Neurogastroenterology and Motility最新文献

Enteric neuroprotection-A matter of balancing redox potentials, limiting inflammation, and boosting resilience. 肠道神经保护--平衡氧化还原电位、限制炎症和增强复原力。

IF 3.5 3区医学

Neurogastroenterology and Motility Pub Date : 2025-08-01 Epub Date: 2024-07-22 DOI: 10.1111/nmo.14871

Ulrikke Voss

{"title":"Enteric neuroprotection-A matter of balancing redox potentials, limiting inflammation, and boosting resilience.","authors":"Ulrikke Voss","doi":"10.1111/nmo.14871","DOIUrl":"10.1111/nmo.14871","url":null,"abstract":"The enteric nervous system (ENS) orchestrates intricate and autonomous functions throughout the gastrointestinal (GI) tract. Disruptions in ENS function are associated GI disorders. This mini review focuses on the past decade's research, utilizing rodent models, with an emphasis on protecting enteric neurons from loss. The review specifically looks at efforts to reduce oxidative stress, limit inflammation, and enhance neuronal resilience. Protective interventions including administration of antioxidants and compounds targeting cellular redox buffer systems, are evaluated for their effectiveness in preventing loss of enteric neurons in the ischemia-reperfusion model and streptozotocin-induced diabetes model. Interventions such as engrafting mesenchymal stem cells and targeting inflammatory signaling pathways in enteric neurons and glial cells are evaluated in inflammatory bowel disease models including the Winnie mouse, DSS-, and DNBS/TNBS-induced colitis models. The review also touches upon neuronal resilience, particularly in the context of Parkinson's disease models. Including estrogen's neuroprotective role, and the influence of metal ions on enteric neuronal protection. Understanding the dynamic interplay within the ENS and its role in disease pathogenesis holds promise for developing targeted therapies to effectively manage and treat various GI ailments.","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":" ","pages":"e14871"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141748694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The human colon: Evidence for degenerative changes during aging and the physiological consequences. 人类结肠：衰老过程中的退行性变化及其生理后果的证据。

IF 3.5 3区医学

Neurogastroenterology and Motility Pub Date : 2025-08-01 Epub Date: 2024-06-17 DOI: 10.1111/nmo.14848

Nicholas Baidoo, Gareth J Sanger

{"title":"The human colon: Evidence for degenerative changes during aging and the physiological consequences.","authors":"Nicholas Baidoo, Gareth J Sanger","doi":"10.1111/nmo.14848","DOIUrl":"10.1111/nmo.14848","url":null,"abstract":"Background: The incidence of constipation increases among the elderly (>65 years), while abdominal pain decreases. Causes include changes in lifestyle (e.g., diet and reduced exercise), disease and medications affecting gastrointestinal functions. Degenerative changes may also occur within the colo-rectum. However, most evidence is from rodents, animals with relatively high rates of metabolism and accelerated aging, with considerable variation in time course. In humans, cellular and non-cellular changes in the aging intestine are poorly investigated.Purpose: To examine all available studies which reported the effects of aging on cellular and tissue functions of human isolated colon, noting the region studied, sex and age of tissue donors and study size. The focus on human colon reflects the ability to access full-thickness tissue over a wide age range, compared with other gastrointestinal regions. Details are important because of natural human variability. We found age-related changes within the muscle, in the enteric and nociceptor innervation, and in the submucosa. Some involve all regions of colon, but the ascending colon appears more vulnerable. Changes can be cell- and sublayer-dependent. Mechanisms are unclear but may include development of \"senescent-like\" and associated inflammaging, perhaps associated with increased mucosal permeability to harmful luminal contents. In summary, reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes within the colon wall may have little impact on symptoms and colonic functions, because of high \"functional reserve,\" but are likely to facilitate the development of constipation during age-related challenges (e.g., lifestyle, disease, and medications), now operating against a reduced functional reserve.","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":" ","pages":"e14848"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141420061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genomic stress in diseases stemming from defects in the second brain. 源于第二大脑缺陷的疾病中的基因组压力。

IF 3.5 3区医学

Neurogastroenterology and Motility Pub Date : 2025-08-01 Epub Date: 2024-07-14 DOI: 10.1111/nmo.14860

