Neurogastroenterology and Motility最新文献

{"title":"Diaphragmatic Flutter Disease: Key Findings in Esophageal Manometry and Biofeedback Treatment.","authors":"Ezquerra-Durán Alberto, Ayala Haro Noé, Isis K Araujo, Elizabeth Barba","doi":"10.1111/nmo.70041","DOIUrl":"10.1111/nmo.70041","url":null,"abstract":"<p><strong>Background: </strong>Diaphragmatic flutter (DF) is a rare condition characterized by involuntary contractions of the diaphragmatic muscle, often accompanied by accessory respiratory muscle contractions. Symptoms can include epigastric pulsations, abdominal pain, and reflux. Diagnosis is challenging, and treatment is based on individual cases. This study presents the first case series of DF assessed using high-resolution esophageal manometry (HREM), electromyography (EMG), and plethysmography belts, and the symptomatic improvement through biofeedback therapy.</p><p><strong>Methods: </strong>This case series includes patients with refractory abdominal spasms referred to the digestive motility department from 2018 to 2024.</p><p><strong>Results: </strong>Two patients were diagnosed with DF using HREM, which reveals a characteristic pattern of oscillating increases in intragastric pressure, repetitive crural diaphragm spasms, and pharyngeal contraction during abdominal spasms. Symptomatic control was achieved following abdomino-thoracic biofeedback (ATB) therapy by plethysmography belts.</p><p><strong>Conclusions: </strong>High-resolution esophageal manometry offers a reliable, non-invasive method for diagnosis of DF, presenting a specific manometric pattern. ATB appears to be an effective treatment for DF, suggesting that voluntary but unconsciously initiated movement disorders may contribute to the condition.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":" ","pages":"e70041"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Decline of Sensory-Motility Coordination in Rectal Evacuation due to Pelvic Floor Dysfunction.","authors":"Xinpeng Wang, Yanhui Gao, Li Xiao, Li Qin, Qi Ai, Bohong Xu, Yu Zhi","doi":"10.1111/nmo.70032","DOIUrl":"10.1111/nmo.70032","url":null,"abstract":"<p><strong>Background: </strong>Constipation, a common defecatory disorder, exhibits various symptoms and individual variability. Abnormalities in rectal sensation and/or motility are prevalent among patients. However, the mechanisms linking rectal sensation and motility, and their impact on rectal evacuation function, remain poorly understood.</p><p><strong>Methods: </strong>Our study gathered data from 154 chronic constipation patients, including rectal sensation and motility, electromyography, motor evoked potentials, defecography, and balloon expulsion test. The aim was to investigate the association between rectal sensation and motility in the context of different symptom profiles and to identify potential influencing factors and to evaluate their effect on rectal evacuation.</p><p><strong>Key results: </strong>Defecatory desire volume affects contrast evacuation (r = -0.181, p = 0.042). Hyposensitive patients show lower balloon expulsion rates, rectoanal gradient, and manometric defecation index than hypersensitive patients (p = 0.002, 0.007, and 0.041). Rectal sensation correlates with rectoanal gradient across all sensitivity levels (p < 0.05). Excessive electromyographic activity affects maximum tolerable volume in rectoanal gradient compared to normal (r = -0.551 vs. -0.434). Neurological conduction dysfunction weakens rectal sensation-motility coordination. Age and gender synergistically affect this coordination in normal rectal sensitivity (p < 0.05), while patients with abnormal rectal sensitivity are more sensitive to constipation severity (p < 0.05).</p><p><strong>Conclusions& inferences: </strong>A decrease in rectal sensitivity may impair normal rectal evacuation, a process that may involve rectal motility changes mediated by rectal sensation. Excessive electromyographic activity and neurological conduction dysfunction may both contribute to the decreased coordination between rectal sensation and motility. Furthermore, the severity of the disease, age, and gender may all influence this association.