{"title":"Comment on \"Increased Long-Term Risks of Gastroesophageal Reflux Disease Phenotypes: A Global Propensity-Matched Cohort Study\".","authors":"Prateek Pandey, Amit Kumar Mishra, Shubham Singh","doi":"10.1111/nmo.70415","DOIUrl":"10.1111/nmo.70415","url":null,"abstract":"","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 8","pages":"e70415"},"PeriodicalIF":3.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13447872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of Body Surface Gastric Mapping Phenotypes for Gastroduodenal Disorders: Ten Points for Discussion.","authors":"Michael Camilleri","doi":"10.1111/nmo.70427","DOIUrl":"https://doi.org/10.1111/nmo.70427","url":null,"abstract":"","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 8","pages":"e70427"},"PeriodicalIF":3.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to the Letter to the Editor Regarding \"Magnesium-Rich Mineral Water Improves Stool Consistency and Bowel Habits in Healthy Subjects: A Randomized Controlled Trial\".","authors":"Hideki Yoneda, Toshihiko Tomita, Shinichiro Shinzaki","doi":"10.1111/nmo.70424","DOIUrl":"https://doi.org/10.1111/nmo.70424","url":null,"abstract":"","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 8","pages":"e70424"},"PeriodicalIF":3.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13485329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Munazza Khan, Maheen Irfan, Masroor Tahir, Taiyiba Irshad, Maheen Hamid
{"title":"Letter to the Editor Concerning: Methodological Limitations in the Assessment of Novice Rater Competency for FLIP Panometry.","authors":"Munazza Khan, Maheen Irfan, Masroor Tahir, Taiyiba Irshad, Maheen Hamid","doi":"10.1111/nmo.70416","DOIUrl":"10.1111/nmo.70416","url":null,"abstract":"","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 8","pages":"e70416"},"PeriodicalIF":3.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13437918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jennifer V Schurman, Craig A Friesen, Kara G Margolis, Miranda A L van Tilburg, Corey Baker, Meenal Singh, Robert J Shulman, Bruno P Chumpitazi
{"title":"Associations of Meal-Related and Somatic Symptoms With Mucosal Eosinophil and Mast Cell Counts in Youth With Disorders of Gut-Brain Interaction.","authors":"Jennifer V Schurman, Craig A Friesen, Kara G Margolis, Miranda A L van Tilburg, Corey Baker, Meenal Singh, Robert J Shulman, Bruno P Chumpitazi","doi":"10.1111/nmo.70406","DOIUrl":"10.1111/nmo.70406","url":null,"abstract":"<p><strong>Introduction: </strong>Meal-related symptoms are commonly identified in disorders of gut-brain interaction (DGBIs). Gastroduodenal low-grade inflammation involving mucosal eosinophils and/or mast cells has been previously described in patients with DGBIs. In children with DGBIs, we sought to determine potential relationships between gastric and duodenal mucosal eosinophils and mast cells with specific meal-related and non-GI somatic symptoms.</p><p><strong>Methods: </strong>Two hundred eight youth with AP-DGBI were evaluated. All patients underwent esophagogastroduodenoscopy (EGD) with biopsies taken from the gastric antrum and duodenum. Patients completed symptom and BASC-3 questionnaires to evaluate somatization and the presence of specific meal-related and non-GI somatic symptoms. A single observer blinded to clinical data reported maximum density of eosinophils and mast cells.</p><p><strong>Key results: </strong>Mucosal eosinophil and mast cell counts did not differ between FD and IBS nor between FD subtypes. After correction for multiple comparisons, there were no associations between eosinophil or mast cell counts with meal-related symptoms. In contrast, duodenal mast cells were positively associated with headaches, dizziness, fatigue, and rhinitis, with predominantly medium effect sizes.</p><p><strong>Conclusions and inferences: </strong>Meal-related symptoms are common in youth with DGBIs, but do not appear to be associated with mucosal eosinophils and mast cell counts. The positive associations of duodenal mast cells with non-GI somatic complaints suggest future studies should determine whether treatments targeting mast cells are beneficial for ameliorating these symptoms in youth with DGBIs.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 8","pages":"e70406"},"PeriodicalIF":3.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13424828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148630796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Drought of Evidence for Water Intake to Manage Constipation Symptoms May Be Ending.","authors":"Eric D Shah","doi":"10.1111/nmo.70392","DOIUrl":"https://doi.org/10.1111/nmo.70392","url":null,"abstract":"","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 7","pages":"e70392"},"PeriodicalIF":3.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148376148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Megan Petrik, Jean Fox, Manavjot Singh, Shuji Mitsuhashi, Douglas A Simonetto, Xiao Jing Wang
{"title":"Role of Communication Skills Training in Enhancing Medical Education and Care for Disorders of Gut-Brain Interaction.","authors":"Megan Petrik, Jean Fox, Manavjot Singh, Shuji Mitsuhashi, Douglas A Simonetto, Xiao Jing Wang","doi":"10.1111/nmo.70400","DOIUrl":"10.1111/nmo.70400","url":null,"abstract":"","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 7","pages":"e70400"},"PeriodicalIF":3.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13379798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sensation of Incomplete Evacuation in Patients With Fecal Incontinence: A Cross-Sectional Study of a Tertiary Referral Cohort.","authors":"Jenny Sjödahl, Anna Ingemansson, Susanna Walter","doi":"10.1111/nmo.70403","DOIUrl":"10.1111/nmo.70403","url":null,"abstract":"<p><strong>Introduction: </strong>Many patients with fecal incontinence (FI) report a sensation of incomplete evacuation (SIE), a symptom that may have clinical relevance but remains insufficiently characterized. This study compared symptoms, categorized high-resolution anorectal manometry (HRAM), and health-related quality of life (HRQL) in patients with FI alone and those with FI and SIE.</p><p><strong>Methods: </strong>In this cross-sectional study, 777 adults with FI referred to a tertiary pelvic floor unit (2015-2022) were included. All participants underwent HRAM and completed questionnaires assessing gastrointestinal symptoms and HRQL. Patients were categorized as FI only or FI with SIE.</p><p><strong>Key results: </strong>Of 777 patients, 585 (75%) reported SIE. Compared with the FI-only group (n = 192, 25%), patients with SIE had higher stool frequency (mean (SD) 2.9 (2.8) vs. 2.0 (1.7)), more prolonged defecation time (≥ 20 min: 14% vs. 6%), and more frequent straining (≥ 20 min: 14% vs. 3%) (all p < 0.001). Weekly soiling was more prevalent (92% vs. 86%, p = 0.02), as were bladder emptying difficulties, abdominal, and anorectal pain. FI severity and frequency did not differ between groups (p > 0.05). The proportion of patients across categorized HRAM parameters was similar (all p > 0.05). HRQL was consistently worse across all domains in patients with additional SIE (all p < 0.001).</p><p><strong>Conclusions: </strong>Coexisting SIE was associated with greater symptom burden, more pain, and substantially impaired HRQL in patients with FI, despite comparable distributions across categorized HRAM parameters and similar FI severity. Recognition of incomplete evacuation is therefore essential in FI care.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 7","pages":"e70403"},"PeriodicalIF":3.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13402968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the Editor: \"Magnesium-Rich Mineral Water Improves Stool Consistency and Bowel Habits in Healthy Subjects: A Randomized Controlled Trial\".","authors":"Muhammad Saleem, Muhammad Umair","doi":"10.1111/nmo.70390","DOIUrl":"https://doi.org/10.1111/nmo.70390","url":null,"abstract":"","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 7","pages":"e70390"},"PeriodicalIF":3.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148391406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}