Neurogastroenterology and Motility最新文献

{"title":"Response to Comment on \"Associations of Meal-Related and Somatic Symptoms With Mucosal Eosinophil and Mast Cell Counts in Youth With Disorders of Gut-Brain Interaction\".","authors":"Craig A Friesen, Jennifer V Schurman","doi":"10.1111/nmo.70455","DOIUrl":"https://doi.org/10.1111/nmo.70455","url":null,"abstract":"","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 10","pages":"e70455"},"PeriodicalIF":3.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Types of Neurons in the Myenteric Plexus of Human Gastric Corpus Identified by Multi-Layer Immunohistochemical Coding and Vagal Tracing.","authors":"M E Johnson, M Wee, B N Chen, A Humenick, R A Peterson, W P Yew, T J Hibberd, D A Wattchow, L Kow, T L Powley, S J H Brookes","doi":"10.1111/nmo.70460","DOIUrl":"10.1111/nmo.70460","url":null,"abstract":"<p><strong>Background: </strong>Enteric neurons regulate motility, secretion, blood flow, and immune function of the gut. Characterizing neuron types is essential for understanding how the enteric nervous system works and how it goes wrong in disease.</p><p><strong>Methods: </strong>We examined the myenteric plexus of the human gastric corpus from surgical specimens. Multiplexed immunohistochemistry assessed 15 markers, including pan-neuronal (HuC/D), neurotransmitter-related enzymes, nitric oxide synthase (NOS), choline acetyltransferase (ChAT), tyrosine hydroxylase (TH), vesicular acetylcholine transporter (VAChT), the transmitter serotonin (by 5-HT accumulation), neuropeptides substance P (SP), enkephalin (ENK), calcitonin gene-related peptide (CGRP), somatostatin (SOM), vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY), calcium-binding proteins calbindin (Calb), calretinin (Calret) and the structural protein neurofilament 200 (NF200). These markers were applied to 1084 myenteric neurons from the gastric corpus of 7 individuals. Biotinamide tracing was used to label axons from intramural vagal nerve branches visible at the edge of the preparation.</p><p><strong>Key results: </strong>Twelve classes of enteric neurons were distinguished by significant associations between immunohistochemical markers (\"chemical coding\"), including motor neurons and likely interneurons, secretomotor, and vasomotor neurons. Dense clusters of axonal varicosities (\"baskets\") labeled by VAChT, ENK, SP, or TH were abundant around ChAT+ myenteric cell bodies but disproportionately scarce around NOS+ cells. Vagal baskets labeled by biotinamide did not show an overall preference for either NOS+ or ChAT+ cells.</p><p><strong>Conclusions: </strong>Multiple types of human gastric myenteric neurons can be distinguished by their immunohistochemical profiles. Vagal efferent pathways are associated with all classes of myenteric neurons in the gastric corpus, whereas some enteric pathways likely exhibit selective connectivity with integrative potential.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 10","pages":"e70460"},"PeriodicalIF":3.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailored Prokinetic Therapy in Gastroparesis Using Gastric Emptying and Contractility.","authors":"Jonathan Kuang Ziyang, Braden Kuo, Brian Surjanhata","doi":"10.1111/nmo.70463","DOIUrl":"10.1111/nmo.70463","url":null,"abstract":"<p><strong>Background and aims: </strong>Physiologic biomarkers to predict prokinetic response in patients with gastroparesis-like symptoms are needed to better tailor management. This study aims to investigate phenotypes of antral high-amplitude contraction (HAC) counts relative to gastric emptying delay in patients with upper gastrointestinal (UGI) symptoms and examine response to prokinetics.</p><p><strong>Methods: </strong>We retrospectively analyzed patients with UGI symptoms undergoing wireless motility capsule (WMC) testing. Data were collected on demographics, gastric emptying time (GET), Gastroparesis Cardinal Symptom Index (GCSI) scores, and prokinetic use. The number of HACs during a fasting period was counted. A single HAC was defined as a pressure amplitude > 65 mmHg within 20 min. Subjects were classified based on GET and HAC counts. The Wilcoxon signed-rank test compared GCSI scores at baseline and 6 months, in those with and without prokinetic use.