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":" ","pages":"e70032"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for Swallowing Disorders in Patients With Poststroke Utilizing the Gugging Swallowing Screen and Its Adoption in Dietary Management.","authors":"Linghui Huang, Xingxing Cao, Jiahao Wu, Yifeng Quan, Yanan Zuo, Xi Zhang, Zhaoxiang Meng","doi":"10.1111/nmo.70049","DOIUrl":"10.1111/nmo.70049","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the effectiveness of the Gugging Swallowing Screen (GUSS) in swallowing disorder screening of patients with poststroke and assess its adoption value in dietary management.</p><p><strong>Methods: </strong>Swallowing function in 174 patients with poststroke was screened using the GUSS scale and the water swallow test (WST). Patients with swallowing disorders were randomly assigned to the observation group (OG) and the control group (CG). The CG received standard treatment and care, while the OG also underwent GUSS-based swallowing function assessment and a graded dietary management plan. The effectiveness of improvements in swallowing function, psychological health assessments, and the incidence of complications was compared.</p><p><strong>Results: </strong>The effect sizes (ES) and standardized response mean (SRM) of GUSS scale were markedly superior to those of WST (p < 0.05). OG exhibited a markedly higher rate of improvement in swallowing function versus CG (p < 0.05). Adverse events were markedly less frequent in OG versus CG (p < 0.05). Alb, PA, and TNF in OG were superior to those in CG after treatment (p < 0.05). The psychological function, physical function, social function, material life status scores, and overall quality of life (QoL) evaluation questionnaire scores of OG patients were superior to those in CG at discharge (p < 0.05). The incidence of adverse reactions in OG was substantially inferior to that in CG (p < 0.05).</p><p><strong>Conclusion: </strong>GUSS is an effective screening tool for identifying swallowing disorders in patients with poststroke. Swallowing dysfunction severity-based tailoring dietary management plans can markedly improve patients' swallowing function and lower the risk of swallowing-related complications.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":" ","pages":"e70049"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Basic Science Editor and New Journal Management Committee Chair of Neurogastroenterology and Motility!","authors":"Maura Corsetti, Frank Zerbib, Christopher Black, Andrea Shin, Kirsteen Browning, Daniel Keszthelyi, Mike Jones","doi":"10.1111/nmo.70112","DOIUrl":"10.1111/nmo.70112","url":null,"abstract":"","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":" ","pages":"e70112"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additional Diagnostic Yield of Ambulatory 24-h High Resolution Manometry With Impedance in Patients With Non-Cardiac Chest Pain or Non-Obstructive Dysphagia.","authors":"Jutta Keller, Marek Boedler, Dorothea Jasper, Viola Andresen, Ulrich Rosien, Thomas Rösch, Peter Layer","doi":"10.1111/nmo.70048","DOIUrl":"10.1111/nmo.70048","url":null,"abstract":"<p><strong>Background: </strong>In patients with non-cardiac chest pain (NCCP) and non-obstructive dysphagia (NOD), standard esophageal high resolution manometry (HRM) with water swallows and/or solid meals may miss intermittent dysmotility. To what extent prolonged 24 h-measurements may increase the diagnostic sensitivity is currently unclear.</p><p><strong>Methods: </strong>75 patients (47 female, 58 ± 16 years) with NCCP and/or NOD underwent standard HRM (single water swallows plus rice meal) and ambulatory 24-h-HRM with impedance. Results were analyzed according to Chicago Classification v3.0 for water-swallow-HRM; adapted criteria were used for rice-meal and 24-h-HRM. Patients were followed by chart review.</p><p><strong>Key results: </strong>Contractility parameters obtained by different HRM procedures always correlated (R > 0.27, p < 0.05). During 24 h-measurements, all parameters showed circadian variability (p < 0.001). In comparison with water-swallow-HRM, rice-meal-HRM markedly increased the proportion of patients diagnosed with achalasia III, esophagogastric outlet obstruction with spastic features, distal esophageal spasm, or hypercontractility (10.7% vs. 21.3%, p = 0.039). The diagnostic gain regarding spastic and/or hypercontractile disorders was further increased by 24-h-HRM (61.3% of patients, p < 0.001). In 11 out of 21 patients with normal results in both water-swallow- and rice-meal-HRM (15% of total cohort), 24-h-HRM detected a major motor disorder. Results of 24-h-HRM altered treatment recommendations in 41 patients (54%).