Noise & Health最新文献

{"title":"Application Effect of Comprehensive Noise Reduction Technology in Outpatients with Vitiligo: A Retrospective Study.","authors":"Yong Liu, Jingjing Wang, Jianli Huo, Shaoguang Zhang, Li Han, Yong Lei, Ya'nan Wang","doi":"10.4103/nah.nah_60_23","DOIUrl":"10.4103/nah.nah_60_23","url":null,"abstract":"<p><strong>Objective: </strong>Noise is a kind of perceived public nuisance that is closely related to people's subjective feelings and lives. This study explores the clinical application effect of comprehensive noise reduction technology in outpatients with vitiligo.</p><p><strong>Methods: </strong>A total of 76 patients with vitiligo were selected in the Department of Dermatology at Baoding No. 2 Central Hospital from January 2020 to January 2021, as the control group (CG), receiving 5S management mode, and 80 patients with vitiligo from February 2021 to October 2022 were selected as the study group (SG), receiving comprehensive noise reduction technology combined with the 5S management mode for this retrospective study. The effects of different management modes on these patients were observed.</p><p><strong>Results: </strong>SG had higher nursing quality scores in service attitude, service initiative, communication skills, environmental management and item management and overtly a lower noise level than CG (all P < 0.001). The Hamilton Anxiety Scale (HAMA) scores of the two groups at the end of treatment were significantly lower than those on admission (P < 0.05), with SG showing a lower score than CG (P < 0.001). Correlation analysis showed that noise levels and HAMA scores had a positive correlation (r = 0.423, P < 0.001). Patients with negative feelings about medical treatment caused by various noise sources in SG were obviously less than those in CG (P < 0.05). Both the groups had a statistical difference in overall satisfaction (P < 0.05).</p><p><strong>Conclusion: </strong>The investigation and data analysis demonstrated that comprehensive noise reduction in outpatients with vitiligo had a considerable effect. This technology can standardise the behaviour of medical staff, enhance nursing quality, reduce noise levels and alleviate patients' anxiety and improve their satisfaction. It has great benefits for the outpatient environment and patients.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":"26 120","pages":"37-43"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11141697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140852051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Akson Therapy on Acoustic Parameters in Patients with Functional Dysphonia.","authors":"Honglei Xu, Ben Ye","doi":"10.4103/nah.nah_99_23","DOIUrl":"10.4103/nah.nah_99_23","url":null,"abstract":"<p><strong>Objective: </strong>Functional dysphonia can impair the language expression ability and adversely affect the career development of some patients. Therefore, an active exploration of effective treatment options is imperative. This study investigated the effect of Akson therapy on acoustic parameters in patients with functional dysphonia.</p><p><strong>Materials and methods: </strong>In this retrospective analysis, 79 patients with functional dysphonia who received conventional voice correction training from June 2020 to June 2021 were included in the reference group (RG). Our hospital has implemented Akson therapy since July 2021. Correspondingly, 72 patients with functional dysphonia who underwent Akson therapy from July 2021 to July 2022 were enrolled in the observation group (OG). The acoustic parameters such as fundamental frequency (F0), jitter, shimmer, and normalized noise energy (NNE); the aerodynamic parameters including maximum phonation time (MPT), mean airflow rate (MFR), and Voice Handicap Index-10 (VHI-10) score; and the Grade, Roughness, Breathiness, Asthenia, and Strain scale (GRBAS) score were measured before and after treatment and compared between the two groups.</p><p><strong>Results: </strong>The F0, jitter, shimmer, NNE, MPT, and MFR values as well as the VHI-10 score and the grade (G), roughness (R), and breathiness (B) scores on the GRBAS did not significantly differ between the two groups before treatment (P > 0.05). However, significantly lower F0, jitter, shimmer, NNE, and MFR values and higher MPT levels were found in the OG compared to the RG after treatment (P < 0.001). Furthermore, the VHI-10 score and the G, R, and B scores were significantly lower in the OG than in the RG after treatment (P < 0.001), whereas the asthenia (A) and strain (S) scores remained at 0 before and after treatment.</p><p><strong>Conclusion: </strong>Akson therapy can improve the acoustic parameters of patients with functional dysphonia to a certain extent, indicating its potential application value.