Noise & Health最新文献

{"title":"Sleep Disturbance as a Mediator Between Self-Reported Nighttime Noise Annoyance and Depression, Anxiety, and Suicide: A Mediation Analysis.","authors":"Dian-Jeng Li, Cheng-Fang Yen, Cheng-Chia Yang, Hung-En Liao, Yi-Lung Chen","doi":"10.4103/nah.nah_119_26","DOIUrl":"10.4103/nah.nah_119_26","url":null,"abstract":"<p><strong>Objective: </strong>To examine whether sleep disturbance mediates associations between self-reported nighttime noise annoyance and depression, anxiety, and suicide risk in Taiwanese adults.</p><p><strong>Methods: </strong>We analyzed cross-sectional online survey data from 776 Taiwanese adults collected between December 2024 and May 2025. Self-reported nighttime noise annoyance from road traffic, railways, aircraft, and residential building vibrations was assessed on a 5-point verbal scale. Sleep disturbance was assessed with the Pittsburgh Sleep Quality Index (PSQI), and depression, anxiety, and suicide risk were assessed with validated self-report scales. Mediation analyses estimated total, natural direct, and natural indirect effects using 5000 bootstrap resamples.</p><p><strong>Results: </strong>Self-reported nighttime noise annoyance from road traffic, aircraft, and residential building vibrations was associated with poorer subjective sleep quality. Self-reported nighttime noise annoyance from all four sources was associated with longer sleep latency, more sleep disturbances, greater use of sleeping medication, worse daytime dysfunction, and higher global PSQI scores ( B  = 0.652-0.788; all P < 0.001), but not with sleep duration or habitual sleep efficiency. Significant natural indirect effects through sleep disturbance were observed for anxiety, depression, and suicide risk for road traffic annoyance ( B  = 0.076-0.463) and residential building vibration annoyance ( B  = 0.082-0.503); 95% confidence intervals excluded 0. For residential building vibration annoyance, 40.1%-63.6% of total associations were mediated.</p><p><strong>Conclusion: </strong>Sleep disturbance may mediate associations between self-reported nighttime noise annoyance and depression, anxiety, and suicide risk. Populations reporting nighttime noise annoyance may benefit from sleep assessment and source-specific noise mitigation.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":"28 133","pages":"1082-1088"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Effect of Environmental Noise Exposure on Trouble Sleeping: Mediating Roles of Tinnitus, Hearing Loss and Mental Illnesses.","authors":"Gang Lian, Jing Tu, Wei Li, Yueyuan Gan","doi":"10.4103/nah.nah_212_25","DOIUrl":"10.4103/nah.nah_212_25","url":null,"abstract":"<p><strong>Background: </strong>Environmental noise exposure, tinnitus and hearing loss (HL) are hypothesised to influence trouble sleeping, but their integrated effects and mediating pathways remain unclear. This study evaluates associations amongst noise exposure, auditory health and sleep outcomes and explores mediation by tinnitus and HL.</p><p><strong>Methods: </strong>A total of 8539 participants were enrolled using data from the National Health and Nutrition Examination Survey (NHANES, 2006-2020). Logistic regression and mediation analysis examined associations amongst noise exposure, auditory health and sleep outcomes.</p><p><strong>Results: </strong>Noise exposure (workplace: adjusted odds ratio [OR] = 1.145, 95% confidence interval [CI]: 1.015-1.292, P  = 0.027; off-work: adjusted OR = 1.165, 95% CI: 1.005-1.348, P  = 0.042) and tinnitus (adjusted OR = 1.648, 95% CI: 1.442-1.882, P < 0.001) were positively associated with trouble sleeping, and speech-frequency HL (SFHL) showed a protective effect (adjusted OR = 0.767, 95% CI: 0.660-0.891, P  = 0.001). The association between noise exposure and trouble sleeping was significantly mediated by tinnitus and depression (accounting for 12.76%-37.80% of total effects) but not by SFHL. Subgroup analyses showed that SFHL was only significantly associated with trouble sleeping in the subgroups of those unexposed to a noise environment, whereas tinnitus was significant in each subgroup. Restricted cubic spline analyses showed that hearing thresholds ≥20 dB were linked to reduced risk of trouble sleeping, with nonlinear (inverted U-shaped) trends in the subgroups of noise-exposed workplace and noise-unexposed off-work.