Nature PhysicsPub Date : 2025-03-28DOI: 10.1038/s41567-025-02810-2
{"title":"Optical control of an excitable enzyme circuit for engineering dynamic cell shapes","authors":"","doi":"10.1038/s41567-025-02810-2","DOIUrl":"https://doi.org/10.1038/s41567-025-02810-2","url":null,"abstract":"Light-switchable enzymes hold great promise for mediating molecular activations in living cells, yet their full potential in realizing versatile controls in nonlinear networks remains unexplored. Now, optical control is demonstrated over a key enzyme involved in animal cell division, and a diverse array of dynamic cell shapes is achieved by biochemically hacking an endogenous signalling circuit.","PeriodicalId":19100,"journal":{"name":"Nature Physics","volume":"17 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature PhysicsPub Date : 2025-03-28DOI: 10.1038/s41567-025-02829-5
{"title":"Twist angle serves as a tuning knob for superconductivity","authors":"","doi":"10.1038/s41567-025-02829-5","DOIUrl":"https://doi.org/10.1038/s41567-025-02829-5","url":null,"abstract":"Ultra-low-temperature scanning tunnelling spectroscopy measurements indicate that twisting the layers in heterostructures making up a single layer of superconducting NbSe2 on graphene leads to momentum-dependent changes in the superconducting gap. This ability could enable the development of artificial superconductors with nontrivial magnetic and topological properties.","PeriodicalId":19100,"journal":{"name":"Nature Physics","volume":"17 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature PhysicsPub Date : 2025-03-27DOI: 10.1038/s41567-025-02848-2
Jiarui Xiong, Liang Wang, Jialun Lin, Lei Ni, Rongrong Zhang, Shuai Yang, Yajia Huang, Jun Chu, Fan Jin
{"title":"Quantifying second-messenger information transmission in bacteria","authors":"Jiarui Xiong, Liang Wang, Jialun Lin, Lei Ni, Rongrong Zhang, Shuai Yang, Yajia Huang, Jun Chu, Fan Jin","doi":"10.1038/s41567-025-02848-2","DOIUrl":"https://doi.org/10.1038/s41567-025-02848-2","url":null,"abstract":"<p>Bacterial second messengers are crucial for transmitting environmental information to cells. However, quantifying their information transmission capacity remains challenging. Here we develop a framework for quantifying information processing in cellular signalling systems. We engineer an isolated cyclic adenosine monophosphate (cAMP) signalling channel in <i>Pseudomonas aeruginosa</i> using targeted gene knockouts, optogenetics and a fluorescent cAMP probe. This design enables precise optical control and real-time monitoring of cAMP dynamics. By integrating experimental data with information theory, we reveal the optimal frequency for light-mediated cAMP signalling that maximizes information transmission, reaching about 40 bits per hour. This rate correlates strongly with cAMP degradation kinetics and uses a two-state encoding scheme. Our findings suggest a mechanism for fine-tuned regulation of multiple genes through temporal encoding of second-messenger signals, providing insights into bacterial adaptation strategies.</p>","PeriodicalId":19100,"journal":{"name":"Nature Physics","volume":"34 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature PhysicsPub Date : 2025-03-26DOI: 10.1038/s41567-025-02836-6
Thinh P. Le
{"title":"The limits of quantum correlations","authors":"Thinh P. Le","doi":"10.1038/s41567-025-02836-6","DOIUrl":"https://doi.org/10.1038/s41567-025-02836-6","url":null,"abstract":"Measurements on quantum particles produce random outcomes whose correlations can sometimes never be explained by classical physics. The complete set of possible quantum correlations for two particles under two measurements has now been identified.","PeriodicalId":19100,"journal":{"name":"Nature Physics","volume":"28 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature PhysicsPub Date : 2025-03-26DOI: 10.1038/s41567-025-02782-3
Victor Barizien, Jean-Daniel Bancal
{"title":"Quantum statistics in the minimal Bell scenario","authors":"Victor Barizien, Jean-Daniel Bancal","doi":"10.1038/s41567-025-02782-3","DOIUrl":"https://doi.org/10.1038/s41567-025-02782-3","url":null,"abstract":"<p>In any experimental setting, quantum physics provides the statistical distributions that the observed outcomes are expected to follow. The set formed by all these distributions contains the imprint of quantum theory and captures some of its core properties. So far, only partial explicit descriptions of this set have been found for Bell-type settings in which entangled states can be shared and measured by independent observers. Here we obtain the complete explicit and analytical description of a full set of quantum statistics in terms of its extremal points. This is made possible by finding all bipartite quantum states and pairs of binary measurements that can be self-tested, that is, reconstructed from empirical statistics only. Our description precisely reveals some of the extent and limitations of quantum theory.</p>","PeriodicalId":19100,"journal":{"name":"Nature Physics","volume":"29 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature PhysicsPub Date : 2025-03-25DOI: 10.1038/s41567-025-02797-w