</p><p><strong>Conclusions&inferences: </strong>24-h-HRM revealed spastic and/or hypercontractile esophageal motor disorders in about 60% of patients with NCCP/NOD and markedly improved diagnostic yield compared with standard HRM, probably partly due to the observed circadian variability of esophageal motility. 24-h-HRM findings frequently altered treatment recommendations, but the ultimate clinical consequences of the increased diagnostic yield have to be examined further.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":" ","pages":"e70048"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TTX-R and TTX-S Sodium Channels in CGRP-Positive Dorsal Root Ganglia Neurons Mediate Referred Somatic Hyperalgesia in Ulcerative Colitis Mice.","authors":"Yongbin Liu, Ziyan Yuan, Hongzhou He, Huanhuan Liu, Yuwei Wu, Simeng Xue, Zhijun Diao, Haifa Qiao","doi":"10.1111/nmo.70051","DOIUrl":"10.1111/nmo.70051","url":null,"abstract":"<p><strong>Background: </strong>Ulcerative colitis (UC) frequently co-exists with referred somatic hyperalgesia in clinical presentations. However, the peripheral neurophysiological mechanisms of visceral referred pain remain unclear. This study aimed to clarify the neurobiological mechanisms that underpin the referred somatic hyperalgesia associated with UC.</p><p><strong>Methods: </strong>A UC mouse model was constructed via the administration of dextran sulfate sodium (DSS). Referred somatic regions in these mice were identified by measuring the number of Evans blue extravasations and pain threshold levels. Electrophysiological and immunofluorescent staining approaches were applied to evaluate the alterations in kinetic properties and expression of TTX-R (Na_v1.8) and TTX-S (Na_v1.7) channels in calcitonin gene-related peptide (CGRP)-positive dorsal root ganglion (DRG) neurons in the referred regions. Pharmacological methods were utilized to elucidate the necessary role of the Na_v1.8 and Na_v1.7 channels in somatic referred hyperalgesia.</p><p><strong>Key results: </strong>Oral administration of DSS to mice for 7 days resulted in significant colon damage, neurogenic inflammation, and referred somatic hyperalgesia. The mechanisms underlying these effects may involve the activation of TTX-R and TTX-S channels, and the upregulation of co-expressed Na_v1.8 and Na_v1.7 with CGRP, resulting in an increased excitability of CGRP⁺ DRG neurons in sensitized regions. Selectively inhibiting either Na_v1.8 or Na_v1.7 channels could mitigate the referred somatic hyperalgesia induced by DSS.</p><p><strong>Conclusions and inferences: </strong>The functional alterations in Na_v1.8 and Na_v1.7 channels within CGRP⁺ DRG neurons are pivotal to the development of neurogenic inflammation and referred somatic hyperalgesia. These findings lay a foundation for exploring novel therapeutic targets to relieve visceral referred pain.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":" ","pages":"e70051"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finding the Line Between Avoidant/Restrictive Food Intake Disorder and Refractory Disorders of Gut-Brain Interaction Using Lenient vs. Strict Severity Criteria: A Retrospective Exploratory Analysis From a Single Tertiary Neurogastroenterology Centre.","authors":"Lee David Martin, Asma Fikree, Natalia Zarate-Lopez, Karin Martinkova, Concetta Brugaletta, Chris Perrin, Ursula Philpot","doi":"10.1111/nmo.70043","DOIUrl":"10.1111/nmo.70043","url":null,"abstract":"<p><strong>Background: </strong>Avoidant/restrictive food intake disorder (ARFID) is common among adults with disorders of gut-brain interaction (DGBI) presenting to gastroenterology settings. Symptoms overlap between ARFID and DGBI. How the severity of ARFID is defined can impact rates of diagnosis. Importantly, a diagnosis of ARFID can only be applied when the eating disturbance exceeds that expected from the DGBI condition. This leads to diagnostic challenges for the gastroenterology team. We aimed to explore how we could better identify \"ARFID presentation\" by reaching a clinically meaningful cut-off and distinct categories for separating DGBI from ARFID and where DGBI and ARFID overlap.