Nature Physics最新文献_第6页

Cooperative hydrodynamics accompany multicellular-like colonial organization in the unicellular ciliate Stentor 在单细胞纤毛虫Stentor中，合作流体动力学伴随着多细胞样群体组织

IF 19.6 1区物理与天体物理

Nature Physics Pub Date : 2025-03-31 DOI: 10.1038/s41567-025-02787-y

Shashank Shekhar, Hanliang Guo, Sean P. Colin, Wallace Marshall, Eva Kanso, John H. Costello

{"title":"Cooperative hydrodynamics accompany multicellular-like colonial organization in the unicellular ciliate Stentor","authors":"Shashank Shekhar, Hanliang Guo, Sean P. Colin, Wallace Marshall, Eva Kanso, John H. Costello","doi":"10.1038/s41567-025-02787-y","DOIUrl":"https://doi.org/10.1038/s41567-025-02787-y","url":null,"abstract":"Many single-celled organisms exhibit both solitary and colonial existence. An important step towards multicellularity, which is associated with benefits such as enhanced nutrient uptake, was the formation of colonies of unicellular organisms. However, the initial drivers that favoured individual cells aggregating into more complex colonies are less clear. Here we show that hydrodynamic coupling between proximate neighbours results in faster feeding flows for neighbouring ciliates, such that individuals within a dynamic colony have stronger average feeding flows than solitary individuals. Flows generated by individuals acting together reach higher velocities, thus allowing access to a wider range of prey resources than individuals acting on their own. Moreover, we find that accrued feeding benefits are typically asymmetric: whereas all individuals benefit from acting together, those with slower solitary currents gain more from partnering than those with faster currents. We find that colonial organization in simple unicellular organisms is beneficial for all its members. This provides fundamental insights into the selective forces favouring the early evolution of multicellular organization.","PeriodicalId":19100,"journal":{"name":"Nature Physics","volume":"13 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circadian coupling orchestrates cell growth 昼夜节律耦合协调细胞生长

IF 19.6 1区物理与天体物理

Nature Physics Pub Date : 2025-03-31 DOI: 10.1038/s41567-025-02838-4

Nica Gutu, Malthe S. Nordentoft, Marlena Kuhn, Carolin Ector, Marie Möser, Anna-Marie Finger, Mathias Spliid Heltberg, Mogens Høgh Jensen, Ulrich Keilholz, Achim Kramer, Hanspeter Herzel, Adrián E. Granada

{"title":"Circadian coupling orchestrates cell growth","authors":"Nica Gutu, Malthe S. Nordentoft, Marlena Kuhn, Carolin Ector, Marie Möser, Anna-Marie Finger, Mathias Spliid Heltberg, Mogens Høgh Jensen, Ulrich Keilholz, Achim Kramer, Hanspeter Herzel, Adrián E. Granada","doi":"10.1038/s41567-025-02838-4","DOIUrl":"https://doi.org/10.1038/s41567-025-02838-4","url":null,"abstract":"Single-cell circadian oscillators exchange extracellular information to sustain coherent circadian rhythms at the tissue level. The circadian clock and the cell cycle couple within cells but the mechanisms underlying this interplay are poorly understood. We show that the loss of extracellular circadian synchronization disrupts circadian and cell cycle coordination within individual cells, impeding collective tissue growth. We use the theory of coupled oscillators combined with live population, and single-cell recordings and precise experimental perturbations. Coherent circadian rhythms yield oscillatory growth patterns, which unveil a global timing regulator of tissue dynamics. Knocking out core circadian elements abolishes the observed effects, highlighting the central role of circadian clock regulation. Our results underscore the role of tissue-level circadian disruption in regulating proliferation, thereby linking disrupted circadian clocks with oncogenic processes. These findings illuminate the intricate interplay between circadian rhythms, cellular signalling and tissue physiology and enhance our understanding of tissue homeostasis and growth regulation in the context of both health and disease.","PeriodicalId":19100,"journal":{"name":"Nature Physics","volume":"69 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crystal-symmetry-paired spin–valley locking in a layered room-temperature metallic altermagnet candidate 层状室温金属交替磁体候选材料中的晶体对称配对自旋谷锁定

