Neurogastroenterology and Motility最新文献_第8页

Comparison of High-Resolution Anorectal Manometry and Magnetic Resonance Defecography in Patients With Obstructive Defecation: Are Both Tests Necessary? 高分辨率肛肠测压与磁共振排便成像在梗阻性排便患者中的比较：两者都有必要吗？

IF 2.9 3区医学

Neurogastroenterology and Motility Pub Date : 2025-08-11 DOI: 10.1111/nmo.70131

Haily Vora, Brian Lacy

{"title":"Comparison of High-Resolution Anorectal Manometry and Magnetic Resonance Defecography in Patients With Obstructive Defecation: Are Both Tests Necessary?","authors":"Haily Vora, Brian Lacy","doi":"10.1111/nmo.70131","DOIUrl":"https://doi.org/10.1111/nmo.70131","url":null,"abstract":"Introduction: Investigation of an evacuation disorder is often pursued in patients with symptoms of obstructive defecation. High-resolution anorectal manometry (HR-ARM) is a simple, safe, and widely available test to diagnose pelvic floor dysfunction. A more costly and less accessible test is magnetic resonance defecography (MRD). This study aims to quantify the added value of MRD in diagnosing pelvic floor disorders.Methods: HR-ARM and MRD performed in patients with a diagnosis of constipation between January 1, 2020 and May 15, 2022 at Mayo Clinic were identified using Epic Slicer Dicer. Univariate and multivariate analyses were used to compare findings on MRD in patients with and without abnormal HR-ARM. Categorical variables were compared using the Pearson's chi-square test, and continuous variables were compared using the two-sample t-test.Results: Seventy-six consecutive patients (81.8% female, 94.8% White, ages 19-82) who underwent both HR-ARM and MRD were included. The majority had evidence of dyssynergia on HR-ARM (n = 49, 64.5%). Patients with dyssynergia on HR-ARM were significantly more likely to have prolonged balloon expulsion at both > 60 and > 30 s (p < 0.001) and incomplete gel expulsion on MRD (p < 0.001). However, they were not more likely to have a clinically significant rectocele measuring > 2 cm (p = 0.17) or evidence of rectal prolapse (p = 0.07).Discussion: Anatomic findings on MRD were similar between patients with and without evidence of dyssynergia identified by HR-ARM. In this retrospective review, simultaneously undergoing MRD in addition to HR-ARM does not appear to provide significant additional diagnostic information to guide therapeutic recommendations. Large prospective studies to evaluate the added value of MRD are needed.","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":" ","pages":"e70131"},"PeriodicalIF":2.9,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evidence for Brain-To-Gut and Gut-To-Brain Pathways in Primary Care Patients With Disorders of Gut-Brain Interaction, Inflammatory Bowel Disease and Gastroesophageal Reflux Disease. 肠-脑相互作用紊乱、炎症性肠病和胃食管反流病的初级保健患者脑-肠和肠-脑通路的证据

IF 2.9 3区医学

Neurogastroenterology and Motility Pub Date : 2025-08-04 DOI: 10.1111/nmo.70117

N A Koloski, M P Jones, A Shah, G Holtmann, N J Talley

{"title":"Evidence for Brain-To-Gut and Gut-To-Brain Pathways in Primary Care Patients With Disorders of Gut-Brain Interaction, Inflammatory Bowel Disease and Gastroesophageal Reflux Disease.","authors":"N A Koloski, M P Jones, A Shah, G Holtmann, N J Talley","doi":"10.1111/nmo.70117","DOIUrl":"https://doi.org/10.1111/nmo.70117","url":null,"abstract":"Background: Apart from disorders of gut-brain interaction (DGBI), little data exist on the magnitude of the brain-to-gut pathway in other chronic gastrointestinal conditions such as gastroesophageal reflux disease (GERD) or inflammatory bowel disease (IBD) and what factors modify order of diagnosis. We aimed to determine the proportion of patients who received a diagnosis of a DGBI, GERD, or IBD prior to a new psychological diagnosis (gut-to-brain), and vice versa (brain-to-gut), and whether specific factors moderate the order of diagnosis.Method: Data was collected from a retrospective study of 1,129,104 patients attending general practices in the United Kingdom. Patients diagnosed with DGBI, GERD, or IBD and a psychological disorder (anxiety and/or depression) were included (excluding those with other organic GI disease). Information on which diagnosis appeared first was recorded. Multiple logistic regression was performed to compare a diagnosis of a DGBI, GERD, or IBD first versus a psychological diagnosis first on sociodemographic factors, medical conditions, and medication usage.Key results: Just over half of patients were diagnosed with a psychological condition first versus after for IBS (53.9%) and ulcerative colitis (55.6%). This proportion was higher for FD (61.5%) and GERD (64.2%) but lower for Crohn's disease (45.7%). In a multivariate model, being female (OR = 1.37, 95% CI 1.25, 1.49), prior PPI (OR = 9.17, 95% CI 8.4, 10.0), antibiotic (OR = 2.54, 95% CI 2.29, 2.81) and NSAID use (OR = 1.29, 95% CI 1.18, 1.42), and prior gastroenteritis (OR = 2.19, 95% CI, 1.79, 2.67) were significant predictors for being diagnosed with GERD first. Similar results were found for DGBI.Conclusions & inferences: Prior medication usage and gastroenteritis may play a role in generating gut-to-brain pathway disturbances.","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":" ","pages":"e70117"},"PeriodicalIF":2.9,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The human colon: Evidence for degenerative changes during aging and the physiological consequences. 人类结肠：衰老过程中的退行性变化及其生理后果的证据。