</p><p><strong>Results: </strong>In 135 patients, four distinct phenotypes were identified: non-delayed GET non-elevated HAC count (54.8%), non-delayed GET elevated HAC count (9.6%), delayed GET non-elevated HAC count (20.7%), and delayed GET elevated HAC count (14.8%). A total of 48.1% of all patients were on prokinetics. Those with delayed GET and elevated HAC counts showed significant improvement in GCSI scores only in subjects using prokinetics (2.95 vs. 1.98, diff -0.98, p = 0.03). In non-delayed GET, non-elevated HAC count, GCSI scores improved both with (2.61 vs. 1.68, diff -0.93, p < 0.01) and without (2.47 vs. 1.87, diff -0.61, p < 0.01) prokinetics.</p><p><strong>Conclusion: </strong>We identified a specific phenotype of delayed GET elevated HAC count, representing patients with poor capsule exiting efficiency, which could be a biomarker for tailored prokinetic therapy.</p><p><strong>Trial registration: </strong>NCT02022826.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 10","pages":"e70463"},"PeriodicalIF":3.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Fat Diet Alters Gastrointestinal Function and Results in Reduced Enteric Neuron Density.","authors":"Marta Chavero-Pieres, Maria Francesca Viola, Zheng Wang, Marcello Delfini, Iris Appeltans, Naomi Fabre, Guy Boeckxstaens, Nathalie Stakenborg","doi":"10.1111/nmo.70470","DOIUrl":"10.1111/nmo.70470","url":null,"abstract":"<p><strong>Introduction: </strong>Obese patients suffer from cardiovascular, metabolic and gastrointestinal disorders, including constipation, proposed to result from high fat diet (HFD)-induced enteric neuron loss. However, these studies used high-fat purified diets, containing reduced amounts of fiber compared to non-purified diets, known to alter gut physiology and microbiome composition. Therefore, we evaluated the effect of purified HFD-induced obesity on enteric neuron density and gastrointestinal transit compared to its proper control diet, that is, a purified control diet.</p><p><strong>Methods: </strong>Wild type mice were fed a standard chow diet, purified low fat diet (LFD) or HFD. Colonic transit was measured via glass bead expulsion following 12, 18, and 24 weeks of diet. Colonic muscularis externa was collected for immunofluorescent stainings of enteric neurons.</p><p><strong>Results: </strong>Starting from 18 weeks of HFD, a decline in enteric neuron number was observed compared to LFD. In addition, delayed colonic transit was observed in HFD-fed mice when compared to LFD-fed animals after 18 weeks of exposure.</p><p><strong>Conclusions: </strong>Our study demonstrates that prolonged exposure to a HFD results in a reduced enteric neuron density and delayed colonic transit, and underscores the need to use a proper control diet when evaluating the impact of a HFD on gut physiology.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 10","pages":"e70470"},"PeriodicalIF":3.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Genome-Wide Meta-Analysis of Functional Dyspepsia in 1,168,899 Individuals Implicates Immune Pathways in Disease Susceptibility.","authors":"Cristian Díaz-Muñoz, Bert Broeders, Ferdinando Bonfiglio, Andreea Zamfir-Taranu, Joris Arts, Peter Banovcin, Luis Bujanda, Vasile Drug, Dan Dumitrascu, Guillaume Gourcerol, Sébastien Kindt, Peter Lipták, Chloé Melchior, Carolina Malagelada, Edoardo Vincenzo Savarino, Artemis Trikola, Jara Lehoucq, Florencia Carbone, Jan Tack, Mauro D'Amato","doi":"10.1111/nmo.70469","DOIUrl":"10.1111/nmo.70469","url":null,"abstract":"<p><strong>Background: </strong>Functional dyspepsia (FD) affects over 7% of the global population, impairing quality of life and driving significant healthcare burden. Although genetic contributions to FD pathophysiology have been suspected, large, well-powered genetic studies remain limited. We aimed to identify FD genetic risk factors and implicated biological pathways.</p><p><strong>Methods: </strong>We performed a FD genome-wide association study in 1,168,899 European individuals, including 29,584 FD cases from five large biobanks. We dissected the genetic architecture of FD and its overlap with gastrointestinal and psychiatric disorders and conducted comprehensive gene-prioritization, regulatory, and cell-type enrichment analyzes to identify pathophysiological mechanisms and actionable targets.