IF 19.6 1区物理与天体物理

Nature Physics Pub Date : 2025-03-31 DOI: 10.1038/s41567-025-02864-2

Fayuan Zhang, Xingkai Cheng, Zhouyi Yin, Changchao Liu, Liwei Deng, Yuxi Qiao, Zheng Shi, Shuxuan Zhang, Junhao Lin, Zhengtai Liu, Mao Ye, Yaobo Huang, Xiangyu Meng, Cheng Zhang, Taichi Okuda, Kenya Shimada, Shengtao Cui, Yue Zhao, Guang-Han Cao, Shan Qiao, Junwei Liu, Chaoyu Chen

{"title":"Crystal-symmetry-paired spin–valley locking in a layered room-temperature metallic altermagnet candidate","authors":"Fayuan Zhang, Xingkai Cheng, Zhouyi Yin, Changchao Liu, Liwei Deng, Yuxi Qiao, Zheng Shi, Shuxuan Zhang, Junhao Lin, Zhengtai Liu, Mao Ye, Yaobo Huang, Xiangyu Meng, Cheng Zhang, Taichi Okuda, Kenya Shimada, Shengtao Cui, Yue Zhao, Guang-Han Cao, Shan Qiao, Junwei Liu, Chaoyu Chen","doi":"10.1038/s41567-025-02864-2","DOIUrl":"https://doi.org/10.1038/s41567-025-02864-2","url":null,"abstract":"Previous theoretical efforts have predicted a type of unconventional antiferromagnet characterized by a crystal symmetry that connects antiferromagnetic sublattices in real space and simultaneously couples spin and momentum in reciprocal space. This results in a unique crystal-symmetry-paired spin–valley locking and related properties including piezomagnetism and non-collinear spin current even without spin–orbit coupling. However, most known unconventional antiferromagnets do not meet the necessary symmetry requirements for non-relativistic spin current, and this limits applications in spintronic devices. Here we demonstrate crystal-symmetry-paired spin–valley locking in a layered room-temperature antiferromagnetic compound, Rb1−δV2Te2O. Spin-resolved photoemission measurements directly show the opposite spin splitting between crystal-symmetry-paired valleys. Quasi-particle interference patterns show the suppression of intervalley scattering due to the spin selection rules that are a direct consequence of the spin–valley locking. These results suggest that Rb1−δV2Te2O is a potential room-temperature altermagnet candidate. Our observations highlight a methodology that enables both the advantages of layered materials and possible control through crystal symmetry manipulation for advancements in magnetism, electronics and information technology.","PeriodicalId":19100,"journal":{"name":"Nature Physics","volume":"183 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Yielding behaviour of active particles in bulk and in confinement 活性粒子在体积和约束下的屈服行为

IF 19.6 1区物理与天体物理

Nature Physics Pub Date : 2025-03-31 DOI: 10.1038/s41567-025-02843-7

Yagyik Goswami, G. V. Shivashankar, Srikanth Sastry

{"title":"Yielding behaviour of active particles in bulk and in confinement","authors":"Yagyik Goswami, G. V. Shivashankar, Srikanth Sastry","doi":"10.1038/s41567-025-02843-7","DOIUrl":"https://doi.org/10.1038/s41567-025-02843-7","url":null,"abstract":"Collective behaviour in dense assemblies of self-propelled active particles occurs in a wide range of biological phenomena, including the dynamical transitions of cellular and subcellular biological assemblies such as the cytoskeleton and the cell nucleus. Here, motivated by observations of mechanically induced changes in the dynamics of such systems and the apparent role of confinement geometry, we show that the fluidization transition broadly resembles yielding in amorphous solids, which is consistent with recent suggestions. More specifically, however, we find that a detailed analogy holds with the yielding transition under cyclic shear deformation, for large but finite persistence times. The fluidization transition is accompanied by driving-induced annealing, strong dependence on the initial state of the system, a divergence of timescales to reach steady states and a discontinuous onset of diffusive motion. We also observe a striking dependence of transition on persistence times and on the nature of confinement. Collectively, our results have implications for biological assemblies in confined geometries, including epigenetic cell-state transitions.","PeriodicalId":19100,"journal":{"name":"Nature Physics","volume":"19 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermopower probes of emergent local moments in magic-angle twisted bilayer graphene 魔角扭曲双层石墨烯中涌现局部矩的热能探针

