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Application of Music Therapy in Improving Sleep Quality and Psychological Health of Pregnant Women with Hypertension: A Retrospective Study. 应用音乐疗法改善高血压孕妇的睡眠质量和心理健康:一项回顾性研究。
IF 1.3 4区 医学
Noise & Health Pub Date : 2024-07-01 Epub Date: 2024-09-30 DOI: 10.4103/nah.nah_58_24
Yun Rong, Jingwen Jiang, Xueling Zhang, Yuntao Bu
{"title":"Application of Music Therapy in Improving Sleep Quality and Psychological Health of Pregnant Women with Hypertension: A Retrospective Study.","authors":"Yun Rong, Jingwen Jiang, Xueling Zhang, Yuntao Bu","doi":"10.4103/nah.nah_58_24","DOIUrl":"10.4103/nah.nah_58_24","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the study was to retrospectively study the effect of music therapy on sleep quality and mental health level of pregnant women with hypertension in pregnancy (HIP).</p><p><strong>Methods: </strong>A total of 188 pregnant women with gestational hypertension admitted to The Fourth Hospital of Shijiazhuang from January 2022 to January 2023 were selected as the research objects. Based on various management methods documented in the medical record system, the individuals were divided into a control group (n = 88, routine management) and an observation group (n = 100, routine management + music therapy). The State-Trait Anxiety Inventory (STAI), Athens Insomnia Scale (AIS), and pregnancy outcomes were compared between the two groups.</p><p><strong>Results: </strong>No significant difference in the STAI and AIS scores before treatment was found between the two groups on admission (P > 0.05). The AIS and STAI scores in the observation group were lower than those in the control group 2 days after delivery (P < 0.05). The total incidence of adverse pregnancy outcomes in the observation group (8.00%) was lower than that in the control group (11.37%), but no significant difference between the two groups (P > 0.05).</p><p><strong>Conclusions: </strong>The implementation of music therapy for patients with HIP can alleviate their negative emotions to a certain extent and can improve sleep, offering certain clinical promotion value.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of Therapeutic Options for Noise-Induced Hearing Loss: Retroauricular Injection of Methylprednisolone Sodium Succinate Combined with Hyperbaric Oxygenation. 噪声性听力损失的治疗方案分析:耳后注射甲泼尼龙琥珀酸钠与高压氧相结合。
IF 1.3 4区 医学
Noise & Health Pub Date : 2024-07-01 Epub Date: 2024-09-30 DOI: 10.4103/nah.nah_60_24
Yan Yao, Lei Li
{"title":"Analysis of Therapeutic Options for Noise-Induced Hearing Loss: Retroauricular Injection of Methylprednisolone Sodium Succinate Combined with Hyperbaric Oxygenation.","authors":"Yan Yao, Lei Li","doi":"10.4103/nah.nah_60_24","DOIUrl":"10.4103/nah.nah_60_24","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical effect of retroaural injection of methylprednisolone sodium succinate combined with hyperbaric oxygen (HBO) on the treatment of noise-induced hearing loss.</p><p><strong>Methods: </strong>Case data of 220 patients with hearing loss treated at the Zhongda Hospital Southeast University from January 1, 2019 to August 1, 2023 were obtained. As per the treatment plan, the recruited patients were divided into two cohorts: 158 cases in the combined-treatment group (retroaural injection of methylprednisolone sodium succinate combined with HBO) and 62 cases in the single-hormone group (retroaural injection of methylprednisolone sodium succinate). Comparison of the clinical efficacies and postoperative complication rates of the two groups was performed after treatment. MS-Excel was used to build a database for all data, and SPSS26.0 was utilized in the statistical analysis of recorded data.</p><p><strong>Results: </strong>For patients with low-frequency, high-frequency, and flat descending type, the combined-treatment group showed significantly higher clinical effective rate than the single-hormone group (P < 0.05). For patients with disease duration ≤7 days, the combined-treatment group attained a significantly higher clinical effective rate was than the single-hormone group (P < 0.05). The safety of patients in both groups was evaluated mainly through their adverse reactions. The total incidence of adverse reactions in the single-hormone group reached 9.68%, and that in the combined-treatment group was 8.23%. The two groups revealed no significant difference in terms of incidence of adverse reactions (P > 0.05).</p><p><strong>Conclusion: </strong>HBO combined with retroaural injection of methylprednisolone sodium succinate has good clinical efficacy and safety in the treatment of hearing loss.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Five-Element Music Stimulation in Perioperative Period on Sleep Status and Psychological Regulation in Patients Undergoing Orthopedic Surgery. 围术期五元素音乐刺激对骨科手术患者睡眠状态和心理调节的影响