IF 3.5 3区医学

Neurogastroenterology and Motility Pub Date : 2025-08-01 Epub Date: 2024-06-17 DOI: 10.1111/nmo.14848

Nicholas Baidoo, Gareth J Sanger

{"title":"The human colon: Evidence for degenerative changes during aging and the physiological consequences.","authors":"Nicholas Baidoo, Gareth J Sanger","doi":"10.1111/nmo.14848","DOIUrl":"10.1111/nmo.14848","url":null,"abstract":"Background: The incidence of constipation increases among the elderly (>65 years), while abdominal pain decreases. Causes include changes in lifestyle (e.g., diet and reduced exercise), disease and medications affecting gastrointestinal functions. Degenerative changes may also occur within the colo-rectum. However, most evidence is from rodents, animals with relatively high rates of metabolism and accelerated aging, with considerable variation in time course. In humans, cellular and non-cellular changes in the aging intestine are poorly investigated.Purpose: To examine all available studies which reported the effects of aging on cellular and tissue functions of human isolated colon, noting the region studied, sex and age of tissue donors and study size. The focus on human colon reflects the ability to access full-thickness tissue over a wide age range, compared with other gastrointestinal regions. Details are important because of natural human variability. We found age-related changes within the muscle, in the enteric and nociceptor innervation, and in the submucosa. Some involve all regions of colon, but the ascending colon appears more vulnerable. Changes can be cell- and sublayer-dependent. Mechanisms are unclear but may include development of \"senescent-like\" and associated inflammaging, perhaps associated with increased mucosal permeability to harmful luminal contents. In summary, reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes within the colon wall may have little impact on symptoms and colonic functions, because of high \"functional reserve,\" but are likely to facilitate the development of constipation during age-related challenges (e.g., lifestyle, disease, and medications), now operating against a reduced functional reserve.","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":" ","pages":"e14848"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141420061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enteric neuroprotection-A matter of balancing redox potentials, limiting inflammation, and boosting resilience. 肠道神经保护--平衡氧化还原电位、限制炎症和增强复原力。

IF 3.5 3区医学

Neurogastroenterology and Motility Pub Date : 2025-08-01 Epub Date: 2024-07-22 DOI: 10.1111/nmo.14871

Ulrikke Voss

{"title":"Enteric neuroprotection-A matter of balancing redox potentials, limiting inflammation, and boosting resilience.","authors":"Ulrikke Voss","doi":"10.1111/nmo.14871","DOIUrl":"10.1111/nmo.14871","url":null,"abstract":"The enteric nervous system (ENS) orchestrates intricate and autonomous functions throughout the gastrointestinal (GI) tract. Disruptions in ENS function are associated GI disorders. This mini review focuses on the past decade's research, utilizing rodent models, with an emphasis on protecting enteric neurons from loss. The review specifically looks at efforts to reduce oxidative stress, limit inflammation, and enhance neuronal resilience. Protective interventions including administration of antioxidants and compounds targeting cellular redox buffer systems, are evaluated for their effectiveness in preventing loss of enteric neurons in the ischemia-reperfusion model and streptozotocin-induced diabetes model. Interventions such as engrafting mesenchymal stem cells and targeting inflammatory signaling pathways in enteric neurons and glial cells are evaluated in inflammatory bowel disease models including the Winnie mouse, DSS-, and DNBS/TNBS-induced colitis models. The review also touches upon neuronal resilience, particularly in the context of Parkinson's disease models. Including estrogen's neuroprotective role, and the influence of metal ions on enteric neuronal protection. Understanding the dynamic interplay within the ENS and its role in disease pathogenesis holds promise for developing targeted therapies to effectively manage and treat various GI ailments.","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":" ","pages":"e14871"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141748694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genomic stress in diseases stemming from defects in the second brain. 源于第二大脑缺陷的疾病中的基因组压力。

IF 3.5 3区医学

Neurogastroenterology and Motility Pub Date : 2025-08-01 Epub Date: 2024-07-14 DOI: 10.1111/nmo.14860

