PCC-hippocampal functional connectivity associated with stress biomarker changes after meditation training for healthy adults

IF 2 4区医学 Q3 NEUROSCIENCES

Neuroscience Letters Pub Date : 2025-05-23 DOI:10.1016/j.neulet.2025.138272

Diane Joss , Gunes Sevinc , John W. Denninger , Sat Bir Singh Khalsa , Elizabeth A. Hoge , Manoj Bhasin , Jeffery A. Dusek , Eric Macklin , Towia A. Libermann , Gregory L. Fricchione , Herbert Benson , Sara W. Lazar

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Abstract

Meditation training has been shown to improve physical and mental health and promote neural plasticity, but more research is needed on the relationships between these effects. This study analyzed the Resting State Functional Connectivity (RSFC) of posterior cingulate cortex (PCC) among 94 chronically stressed but otherwise healthy adults randomized 1:1:1 to receive eight weeks of in-person one-on-one interventions focused either on meditation (n = 32), yoga (n = 31), or stress education (n = 31). We found only in the meditation arm, there was a significant reduction of PCC RSFC with the left hippocampus (p < 0.05, FWE corrected). Post-intervention changes of PCC-hippocampal RSFC were significantly (all p ≤ 0.01) correlated with changes of perceived stress (r = 0.54), allostatic load index (r = 0.58), and NF-κB anti-inflammatory gene expression (r = -0.55), suggesting the neural effects of meditation are closely associated with biomarkers of physical wellness. No significant changes with PCC RSFC were observed within the yoga or stress education arm, suggesting this neurobiological mechanism might be unique to meditation training.

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健康成人冥想训练后与应激生物标志物变化相关的pcc -海马功能连通性

冥想训练已被证明可以改善身心健康，促进神经可塑性，但这些影响之间的关系还需要更多的研究。本研究分析了94名慢性压力但其他方面健康的成年人后扣带皮层（PCC）的静息状态功能连接（RSFC），以1:1:1的比例随机分配，接受8周的一对一干预，重点是冥想（ = 32）、瑜伽（ = 31）或压力教育（ = 31）。我们发现，只有在冥想组，左海马的PCC RSFC显著减少(p

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来源期刊

Neuroscience Letters 医学-神经科学

CiteScore

5.20

自引率

0.00%

发文量

408

审稿时长

50 days

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