IF 1.3 4区 医学
Noise & Health Pub Date : 2024-07-01 Epub Date: 2024-09-30 DOI: 10.4103/nah.nah_77_24
Zhihui Ren, Yanwen Xue
{"title":"Effects of Five-Element Music Stimulation in Perioperative Period on Sleep Status and Psychological Regulation in Patients Undergoing Orthopedic Surgery.","authors":"Zhihui Ren, Yanwen Xue","doi":"10.4103/nah.nah_77_24","DOIUrl":"10.4103/nah.nah_77_24","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to explore the effect of five-element music therapy on sleep status during perioperative period and psychological regulation in patients undergoing orthopedic surgery.</p><p><strong>Methods: </strong>The medical records of patients who underwent orthopedic surgery from March 2021 to December 2023 in the Gansu Provincial Hospital of Traditional Chinese Medicine were retrospectively analyzed. Patients were divided into two groups in accordance with the nursing time period. The control group (88 patients) received routine nursing, and the observation group (78 patients) received five-element music management in the perioperative period based on routine nursing. The management time was from admission to one week after surgery, with 30 min/times, TID. The sleep, physical signs, pain condition, and anxiety status of the two groups were compared on admission, before surgery, and one week after surgery.</p><p><strong>Results: </strong>On admission, no significant difference in the scores of the Pittsburgh Sleep Quality Index (PSQI), the pain rating index (PRI), and the Self-Rating Anxiety Scale (SAS) was found between the two groups (P > 0.05). Before and one week after surgery, the PSQI, PRI, and SAS scores of the observation group were significantly lower than those of the control group (P < 0.001). No significant difference was found in systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) between the two groups on admission and one week after surgery (P > 0.05). Before surgery, the observation group had significantly lower indices of SBP, DBP, and HR than the control group (P < 0.05).</p><p><strong>Conclusion: </strong>Five-element music stimulation in the perioperative period can improve the pain and anxiety of patients undergoing orthopedic surgery and enhance their sleep status.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11540001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Comprehensive Noise Reduction Management on the Postoperative Negative Emotion, Stress Response Hormone and Sleep Status of Burn Patients: Single-Centre Retrospective Analysis. 综合降噪管理对烧伤患者术后负面情绪、应激反应激素和睡眠状态的影响:单中心回顾性分析。
IF 1.3 4区 医学
Noise & Health Pub Date : 2024-07-01 Epub Date: 2024-09-30 DOI: 10.4103/nah.nah_80_24
Zhuo Dai, Xiaojiao Cheng, Fang Chen
{"title":"Effect of Comprehensive Noise Reduction Management on the Postoperative Negative Emotion, Stress Response Hormone and Sleep Status of Burn Patients: Single-Centre Retrospective Analysis.","authors":"Zhuo Dai, Xiaojiao Cheng, Fang Chen","doi":"10.4103/nah.nah_80_24","DOIUrl":"10.4103/nah.nah_80_24","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to explore the effect of comprehensive noise reduction management on the postoperative recovery of burn patients.</p><p><strong>Methods: </strong>Data of 156 patients admitted to Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University from October 2022 to July 2023 were retrospectively analysed. The patients were divided into two groups according to the management method: group A (n = 76, standard care of burns) and group B (n = 80, standard care of burns+comprehensive noise reduction management). The stress response level, anxiety and depression level, sleep quality and satisfaction of the two groups were compared before and after the management.