Lobke Marie M Mombeek, Werend Boesmans, David M Wilson

{"title":"Genomic stress in diseases stemming from defects in the second brain.","authors":"Lobke Marie M Mombeek, Werend Boesmans, David M Wilson","doi":"10.1111/nmo.14860","DOIUrl":"10.1111/nmo.14860","url":null,"abstract":"This review discusses the less-explored realm of DNA damage and repair within the enteric nervous system (ENS), often referred to as the \"second brain.\" While the central nervous system has been extensively studied for its DNA repair mechanisms and associated neuropathologies, the ENS, which can autonomously coordinate gastrointestinal function, experiences unique challenges and vulnerabilities related to its genome integrity. The susceptibility of the ENS to DNA damage is exacerbated by its limited protective barriers, resulting in not only endogenous genotoxic exposures, such as oxidative stress, but also exogenous threats, such as ingested environmental contaminants, local inflammatory responses, and gut dysbiosis. Here, we discuss the evidence for DNA repair defects in enteric neuropathies, most notably, the reported relationship between inherited mutations in RAD21 and LIG3 with chronic intestinal pseudo-obstruction and mitochondrial gastrointestinal encephalomyopathy disorders, respectively. We also introduce the lesser-recognized gastrointestinal complications in DNA repair syndromes, including conditions like Cockayne syndrome. The review concludes by pointing out the potential role of DNA repair defects in not only congenital disorders but also aging-related gut dysfunction, as well as the crucial need for further research to establish direct causal links between DNA damage accumulation and ENS-specific pathologic phenotypes.","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":" ","pages":"e14860"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141616821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Possible Role of Butyric Acid in Long-Term Symptom Relief in Irritable Bowel Syndrome Patients Following Fecal Microbiota Transplantation. 丁酸在肠易激综合征患者粪便菌群移植后长期症状缓解中的可能作用。

IF 2.9 3区医学

Neurogastroenterology and Motility Pub Date : 2025-08-01 DOI: 10.1111/nmo.70115

Magdy El-Salhy, Jørgen Valeur, Ingeborg Brønstad, Odd Helge Gilja, Jan Gunnar Hatlebakk

{"title":"Possible Role of Butyric Acid in Long-Term Symptom Relief in Irritable Bowel Syndrome Patients Following Fecal Microbiota Transplantation.","authors":"Magdy El-Salhy, Jørgen Valeur, Ingeborg Brønstad, Odd Helge Gilja, Jan Gunnar Hatlebakk","doi":"10.1111/nmo.70115","DOIUrl":"https://doi.org/10.1111/nmo.70115","url":null,"abstract":"Background: We previously found that the fecal levels of short-chain fatty acids (SCFAs) changed in irritable bowel syndrome (IBS) patients at 1 month and 1 year after fecal microbiota transplantation (FMT). This study analyzed SCFAs at 2 and 3 years after FMT in the same IBS patients included in those previous studies.Methods: This study randomized 113 IBS patients into placebo, 30-g, and 60-g groups, who received FMT with 30 g of their own feces and with 30 g and 60 g of the donor's feces, respectively. The patients completed four questionnaires to assess IBS symptoms, fatigue, and quality of life, and supplied fecal samples at the baseline and at 2 and 3 years after FMT. The fecal SCFA levels were measured using gas chromatography.Results: The butyric acid level was significantly increased at 2 and 3 years after FMT in the 30-g and 60-g groups, and was significantly higher than that in the placebo group. The total SCFA and acetic acid levels decreased significantly in the 30-g and 60-g groups at 2 and 3 years after FMT, while the propionic acid level decreased in the 60-g group at both time points. The butyric acid level was inversely correlated with IBS symptoms and fatigue.Conclusion and inferences: The increased butyric acid levels in IBS patients at 2 and 3 years after FMT and their inverse correlation with both IBS symptoms and fatigue suggest that butyric acid contributes to the long-term improvement seen after FMT (www.Clinicaltrials: gov: NCT03822299).","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":" ","pages":"e70115"},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut Neuropathies and Intestinal Motility Disorders. 肠道神经病变和肠道运动障碍。

IF 3.5 3区医学

Neurogastroenterology and Motility Pub Date : 2025-08-01 Epub Date: 2025-01-08 DOI: 10.1111/nmo.14995

David A Wattchow, Simon J H Brookes, Nick J Spencer, Roberto De Giorgio, Marcello Costa, Phil G Dinning

引用次数: 0

Enteric neuropathy and the vagus nerve: Therapeutic implications. 肠道神经病与迷走神经：治疗意义。

IF 3.5 3区医学

Neurogastroenterology and Motility Pub Date : 2025-08-01 Epub Date: 2024-06-14 DOI: 10.1111/nmo.14842

Bruno Bonaz

引用次数: 0

Molecular mechanisms of enteric neuropathies in high-fat diet feeding and diabetes. 高脂饮食喂养和糖尿病肠神经病变的分子机制。

IF 2.9 3区医学

Neurogastroenterology and Motility Pub Date : 2025-08-01 Epub Date: 2024-08-09 DOI: 10.1111/nmo.14897

Francesca Cingolani, Arun Balasubramaniam, Shanthi Srinivasan

引用次数: 0

Abstracts of the 2025 ANMS Annual Meeting Scientific Program: Advancing Patient Care Through Cutting-Edge Research August 8-10, 2025 Minneapolis, Minnesota, USA. 2025年ANMS年度会议科学计划：通过前沿研究推进患者护理摘要2025年8月8日至10日，美国明尼苏达州明尼阿波利斯。

IF 2.9 3区医学

Neurogastroenterology and Motility Pub Date : 2025-08-01 DOI: 10.1111/nmo.70109

引用次数: 0