the role of galanin-like peptide (GALP) in appetite regulation. For the first time, the present study examines the effects of this peptide on feed consumption and behavioral changes, as well as its interaction with dopaminergic and neuropeptide Y (NPY) systems in broilers. In experiment 1, broilers were injected with GALP (0.5, 1, and 2 μg) and saline. In experiment 2, saline, NPY1 receptor antagonist (BIBO-3304), GALP (2 μg), and BIBO-3304 + GALP were administrated. Experiments 3–6 were identical to experiment 2, except that NPY2 receptor antagonist (BIIE 0246), NPY5 receptor antagonist (CGP 71683A), D1 receptor antagonist (SCH39166), and D2 receptor antagonist (L-741,626) were injected instead of BIBO-3304. After that, cumulative meal consumption was recorded for 2 h. Also, behavioral changes in the broilers receiving GALP (0.5, 1, and 2 μg) were monitored for thirty minutes after infusion. Following the administration of GALP (1 and 2 μg), food intake and the number of feeding and exploratory pecks of chicks increased (P < 0.05), while other behaviors did not change significantly (P ≥ 0.05). Co-infusion of BIBO-3304 + GALP suppressed the orexigenic effect of GALP (P < 0.05). Infusion of BIIE 0246, CGP 71683A, and L-741,626 with GALP, had no significant effect on GALP-induced hyperphagia (P ≥ 0.05). However, the orexigenic effects of GALP were stimulated following the co-administration of SCH39166A + GALP (P < 0.05). These findings indicate that NPY1 and D1 receptors can mediate GALP-induced hyperphagia in broilers.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"844 ","pages":"Article 138042"},"PeriodicalIF":2.5,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Type II Diabetes on upper extremity muscle characteristics in older adults II 型糖尿病对老年人上肢肌肉特征的影响。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-15 DOI: 10.1016/j.neulet.2024.138039

Lauren I. Gulley Cox , Nicholas Dias , Chuan Zhang , Yingchun Zhang , Stacey L. Gorniak

{"title":"Effects of Type II Diabetes on upper extremity muscle characteristics in older adults","authors":"Lauren I. Gulley Cox , Nicholas Dias , Chuan Zhang , Yingchun Zhang , Stacey L. Gorniak","doi":"10.1016/j.neulet.2024.138039","DOIUrl":"10.1016/j.neulet.2024.138039","url":null,"abstract":"<div><div>With one in every four older adults living with T2D and one in every two older adults meeting the criteria for prediabetes, neuromuscular changes due to T2D are likely to impact functional activities in this population. Limited work in evaluating motor unit number and size across muscles in the upper extremity in persons with Type II Diabetes (T2D) exists, mostly due to the traditional belief bias that the upper extremity is relatively spared in T2D as compared to the lower extremities. The purpose of the current study was to evaluate motor unit number and size (using electrophysiological motor unit number index (MUNIX) and motor unit size index (MUSIX)) across the upper extremity in older adults with T2D (n = 13) as compared to healthy age- and sex-matched controls (n = 12). Persons with T2D presented with more motor units and larger motor unit sizes (p < 0.05) as compared to age- and sex-matched control participants. These changes were not dependent upon muscle location within a limb, indicating systemic neuromuscular changes associated with T2D. These group effects were clarified when health state covariates (e.g., blood pressure) were accounted for. Findings are consistent with emerging data that show altered neuromuscular characteristics with health state considerations in persons with T2D.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"844 ","pages":"Article 138039"},"PeriodicalIF":2.5,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cinnamaldehyde induces a TRPA1-mediated nociceptive behavior in planarians 肉桂醛诱导扁形动物产生 TRPA1 介导的痛觉行为

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-15 DOI: 10.1016/j.neulet.2024.138041

Rémy Morana, Bénédicte Darbon, Lalee Herrmann, Yannick Menger, Guillaume Reho, Hervé Cadiou