Michael Meth, Jinglei Zhang, Jan F. Haase, Claire Edmunds, Lukas Postler, Andrew J. Jena, Alex Steiner, Luca Dellantonio, Rainer Blatt, Peter Zoller, Thomas Monz, Philipp Schindler, Christine Muschik, Martin Ringbauer
{"title":"Simulating two-dimensional lattice gauge theories on a qudit quantum computer","authors":"Michael Meth, Jinglei Zhang, Jan F. Haase, Claire Edmunds, Lukas Postler, Andrew J. Jena, Alex Steiner, Luca Dellantonio, Rainer Blatt, Peter Zoller, Thomas Monz, Philipp Schindler, Christine Muschik, Martin Ringbauer","doi":"10.1038/s41567-025-02797-w","DOIUrl":"https://doi.org/10.1038/s41567-025-02797-w","url":null,"abstract":"<p>Particle physics describes the interplay of matter and forces through gauge theories. Yet, the intrinsic quantum nature of gauge theories makes important problems notoriously difficult for classical computational techniques. Quantum computers offer a promising way to overcome these roadblocks. We demonstrate two essential requirements on this path: first, we perform a quantum computation of the properties of the basic building block of two-dimensional lattice quantum electrodynamics, involving both gauge fields and matter. Second, we show how to refine the gauge-field discretization beyond its minimal representation, using a trapped-ion qudit quantum processor, where quantum information is encoded in several states per ion. Such qudits are ideally suited for describing gauge fields, which are naturally high dimensional, leading to reduced register size and circuit complexity. We prepare the ground state of the model using a variational quantum eigensolver and observe the effect of dynamical matter on quantized magnetic fields. By controlling the qudit dimension, we also show how to seamlessly observe the effect of different gauge-field truncations. Finally, we experimentally study the dynamics of pair creation and magnetic energy. Our results open the door for hardware-efficient quantum simulations of gauge theories with qudits in near-term quantum devices.</p>","PeriodicalId":19100,"journal":{"name":"Nature Physics","volume":"63 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143695443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature PhysicsPub Date : 2025-03-24DOI: 10.1038/s41567-025-02807-x
Jinghui Liu, Tom Burkart, Alexander Ziepke, John Reinhard, Yu-Chen Chao, Tzer Han Tan, S. Zachary Swartz, Erwin Frey, Nikta Fakhri
{"title":"Light-induced cortical excitability reveals programmable shape dynamics in starfish oocytes","authors":"Jinghui Liu, Tom Burkart, Alexander Ziepke, John Reinhard, Yu-Chen Chao, Tzer Han Tan, S. Zachary Swartz, Erwin Frey, Nikta Fakhri","doi":"10.1038/s41567-025-02807-x","DOIUrl":"https://doi.org/10.1038/s41567-025-02807-x","url":null,"abstract":"<p>Chemo-mechanical waves play a key role in force generation and long-range signal transmission in cells that dynamically change shape, for example, during cell division or morphogenesis. Reconstituting and controlling such chemically controlled cell deformations is a crucial but unsolved challenge for the development of synthetic cells. Here we present an optogenetic method to investigate the mechanism responsible for coordinating surface contraction waves that occur in oocytes of the starfish <i>Patiria miniata</i> during meiotic cell division. Using optogenetic stimuli, we create chemo-mechanical cortical excitations that are decoupled from meiotic cues and drive various shape deformations, ranging from local pinching to surface contraction waves and breakdown of the cell. A quantitative model entailing both chemical and geometry dynamics allows us to predict and explain the variety of mechanical responses to optogenetic stimuli. Finally, we qualitatively map the observed shape dynamics to understand how the versatility of intracellular protein dynamics can give rise to a broad range of mechanical phenotypes. More broadly, our results suggest a route towards real-time control over dynamical deformations in living organisms and can advance the design of synthetic cells and life-like cellular functions.</p>","PeriodicalId":19100,"journal":{"name":"Nature Physics","volume":"25 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature PhysicsPub Date : 2025-03-24DOI: 10.1038/s41567-025-02839-3
Alfredo Sciortino, Hammad A. Faizi, Dmitry A. Fedosov, Layne Frechette, Petia M. Vlahovska, Gerhard Gompper, Andreas R. Bausch