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":"26 120","pages":"1-7"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11141702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140868286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Noise Reduction Earplugs in Patients undergoing Total Knee Arthroplasty: A Retrospective Study.","authors":"Xi Wen, Huaixia Yang, Juan Wang","doi":"10.4103/nah.nah_88_23","DOIUrl":"10.4103/nah.nah_88_23","url":null,"abstract":"<p><strong>Background: </strong>Patients undergoing total knee arthroplasty (TKA) need to tolerate the effects of noise.</p><p><strong>Materials and methods: </strong>This study retrospectively analyzed the clinical data of 167 TKA patients at The Affiliated Hospital of Southwest Medical University from April 2019 to April 2021. A total of 154 patients who met inclusion criteria were divided into the conventional noise reduction management group (CMG) and the noise reduction earplug group (EPG), following different management schemes. The CMG received routine noise reduction management after surgery, while the EPG used noise reduction earplugs based on the CMG. The clinical indexes of the two groups were compared.</p><p><strong>Results: </strong>In this study, 79 patients were included in the CMG, and 75 patients were included in the EPG. The results showed that the Pittsburgh Sleep Quality Index (PSQI) scores of both groups 2 weeks after surgery were significantly lower than those before management (ZEPG = 5.995, ZCMG = 4.109, all P < 0.001), and the EPG exhibited a significantly lower PSQI score than the CMG (Z = -2.442, P < 0.05). Two weeks after surgery, the EPG had significantly lower levels of systolic blood pressure (ZSBP = -4.303) and diastolic blood pressure (ZDBP = -3.115), as well as lower scores on the Hospital Anxiety and Depression Scale-Anxiety (HADS-A; ZHADS-A = -7.140) and Hospital Anxiety and Depression Scale-Depression (HADS-D; ZHADS-D = -4.545) compared to the CMG (all P < 0.05). In addition, no significant correlation existed between the duration of wearing earplugs and the HADS-A and HADS-D scores (r = -0.201, r = -0.002, P > 0.05).</p><p><strong>Conclusion: </strong>Noise reduction earplugs can improve sleep quality and regulate negative emotions of patients undergoing TKA treatment through a complex mechanism involving noise, which is beneficial to the prognosis of the disease.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":"26 120","pages":"19-24"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11141701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140850829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation on the Effect of Ward-Noise Reduction Management Combined with Monitoring-Training-Planning Management Mode in Hospitalized Patients with Heart Failure.","authors":"Yuan Xue, Bingqing Lu, Yongming He, Minxia Lu","doi":"10.4103/nah.nah_80_23","DOIUrl":"10.4103/nah.nah_80_23","url":null,"abstract":"<p><strong>Background: </strong>Noise from medical institutions such as hospitals usually exceeds the level recommended by the World Health Organization. This study aimed to explore the application effect of ward-noise reduction management combined with monitoring-training-planning (MTP) management mode in hospitalized patients with heart failure.</p><p><strong>Materials and methods: </strong>Among the 168 research objects, 55 patients with heart failure receiving ward-noise reduction management combined with MTP management mode from April 2022 to March 2023 were included in group A, 52 patients with heart failure who underwent MTP management mode from March 2021 to March 2022 were selected as group B, and 61 patients who underwent routine management measures from March 2020 to February 2021 served as the control group. The vital signs, Self-rating Anxiety Scale (SAS) scores, Self-rating Depression Scale (SDS) scores, physical function indices, sleep quality score, and satisfaction degree of patients in the three groups were compared before and after management.</p><p><strong>Results: </strong>After 1 month of management, group A had lower heart rate, diastolic blood pressure, systolic blood pressure, and respiratory rate compared to group B and the control group (P < 0.001). The SAS score, SDS score, and Pittsburgh Sleep Quality Index score after management in group A were lower than those in group B and the control group (P < 0.001). Group A had a higher 6-Minute Walk Distance than group B and the control group (P < 0.001). Group A had a higher satisfaction degree after management compared to group B (P < 0.01) and the control group (P < 0.001). Group A had lower noise level than group B and the control group (P < 0.001), and there was no significant difference in noise level between group B and the control group (P > 0.05).</p><p><strong>Conclusion: </strong>Ward-noise reduction management combined with MTP management mode can reduce the noise level in the ward and improve the psychological state and sleep quality of patients with heart failure.