{"title":"Cinnamaldehyde induces a TRPA1-mediated nociceptive behavior in planarians","authors":"Rémy Morana, Bénédicte Darbon, Lalee Herrmann, Yannick Menger, Guillaume Reho, Hervé Cadiou","doi":"10.1016/j.neulet.2024.138041","DOIUrl":"10.1016/j.neulet.2024.138041","url":null,"abstract":"<div><div>Nociception is defined as “the neural process of encoding noxious stimuli” by the International Association for the Study of Pain (IASP). Nociception relies on detecting noxious stimuli arising from a potentially or actually tissue-damaging event via specialized cells called nociceptors. In planarians, nociceptive behavior is often indicated by a ‘scrunching’ gait, in contrast to the usual gliding behavior displayed in normal conditions. The present study extends our previous study Reho et al. (2024) by testing a new potentially irritant molecule, Cinnamaldehyde (CA), which could induce scrunching gaits. We reproduced the nociceptive chemical tests from our previous study using CA instead of Allyl isothiocyanate (AITC) on <em>Girardia dorotocephala</em> (<em>Gd</em>) implementing an open field behavioral analysis. CA induced a dose-dependent increase in scrunching gait similar to the action of AITC and was expectedly partially suppressed by morphine and meloxicam. Knocking down the expression of the Gd-TRPA1 ion channel by RNA interference also suppressed the behavioral reaction to the molecule. In conclusion, we demonstrated that CA induced a nociceptive behavior in planarians through an action on the ion channel TRPA1.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"844 ","pages":"Article 138041"},"PeriodicalIF":2.5,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fatty acid-binding protein 7 gene deletion promotes decreases in brain cannabinoid type 1 receptor binding 脂肪酸结合蛋白 7 基因缺失会导致大脑大麻素 1 型受体结合力下降。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-13 DOI: 10.1016/j.neulet.2024.138040

Huy Lu , Nicole Roeder , Brittany Richardson , John Hamilton , Abhisheak Sharma , Yuji Owada , Yoshiteru Kagawa , Panayotis Thanos

{"title":"Fatty acid-binding protein 7 gene deletion promotes decreases in brain cannabinoid type 1 receptor binding","authors":"Huy Lu , Nicole Roeder , Brittany Richardson , John Hamilton , Abhisheak Sharma , Yuji Owada , Yoshiteru Kagawa , Panayotis Thanos","doi":"10.1016/j.neulet.2024.138040","DOIUrl":"10.1016/j.neulet.2024.138040","url":null,"abstract":"<div><div>Fatty acid-binding protein 7 (FABP7) aids in the intracellular transport of endogenous cannabinoids and is involved in regulating the stress response system. This study examined the role of FABP7 in chronic stress exposure through the binding of CB1 receptors. Adult male FABP7<sup>+/+</sup> and FABP7<sup>-/-</sup> mice were treated with the unpredictable chronic mild stress (UCMS) procedure. After 28 days of treatment, mice were euthanized, and CB1 was measured with in vitro autoradiography using [3H] SR141716A. FABP7<sup>-/-</sup> mice, irrespective of stress treatment, showed reduced [3H] SR141716A binding in the amygdala, secondary somatosensory cortex, and ventral caudate putamen compared with the FABP7<sup>+/+</sup> mice. Additionally, FABP7<sup>-/-</sup> mice treated with UCMS exhibited a reduction in CB1 binding in the globus pallidus and ventral caudate putamen compared with UCMS-treated FABP7<sup>+/+</sup> mice. Genetic deletion of FABP7 can decrease CB1 expression in various brain regions; however, the underlying mechanism remains unclear.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"844 ","pages":"Article 138040"},"PeriodicalIF":2.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimized primary dorsal root ganglion cell culture protocol for reliable K+ current patch-clamp recordings 优化原代背根神经节细胞培养方案，实现可靠的 K+ 电流膜片钳记录。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-12 DOI: 10.1016/j.neulet.2024.138038

Feyza Alyu Altinok , Ilhem Dallali , Abderaouf Boubekka , Ahmed Hasan , Yusuf Ozturk