{"title":"Active membrane deformations of a minimal synthetic cell","authors":"Alfredo Sciortino, Hammad A. Faizi, Dmitry A. Fedosov, Layne Frechette, Petia M. Vlahovska, Gerhard Gompper, Andreas R. Bausch","doi":"10.1038/s41567-025-02839-3","DOIUrl":"https://doi.org/10.1038/s41567-025-02839-3","url":null,"abstract":"<p>Living cells can adapt their shape in response to their environment, a process driven by the interaction between their flexible membrane and the activity of the underlying cytoskeleton. However, the precise physical mechanisms of this coupling remain unclear. Here we show how cytoskeletal forces acting on a biomimetic membrane affect its deformations. Using a minimal cell model that consists of an active network of microtubules and molecular motors encapsulated inside lipid vesicles, we observe large shape fluctuations and travelling membrane deformations. Quantitative analysis of membrane and microtubule dynamics demonstrates how active forces set the temporal scale of vesicle fluctuations, giving rise to fluctuation spectra that differ in both their spatial and temporal decays from their counterparts in thermal equilibrium. Using simulations, we extend the classical framework of membrane fluctuations to active cytoskeleton-driven vesicles, demonstrating how correlated activity governs membrane dynamics and the roles of confinement, membrane material properties and cytoskeletal forces. Our findings provide a quantitative foundation for understanding the shape-morphing abilities of living cells.</p>","PeriodicalId":19100,"journal":{"name":"Nature Physics","volume":"57 6 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature PhysicsPub Date : 2025-03-21DOI: 10.1038/s41567-025-02811-1
Aziza Almanakly, Beatriz Yankelevich, Max Hays, Bharath Kannan, Réouven Assouly, Alex Greene, Michael Gingras, Bethany M. Niedzielski, Hannah Stickler, Mollie E. Schwartz, Kyle Serniak, Joel Î-j. Wang, Terry P. Orlando, Simon Gustavsson, Jeffrey A. Grover, William D. Oliver
{"title":"Deterministic remote entanglement using a chiral quantum interconnect","authors":"Aziza Almanakly, Beatriz Yankelevich, Max Hays, Bharath Kannan, Réouven Assouly, Alex Greene, Michael Gingras, Bethany M. Niedzielski, Hannah Stickler, Mollie E. Schwartz, Kyle Serniak, Joel Î-j. Wang, Terry P. Orlando, Simon Gustavsson, Jeffrey A. Grover, William D. Oliver","doi":"10.1038/s41567-025-02811-1","DOIUrl":"https://doi.org/10.1038/s41567-025-02811-1","url":null,"abstract":"<p>Quantum interconnects facilitate entanglement distribution between non-local computational nodes in a quantum network. For superconducting processors, microwave photons are a natural means to mediate this distribution. However, many existing architectures limit node connectivity and directionality. In this work, we construct a chiral quantum interconnect between two nominally identical modules in separate microwave packages. Our approach uses quantum interference to emit and absorb microwave photons on demand and in a chosen direction between these modules. We optimize our protocol using model-free reinforcement learning to maximize the absorption efficiency. By halting the emission process halfway through its duration, we generate remote entanglement between modules in the form of a four-qubit <i>W</i> state with approximately 62% fidelity in each direction, limited mainly by propagation loss. This quantum network architecture enables all-to-all connectivity between non-local processors for modular and extensible quantum simulation and computation.</p>","PeriodicalId":19100,"journal":{"name":"Nature Physics","volume":"73 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature PhysicsPub Date : 2025-03-20DOI: 10.1038/s41567-025-02804-0
Heonjoon Park, Jiaqi Cai, Eric Anderson, Xiao-Wei Zhang, Xiaoyu Liu, William Holtzmann, Weijie Li, Chong Wang, Chaowei Hu, Yuzhou Zhao, Takashi Taniguchi, Kenji Watanabe, Jihui Yang, David Cobden, Jiun-haw Chu, Nicolas Regnault, B. Andrei Bernevig, Liang Fu, Ting Cao, Di Xiao, Xiaodong Xu
{"title":"Ferromagnetism and topology of the higher flat band in a fractional Chern insulator","authors":"Heonjoon Park, Jiaqi Cai, Eric Anderson, Xiao-Wei Zhang, Xiaoyu Liu, William Holtzmann, Weijie Li, Chong Wang, Chaowei Hu, Yuzhou Zhao, Takashi Taniguchi, Kenji Watanabe, Jihui Yang, David Cobden, Jiun-haw Chu, Nicolas Regnault, B. Andrei Bernevig, Liang Fu, Ting Cao, Di Xiao, Xiaodong Xu","doi":"10.1038/s41567-025-02804-0","DOIUrl":"https://doi.org/10.1038/s41567-025-02804-0","url":null,"abstract":"<p>The recent observation of the fractional quantum anomalous Hall effect in moiré fractional Chern insulators provides an opportunity to investigate zero magnetic field anyons. One approach for potentially realizing non-abelian anyons is to engineer higher flat Chern bands that mimic higher Landau levels. We investigate the interaction, topology and ferromagnetism of the second moiré miniband in twisted MoTe<sub>2</sub> bilayers. At half-filling of the second miniband, we observed spontaneous ferromagnetism and an incipient Chern insulator state. The Chern numbers of the top two moiré flat bands exhibited opposite signs for twist angles above 3.1° but had the same sign near 2.6°, consistent with theoretical predictions. In the 2.6° device, increasing the magnetic field induced a topological phase transition due to band-crossing between opposite valleys, resulting in an emergent state with Chern number <i>C</i> = −2. Additionally, an insulating state at half-filling of the second valley-polarized band indicates that a charge-ordered state is favoured over the fractional Chern insulator state. These findings lay a foundation for understanding the higher flat Chern bands, which are crucial for the discovery of non-abelian fractional Chern insulators.</p>","PeriodicalId":19100,"journal":{"name":"Nature Physics","volume":"17 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}