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":"26 120","pages":"30-36"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11141696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140855577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Levels of Interferon Gamma associated with Hearing Loss and Hearing Loss Sensation through the Handicap Questionnaire Inventory for the Elderly Screening Version.","authors":"Fernanda Prates Cordeiro, Luciana Lozza Moraes Marchiori, Denilson Castro Teixeira, Rodrigo Antonio Carvalho Andraus, Regina Célia Poli","doi":"10.4103/nah.nah_4_23","DOIUrl":"10.4103/nah.nah_4_23","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to verify the association between the auditory handicap found in the Hearing Handicap Inventory for the Elderly-Screening Version (HHIE-S) questionnaire and hearing loss and the plasma levels of inflammatory biomarkers.</p><p><strong>Materials and methods: </strong>Cross-sectional study with 76 participants, 67 (88%) females and 9 (12%) males, with a mean age of 70 years. Tonal threshold audiometry and self-assessment with HHIE-S questionnaire were performed to measure the plasma levels of interleukin-2 (IL-2), IL-4, IL-6, and IL-10; tumor necrosis factor alpha; and interferon gamma (IFN-γ) flow cytometry method. For all data analyzed, the significance level adopted was P < 0.05 and 95% confidence interval.</p><p><strong>Results: </strong>An inverse correlation was observed between the increase in plasma levels of IFN-γ and normal auditory handicap (P = 0.015; rs = -0.280). The severe handicap group showed an increase in the averages I (P = 0.005; rs = 0.350) and II (P = 0.016; rs = 0.368) in the right ear and the light/moderate handicap group increased the means I (P = 0.027; rs = 0.350) and II (P = 0.046; rs = 0.310) of the left ear. A statistically significant association was found between the speech recognition threshold (SRT) test results of the right ear and the severe handicap group (P = 0.002; rs = 0.271).</p><p><strong>Conclusions: </strong>There was an association between the increase in plasma levels of IFN-γ and normal auditory handicap. Additionally, statistically significant associations were observed between the mild/moderate and severe handicap groups with the increase in hearing means and an increase in SRT associated with the severe handicap group.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":"26 120","pages":"44-50"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11141700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140857489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized Music Therapy for Elderly Patients with Chronic Renal Failure to Improve their Quality of Life and Mental Health: A Retrospective Study.","authors":"Ling Wang, Panpan Liu, Xin He","doi":"10.4103/nah.nah_94_23","DOIUrl":"10.4103/nah.nah_94_23","url":null,"abstract":"<p><strong>Background: </strong>Chronic renal failure (CRF) poses significant clinical risks. Therefore, attention should be paid to the daily nursing of such patients, and better clinical nursing programs should be provided.</p><p><strong>Methods: </strong>The data of 120 patients with CRF at Yantai Yuhuangding Hospital from March 2020 to March 2022 were retrospectively analyzed. After 8 patients were excluded, 112 patients were finally included in this study. The included patients were divided into group A (58 patients receiving clinical routine nursing) and group B (54 patients receiving clinical routine nursing and personalized music) according to different nursing schemes. The anxiety level, depression level, quality of life (QOL), and clinical satisfaction of the patients in both groups were compared before and after nursing.</p><p><strong>Results: </strong>Before the implementation of nursing, no significant difference existed in the levels of anxiety, depression, and QOL between the two groups (P > 0.05). After nursing, group B had significantly lower levels of anxiety and depression and significantly higher QOL than group A (P < 0.001). No significant difference in clinical nursing satisfaction was found between the two groups (P > 0.05).</p><p><strong>Conclusion: </strong>The implementation of personalized music can improve the QOL and psychological states of patients, with clinical application value.