</p><p><strong>Key results: </strong>We show FD is a complex, highly polygenic trait with a significant genetic component (3.63% heritability) but lower than similar gastrointestinal disorders like irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD). Mendelian randomization revealed causal effects of depression and anxiety on FD risk. We observed substantial local genetic correlations with IBS and GERD, including shared genome-wide significant signals at the human leukocyte antigen region, supporting immune-mediated mechanisms. Gene-prioritization analyzes converged on DEAH-Box Helicase 36 (DHX36), involved in immune responses to microbial infections. Integrative expression-quantitative trait loci and colocalization analyzes indicated that higher genetic risk of FD is causally associated with a reduced DHX36 expression in gastrointestinal tissues, potentially triggering increased proinflammatory cytokine production.</p><p><strong>Conclusions & inferences: </strong>This study implicates immune-driven pathways in FD susceptibility, adds insights into the pathophysiological mechanisms of the disease, and reveals DHX36 as a candidate target for future investigation.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 10","pages":"e70469"},"PeriodicalIF":3.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13680535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methods and Techniques for Closed-Loop Gastrointestinal Pacing.","authors":"Chaveeka Weerakoon, Leo K Cheng, Peng Du, Niranchan Paskaranandavadivel, Nipuni D Nagahawatte","doi":"10.1111/nmo.70467","DOIUrl":"10.1111/nmo.70467","url":null,"abstract":"<p><strong>Purpose: </strong>Gastrointestinal slow waves are rhythmic electrical events that contribute to the coordination of motility. Functional motility disorders such as gastroparesis are linked to abnormal slow wave activity, and current treatments do not target the underlying electrical dysfunction. Gastrointestinal electrical pacing restores normal rhythms, but open-loop pacing lacks adaptation to underlying slow wave activity, leading to reduced energy efficiency and potential overstimulation.</p><p><strong>Methods: </strong>A novel closed-loop pacing system was developed to detect gastric and intestinal slow waves and dynamically pace in response to the underlying rhythm. High-resolution electrode arrays were placed on the serosal surface of anesthetized pigs for simultaneous pacing and mapping. The control strategy comprised two steps: (i) continuous detection and classification of slow waves as normal rhythm (stomach: 15-25 s; small intestine: 3-5 s) or abnormal rhythm; and (ii) pacing delivery and entrainment assessment, with pulses (100-400 ms, 3-8 mA) triggered by abnormal rhythms or failed entrainment.</p><p><strong>Results: </strong>Detection of slow wave events achieved an accuracy of 78% for both the stomach and the small intestine. Entrainment detection yielded an accuracy of 73% for the stomach and 67% for the small intestine. Closed-loop pacing successfully restored abnormal gastric and small intestinal slow wave periods to normal physiological ranges and reduced the number of pulses delivered by 60% compared to open-loop pacing.</p><p><strong>Conclusion: </strong>Closed-loop pacing significantly reduced pulse delivery, demonstrating the feasibility of a targeted, adaptive approach that may reduce pacing burden, although effects on motility and gastric emptying warrant further investigation.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 10","pages":"e70467"},"PeriodicalIF":3.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13680536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal Symptom Events and Motility Alterations Associated With GLP-1 Receptor Agonists.","authors":"Julio Zuniga Cisneros, Camille Lupianez-Merly, Saam Dilmaghani, Ryan J Lennon, Sara Then, Phil Fiero, Rob Blundo, Gianrico Farrugia, Michael Camilleri, Madhusudan Grover","doi":"10.1111/nmo.70458","DOIUrl":"https://doi.org/10.1111/nmo.70458","url":null,"abstract":"<p><strong>Background: </strong>Gastrointestinal symptom events (GISE) are common with glucagon-like peptide-1 receptor agonists (GLP-1RA). We aimed to determine the prevalence of GISE and clinical factors associated with GISE.</p><p><strong>Methods: </strong>An integrated platform database was used to collect real-world data. Using a retrospective cohort study design, Kaplan-Meier analysis was used to estimate GISE-free survival over 60 months. To identify predictors of GISE, the cohort was randomly split 80/20 into training and testing sets. A LASSO-penalized Cox model was used to identify relevant associations, after which main-effect and interaction models were constructed. Gastric emptying scintigraphy (GES) of solids was extracted from electronic medical records, where available.