{"title":"Optimized primary dorsal root ganglion cell culture protocol for reliable K+ current patch-clamp recordings","authors":"Feyza Alyu Altinok , Ilhem Dallali , Abderaouf Boubekka , Ahmed Hasan , Yusuf Ozturk","doi":"10.1016/j.neulet.2024.138038","DOIUrl":"10.1016/j.neulet.2024.138038","url":null,"abstract":"<div><div>DRG primary neuron cultures, derived from rodents, closely mimic properties of sensory neurons <em>in vivo</em> and are highly useful for studying pain and neurological disorders. These cultures are pivotal in patch-clamp electrophysiology for sensory neuron properties analysis. A detailed, replicable protocol in scientific research ensures experiment accuracy and reproducibility. This paper provides comprehensive details for replicating the protocol and achieving consistent results in primary DRG cell culture as used for patch-clamp recordings. We outlined a comprehensive protocol for establishing primary DRG cell culture, optimized for improved gigaseal formation in whole-cell patch-clamp recordings. Additionally, we conducted a simulation study focused on recording macroscopic K<sup>+</sup> channels. The findings established an optimized novel protocol that works reliably for whole-cell patch-clamp recordings and data analysis using primary DRG cells prepared as described in this publication. The details for the protocol in the literature are dispersed across various publications, making it challenging to find a comprehensive summary in one source. This study confirms, for the first time, the efficacy of using fewer protocol steps, which reduces stress and variability in obtaining suitable cells for patch-clamp recordings compared to existing methods in the literature. Given the challenges posed by the dissociation process of primary DRG cells and the importance of comprehensive method documentation in the literature, the protocol presented provides improved and consistent applications of primary DRG cell culture in patch-clamp recordings.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"844 ","pages":"Article 138038"},"PeriodicalIF":2.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repeated human cranial bone-derived mesenchymal stem cell transplantation improved electrophysiological recovery in a spinal cord injury rat model 人类颅骨间充质干细胞的重复移植改善了脊髓损伤大鼠模型的电生理恢复。

IF 2.5 4区医学

Neuroscience Letters Pub Date : 2024-11-08 DOI: 10.1016/j.neulet.2024.138031

Yuyo Maeda , Takafumi Mitsuhara , Masaaki Takeda , Misaki Okamoto , Takashi Otsuka , Takeshi Hara , Masashi Kuwabara , Nobutaka Horie

{"title":"Repeated human cranial bone-derived mesenchymal stem cell transplantation improved electrophysiological recovery in a spinal cord injury rat model","authors":"Yuyo Maeda , Takafumi Mitsuhara , Masaaki Takeda , Misaki Okamoto , Takashi Otsuka , Takeshi Hara , Masashi Kuwabara , Nobutaka Horie","doi":"10.1016/j.neulet.2024.138031","DOIUrl":"10.1016/j.neulet.2024.138031","url":null,"abstract":"<div><div>Mesenchymal stem cell (MSC)-based therapy has been applied in several clinical trials of spinal cord injury (SCI). We have successfully established MSCs from human cranial bone and developed a longitudinal neuromonitoring technique for rodents. In addition to single transplantation, the potential of multiple transplantations has been suggested as a new therapeutic strategy. However, there are no reports on the electrophysiological effects of multiple MSC transplantations in SCI using transcranial electrical stimulation motor-evoked potentials (tcMEPs). Here, we aimed to elucidate the efficacy and mechanism of action of multiple MSC transplantations using tcMEPs. After establishing a weight-drop-induced SCI rat model, we performed repeated intravenous transplantation of human cranial bone-derived MSCs (hcMSCs) on days 1 and 3 post-SCI. Motor function and tcMEP recovery were evaluated 6 weeks post-transplantation. Tissue repair post-SCI was assessed using immunostaining for myelin and neurons in the injured posterior cord. Repeated hcMSC transplantation significantly improved motor function and electrophysiological recovery compared to single transplantation and control treatment. Repeated hcMSC transplantation promoted electrophysiological functional recovery by exerting a protective effect on the functional structure of pyramidal tract axons. Thus, acute-phase repeated transplantation could be a novel and effective therapeutic strategy for the clinical application of MSCs in SCI.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"844 ","pages":"Article 138031"},"PeriodicalIF":2.5,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0