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":"26 120","pages":"8-13"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11141698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140861364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization and Prediction of Speech Intelligibility at the Output of Hearing Aids in a Noisy Working Environment.","authors":"Antoine Malrin, Joël Ducourneau, Patrick Chevret","doi":"10.4103/nah.nah_8_23","DOIUrl":"10.4103/nah.nah_8_23","url":null,"abstract":"<p><strong>Objective: </strong>Hearing aids are more and more technically advanced, but do not necessarily guarantee the reproduction of useful signals in all working environments. This is particularly the case for speech intelligibility. This study focuses on the prediction of hearing aid performance in the case of a moderate deafness setting, in service and industrial work environments. To improve intelligibility, hearing aids propose signal processing options such as noise reduction and compression. These processes can transform hearing aids into nonlinear systems. The aim of this study is to develop a nonlinear method for the characterization of hearing aids.</p><p><strong>Materials and methods: </strong>The method is based on the synchronized swept sine (SSS) signal method.^[16] The SSS method is applied for determining hearing aid frequency responses fitted according to the present methodology and several processing options. The characterization of hearing aid's program containing the noise reduction function is specifically analyzed. Indeed, to be fully active and efficient, the hearing aid, with the noise reduction feature activated, needs to be immersed in a noisy environment which does not allow nonlinear characterization. A linear approach is taken to study this feature. Three hearing aids commonly sold by hearing care professionals are studied here; all of them have three different programs. The characterization for each program is discussed.</p><p><strong>Results: </strong>The statistical study showed that the intelligibility, assessed using the speech transmission index in these sound environments, is well estimated for every program, although certain differences are observed when the compression effect is too high in the service work sector.</p><p><strong>Conclusion: </strong>The characterizations of hearing aids using the programs studied did not highlight the presence of frequency nonlinearities. The characterization method could not take into account amplitude nonlinearities when there is too much gain compression in the hearing process. Globally, all the hearing aid programs provided a very significant improvement in intelligibility in service and industrial work contexts.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":"25 118","pages":"183-194"},"PeriodicalIF":0.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10747809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41183248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between the Degree of Hearing Loss and the Levels of Anxiety and Depression in Patients with Tinnitus.","authors":"Lin Zhang, Huanle Du, Huihua You","doi":"10.4103/nah.nah_46_23","DOIUrl":"10.4103/nah.nah_46_23","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to explore the correlation between the degree of hearing loss (HL) and the degrees of anxiety and depression in patients with tinnitus.</p><p><strong>Materials and methods: </strong>This retrospective study involved the use of basic clinical data from 600 enrolled patients with tinnitus who visited the otolaryngology clinic in Affiliated Jinhua Hospital, Zhejiang University School of Medicine from April 2020 to June 2022. The tinnitus handicap inventory (THI) scale was used to assess the tinnitus status among the participants. The pure tone audiometry (PTA) test was used to conduct audiological assessments for all patients to determine their hearing condition. The self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used to assess the levels of anxiety and depression among the participants, respectively. The correlation between the HL and anxiety/depression scores from the questionnaires was tested through Pearson correlation analysis.</p><p><strong>Results: </strong>Among the 600 enrolled patients with tinnitus, most patients had mild-to-moderate degree of tinnitus, accounting for 248 cases (41.3%) and 179 cases (29.8%), respectively. PTA results showed that a large proportion of patients with tinnitus were accompanied with HL (467 cases, 77.8%). Among them, patients with mild HL accounted for the largest proportion with a total of 241 cases (40.2%). Based on the results of SAS and SDS test, almost half of the patients had symptoms of anxiety and depression, accounting for 52.3% (314 cases) and 48.8% (293 cases), respectively. Similarly, patients with mild anxiety and depression occupy the largest proportion, accounting for 35.8% (215 cases) and 23% (138 cases), respectively. Pearson correlation analysis showed that the degree of HL was closely related to THI/SAS/SDS scores (P < 0.001).</p><p><strong>Conclusion: </strong>These findings indicate a strong positive correlation between the degree of HL and anxiety/depression scores in patients with tinnitus.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":"25 118","pages":"195-201"},"PeriodicalIF":0.