</p><p><strong>Methods: </strong>A retrospective review of electronic health records (EHR) was conducted on 33 patients 88% female (29/33), with a median age of 44.3 ± 15.5 (range 18-73 years). All had a Rome IV diagnosed DGBI and were refractory to standard medical care, requiring both gastro-psychology and dietitian input in a tertiary care Neurogastroenterology service during 2019. Severity criteria for meeting either strict or lenient ARFID criteria A were defined based on DSM-5 and best practice recommendations.</p><p><strong>Results: </strong>The majority (82%) met a form of ARFID criteria A. However, by applying severity levels, 33% met criteria for strict ARFID, while 49% met lenient criteria, and 18% did not meet any criteria.</p><p><strong>Discussion: </strong>Adults with refractory DGBI who require both dietetic and psychological support can meet both lenient and strict ARFID severity criteria. Future research should explore if utilizing severity markers can help separate the heterogeneity of DGBI + ARFID and inform diagnostic and treatment approaches.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":" ","pages":"e70043"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding Anxiety and/or Depressive Status in Functional Constipation: Insights From Surface-Based Functional-Structural Coupling Analysis.","authors":"Xiang Yu, Yuwei Li, Chen Xu, Yi Ji, Chao Wang, Chaoqun Ma, Xiaoyu Wu, Zhushan Wang, Feng Liu, Peng Li, Yiming Li, Yawu Liu","doi":"10.1111/nmo.70050","DOIUrl":"10.1111/nmo.70050","url":null,"abstract":"<p><strong>Background: </strong>While patients with functional constipation (FC) are more susceptible to psychiatric issues such as anxiety and depression, the mechanism underlying gut-brain interactions remains elusive.</p><p><strong>Methods: </strong>This study included 39 FC patients with anxiety/depressive status (FCAD), 32 FC patients without anxiety/depressive status (FCNAD), and 42 healthy controls. Participants underwent clinical examinations and MRI scans, and changes in functional-structural coupling were assessed using surface-based regional homogeneity and cortical thickness. Receiver operating characteristic (ROC) curve analyses were performed to assess the predictive value of these changes.</p><p><strong>Key results: </strong>Abnormal coupling changes were exclusively observed in the FCAD group at both global and regional levels, primarily including significantly decreased coupling indices in the left hemisphere and regions within the bilateral visual cortex, left dorsolateral prefrontal cortex, and left posterior cingulate cortex. The FCAD and FCNAD groups were compared and analyzed using ROC curves, which revealed that coupling ratios in the bilateral visual cortex yielded higher predictive accuracy. Specifically, in the 12th sub-region of the left hemisphere, the coupling ratio achieved a sensitivity of 71.9% and a specificity of 74.4%. Meanwhile, the 8th sub-region of the right hemisphere showed a sensitivity of 78.1% and a specificity of 71.8%.</p><p><strong>Conclusions and inferences: </strong>These results collectively highlighted asymmetric hemispheric decoupling and impairments in brain regions associated with visual and default mode networks in FCAD patients. These findings offer novel insights into the neurophysiological mechanisms underlying FCAD and may inform the development of more personalized treatment approaches.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":" ","pages":"e70050"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture at Baliao Points Attenuates Visceral Hypersensitivity in Irritable Bowel Syndrome via Gut-Microbiota-Mast Cell-TPRV1 Axis Modulation.","authors":"Meng-Yang Sun, Hai-Hui Xing, Xu Lin, Hong-haoWu, Bang-Guo Cheng, Xue Liu, Min Ni","doi":"10.1111/nmo.70137","DOIUrl":"https://doi.org/10.1111/nmo.70137","url":null,"abstract":"<p><strong>Background: </strong>Visceral hypersensitivity (VH) is a key pathophysiological feature of irritable bowel syndrome (IBS), contributing to chronic abdominal pain and discomfort. While electroacupuncture (EA) has demonstrated efficacy in alleviating IBS symptoms, the mechanisms underlying its effects at the Baliao acupoint remain unclear.