Possible Role of Butyric Acid in Long-Term Symptom Relief in Irritable Bowel Syndrome Patients Following Fecal Microbiota Transplantation.

IF 2.9 3区医学 Q1 CLINICAL NEUROLOGY

Neurogastroenterology and Motility Pub Date : 2025-08-01 DOI:10.1111/nmo.70115

Magdy El-Salhy, Jørgen Valeur, Ingeborg Brønstad, Odd Helge Gilja, Jan Gunnar Hatlebakk

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引用次数: 0

Abstract

Background: We previously found that the fecal levels of short-chain fatty acids (SCFAs) changed in irritable bowel syndrome (IBS) patients at 1 month and 1 year after fecal microbiota transplantation (FMT). This study analyzed SCFAs at 2 and 3 years after FMT in the same IBS patients included in those previous studies.

Methods: This study randomized 113 IBS patients into placebo, 30-g, and 60-g groups, who received FMT with 30 g of their own feces and with 30 g and 60 g of the donor's feces, respectively. The patients completed four questionnaires to assess IBS symptoms, fatigue, and quality of life, and supplied fecal samples at the baseline and at 2 and 3 years after FMT. The fecal SCFA levels were measured using gas chromatography.

Results: The butyric acid level was significantly increased at 2 and 3 years after FMT in the 30-g and 60-g groups, and was significantly higher than that in the placebo group. The total SCFA and acetic acid levels decreased significantly in the 30-g and 60-g groups at 2 and 3 years after FMT, while the propionic acid level decreased in the 60-g group at both time points. The butyric acid level was inversely correlated with IBS symptoms and fatigue.

Conclusion and inferences: The increased butyric acid levels in IBS patients at 2 and 3 years after FMT and their inverse correlation with both IBS symptoms and fatigue suggest that butyric acid contributes to the long-term improvement seen after FMT (www.

Clinicaltrials: gov: NCT03822299).

查看原文本刊更多论文

丁酸在肠易激综合征患者粪便菌群移植后长期症状缓解中的可能作用。

背景：我们之前发现肠易激综合征（IBS）患者粪便中短链脂肪酸（SCFAs）水平在粪便微生物群移植（FMT）后1个月和1年发生变化。本研究分析了先前研究中相同IBS患者FMT后2年和3年的SCFAs。方法：本研究将113例IBS患者随机分为安慰剂组、30 g组和60 g组，分别用30 g自己的粪便和30 g和60 g供者的粪便进行FMT治疗。患者完成了四份问卷，以评估IBS症状、疲劳和生活质量，并在基线和FMT后2年和3年提供粪便样本。用气相色谱法测定粪便中短链脂肪酸水平。结果：30 g组和60 g组在FMT后2年和3年丁酸水平显著升高，且显著高于安慰剂组。在FMT后2年和3年，30 g和60 g组的总SCFA和乙酸水平显著下降，而60 g组的丙酸水平在两个时间点都有所下降。丁酸水平与IBS症状和疲劳呈负相关。结论和推论：在FMT后2年和3年，IBS患者的丁酸水平升高，以及它们与IBS症状和疲劳的负相关表明，丁酸有助于FMT后的长期改善（www.Clinicaltrials: gov: NCT03822299）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurogastroenterology and Motility 医学-临床神经学

CiteScore

7.80

自引率

8.60%

发文量

178

审稿时长

3-6 weeks

期刊介绍： Neurogastroenterology & Motility (NMO) is the official Journal of the European Society of Neurogastroenterology & Motility (ESNM) and the American Neurogastroenterology and Motility Society (ANMS). It is edited by James Galligan, Albert Bredenoord, and Stephen Vanner. The editorial and peer review process is independent of the societies affiliated to the journal and publisher: Neither the ANMS, the ESNM or the Publisher have editorial decision-making power. Whenever these are relevant to the content being considered or published, the editors, journal management committee and editorial board declare their interests and affiliations.