Drug-Therapeutic Strategies for Noise-Induced Hearing Loss: A Narrative Review.

IF 1.3 4区医学 Q3 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Noise & Health Pub Date : 2025-05-01 Epub Date: 2025-06-26 DOI:10.4103/nah.nah_187_24

Zehui Deng, Fei Lin, Ling Zhou, Shaojuan Wang, Jie Li, Longxi He

引用次数: 0

Abstract

With the rapid development of industrialisation, noise exposure is becoming increasingly prevalent. The detrimental effects of noise-induced hearing loss (NIHL) have become clinically relevant. Therefore, effective drug therapeutic strategies for NIHL are urgently needed. This article reviewed the pathophysiology and potential molecular mechanisms of NIHL and classified and summarised the drug therapeutic strategies. Drug therapeutic strategies of NIHL can be further studied in agents such as corticosteroids, antioxidants, neurotrophic factors, herbal medicine, magnesium and statins. Given the current research progress, ongoing positive test results and pilot studies may lead to new pharmacological regimens to alleviate NIHL.

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噪音性听力损失的药物治疗策略：叙述性回顾。

随着工业化的快速发展，噪声暴露问题日益普遍。噪声性听力损失（NIHL）的有害影响已成为临床相关。因此，迫切需要有效的NIHL药物治疗策略。本文综述了NIHL的病理生理和潜在的分子机制，并对药物治疗策略进行了分类和总结。NIHL的药物治疗策略可以在皮质类固醇、抗氧化剂、神经营养因子、草药、镁和他汀类药物等方面进一步研究。鉴于目前的研究进展，正在进行的阳性试验结果和试点研究可能会导致新的药物方案来缓解NIHL。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Noise & Health AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY-PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

CiteScore

2.10

自引率

14.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Noise and Health is the only International Journal devoted to research on all aspects of noise and its effects on human health. An inter-disciplinary journal for all professions concerned with auditory and non-auditory effects of occupational, environmental, and leisure noise. It aims to provide a forum for presentation of novel research material on a broad range of topics associated with noise pollution, its control and its detrimental effects on hearing and health. It will cover issues from basic experimental science through clinical evaluation and management, technical aspects of noise reduction systems and solutions to environmental issues relating to social and public health policy.