A Randomized Waitlist-Controlled Trial of a Positive Psychology Intervention for Irritable Bowel Syndrome: The WISH Proof-of-Concept Trial.

IF 2.9 3区医学 Q1 CLINICAL NEUROLOGY

Neurogastroenterology and Motility Pub Date : 2025-08-24 DOI:10.1111/nmo.70146

Elizabeth N Madva, Jeff C Huffman, Crystal Castillo, Lauren E Harnedy, Tesiya Franklin, M Tim Song, Helen Burton-Murray, Brian Healy, Kyle Staller, Stephen Bartels, Braden Kuo, Laurie Keefer, Christopher M Celano

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引用次数: 0

Abstract

Background: Though greater positive psychological well-being (PPWB) is associated with both improved physical and mental health in irritable bowel syndrome (IBS), it has not yet been explored as a primary target of brain-gut behavior therapies (BGBTs). Accordingly, we developed a novel, 9-week, phone-delivered BGBT to cultivate PPWB in IBS, and examined its feasibility, acceptability, and preliminary effects in a randomized waitlist-controlled proof-of-concept trial.

Methods: Twenty-two adults with IBS meeting Rome IV criteria were randomized, stratified by gender and IBS subtype, to the intervention (n = 12) or waitlist-control (WLC; n = 10) groups. Participants completed specific positive psychology (PP) activities and phone sessions weekly with an interventionist. Intervention feasibility was assessed by the proportion of completed sessions, and acceptability by weekly ease/utility ratings. Exploratory psychological and health-related self-report measures were collected pre- and post-intervention.

Key results: Participants (N = 22; ages 19-79; 55% female) completed 85% of sessions, above our a priori feasibility threshold of 65%. The intervention was rated as easy to complete (mean = 7.2/10, 95% CI: [6.70, 7.75]) and subjectively helpful (mean = 7.6/10, 95% CI: [7.14, 8.01]). Of the 18 participants who completed the intervention, 11 (61%) no longer met criteria for IBS post-intervention. Compared to the WLC, the intervention led to promising but nonsignificant improvements in exploratory clinical outcomes including IBS symptom severity, IBS health-related quality of life, and resilience, with effect sizes ranging from 0.1 to 0.7.

Conclusions and inferences: This 9-week, phone-delivered intervention targeting greater PPWB in IBS was feasible, well-accepted, and associated with promising improvements in key IBS-related outcomes, highlighting the need for further testing.

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积极心理学干预肠易激综合征的随机候补对照试验：WISH概念验证试验。

背景：虽然更高的积极心理健康（PPWB）与肠易激综合征（IBS）患者身心健康的改善有关，但尚未将其作为脑-肠行为疗法（BGBTs）的主要目标进行探索。因此，我们开发了一种新颖的、为期9周的、电话递送的BGBT来培养IBS患者的PPWB，并在一项随机候补对照的概念验证试验中检验了其可行性、可接受性和初步效果。方法：将22名符合Rome IV标准的IBS成人患者按性别和IBS亚型随机分为干预组（n = 12）和候补对照组（WLC; n = 10）。参与者完成了特定的积极心理学（PP）活动，并每周与一名干预者进行电话交谈。干预的可行性通过完成疗程的比例来评估，可接受性通过每周的易用性/效用评级来评估。在干预前和干预后收集探索性心理和健康相关自我报告测量。主要结果：参与者（N = 22，年龄19-79岁，55%为女性）完成了85%的疗程，高于我们的先验可行性阈值65%。干预被评为容易完成（平均= 7.2/10,95% CI:[6.70, 7.75]）和主观上有帮助（平均= 7.6/10,95% CI:[7.14, 8.01]）。在完成干预的18名参与者中，11名（61%）在干预后不再符合肠易激综合征的标准。与WLC相比，干预导致探索性临床结果有希望但不显著的改善，包括IBS症状严重程度，IBS健康相关生活质量和恢复力，效应量范围为0.1至0.7。结论和推论：这项为期9周的针对IBS患者更大PPWB的电话干预是可行的，被广泛接受，并且与IBS关键相关结果的改善有希望相关，强调了进一步测试的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurogastroenterology and Motility 医学-临床神经学

CiteScore

7.80

自引率

8.60%

发文量

178

审稿时长

3-6 weeks

期刊介绍： Neurogastroenterology & Motility (NMO) is the official Journal of the European Society of Neurogastroenterology & Motility (ESNM) and the American Neurogastroenterology and Motility Society (ANMS). It is edited by James Galligan, Albert Bredenoord, and Stephen Vanner. The editorial and peer review process is independent of the societies affiliated to the journal and publisher: Neither the ANMS, the ESNM or the Publisher have editorial decision-making power. Whenever these are relevant to the content being considered or published, the editors, journal management committee and editorial board declare their interests and affiliations.