Lobke Marie M Mombeek, Werend Boesmans, David M Wilson

{"title":"Genomic stress in diseases stemming from defects in the second brain.","authors":"Lobke Marie M Mombeek, Werend Boesmans, David M Wilson","doi":"10.1111/nmo.14860","DOIUrl":"10.1111/nmo.14860","url":null,"abstract":"This review discusses the less-explored realm of DNA damage and repair within the enteric nervous system (ENS), often referred to as the \"second brain.\" While the central nervous system has been extensively studied for its DNA repair mechanisms and associated neuropathologies, the ENS, which can autonomously coordinate gastrointestinal function, experiences unique challenges and vulnerabilities related to its genome integrity. The susceptibility of the ENS to DNA damage is exacerbated by its limited protective barriers, resulting in not only endogenous genotoxic exposures, such as oxidative stress, but also exogenous threats, such as ingested environmental contaminants, local inflammatory responses, and gut dysbiosis. Here, we discuss the evidence for DNA repair defects in enteric neuropathies, most notably, the reported relationship between inherited mutations in RAD21 and LIG3 with chronic intestinal pseudo-obstruction and mitochondrial gastrointestinal encephalomyopathy disorders, respectively. We also introduce the lesser-recognized gastrointestinal complications in DNA repair syndromes, including conditions like Cockayne syndrome. The review concludes by pointing out the potential role of DNA repair defects in not only congenital disorders but also aging-related gut dysfunction, as well as the crucial need for further research to establish direct causal links between DNA damage accumulation and ENS-specific pathologic phenotypes.","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":" ","pages":"e14860"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141616821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut Neuropathies and Intestinal Motility Disorders. 肠道神经病变和肠道运动障碍。

IF 3.5 3区医学

Neurogastroenterology and Motility Pub Date : 2025-08-01 Epub Date: 2025-01-08 DOI: 10.1111/nmo.14995

David A Wattchow, Simon J H Brookes, Nick J Spencer, Roberto De Giorgio, Marcello Costa, Phil G Dinning

引用次数: 0

Enteric neuropathy and the vagus nerve: Therapeutic implications. 肠道神经病与迷走神经：治疗意义。

IF 3.5 3区医学

Neurogastroenterology and Motility Pub Date : 2025-08-01 Epub Date: 2024-06-14 DOI: 10.1111/nmo.14842

Bruno Bonaz

引用次数: 0

Molecular mechanisms of enteric neuropathies in high-fat diet feeding and diabetes. 高脂饮食喂养和糖尿病肠神经病变的分子机制。

IF 3.5 3区医学

Neurogastroenterology and Motility Pub Date : 2025-08-01 Epub Date: 2024-08-09 DOI: 10.1111/nmo.14897

Francesca Cingolani, Arun Balasubramaniam, Shanthi Srinivasan

引用次数: 0

Possible Role of Butyric Acid in Long-Term Symptom Relief in Irritable Bowel Syndrome Patients Following Fecal Microbiota Transplantation. 丁酸在肠易激综合征患者粪便菌群移植后长期症状缓解中的可能作用。

IF 2.9 3区医学

Neurogastroenterology and Motility Pub Date : 2025-08-01 DOI: 10.1111/nmo.70115

Magdy El-Salhy, Jørgen Valeur, Ingeborg Brønstad, Odd Helge Gilja, Jan Gunnar Hatlebakk

{"title":"Possible Role of Butyric Acid in Long-Term Symptom Relief in Irritable Bowel Syndrome Patients Following Fecal Microbiota Transplantation.","authors":"Magdy El-Salhy, Jørgen Valeur, Ingeborg Brønstad, Odd Helge Gilja, Jan Gunnar Hatlebakk","doi":"10.1111/nmo.70115","DOIUrl":"https://doi.org/10.1111/nmo.70115","url":null,"abstract":"Background: We previously found that the fecal levels of short-chain fatty acids (SCFAs) changed in irritable bowel syndrome (IBS) patients at 1 month and 1 year after fecal microbiota transplantation (FMT). This study analyzed SCFAs at 2 and 3 years after FMT in the same IBS patients included in those previous studies.Methods: This study randomized 113 IBS patients into placebo, 30-g, and 60-g groups, who received FMT with 30 g of their own feces and with 30 g and 60 g of the donor's feces, respectively. The patients completed four questionnaires to assess IBS symptoms, fatigue, and quality of life, and supplied fecal samples at the baseline and at 2 and 3 years after FMT. The fecal SCFA levels were measured using gas chromatography.Results: The butyric acid level was significantly increased at 2 and 3 years after FMT in the 30-g and 60-g groups, and was significantly higher than that in the placebo group. The total SCFA and acetic acid levels decreased significantly in the 30-g and 60-g groups at 2 and 3 years after FMT, while the propionic acid level decreased in the 60-g group at both time points. The butyric acid level was inversely correlated with IBS symptoms and fatigue.Conclusion and inferences: The increased butyric acid levels in IBS patients at 2 and 3 years after FMT and their inverse correlation with both IBS symptoms and fatigue suggest that butyric acid contributes to the long-term improvement seen after FMT (www.Clinicaltrials: gov: NCT03822299).","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":" ","pages":"e70115"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of reactive enteric glia-macrophage interactions in acute and chronic inflammation. 反应性肠胶质细胞-巨噬细胞相互作用在急性和慢性炎症中的作用。