</p><p><strong>Conclusions: </strong>> Workplace and off-work noise exposures are closely associated with trouble sleeping, with tinnitus mediating this association and SFHL exerting a protective effect. The findings highlight the importance of controlling noise exposure and implementing preventive interventions for tinnitus to alleviate noise-related sleep issues.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":"28 133","pages":"1070-1081"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived ICU Alarm-Noise Burden, Staff-Reported Health Effects, and Contextual Objective Night-Time Acoustic Monitoring in an Adult Intensive Care Unit.","authors":"Wei Jun Dan Ong, Adrian Ujin Yap, Woon Hean Keenan Chong, Lawrence Ace Azul, Nur Rafidah Binte Abdul Gaffor, Jia Xin Li, Rodel Arce Montero, Faheem Ahmed Khan","doi":"10.4103/nah.nah_111_26","DOIUrl":"10.4103/nah.nah_111_26","url":null,"abstract":"<p><strong>Objective: </strong>To examine intensive care unit (ICU) staff-perceived alarm-noise burden and related health, communication, workload, and alarm-response outcomes, contextualized by usual-care night-time acoustic monitoring.</p><p><strong>Methods: </strong>We conducted a single-center observational study combining an electronic survey of ICU healthcare professionals with contextual bed-level night-time acoustic monitoring. The survey assessed perceived unit noise, alarm-related health and performance effects, communication interference, alarm-response behavior, alarm-governance perceptions, modified workload, and noise sensitivity. Acoustic outcomes included the equivalent continuous sound level, the maximum sound level, and the time above 80 dBA. Acoustic data were not linked to individual staff responses. Descriptive statistics, Cronbach's alpha, Spearman correlations, and exploratory multivariable regression were used.</p><p><strong>Results: </strong>Among 124 respondents, 83 were nurses, 20 were respiratory therapists, 18 were physicians, and 3 were allied health/other staff. Median perceived unit noise was 7/10 (interquartile range, 5-8), and 67 respondents (54.0%) rated noise as high. Excessive alarms triggered physical symptoms in 70 (56.5%), reduced work performance or motivation in 63 (50.8%), affected concentration or attention in 60 (48.4%), and interfered with communication in 48 (38.7%). Twenty-eight respondents (22.6%) reported missed alarms due to sensory overload.</p><p><strong>Conclusion: </strong>ICU alarm noise was perceived as an occupational health and workflow burden. Contextual acoustic monitoring showed measurable night-time sound exposure. Quiet ICU interventions should combine alarm hygiene, escalation governance, workflow redesign, central alarm visibility, and objective acoustic surveillance while preserving patient safety.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":"28 133","pages":"993-1003"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Gestational Diabetes Mellitus as an Independent Risk Factor for Hearing Impairment in Hyperbilirubinemia Newborns: A Prospective Birth Cohort With Genetic Profiling.","authors":"LiQin Ruan, XiaoXiao Su, LingJing Yan, Zong Zheng","doi":"10.4103/nah.nah_83_26","DOIUrl":"10.4103/nah.nah_83_26","url":null,"abstract":"<p><strong>Background: </strong>Gestational diabetes mellitus (GDM) may exacerbate hyperbilirubinemia-induced auditory neurotoxicity via oxidative stress, whereas genetic susceptibility (e.g., GJB2 variants) heightens cochlear vulnerability. However, the tripartite interplay among maternal metabolic dysregulation, neonatal hyperbilirubinemia and genetic predisposition remains poorly characterized.</p><p><strong>Objective: </strong>This study aimed to investigate the synergistic interaction between GDM and neonatal hyperbilirubinemia in auditory dysfunction, focusing on the modifying role of deafness-associated genetic variants (GJB2, SLC26A4, and mtDNA).