IF 19.6 1区物理与天体物理

Nature Physics Pub Date : 2025-03-31 DOI: 10.1038/s41567-025-02849-1

Ayan Ghosh, Souvik Chakraborty, Ranit Dutta, Adhip Agarwala, K. Watanabe, T. Taniguchi, Sumilan Banerjee, Nandini Trivedi, Subroto Mukerjee, Anindya Das

{"title":"Thermopower probes of emergent local moments in magic-angle twisted bilayer graphene","authors":"Ayan Ghosh, Souvik Chakraborty, Ranit Dutta, Adhip Agarwala, K. Watanabe, T. Taniguchi, Sumilan Banerjee, Nandini Trivedi, Subroto Mukerjee, Anindya Das","doi":"10.1038/s41567-025-02849-1","DOIUrl":"https://doi.org/10.1038/s41567-025-02849-1","url":null,"abstract":"Recent experiments on magic-angle twisted bilayer graphene have shown the formation of flat bands, suggesting that electronic correlation effects are likely to dominate in this material. However, a global transport measurement showing distinct signatures of strong correlations—such as local moments arising from the flat bands—is missing. Here we demonstrate the presence of emergent local moments through their impact on entropy extracted from thermopower measurements. In addition to sign changes in the thermopower at the Dirac point and full filling of the flat bands, we observe sign changes near the quarter-filled bands that do not vary with temperature from 5 K to 60 K. This is in contrast to temperature-dependent crossing points seen in our study on twisted bilayer graphene devices with weaker correlations. Furthermore, we find that applying a magnetic field reduces the thermopower, consistent with spin entropy suppression observed in layered oxides under partial spin polarization. Neither the robust crossing points nor the suppression by a magnetic field can be explained solely from the contributions of band fermions; instead, our data suggest a dominant contribution coming from the entropy of the emergent localized moments of a strongly correlated flat band.","PeriodicalId":19100,"journal":{"name":"Nature Physics","volume":"38 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct observation of colloidal quasicrystallization 胶体准结晶的直接观察

IF 19.6 1区物理与天体物理

Nature Physics Pub Date : 2025-03-31 DOI: 10.1038/s41567-025-02859-z

Yan Gao, Brennan Sprinkle, David W. M. Marr, Ning Wu

{"title":"Direct observation of colloidal quasicrystallization","authors":"Yan Gao, Brennan Sprinkle, David W. M. Marr, Ning Wu","doi":"10.1038/s41567-025-02859-z","DOIUrl":"https://doi.org/10.1038/s41567-025-02859-z","url":null,"abstract":"Discovered first in synthetic alloys and subsequently in nature, quasicrystals exhibit forbidden symmetries and long-range orientational order but lack translational periodicity. Despite numerous theoretical and numerical studies, the fabrication of quasicrystals remains a challenge, with limited means available for observing their formation in situ. As a result, questions remain regarding the detailed mechanisms of quasicrystal formation and stabilization. Observable under optical microscopes, micrometre-scale colloidal systems have been used for decades as atomic models with considerably slowed-down dynamics and tuneable interactions through surface modification, solution composition and applied external fields. Here we show that two-dimensional dodecagonal quasicrystals can be reversibly assembled from single-component microspheres using a combination of orthogonally applied magnetic and electric fields. Varying the magnitude and frequency of the applied fields not only determines the resulting structures but also sets the phase transition dynamics via an effective system temperature. We hypothesize that these quasicrystals are energetically stabilized with their formation driven by an isotropic double-well pair potential, although the origin of the second minimum remains an open question.","PeriodicalId":19100,"journal":{"name":"Nature Physics","volume":"36 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The mechanics of protein sweet spots 蛋白质甜点的机制

IF 19.6 1区物理与天体物理

Nature Physics Pub Date : 2025-03-28 DOI: 10.1038/s41567-025-02826-8

Qian-Yuan Tang

引用次数: 0

A qudit quantum computer for simulation of two-dimensional quantum electrodynamics 用于模拟二维量子电动力学的量子计算机

IF 19.6 1区物理与天体物理

Nature Physics Pub Date : 2025-03-28 DOI: 10.1038/s41567-025-02821-z

引用次数: 0

Acousto-dewetting enables droplet microfluidics on superhydrophilic surfaces 声脱湿使液滴微流体在超亲水性表面上形成