IF 3.5 3区医学

Neurogastroenterology and Motility Pub Date : 2025-08-01 Epub Date: 2024-10-20 DOI: 10.1111/nmo.14947

Schneider Reiner, Schneider Linda, Hamza Ebrahim, Leven Patrick, Wehner Sven

{"title":"The role of reactive enteric glia-macrophage interactions in acute and chronic inflammation.","authors":"Schneider Reiner, Schneider Linda, Hamza Ebrahim, Leven Patrick, Wehner Sven","doi":"10.1111/nmo.14947","DOIUrl":"10.1111/nmo.14947","url":null,"abstract":"Enteric glia are a heterogeneous population of peripheral glia within the enteric nervous system and play pivotal roles in gut homeostasis, tissue integrity, coordination of motility, and intestinal immune responses. Under physiological conditions, they communicate with enteric neurons to control intestinal motility. In contrast, enteric glia undergo reactive changes in response to inflammatory signals during enteric neuroinflammation and participate in immune control. In this state, these glia are called reactive enteric glia, which promote cytokine and chemokine secretion and perpetuate immune cell recruitment, thereby affecting disease progression. Interestingly, reactive glia exhibit a huge plasticity and adapt to or shape the immune environment towards a resolving phenotype during inflammation and neuropathies. Recent studies revealed a bidirectional communication between enteric glia and resident and infiltrating immune cells under healthy conditions and in the context of inflammation-based intestinal disorders and neuropathies. While recent reviews give a superb general overview of enteric glial reactivity, we herein discuss the latest evidence on enteric glial reactivity in two prominent inflammatory conditions: acute postoperative inflammation, resulting in postoperative ileus, and chronic inflammation in inflammatory bowel diseases. We define their plasticity during inflammation and the interplay between reactive enteric glia and intestinal macrophages. Finally, we sketch important questions that should be addressed to clarify further the impact of enteric glial reactivity on intestinal inflammation.","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":" ","pages":"e14947"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastric and sacral electrical stimulation for motility disorders-A clinical perspective. 胃和骶椎电刺激治疗运动障碍--临床视角。

IF 3.5 3区医学

Neurogastroenterology and Motility Pub Date : 2025-08-01 Epub Date: 2024-08-04 DOI: 10.1111/nmo.14884

Charlotte Desprez, Anne-Marie Leroi, Guillaume Gourcerol

引用次数: 0

Chemotherapy-Induced Neuropathy Affecting the Gastrointestinal Tract. 影响胃肠道的化疗引起的神经病变。

IF 3.5 3区医学

Neurogastroenterology and Motility Pub Date : 2025-08-01 Epub Date: 2024-12-09 DOI: 10.1111/nmo.14976

Gema Vera, Kulmira Nurgali, Raquel Abalo

{"title":"Chemotherapy-Induced Neuropathy Affecting the Gastrointestinal Tract.","authors":"Gema Vera, Kulmira Nurgali, Raquel Abalo","doi":"10.1111/nmo.14976","DOIUrl":"10.1111/nmo.14976","url":null,"abstract":"Background: Cancer is a major global cause of morbidity and mortality. Survivorship is increasing, bringing new challenges. Cancer treatment, including chemotherapeutic drugs, immunotherapy, and radiotherapy, can have severe and impactful gastrointestinal side effects occurring shortly after treatment (acute toxicity) or persisting for years after treatment ends (late/chronic toxicity).Purpose: The aim of this article is to review the neurotoxic effects of chemotherapy on the enteric nervous system (ENS) and the gut extrinsic innervation. These effects could contribute to the development of long-term gastrointestinal dysfunctions. Research, primarily conducted in animal models, indicates that antitumoral drugs can lead to chemotherapy-induced enteric neuropathy (CIEN). Studies, mainly performed in the myenteric plexus, show that CIEN is characterized by a reduced density of nerve cells and fibers, as well as an imbalanced representation of neuronal subpopulations or their markers, with enteric glial cells also affected. These alterations underlie changes in neuronal activity and gastrointestinal motor function. Although research on the submucosal plexus remains limited, evidence suggests that CIEN affects the entire ENS. Furthermore, scarce studies show that CIEN also occurs in humans. Moreover, emerging experimental data on chemotherapy-induced alterations in visceral sensitivity suggest that the extrinsic innervation of the gut is also affected, but this has received little attention thus far. Nevertheless, this could contribute to the development of chemotherapy-induced brain-gut axis (BGA) disorders in the long term. Cancer chemotherapy (and probably also immunotherapy and radiotherapy) seems to cause neuropathic effects on the intrinsic and extrinsic innervation of the gastrointestinal tract, with an important impact on gastrointestinal and BGA functions. This is a relatively neglected area deserving further investigation.","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":" ","pages":"e14976"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0