</p><p><strong>Results: </strong>Before the management, no statistically significant differences in cortisol (Cor), anxiety and depression scores and sleep quality were found between the two groups (P > 0.05). After the management, significant differences in Cor, anxiety scores, sleep quality and patient satisfaction were observed between the two groups (P < 0.001).</p><p><strong>Conclusions: </strong>Comprehensive noise reduction management can reduce postoperative stress hormone levels, alleviate negative emotions, such as anxiety, and improve sleep quality and patient satisfaction.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Noise Management in Interventional Radiology Suites on Patients Undergoing Transarterial Chemoembolization: A Retrospective Study. 介入放射科手术室噪音管理对经动脉化疗栓塞术患者的影响:回顾性研究。
IF 1.3 4区 医学
Noise & Health Pub Date : 2024-07-01 Epub Date: 2024-09-30 DOI: 10.4103/nah.nah_53_24
Yong Lu, Lingyu Ma, Zhuo Chen, Hui Qi, Zhaotian Gu, Lei Wu, Benfang Fan
{"title":"Effect of Noise Management in Interventional Radiology Suites on Patients Undergoing Transarterial Chemoembolization: A Retrospective Study.","authors":"Yong Lu, Lingyu Ma, Zhuo Chen, Hui Qi, Zhaotian Gu, Lei Wu, Benfang Fan","doi":"10.4103/nah.nah_53_24","DOIUrl":"10.4103/nah.nah_53_24","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the effect of noise management in interventional radiology suites on patients undergoing transarterial chemoembolization (TACE).</p><p><strong>Methods: </strong>A retrospective cohort study design was employed. The study included a total of 141 patients with hepatocellular carcinoma who underwent TACE surgery in interventional radiology suite of the First People's Hospital of Nantong from January 2022 to December 2022. The patients were divided into an observation group (received noise management, n = 70) and a control group (did not receive noise management, n = 71) on the basis of whether they received noise management. Patient demographics and surgical data were collected, and heart rate, blood pressure, and anxiety levels were assessed before, during and after surgery. Satisfaction and the incidence of adverse reactions were also documented.</p><p><strong>Results: </strong>No significant differences were found in general characteristics. The comparison between the observation and control groups revealed statistically significant differences in noise levels (P < 0.001). Additionally, anxiety levels significantly differed between the two groups (P = 0.040) as well as across different time points (P < 0.001). However, no significant difference was found in the occurrence of adverse events between groups (P = 0.772). Furthermore, patient satisfaction was significantly higher in the observation group than that in the control group (P < 0.001). Although no significant differences were found in heart rate and systolic blood pressure between groups (P > 0.05), and a significant main effect of time was observed for both variables (P < 0.001).</p><p><strong>Conclusion: </strong>Noise management in the interventional radiology suite effectively alleviates intraoperative anxiety among patients with TACE and improves treatment satisfaction but has no significant effect on physiological changes and the incidence of adverse events.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11540005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the Therapeutic Effectiveness of Music Therapy in Post-Laparoscopic Ovarian Cystectomy Patients: A Single-Center Retrospective Study. 评估音乐疗法对腹腔镜卵巢囊肿切除术后患者的治疗效果:单中心回顾性研究
IF 1.3 4区 医学
Noise & Health Pub Date : 2024-07-01 Epub Date: 2024-09-30 DOI: 10.4103/nah.nah_120_23
Feng Wang, Hui Fu
{"title":"Evaluating the Therapeutic Effectiveness of Music Therapy in Post-Laparoscopic Ovarian Cystectomy Patients: A Single-Center Retrospective Study.","authors":"Feng Wang, Hui Fu","doi":"10.4103/nah.nah_120_23","DOIUrl":"10.4103/nah.nah_120_23","url":null,"abstract":"<p><strong>Background: </strong>The therapeutic effects of music therapy on improving negative emotions and reducing pain are increasingly acknowledged. However, limited clinical research exists on its use in patients post-laparoscopic ovarian cystectomy (LOC).