Diane Joss , Gunes Sevinc , John W. Denninger , Sat Bir Singh Khalsa , Elizabeth A. Hoge , Manoj Bhasin , Jeffery A. Dusek , Eric Macklin , Towia A. Libermann , Gregory L. Fricchione , Herbert Benson , Sara W. Lazar
{"title":"健康成人冥想训练后与应激生物标志物变化相关的pcc -海马功能连通性","authors":"Diane Joss , Gunes Sevinc , John W. Denninger , Sat Bir Singh Khalsa , Elizabeth A. Hoge , Manoj Bhasin , Jeffery A. Dusek , Eric Macklin , Towia A. Libermann , Gregory L. Fricchione , Herbert Benson , Sara W. Lazar","doi":"10.1016/j.neulet.2025.138272","DOIUrl":null,"url":null,"abstract":"<div><div>Meditation training has been shown to improve physical and mental health and promote neural plasticity, but more research is needed on the relationships between these effects. This study analyzed the Resting State Functional Connectivity (RSFC) of posterior cingulate cortex (PCC) among 94 chronically stressed but otherwise healthy adults randomized 1:1:1 to receive eight weeks of in-person one-on-one interventions focused either on meditation (n = 32), yoga (n = 31), or stress education (n = 31). We found only in the meditation arm, there was a significant reduction of PCC RSFC with the left hippocampus (<em>p</em> < 0.05, FWE corrected). Post-intervention changes of PCC-hippocampal RSFC were significantly (all <em>p</em> ≤ 0.01) correlated with changes of perceived stress (<em>r</em> = 0.54), allostatic load index (<em>r</em> = 0.58), and NF-κB anti-inflammatory gene expression (<em>r</em> = -0.55), suggesting the neural effects of meditation are closely associated with biomarkers of physical wellness. No significant changes with PCC RSFC were observed within the yoga or stress education arm, suggesting this neurobiological mechanism might be unique to meditation training.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"864 ","pages":"Article 138272"},"PeriodicalIF":2.0000,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"PCC-hippocampal functional connectivity associated with stress biomarker changes after meditation training for healthy adults\",\"authors\":\"Diane Joss , Gunes Sevinc , John W. Denninger , Sat Bir Singh Khalsa , Elizabeth A. Hoge , Manoj Bhasin , Jeffery A. Dusek , Eric Macklin , Towia A. Libermann , Gregory L. Fricchione , Herbert Benson , Sara W. Lazar\",\"doi\":\"10.1016/j.neulet.2025.138272\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Meditation training has been shown to improve physical and mental health and promote neural plasticity, but more research is needed on the relationships between these effects. This study analyzed the Resting State Functional Connectivity (RSFC) of posterior cingulate cortex (PCC) among 94 chronically stressed but otherwise healthy adults randomized 1:1:1 to receive eight weeks of in-person one-on-one interventions focused either on meditation (n = 32), yoga (n = 31), or stress education (n = 31). We found only in the meditation arm, there was a significant reduction of PCC RSFC with the left hippocampus (<em>p</em> < 0.05, FWE corrected). Post-intervention changes of PCC-hippocampal RSFC were significantly (all <em>p</em> ≤ 0.01) correlated with changes of perceived stress (<em>r</em> = 0.54), allostatic load index (<em>r</em> = 0.58), and NF-κB anti-inflammatory gene expression (<em>r</em> = -0.55), suggesting the neural effects of meditation are closely associated with biomarkers of physical wellness. No significant changes with PCC RSFC were observed within the yoga or stress education arm, suggesting this neurobiological mechanism might be unique to meditation training.</div></div>\",\"PeriodicalId\":19290,\"journal\":{\"name\":\"Neuroscience Letters\",\"volume\":\"864 \",\"pages\":\"Article 138272\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-05-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuroscience Letters\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0304394025001600\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroscience Letters","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0304394025001600","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
PCC-hippocampal functional connectivity associated with stress biomarker changes after meditation training for healthy adults
Meditation training has been shown to improve physical and mental health and promote neural plasticity, but more research is needed on the relationships between these effects. This study analyzed the Resting State Functional Connectivity (RSFC) of posterior cingulate cortex (PCC) among 94 chronically stressed but otherwise healthy adults randomized 1:1:1 to receive eight weeks of in-person one-on-one interventions focused either on meditation (n = 32), yoga (n = 31), or stress education (n = 31). We found only in the meditation arm, there was a significant reduction of PCC RSFC with the left hippocampus (p < 0.05, FWE corrected). Post-intervention changes of PCC-hippocampal RSFC were significantly (all p ≤ 0.01) correlated with changes of perceived stress (r = 0.54), allostatic load index (r = 0.58), and NF-κB anti-inflammatory gene expression (r = -0.55), suggesting the neural effects of meditation are closely associated with biomarkers of physical wellness. No significant changes with PCC RSFC were observed within the yoga or stress education arm, suggesting this neurobiological mechanism might be unique to meditation training.
期刊介绍:
Neuroscience Letters is devoted to the rapid publication of short, high-quality papers of interest to the broad community of neuroscientists. Only papers which will make a significant addition to the literature in the field will be published. Papers in all areas of neuroscience - molecular, cellular, developmental, systems, behavioral and cognitive, as well as computational - will be considered for publication. Submission of laboratory investigations that shed light on disease mechanisms is encouraged. Special Issues, edited by Guest Editors to cover new and rapidly-moving areas, will include invited mini-reviews. Occasional mini-reviews in especially timely areas will be considered for publication, without invitation, outside of Special Issues; these un-solicited mini-reviews can be submitted without invitation but must be of very high quality. Clinical studies will also be published if they provide new information about organization or actions of the nervous system, or provide new insights into the neurobiology of disease. NSL does not publish case reports.