</p><p><strong>Methods: </strong>In this prospective cohort study (our hospital, 2023-2025), 350 neonates were classified by an exposure-based 2 × 2 factorial design into four groups: GDM-exposed hyperbilirubinemia ( n  = 98), non-GDM hyperbilirubinemia ( n  = 185), GDM-only ( n  = 42) and healthy controls ( n  = 25). Genetic screening was performed via Sanger sequencing. Serial audiological assessments (automated auditory brainstem response) and brainstem auditory evoked potential [BAEP]) and biochemical monitoring (bilirubin-to-albumin [B/A]), malondialdehyde [MDA] and superoxide dismutase) were conducted at birth, 72 h, 1 month, and 3 months. Cox proportional hazards models, multivariable logistic regression and bootstrapped causal mediation analysis were used to evaluate risk factors and oxidative stress-mediated pathways.</p><p><strong>Results: </strong>GDM-exposed hyperbilirubinemia neonates exhibited a 2.3-fold higher incidence of severe hearing loss compared with those with hyperbilirubinemia alone (34.7% vs. 15.1%, P < 0.001). GJB2 variant carriers showed significantly greater BAEP threshold elevation (Δ = 9.2 ± 3.1 dB vs. 3.1 ± 1.8 dB, P  = 0.002) than their counterparts. The B/A ratio was a GDM-dependent prognostic marker, with B/A > 5.5 predicting hearing loss only in the GDM subgroup (odds ratio = 4.17, 95% confidence interval [CI]: 2.33-7.45). MDA accounted for 38% of the total effect of GDM-hyperbilirubinemia on auditory impairment (indirect effect β  = 0.28, 95% CI: 0.19-0.39).</p><p><strong>Conclusion: </strong>GDM significantly modifies hyperbilirubinemia-induced auditory toxicity through oxidative stress and genetic interaction, particularly in GJB2 carriers. Integrated screening of maternal glycemic status, neonatal bilirubin dynamics, and deafness-associated genes is warranted.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":"28 133","pages":"885-894"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental Noise and Childhood Asthma: A Hypothesis-Generating Review of Potential Neuro-Immune Mechanisms.","authors":"Na Jing, Fengxiang Zhang, Ningxia Zhao, Xiaoyan Xu, Yu Wang, Xianfeng Qu","doi":"10.4103/nah.nah_121_26","DOIUrl":"10.4103/nah.nah_121_26","url":null,"abstract":"<p><p>Childhood asthma is a heterogeneous prevalent chronic airway disease in paediatrics worldwide. It not only directly impairs the cardiopulmonary development, sleep rhythms and social skills of school-aged children, but also significantly increases the burden of medical care on families and the pressure on public health prevention and control. Environmental noise is a significant risk factor for allergic diseases, but its pathogenicity is not solely due to physical stimulation. Rather, it acts as a systemic stressor, reshaping the body's pathological microenvironment through potential indirect pathways. Given the current lack of direct clinical evidence, this article conducts a hypothesis-generating review of the potential neuro-immune mechanisms by which noise may induce or exacerbate childhood asthma. At the immune-inflammatory level, noise disrupts immune homeostasis, facilitates T-helper type 2 (Th2) inflammation, disrupts the airway epithelial barrier through systemic oxidative stress, activates chemokine networks to mediate immune cell recruitment and drives non-Th2 inflammation. At the neuroendocrine level, noise leads to autonomic imbalance and receptor remodelling, triggering vagal rebound; simultaneously, it induces central sensitisation through the 'lung-brain axis', triggering substance P-mediated neurogenic inflammation; and it disrupts sleep rhythms, triggering airway hyperresponsiveness during the nocturnal vagal hypertonic period. Elucidating these two potential mechanisms provides a new theoretical basis for neuro-immune-targeted interventions, psychosomatic treatment and acoustic environment optimisation for childhood asthma.