</p><p><strong>Methods: </strong>In this translational study, we enrolled 40 IBS patients (gender-balanced, aged 30-60 years) who received standardized EA treatment at Baliao acupoints, with pain intensity assessed using visual analogue scale (VAS) scoring. An IBS rat model was established using acetic acid enema combined with restraint stress. Rats received EA at Baliao or sham acupuncture for 2 weeks. Visceral sensitivity was assessed via abdominal withdrawal reflex (AWR), while mast cell (MC) numbers, histamine and substance P (SP) release, and tight junction proteins (ZO-1, occludin) were quantified. Gut-microbiota composition was analyzed by 16S rDNA sequencing, and the alterations of TRPV1⁺ neuron and MAPK signaling were evaluated via immunofluorescence and Western blot.</p><p><strong>Results: </strong>EA at Baliao significantly attenuated VH in both IBS patients (reduced VAS scores, difference -3.000 ± 0.4264) and rats (lower AWR scores, difference 1.050 ± 0.2630), compared to the sham group. Treatment with EA restored gut microbial diversity, promoting beneficial taxa (Bifidobacterium, Akkermansia) while suppressing pathobionts (Helicobacter, Prevotella). Moreover, EA inhibited MC degranulation, reducing histamine (↓40%, p < 0.01) and SP (↓28%, p < 0.05), and enhanced intestinal barrier integrity via ZO-1/occludin upregulation. Crucially, EA suppressed TRPV1+ neuron activation in the colon and dorsal root ganglia, disrupting MC-neuron crosstalk through TRPV1/MAPK pathway modulation.</p><p><strong>Conclusion: </strong>EA (Baliao) alleviates VH by modulating gut microbiota, inhibiting MC activation, and blocking TRPV1 positive neuron mediated signal transmission. These findings highlight its potential as a non-pharmacological therapy for IBS, targeting multiple pathological axes.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":" ","pages":"e70137"},"PeriodicalIF":2.9,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Disturbances, Fatigue and Immune Markers in the Irritable Bowel Syndrome and Inflammatory Bowel Disease, a Systematic Review.","authors":"Sophie Fowler, Laura R C Dowling, Nicole Simm, Nicholas J Talley, Grace L Burns, Simon Keely","doi":"10.1111/nmo.70133","DOIUrl":"https://doi.org/10.1111/nmo.70133","url":null,"abstract":"<p><strong>Background: </strong>The irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD) are gastrointestinal (GI) diseases characterized by abdominal pain and altered bowel patterns. Fatigue and sleep disturbances are prevalent in these GI diseases, with a bidirectional relationship suggested between GI symptoms and sleep quality. If poor sleep results in increased GI symptoms, improving sleep quality may alleviate symptoms. However, if GI symptom burden independently drives poor sleep, alleviating symptoms by disease modification rather than targeting sleep should be the goal of management. Therefore, we aimed to determine if there is a relationship between gastrointestinal symptoms that influences sleep disturbances and/or fatigue.</p><p><strong>Methods: </strong>A systematic literature search in five databases was conducted using PRISMA guidelines to identify studies addressing fatigue, sleep disturbances, and GI diseases until June 2025. Inclusion criteria were original articles with confirmed GI disease diagnosis and healthy control groups. Data extraction included participant demographics, assessment tools, inflammatory findings, medication use, and disease severity. Quality assessment utilized the Newcastle Ottawa Scale.</p><p><strong>Key results: </strong>Of 14,664 articles, 18 studies were included: 7 focused on IBS, 9 on IBD, and 2 on both IBS and IBD. Findings revealed increased fatigue and sleep disturbances in GI patients compared to controls, with IBS patients reporting more fatigue and sleep disturbances than IBD. GI disease severity was strongly associated with sleep quality and fatigue levels.</p><p><strong>Conclusions & inferences: </strong>This systematic review highlights the strong association between fatigue and sleep disturbances and GI diseases, which are further exacerbated by disease severity.</p>","PeriodicalId":19123,"journal":{"name":"Neurogastroenterology and Motility","volume":" ","pages":"e70133"},"PeriodicalIF":2.9,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}