</p><p><strong>Materials and methods: </strong>A total of 147 patients undergoing LOC at our hospital were evaluated. Patients were divided based on the implementation time of music therapy: group A (72 patients, October 2020 to October 2021) received standard clinical treatment, while group B (75 patients, November 2021 to November 2022) received music therapy alongside routine care. The baseline data of patients and the scores of the Short-Form McGill Pain Questionnaire (SF-MPQ), Perceived Stress Scale (PSS), Beck Anxiety Inventory (BAI), and Patient Satisfaction Questionnaire were collected. Pain and psychological stress levels were compared on the first postoperative day and at discharge to assess the clinical value of each treatment approach.</p><p><strong>Results: </strong>Group B exhibited significantly lower PSS, SF-MPQ, and BAI scores (P < 0.001 for all) and higher overall satisfaction at discharge (P < 0.001). These findings suggest that music therapy can reduce psychological stress, decrease pain levels, and improve mood in patients undergoing LOC.</p><p><strong>Conclusion: </strong>This study demonstrates that music therapy positively rehabilitates patients after LOC, offering new insights for future clinical treatment strategies.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastrodin Ameliorates Learning and Memory Impairments Caused by Long-Term Noise Exposure. 天麻素能改善长期暴露于噪音环境造成的学习和记忆障碍
IF 1.3 4区 医学
Noise & Health Pub Date : 2024-07-01 Epub Date: 2024-09-30 DOI: 10.4103/nah.nah_76_24
Lin Wu, Ying Liu, Hu Zhou, Zhenzhen Cao, Jianyun Yu
{"title":"Gastrodin Ameliorates Learning and Memory Impairments Caused by Long-Term Noise Exposure.","authors":"Lin Wu, Ying Liu, Hu Zhou, Zhenzhen Cao, Jianyun Yu","doi":"10.4103/nah.nah_76_24","DOIUrl":"10.4103/nah.nah_76_24","url":null,"abstract":"<p><p>The developing brain is significantly affected by long-term exposure to noise at an early age, leading to functional disorders such as learning and memory impairments. Gastrodin (GAS), a natural organic compound, is an extraction of phenolic glycoside from the rhizome of Gastrodia elata. Clinically, GAS is extensively utilised for the treatment of neurological disorders. This study aimed to explore the effect and mechanism of GAS on noise exposure-induced learning and memory impairments. Rats aged 21 days were exposed to a 90 dB noise environment for 4 weeks and divided into the noise group, the noise + GAS group, and the control group to establish a noise exposure model. After noise exposure treatment, the improvement effect of GAS on the memory of rats was evaluated by Y-maze and Morris water maze. Enzyme-linked immunosorbent assay was utilised to determine the effect of GAS on neurotransmitter levels in the hippocampal tissue of noise-exposed rats. Western blot was applied for the detection of the protein levels of neurotrophic factors. The GAS treatment significantly improved spatial memory and increased the levels of key neurotransmitters (norepinephrine, dopamine and serotonin) and neurotrophic factors (neurotrophin-3 and brain-derived neurotrophic factor) in the hippocampal tissues of noise-exposed rats. These alterations correlate with enhanced cognitive functions, suggesting a neuroprotective effect of GAS against noise-induced cognitive impairments. This study supports the potential of GAS to treat noise-induced learning and memory impairments by modulating neurotransmitter secretion and enhancing the expression levels of neurotrophic factors. These findings offer potential therapeutic avenues for cognitive impairments induced by noise exposure.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11540004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Noise is a Risk Factor for Patients with Ulcerative Colitis and Anxiety. 噪音是溃疡性结肠炎和焦虑症患者的一个风险因素。
IF 1.3 4区 医学
Noise & Health Pub Date : 2024-07-01 Epub Date: 2024-09-30 DOI: 10.4103/nah.nah_51_24
Jiao Zhu, Xiaoyang Ren, Shuixiang He, Chen Mi, Li Zhang, Dan Zhou, Miaosha Luo