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":"28 133","pages":"865-873"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Home-Based White Noise Therapy Combined with Positive Reinforcement-Based Nursing on Sleep Quality and Negative Emotions in Patients After Painless Endoscopic Gastrointestinal Polypectomy.","authors":"XiRong Xu, XueHua Yang, Yan Zhang, JingYe Ji, Li Guo, JianWei Qiu","doi":"10.4103/nah.nah_34_26","DOIUrl":"10.4103/nah.nah_34_26","url":null,"abstract":"<p><strong>Objective: </strong>To explore the efficacy of home-based white noise therapy combined with positive reinforcement-based nursing on sleep quality, negative emotions, hope level, and postoperative complications in patients after painless endoscopic gastrointestinal polypectomy.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on 130 patients who underwent painless endoscopic gastrointestinal polypectomy at Nantong First People's Hospital between November 2023 and November 2024. Patients were categorized into a combination group ( n  = 65, routine care, home-based white noise therapy, and positive reinforcement-based nursing) and a routine group ( n  = 65, routine home care) based on the nursing regimen they received. Pittsburgh Sleep Quality Index (PSQI), Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), Herth Hope Index (HHI) scores, and postoperative complication rates were compared between the two groups after nursing.</p><p><strong>Results: </strong>After care, the combination group had significantly lower PSQI, SAS, and SDS scores (all P < 0.05) and significantly higher HHI scores in all dimensions and total score than the routine group (all P < 0.05). The total complication rate was numerically lower in the combination group than in the routine group (1.54% versus 10.76%), but the difference was not statistically significant (Fisher's exact test, P  = 0.062).</p><p><strong>Conclusion: </strong>Home-based white noise therapy combined with positive reinforcement-based nursing was associated with improved sleep quality, reduced negative emotions, increased hope level, and lower postoperative complication rates in patients after painless endoscopic gastrointestinal polypectomy, suggesting its potential value for clinical application.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":"28 133","pages":"937-944"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Analysis of Environmental Noise in the Intensive Care Unit with the Incidence of Delirium and Heart Rate Variability in Patients After Percutaneous Coronary Intervention.","authors":"Mayire AJi, Xirenguli Zi Neng, Mai Wu Ju Dan ALi Fu, YuHong Wu","doi":"10.4103/nah.nah_55_26","DOIUrl":"10.4103/nah.nah_55_26","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the correlation between environmental noise in the intensive care unit (ICU) and the occurrence of delirium and heart rate variability (HRV) in patients after percutaneous coronary intervention (PCI), thereby providing a clinical basis for optimizing the ICU environment, reducing delirium incidence, and improving patient prognosis.</p><p><strong>Methods: </strong>We enrolled 132 patients admitted to the ICU after PCI between January 2023 and January 2024. Environmental noise was continuously monitored for 72 h. We assessed delirium using the Nursing Delirium Screening Scale, and HRV parameters, including the standard deviation of normal-to-normal RR intervals (SDNN), the root mean square of successive differences between adjacent RR intervals (rMSSD), low-frequency power (LF), and high-frequency power (HF), were recorded via dynamic electrocardiography. We evaluated data using Pearson correlation analysis and logistic regression analysis.</p><p><strong>Results: </strong>The mean ICU noise level was 51.74 ± 4.82 dB, and the incidence of delirium was 35.61%. Noise levels were significantly higher in the delirium group than in the non-delirium group ( P < 0.05). Pearson analysis revealed that noise levels were negatively correlated with SDNN, rMSSD, and HF ( r  = -0.429 to -0.356, P < 0.01), and positively correlated with LF ( r  = 0.398, P  = 0.001). Multivariate logistic regression analysis identified ICU environmental noise [odds ratio (OR) = 1.171], age (OR = 1.060), and postoperative pain score (OR = 1.288) as independent risk factors for delirium ( P < 0.05).