Nature Physics最新文献

Cyclic jetting enables microbubble-mediated drug delivery

IF 19.6 1区物理与天体物理

Nature Physics Pub Date : 2025-02-21 DOI: 10.1038/s41567-025-02785-0

Marco Cattaneo, Giulia Guerriero, Gazendra Shakya, Lisa A. Krattiger, Lorenza G. Paganella, Maria L. Narciso, Outi Supponen

{"title":"Cyclic jetting enables microbubble-mediated drug delivery","authors":"Marco Cattaneo, Giulia Guerriero, Gazendra Shakya, Lisa A. Krattiger, Lorenza G. Paganella, Maria L. Narciso, Outi Supponen","doi":"10.1038/s41567-025-02785-0","DOIUrl":"https://doi.org/10.1038/s41567-025-02785-0","url":null,"abstract":"The pursuit of targeted therapies capable of overcoming biological barriers, including the blood‚Äìbrain barrier, has spurred the investigation of stimuli-responsive microagents that can improve therapeutic efficacy and reduce undesirable side effects. Intravenously administered, ultrasound-responsive microbubbles are promising agents with demonstrated potential in clinical trials, but the mechanism underlying drug absorption remains unclear. Here we show that ultrasound-driven single microbubbles puncture the cell membrane and induce drug uptake through stable cyclic microjets. Our theoretical models successfully reproduce the observed bubble and cell dynamic responses. We find that cyclic jets arise from shape instabilities, as opposed to classical inertial jets that are driven by pressure gradients, enabling microjet formation at mild ultrasound pressures below 100‚ÄâkPa. We also establish a threshold for bubble radial expansion beyond which microjets form and facilitate cellular permeation and show that the stress generated by microjetting outperforms previously suggested mechanisms by at least an order of magnitude. Overall, this work elucidates the physics behind microbubble-mediated targeted drug delivery and provides the criteria for its effective and safe application.","PeriodicalId":19100,"journal":{"name":"Nature Physics","volume":"24 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diffraction minima resolve point scatterers at few hundredths of the wavelength

IF 19.6 1区物理与天体物理

Nature Physics Pub Date : 2025-02-21 DOI: 10.1038/s41567-024-02760-1

Thomas A. Hensel, Jan O. Wirth, Ole L. Schwarz, Stefan W. Hell

引用次数: 0

Topology shapes dynamics of higher-order networks

IF 19.6 1区物理与天体物理

Nature Physics Pub Date : 2025-02-19 DOI: 10.1038/s41567-024-02757-w

Ana P. Millán, Hanlin Sun, Lorenzo Giambagli, Riccardo Muolo, Timoteo Carletti, Joaquín J. Torres, Filippo Radicchi, Jürgen Kurths, Ginestra Bianconi

{"title":"Topology shapes dynamics of higher-order networks","authors":"Ana P. Millán, Hanlin Sun, Lorenzo Giambagli, Riccardo Muolo, Timoteo Carletti, Joaquín J. Torres, Filippo Radicchi, Jürgen Kurths, Ginestra Bianconi","doi":"10.1038/s41567-024-02757-w","DOIUrl":"https://doi.org/10.1038/s41567-024-02757-w","url":null,"abstract":"Higher-order networks capture the many-body interactions present in complex systems, shedding light on the interplay between topology and dynamics. The theory of higher-order topological dynamics, which combines higher-order interactions with discrete topology and nonlinear dynamics, has the potential to enhance our understanding of complex systems, such as the brain and the climate, and to advance the development of next-generation AI algorithms. This theoretical framework, which goes beyond traditional node-centric descriptions, encodes the dynamics of a network through topological signals—variables assigned not only to nodes but also to edges, triangles and other higher-order cells. Recent findings show that topological signals lead to the emergence of distinct types of dynamical state and collective phenomena, including topological and Dirac synchronization, pattern formation and triadic percolation. These results offer insights into how topology shapes dynamics, how dynamics learns topology and how topology evolves dynamically. This Perspective primarily aims to guide physicists, mathematicians, computer scientists and network scientists through the emerging field of higher-order topological dynamics, while also outlining future research challenges.","PeriodicalId":19100,"journal":{"name":"Nature Physics","volume":"13 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Universal dissipative dynamics in strongly correlated quantum gases

IF 19.6 1区物理与天体物理

Nature Physics Pub Date : 2025-02-19 DOI: 10.1038/s41567-025-02800-4

Yajuan Zhao, Ye Tian, Jilai Ye, Yue Wu, Zihan Zhao, Zhihao Chi, Tian Tian, Hepeng Yao, Jiazhong Hu, Yu Chen, Wenlan Chen

引用次数: 0

Local minima in quantum systems

IF 19.6 1区物理与天体物理

Nature Physics Pub Date : 2025-02-18 DOI: 10.1038/s41567-025-02781-4

Chi-Fang Chen, Hsin-Yuan Huang, John Preskill, Leo Zhou

{"title":"Local minima in quantum systems","authors":"Chi-Fang Chen, Hsin-Yuan Huang, John Preskill, Leo Zhou","doi":"10.1038/s41567-025-02781-4","DOIUrl":"https://doi.org/10.1038/s41567-025-02781-4","url":null,"abstract":"Finding ground states of quantum many-body systems is known to be hard for both classical and quantum computers. Consequently, when a quantum system is cooled in a low-temperature thermal bath, the ground state cannot always be found efficiently. Instead, the system may become trapped in a local minimum of the energy. In this work, we study the problem of finding local minima in quantum systems under thermal perturbations. Although local minima are much easier to find than ground states, we show that finding a local minimum is hard on classical computers, even when the task is merely to output a single-qubit observable at any local minimum. By contrast, we prove that a quantum computer can always find a local minimum efficiently using a thermal gradient descent algorithm that mimics natural cooling processes. To establish the classical hardness of finding local minima, we construct a family of two-dimensional Hamiltonians such that any problem solvable by polynomial-time quantum algorithms can be reduced to finding local minima of these Hamiltonians. Therefore, cooling systems to local minima is universal for quantum computation and, assuming that quantum computation is more powerful than classical computation, finding local minima is classically hard but quantumly easy.","PeriodicalId":19100,"journal":{"name":"Nature Physics","volume":"180 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wideband electric field quantum sensing via motional Raman transitions