IF 19.6 1区物理与天体物理

Nature Physics Pub Date : 2025-03-28 DOI: 10.1038/s41567-025-02844-6

Song Liu, Pengcheng Sun, Mingyue Wang, Yujie Jiang, Jiaqi Li, Yuyu Jia, Zhenhuan Sun, Yuting Yang, Hai Liu, Haojian Lu, Zuankai Wang

{"title":"Acousto-dewetting enables droplet microfluidics on superhydrophilic surfaces","authors":"Song Liu, Pengcheng Sun, Mingyue Wang, Yujie Jiang, Jiaqi Li, Yuyu Jia, Zhenhuan Sun, Yuting Yang, Hai Liu, Haojian Lu, Zuankai Wang","doi":"10.1038/s41567-025-02844-6","DOIUrl":"https://doi.org/10.1038/s41567-025-02844-6","url":null,"abstract":"Droplet microfluidics, a versatile technique for the precise manipulation of discrete droplets, has revolutionized biological and chemical research. So far, the successful implementation of droplet microfluidics necessitates the choice of non-wetting surfaces with minimal pinning forces, which hinders its broader adoptions in clinical applications. Here we report acousto-dewetting, a liquid dewetting principle that enables the three-dimensional, remotely controllable and precise operation of droplets on surfaces of any wettability, including superhydrophilic surfaces. This principle originates from the intricate interplay between acoustic streaming and droplet dynamics due to the extreme confinement of ultrasound within droplets, with an enhancement in pressure gradient of three orders of magnitude compared with traditional ultrasound-based approaches. We show that on superhydrophilic surfaces, acousto-dewetting achieves a contact line moving velocity that is two orders of magnitude higher than the previous limit and eliminates the undesired viscous film stemming from viscous dissipations. We developed a droplet microfluidics approach that achieves versatile droplet manipulation in various extreme scenarios associated with superhydrophilic surfaces, and applied it to an in vivo clinical setting for the rapid and safe removal of thrombus as well as drug delivery.","PeriodicalId":19100,"journal":{"name":"Nature Physics","volume":"215 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enzymes as viscoelastic catalytic machines 酶是粘弹性催化机器

IF 19.6 1区物理与天体物理

Nature Physics Pub Date : 2025-03-28 DOI: 10.1038/s41567-025-02825-9

Eyal Weinreb, John M. McBride, Marta Siek, Jacques Rougemont, Renaud Renault, Yoav Peleg, Tamar Unger, Shira Albeck, Yael Fridmann-Sirkis, Sofya Lushchekina, Joel L. Sussman, Bartosz A. Grzybowski, Giovanni Zocchi, Jean-Pierre Eckmann, Elisha Moses, Tsvi Tlusty

{"title":"Enzymes as viscoelastic catalytic machines","authors":"Eyal Weinreb, John M. McBride, Marta Siek, Jacques Rougemont, Renaud Renault, Yoav Peleg, Tamar Unger, Shira Albeck, Yael Fridmann-Sirkis, Sofya Lushchekina, Joel L. Sussman, Bartosz A. Grzybowski, Giovanni Zocchi, Jean-Pierre Eckmann, Elisha Moses, Tsvi Tlusty","doi":"10.1038/s41567-025-02825-9","DOIUrl":"https://doi.org/10.1038/s41567-025-02825-9","url":null,"abstract":"The catalytic cycle involves internal motions and conformational changes that allow enzymes to specifically bind to substrates, reach the transition state and release the product. Such mechanical interactions and motions are often long ranged so that mutations of residues far from the active site can modulate the enzymatic cycle. In particular, regions that undergo high strain during the cycle give mechanical flexibility to the protein, which is crucial for protein motion. Here we directly probe the connection between strain, flexibility and functionality, and we quantify how distant high-strain residues modulate the catalytic function via long-ranged force transduction. We measure the rheological and catalytic properties of wild-type guanylate kinase and of its mutants with a single amino acid replacement in low-/high-strain regions and in binding/non-binding regions. The rheological response of the protein to an applied oscillating force fits a continuum model of a viscoelastic material whose mechanical properties are significantly affected by mutations in high-strain regions, as opposed to mutations in control regions. Furthermore, catalytic activity assays show that mutations in high-strain or binding regions tend to reduce activity, whereas mutations in low-strain, non-binding regions are neutral. These findings suggest that enzymes act as viscoelastic catalytic machines with sequence-encoded mechanical specifications.","PeriodicalId":19100,"journal":{"name":"Nature Physics","volume":"30 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0