</p><p><strong>Results: </strong>Among 78,277 patients, 87% reported no baseline GI symptoms. At 60 months, 53% reported at least one GISE, most commonly abdominal pain (28%) and nausea (25%). Women were at higher risk of GISE than men (Kaplan-Meier HR 1.4). In the prediction model, baseline diarrhea, constipation, abdominal pain, and nausea were associated with higher GISE risk (HRs 2.2, 2.0, 1.7, and 1.6, respectively), and male sex with lower risk (HR 0.79). Concomitant baseline use of metoclopramide (HR 1.6) was also associated with higher risk of GISE, with weaker associations for tricyclic antidepressants, GABA analogs, and opioids (HRs 1.1-1.2). Model discrimination was modest (C-index 0.64 training, 0.63 testing). Among 696 symptomatic patients clinically referred for GES after GLP-1RA initiation, 34.6% (N = 241) exhibited delayed GE. Constipation was more prevalent in those with delayed GE.</p><p><strong>Conclusion: </strong>The 5-year incidence of GISE among patients initiating GLP-1RA therapy was over 50%. While the ability to predict GISE was modest, female sex, baseline GI symptoms, and concomitant medications were associated with an increased risk. Among the small, symptom-selected subgroup referred for testing, only a third had delayed GE.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 10","pages":"e70458"},"PeriodicalIF":3.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Nausea Is Not Just Nausea: A Multi-Center, Cross-Sectional Study of Children and Young Adults.","authors":"Khalil El-Chammas, Lauren Hagenstein, Ashish Chogle, Neha Santucci, Kahleb Graham, Lev Dorfman, Daniel R Kelly, Jason E Dranove, Rachel Rosen, Samuel Nurko, Joseph Croffie, Keshawadhana Balakrishnan, Eric H Chiou, Pippa Simpson, Katja Karrento","doi":"10.1111/nmo.70447","DOIUrl":"https://doi.org/10.1111/nmo.70447","url":null,"abstract":"<p><strong>Background: </strong>Chronic nausea is commonly associated with disorders of gut-brain interaction (DGBI). Pediatric functional nausea (FN) is defined as predominant nausea generally unrelated to meals. It is unclear if FN is a distinct entity or clustered with pain-associated DGBI. This multi-center study aimed to investigate the burden and comorbidities of FN and compare it to other DGBI.</p><p><strong>Methods: </strong>Patients ages 8-21 years with DGBI were enrolled in a cross-sectional, multi-center observational registry across seven outpatient gastroenterology clinics and classified by Rome IV criteria. FN was compared to non-FN DGBI using validated symptom surveys: (1) Nausea Severity Scale (NSS), (2) Abdominal Pain Index (API), (3) PROMIS Global Health Scale (GHS), (4) PROMIS Pediatric Anxiety, (5) PROMIS Pediatric Depression, (6) Children's Somatization Inventory (CSI), and (7) Functional Disability Inventory (FDI).</p><p><strong>Key results: </strong>292 subjects were analyzed. Fifty (17%) met FN criteria, of which 72% were female. Eighty-four and 32% of FN patients also met criteria for functional dyspepsia (FD) post-prandial distress subtype and irritable bowel syndrome (IBS), respectively. FN versus non-FN reported greater abdominal pain (p = 0.008), anxiety (p = 0.007) and depression (p = 0.002). FN versus IBS more commonly had long-term nausea and abdominal pain (p = 0.011, p = 0.014), postural dizziness (p = 0.034), migraines (p < 0.001), lower global health (p = 0.003), along with greater anxiety (p < 0.001) and depression (p < 0.001).</p><p><strong>Conclusions and inferences: </strong>Children who meet formal FN criteria do not have isolated nausea. FN overlaps highly with pain-associated DGBI, and nearly all FN patients report abdominal pain. FN is coupled with extra-intestinal symptoms, mental health comorbidities, and poor global health.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 10","pages":"e70447"},"PeriodicalIF":3.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When Food Avoidance Meets Compatible Diagnostic Criteria: Avoidant/Restrictive Food Intake Disorder Features in Irritable Bowel Syndrome.","authors":"Hiba Mikhael-Moussa, Alexandra Aupetit, Olivia Guérin, Charlotte Desprez, Francesco Monti, Julien Grosjean, Guillaume Gourcerol, Anne-Marie Leroi, Najate Achamrah, Chloé Melchior","doi":"10.1111/nmo.70456","DOIUrl":"https://doi.org/10.1111/nmo.70456","url":null,"abstract":"<p><strong>Background: </strong>Alone, the Nine Item Avoidant/Restrictive Food Intake Disorder (ARFID) Screen (NIAS) only allows for ARFID-like symptom detection, potentially overestimating its prevalence. We aimed to investigate the prevalence of ARFID-like symptoms and DSM-5-compatible ARFID (based on medical chart review) in irritable bowel syndrome (IBS), and to compare characteristics associated with these definitions.