</p><p><strong>Conclusion: </strong>Environmental noise levels in the ICU after PCI generally exceed recommendations. High noise levels are associated with abnormal HRV parameters and an increased risk of delirium. Optimizing the ICU acoustic environment may help reduce the incidence of delirium and improve patient outcomes.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":"28 133","pages":"914-922"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a Nursing Regimen Combining Ward Noise Control with Auricular Acupressure on Sleep Quality and Psychosomatic Symptoms in Patients with Cervical Spondylosis and Insomnia.","authors":"YuHong Yao, Jie Lu, HongMei Li, JieZhen Li, JinRong Chen","doi":"10.4103/nah.nah_43_26","DOIUrl":"10.4103/nah.nah_43_26","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the effects of a nursing regimen combining ward noise control with auricular acupressure on sleep quality and psychosomatic symptoms in patients with cervical spondylosis and insomnia.</p><p><strong>Methods: </strong>This retrospective analysis included 87 patients with cervical spondylosis and insomnia treated at The First Affiliated Hospital of Xinjiang Medical University between October 2023 and October 2025. Based on medical records, patients were assigned to two groups: a control group ( n  = 42, auricular acupressure only) and a study group ( n  = 45, auricular acupressure combined with systematic ward noise control). We compared continuous variables using the independent-samples t -test or paired-samples t -test, and categorical variables using the chi-square test. The two groups were compared regarding clinical efficacy, sleep quality (Pittsburgh Sleep Quality Index, PSQI), psychological symptoms (Symptom Checklist-90, SCL-90), and quality of life (Generic Quality of Life Inventory-74, GQOLI-74).</p><p><strong>Results: </strong>After the implementation of the nursing regimens, the total effective rate in the study group was 91.11%, which was significantly higher than the 71.43% observed in the control group ( P < 0.05). Postregimen scores for all PSQI and SCL-90 subscales decreased significantly compared with baseline in both groups, with the study group demonstrating lower scores than the control group ( P < 0.05). Conversely, scores for all GQOLI-74 subscales increased significantly from baseline in both groups, with the study group showing higher scores than the control group ( P < 0.05).</p><p><strong>Conclusion: </strong>Adding systematic ward noise control to auricular acupressure yields superior therapeutic outcomes in patients with cervical spondylosis and insomnia. This combined approach can effectively improve sleep quality, alleviate psychosomatic symptoms such as anxiety and depression, and enhance the patient's quality of life.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":"28 133","pages":"895-903"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Comprehensive Noise Reduction Nursing on Pain Management and Quality of Life in Patients with T-tube Drainage after Choledocholithiasis Surgery.","authors":"Dandan Cheng, Hui Liu, Zhanchang Xie, Ziwen Liu","doi":"10.4103/nah.nah_108_26","DOIUrl":"10.4103/nah.nah_108_26","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of comprehensive noise reduction nursing on pain management and quality of life in patients with T-tube drainage after choledocholithiasis surgery.</p><p><strong>Methods: </strong>We retrospectively analysed 170 patients who underwent choledocholithiasis surgery with T-tube drainage between January 2023 and June 2025. Patients received either conventional nursing ( n  = 73) or comprehensive noise reduction nursing ( n  = 97). Outcomes included postoperative pain assessed using the Visual Analogue Scale (VAS), sleep quality assessed using the Pittsburgh Sleep Quality Index (PSQI), stress indicators (cortisol [COR] and norepinephrine [NE]), T-tube-related complications, quality of life assessed using the 36-Item Short Form Health Survey (SF-36) and readiness for hospital discharge assessed using the Readiness for Hospital Discharge Scale (RHDS).