IF 19.6 1区物理与天体物理

Nature Physics Pub Date : 2025-02-18 DOI: 10.1038/s41567-024-02753-0

Hao Wu, Grant D. Mitts, Clayton Z. C. Ho, Joshua A. Rabinowitz, Eric R. Hudson

{"title":"Wideband electric field quantum sensing via motional Raman transitions","authors":"Hao Wu, Grant D. Mitts, Clayton Z. C. Ho, Joshua A. Rabinowitz, Eric R. Hudson","doi":"10.1038/s41567-024-02753-0","DOIUrl":"https://doi.org/10.1038/s41567-024-02753-0","url":null,"abstract":"Ultrasensitive detection of the frequency, phase and amplitude of radiofrequency electric fields is crucial for applications in radio communication, cosmology, dark matter searches and high-fidelity qubit control. Quantum harmonic oscillator systems, especially trapped ions, offer high-sensitivity electric field sensing with nanometre spatial resolution but are typically restricted to narrow frequency ranges centred around the motional frequency of the trapped-ion oscillator or the frequency of an optical transition in the ion. Here we present a procedure that enables precise electric field detection over an expanded frequency range. Specifically, we use motional Raman transitions in a single trapped ion to achieve sensitivity across a frequency range over 800 times larger than previous approaches. We show that the method is compatible with both quantum amplification via squeezing and measurement in the Fock basis, allowing a demonstration of performance 3.4(2.0) dB below the standard quantum limit. The approach can be extended to other quantum harmonic oscillator systems, such as superconducting qubit–resonator systems.","PeriodicalId":19100,"journal":{"name":"Nature Physics","volume":"80 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Magnetic flux trapping in hydrogen-rich high-temperature superconductors

IF 19.6 1区物理与天体物理

Nature Physics Pub Date : 2025-02-18 DOI: 10.1038/s41567-025-02823-x

V. S. Minkov, V. Ksenofontov, S. L. Bud’ko, E. F. Talantsev, M. I. Eremets

引用次数: 0

Magnetic order sets the stage

IF 19.6 1区物理与天体物理

Nature Physics Pub Date : 2025-02-17 DOI: 10.1038/s41567-024-02772-x

Michael Smidman

引用次数: 0

Author Correction: Incommensurability enabled quasi-fractal order in 1D narrow-band moiré systems

IF 19.6 1区物理与天体物理

Nature Physics Pub Date : 2025-02-17 DOI: 10.1038/s41567-025-02824-w

Miguel Gonçalves, Bruno Amorim, Flavio Riche, Eduardo V. Castro, Pedro Ribeiro

引用次数: 0

Pressure-enhanced splitting of density wave transitions in La3Ni2O7–δ

IF 19.6 1区物理与天体物理

Nature Physics Pub Date : 2025-02-17 DOI: 10.1038/s41567-024-02754-z

Rustem Khasanov, Thomas J. Hicken, Dariusz J. Gawryluk, Vahid Sazgari, Igor Plokhikh, Loïc Pierre Sorel, Marek Bartkowiak, Steffen Bötzel, Frank Lechermann, Ilya M. Eremin, Hubertus Luetkens, Zurab Guguchia

{"title":"Pressure-enhanced splitting of density wave transitions in La3Ni2O7–δ","authors":"Rustem Khasanov, Thomas J. Hicken, Dariusz J. Gawryluk, Vahid Sazgari, Igor Plokhikh, Loïc Pierre Sorel, Marek Bartkowiak, Steffen Bötzel, Frank Lechermann, Ilya M. Eremin, Hubertus Luetkens, Zurab Guguchia","doi":"10.1038/s41567-024-02754-z","DOIUrl":"https://doi.org/10.1038/s41567-024-02754-z","url":null,"abstract":"The observation of superconductivity in La3Ni2O7–δ under pressure, following the suppression of a high-temperature density wave state, has attracted considerable attention. The nature of this density wave order was not clearly identified. Here we probe the magnetic response of the zero-pressure phase of La3Ni2O7–δ as hydrostatic pressure is applied, and find that the apparent single density wave transition at zero applied pressure splits into two. The comparison of our muon-spin rotation and relaxation experiments with dipole-field numerical analysis reveals the magnetic structure’s compatibility with a stripe-type arrangement of Ni moments, characterized by alternating lines of magnetic moments and non-magnetic stripes at ambient pressure. When pressure is applied, the magnetic ordering temperature increases, whereas the unidentified density wave transition temperature falls. Our findings reveal that the ground state of the La3Ni2O7–δ system is characterized by the coexistence of two distinct orders—a magnetically ordered spin density wave and a lower-temperature ordering that is most probably a charge density wave—with a notable pressure-enhanced separation between them.","PeriodicalId":19100,"journal":{"name":"Nature Physics","volume":"11 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0