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10747803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41183249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personal Listening Device Use and Attitude to Noise in Relation to Depression and Anxiety among Medical Students.","authors":"Jelena Ilić Živojinović, Ivan Soldatović, Dušan Backović, Danka Vukašinović, Silvana Babić, Milena Tomanić, Branislav Ilić, Željko Vlaisavljević","doi":"10.4103/nah.nah_27_23","DOIUrl":"10.4103/nah.nah_27_23","url":null,"abstract":"<p><strong>Background: </strong>High levels of environmental noise may lead to psychological symptoms. The present study has hypothesized that personal listening device (PLD) use and a negative attitude to noise are significantly related to anxiety and/or depression.</p><p><strong>Methods: </strong>This is a cross-sectional study conducted on 431 six-grade students (35% male) at the Faculty of Medicine, University of Belgrade. All students completed the questionnaires related to socio-demographic data, noise/music exposure habits, behaviors related to PLD use, tinnitus, headaches, consumption of alcohol, coffee, energy drinks and cigarettes, YANS (Youth Attitude to Noise Scale), CES-D (The Center for Epidemiologic Studies Depression), and GAD-7 (Generalised Anxiety Disorder Assessment - 7 item scale) questionnaires.</p><p><strong>Results: </strong>There were 396 (91.9%) of investigated students who used PLD, with more frequent use among girls compared to boys (95.0% and 86.8%, respectively; p = 0.002). We found no significant relationship between the frequency of PLD use and depression and anxiety. However, continuous daily PLD use longer than 1 hour was significantly and positively related to depression (p = 0.006). Students with depression had a lower total YANS score compared to those without depression, indicating a more negative attitude toward noise (p = 0.042). Students with no difficulties to concentrate in noise and with a positive attitude to daily noises had about 37% lower chance to suffer from depression and anxiety, respectively.</p><p><strong>Conclusions: </strong>PLD use is common among medical students and may be associated with their mental health. Longer than 1 hour of continuous daily use of PLD may be positively related to depression. We also found a significant relationship between difficulties concentrating in noisy environments and depression, and between negative attitudes to daily noises and anxiety.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":"25 118","pages":"176-182"},"PeriodicalIF":0.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10747810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41183252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Genes, Lifestyles, and Noise Kurtosis on Noise-Induced Hearing Loss.","authors":"Xiaoyu Yin, Zheng Li, Tianyu Zhao, Lei Yang","doi":"10.4103/nah.nah_65_22","DOIUrl":"10.4103/nah.nah_65_22","url":null,"abstract":"<p><strong>Objective: </strong>To explore the association of lifestyles, caspase gene (CASP), and noise kurtosis with noise-induced hearing loss (NIHL).</p><p><strong>Design: </strong>Three hundred seven NIHL individuals and 307 matched controls from factories in Chinese factories participated in this case-control study. Age, sex, noise exposure, exfoliated oral mucosa cells, and lifestyles of participants were gathered by the authors. The single nucleotide polymorphisms (SNPs) were genotyped using the Kompetitive Allele Specific polymerase chain reaction (KASP) method.</p><p><strong>Results: </strong>The risk of NIHL was higher for people who worked in the complex noise environment than for people exposed to steady noise environment (adjusted: OR = 1.806, P = 0.002). Smoking and regular earphone use increased the risk of NIHL (adjusted: OR = 1.486, P = 0.038). The GG genotype of the recessive model and G allele in rs1049216, together with the TT genotype of the recessive model in rs6948 decreased the NIHL risk (adjusted: OR = 0.659, P = 0.017). Oppositely, the AA genotype of additive model in rs12415607 had a higher NIHL risk (adjusted: OR = 1.804, P = 0.024). In the additive models, there was a positive interaction between noise kurtosis and CASP3 polymorphisms (RERI = 1.294, P = 0.013; RERI = 1.198, P = 0.031).</p><p><strong>Conclusions: </strong>Noise kurtosis, three SNPs (rs1049216, rs6948, and rs12415607), smoking and earphone use were found to be related to NIHL, and there was a positive interaction between noise kurtosis and CASP3. Results from this study can be used to prevent and detect NIHL and for genetic testing.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":"25 118","pages":"143-157"},"PeriodicalIF":0.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10747805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41183250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}