{"title":"Noise is a Risk Factor for Patients with Ulcerative Colitis and Anxiety.","authors":"Jiao Zhu, Xiaoyang Ren, Shuixiang He, Chen Mi, Li Zhang, Dan Zhou, Miaosha Luo","doi":"10.4103/nah.nah_51_24","DOIUrl":"10.4103/nah.nah_51_24","url":null,"abstract":"<p><strong>Background: </strong>This work aimed to explore anxiety-associated risk factors in patients diagnosed with ulcerative colitis (UC).</p><p><strong>Methods: </strong>Clinical data from patients diagnosed with UC and hospitalized at the First Affiliated Hospital of Xi'an Jiaotong University between May 2019 and June 2022 were retrospectively analyzed. A total of 260 patients were included and divided into UC with anxiety (n = 86) and UC without anxiety (n = 174) groups according to the Self-Rating Anxiety Scale score. The quality of life and disease activity in patients with UC were assessed using the Inflammatory Bowel Disease Questionnaire and Mayo Score, respectively. Clinical data, disease characteristics, quality of life, disease activity, and noise exposure were compared between the groups, and factors contributing to anxiety in patients with UC were explored through multivariate logistic regression analysis.</p><p><strong>Results: </strong>No significant difference was found between the groups in terms of disease duration (P = 0.73), distribution of disease (P = 0.86), or medication use (P = 0.86). However, compared to UC patients without anxiety, those with anxiety were older (P < 0.05), predominantly female (P < 0.05), had lower quality of life (P < 0.05), experienced higher disease activity (P < 0.05), and had greater noise exposure (P < 0.05). The quality of life [odds ratio (OR) = 0.558, 95% confidence interval (CI) = 0.348-0.895, P = 0.02] was a protective factor for anxiety in patients with UC. Disease activity (OR = 1.680, 95% CI = 1.103-2.561, P = 0.02) and noise exposure (OR = 2.148, 95% CI = 1.084-4.106, P = 0.01) were significant risk factors for anxiety in patients with UC.</p><p><strong>Conclusion: </strong>Noise exposure and disease activity were associated with an increased risk of anxiety in patients with UC, whereas higher quality of life was protective against anxiety in UC patients.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Noise Exposure Promotes Alzheimer's Disease-Like Lesions and DNA Damage. 噪音会促进阿尔茨海默病样病变和 DNA 损伤
IF 1.3 4区 医学
Noise & Health Pub Date : 2024-07-01 Epub Date: 2024-09-30 DOI: 10.4103/nah.nah_26_24
Xiao-Jie Dai, Jun-Hua Liao, Yi Jia, Rui Cao, Mei-Ning Zhou
{"title":"Noise Exposure Promotes Alzheimer's Disease-Like Lesions and DNA Damage.","authors":"Xiao-Jie Dai, Jun-Hua Liao, Yi Jia, Rui Cao, Mei-Ning Zhou","doi":"10.4103/nah.nah_26_24","DOIUrl":"10.4103/nah.nah_26_24","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to explore the mechanism by which noise contributes to the development of Alzheimer's disease (AD)-like lesions.</p><p><strong>Method: </strong>Male Wistar rats (24 months) were allocated into two groups (n = 6 per groups): a noise group exposed to 98 dB sound pressure-level white noise for 4 hours daily from 8:00 to 12:00 for 30 days, and a control group without noise exposure. The cognitive functions of the rats were assessed using new-object recognition and Morris water maze tests. Then, hippocampal tissues were collected, and the levels of amyloid β 1-42 (Aβ1-42), Aβ1-40, brain-derived neurotrophic factor (BDNF), and tropomyosin receptor kinase B (TrkB) were measured using enzyme-linked immunosorbent assay (ELISA). Protein expression was evaluated through Western blot.</p><p><strong>Results: </strong>Noise exposure significantly impaired cognitive and recognition abilities, increased the escape latency, and decreased the number of crossings through the platform quadrant intersection and the time spent in the target quadrant (P < 0.01). The new-object exploration and recognition index of the rats in the noise group markedly decreased (P < 0.01). ELISA results indicated increases in Aβ1-40 and Aβ1-42 levels and decreases in BDNF and TrkB levels in the rat hippocampus in the noise group (P < 0.01). Western blot analyses revealed that beta-site amyloid precursor protein (APP) cleaving enzyme 1, phosphorylated tau protein, gamma-H2A histone family, member X, checkpoint kinase 2, p53, and p21 were remarkably elevated in the noise group (P < 0.01).</p><p><strong>Conclusion: </strong>Chronic noise exposure can cause hippocampal genetic damage in aged rats, leading to cognitive disorders and the development of lesions similar to those observed in AD. Thus, noise is a potential risk factor for neurodegenerative disorders.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Noise Exposure and Risk of Hearing Loss for Young People in Amusement Arcades. 游乐场噪音暴露和青少年听力损失风险评估。
IF 1.3 4区 医学
Noise & Health Pub Date : 2024-07-01 Epub Date: 2024-09-30 DOI: 10.4103/nah.nah_59_23
Nengsong Zou, Hongwei Wang, Zhixuan Huang, Qiaochu Wang
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