</p><p><strong>Results: </strong>The noise reduction group showed significantly lower VAS scores on postoperative days 1, 3 and 7 (all P < 0.05). On postoperative day 7, the noise reduction group had better PSQI scores (except sleep medication use, P  = 0.307) and lower serum COR and NE levels than the conventional nursing group (all P < 0.05). T-tube-related complications were fewer in the noise reduction group (9.28% vs. 21.92%, P < 0.05). Before discharge, the noise reduction group exhibited higher SF-36 scores in most dimensions (all P < 0.05), though differences in social functioning and role-emotional were not significant. RHDS scores were also significantly higher in the noise reduction group (all P < 0.05). Sensitivity analyses confirmed the robustness of the main findings, with no significant differences in baseline characteristics or perioperative management between the two study periods. In addition, a contemporaneous subgroup analysis (patients admitted after June 2024) demonstrated consistent results across most study endpoints.</p><p><strong>Conclusion: </strong>Comprehensive noise reduction nursing was associated with reduced postoperative pain, improved sleep quality, fewer T-tube-related complications and stress responses and better quality of life and discharge readiness in patients after choledocholithiasis surgery with T-tube drainage.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":"28 133","pages":"1026-1035"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noise-Induced Hepatic Stress Is Associated with Transglutaminase Activation and TG7 Upregulation in Rats.","authors":"Shomookh E Aljuhani, Ibtesam S Almami, Heba F Gomaa","doi":"10.4103/nah.nah_101_26","DOIUrl":"10.4103/nah.nah_101_26","url":null,"abstract":"<p><strong>Objective: </strong>Environmental noise is increasingly recognized as a systemic stressor capable of inducing oxidative and inflammatory responses beyond the auditory system. This study aimed to investigate the effects of chronic noise exposure on transglutaminase (TG) activation, particularly TG7, and its association with hepatic stress responses in rat liver tissue.</p><p><strong>Methods: </strong>Thirty adult male Wistar albino rats were randomly assigned to control, short-term noise exposure (LT1), and long-term noise exposure (LT2) groups. Gene expression of TG isoforms (TG1, TG2, TG3, TG6, and TG7), inflammatory markers (IL6 and TNF-α), and apoptotic markers (CASP3 and P53) was evaluated using quantitative real-time PCR. Total TG enzymatic activity was assessed colorimetrically. TG7 protein expression and localization were examined by immunohistochemistry and immunofluorescence. DNA integrity was evaluated by agarose gel electrophoresis. Biochemical parameters, including serum malondialdehyde (MDA), interleukin-1 beta (IL1β), cortisone, aspartate aminotransferase, alanine aminotransferase, glucose, insulin, and total cholesterol, were also measured.</p><p><strong>Results: </strong>Noise exposure induced selective upregulation of TG isoforms, with TG7 showing the highest increase (∼10-12-fold). Total transglutaminase enzymatic activity was significantly increased in both noise-exposed groups, with a higher increase in LT1 (*** P < 0.001) and a significant increase in LT2 (** P < 0.01) compared with control, while no significant difference was observed between LT1 and LT2. IL6 and TNF-α increased progressively, particularly in LT2, whereas CASP3 expression was elevated in LT1 but reduced in LT2. DNA analysis revealed mild alterations in genomic integrity without clear internucleosomal fragmentation. TG7 protein showed strong localization within hepatocyte cytoplasm and perisinusoidal regions. Biochemical analysis demonstrated significant increases in MDA (up to 61.28%), IL1β, cortisone, liver enzymes, glucose, insulin, and total cholesterol.</p><p><strong>Conclusion: </strong>Chronic noise exposure induces early TG activation, particularly TG7, accompanied by sustained oxidative stress and inflammatory responses in liver tissue. These findings identify TG7 as a potential stress-responsive mediator in noise-induced hepatic injury.</p>","PeriodicalId":19195,"journal":{"name":"Noise & Health","volume":"28 133","pages":"1004-1017"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}