</p><p><strong>Methods: </strong>Adult patients with IBS according to Rome IV criteria, consulting in our tertiary care center between January 2024 and February 2025, were included. Patient data were collected using validated questionnaires, including NIAS-Fr. ARFID-like symptoms were defined as meeting the cut-off for at least one NIAS-Fr subscale (≥ 10 on \"picky\" or \"fear,\" or ≥ 9 on \"appetite\"). A medical chart review using our center's clinical data warehouse was conducted for detecting medical impairment and eating disorder (ED) diagnosis. Patients with a positive NIAS-Fr, without ED, and with at least one medical/psychosocial impairment were considered to be in the \"DSM-5 compatible ARFID\" group. Univariate and multiple logistic regression analyses were conducted.</p><p><strong>Key results: </strong>Among the 326 included patients, 47.5% had ARFID-like symptoms, and 33.4% met DSM-5-compatible criteria for ARFID. Functional dyspepsia (FD) was prevalent in 60.4% of patients. Depressive symptoms, somatic symptom severity, and FD were independently associated with having ARFID-like symptoms (Nagelkerke R² = 0.138). Depressive symptoms and IBS symptom severity were independently associated with DSM-5 compatible ARFID (Nagelkerke R² = 0.203).</p><p><strong>Conclusions and inferences: </strong>ARFID-like symptoms were more prevalent than DSM-5-compatible ARFID in our population. Applying DSM-5-compatible criteria was associated with more severe gastrointestinal and depressive symptoms. Standardized DSM-5 ARFID assessment methods remain to be established.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 10","pages":"e70456"},"PeriodicalIF":3.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13631691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global IBS, Local Patterns: Regional Variability in Pain, Bloating, and Impact on Daily Life Among Asian/Australian and European Patients From the Aegis Epidemiology Survey.","authors":"Christian von Muhlenbrock, Florencia Carbone, Cedric Van de Bruaene, Lukas Michaja Balsiger, Luis G Alcala-Gonzalez, Karin Herrera, Esther Colomier, Jan Tack, Tim Vanuytsel","doi":"10.1111/nmo.70453","DOIUrl":"10.1111/nmo.70453","url":null,"abstract":"<p><strong>Background: </strong>Irritable bowel syndrome (IBS) shows substantial geographic variability in symptom presentation, but regional differences in the clinical relevance of bloating remain poorly understood. We aimed to characterize regional differences in IBS phenotype, symptom burden, psychological and quality-of-life measures, and meal-related symptoms between Asian/Australian and European populations, with particular emphasis on the contribution of bloating to disease burden.</p><p><strong>Methods: </strong>We performed a cross-sectional analysis of the multinational AEGIS survey including adults fulfilling Rome IV criteria for IBS from 11 centers across Asia/Australia and Europe. Participants completed validated assessments of IBS subtype, symptom severity, quality of life, psychological burden, and dietary triggers. Regional comparisons used nonparametric and chi-square tests.</p><p><strong>Results: </strong>Among 1074 participants, 339 met Rome IV criteria for IBS. The proportion of IBS patients was lower in Asia/Australia than in Europe (20.9% vs. 40.9%, p = 0.039). IBS-D (57.1% vs. 35.9%, p < 0.001) predominated in Asia/Australia, whereas IBS-M (31.6% vs. 20.0%, p = 0.028) was more common in Europe. European patients demonstrated higher psychological burden and greater overall symptom severity despite comparable abdominal pain intensity. Bloating severity was significantly higher in European participants (p < 0.001) and showed a substantially stronger association with impaired quality of life than pain (r = -0.552, p < 0.001 vs. r = -0.260, p = 0.005). Postprandial symptoms were more common in Europe, whereas in Asia/Australia, they were associated with greater consumption of dairy products, gluten-containing foods, coffee, and carbonated beverages.</p><p><strong>Conclusions: </strong>IBS phenotype and symptom burden differ across regions. Bloating, rather than abdominal pain, was more strongly associated with impaired quality of life, supporting symptom-centered and culturally tailored IBS management.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":"38 10","pages":"e70453"},"PeriodicalIF":3.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}