Hyeokjun Yoon, Jin-Hoon Kim, David Sadat, Arjun Barrett, Seung Hwan Ko, Canan Dagdeviren
{"title":"Decoding tissue biomechanics using conformable electronic devices","authors":"Hyeokjun Yoon, Jin-Hoon Kim, David Sadat, Arjun Barrett, Seung Hwan Ko, Canan Dagdeviren","doi":"10.1038/s41578-024-00729-3","DOIUrl":"https://doi.org/10.1038/s41578-024-00729-3","url":null,"abstract":"<p>Understanding the human body’s tissue biomechanics — the physical deformation and variations in intrinsic mechanical properties — has considerable potential in health monitoring, disease diagnosis and bioengineering. However, current tools for decoding tissue biomechanics rely on rigid and bulky devices that are not compatible with biological tissues. Such a discrepancy results in inaccurate measurement and even pain and discomfort for the subjects undergoing the measurement. To overcome the limitations of current tools, conformable electronic devices have been developed for monitoring internal and external tissue biomechanics. Moreover, by adopting advanced machine-learning approaches, more insights can be gained from the collected data. In this Review, we provide a comprehensive overview of conformable electronic devices for tissue biomechanics decoding. We discuss basic principles for external and internal tissue decoding, focusing on electromechanical transduction for external tissue decoding and on ultrasonography for internal tissue decoding. Then, we highlight various data analysis methods, including machine-learning algorithms. Finally, we outline challenges and future directions.</p>","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"75 1","pages":""},"PeriodicalIF":83.5,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dhiren K. Pradhan, David C. Moore, A. Matt Francis, Jacob Kupernik, W. Joshua Kennedy, Nicholas R. Glavin, Roy H. Olsson III, Deep Jariwala
{"title":"Materials for high-temperature digital electronics","authors":"Dhiren K. Pradhan, David C. Moore, A. Matt Francis, Jacob Kupernik, W. Joshua Kennedy, Nicholas R. Glavin, Roy H. Olsson III, Deep Jariwala","doi":"10.1038/s41578-024-00731-9","DOIUrl":"10.1038/s41578-024-00731-9","url":null,"abstract":"Silicon microelectronics, consisting of complementary metal–oxide–semiconductor technology, have changed nearly all aspects of human life from communication to transportation, entertainment and health care. Despite their widespread and mainstream use, current silicon-based devices are unreliable at temperatures exceeding 125 °C. The emergent technological frontiers of space exploration, geothermal energy harvesting, nuclear energy, unmanned avionic systems and autonomous driving will rely on control systems, sensors and communication devices that operate at temperatures as high as 500 °C and beyond. At these extreme temperatures, active (heat exchanger and phase-change cooling) or passive (fins and thermal interface materials) cooling strategies add considerable mass and complicate the systems, which is often infeasible. Thus, new material solutions beyond conventional silicon complementary metal–oxide–semiconductor devices are necessary for high-temperature, resilient electronic systems. The ultimate realization of high-temperature electronic systems requires united efforts to develop, integrate and ultimately manufacture non-silicon-based logic and memory technologies, non-traditional metals for interconnects and ceramic packaging technology. Digital electronics capable of operating at elevated temperatures are gaining importance in aerospace, space and geothermal energy as well as oil and gas exploration. This Review presents recent advances and future outlook on critical materials and devices for the same.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"9 11","pages":"790-807"},"PeriodicalIF":79.8,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shahad K. Alsaiari, Behnaz Eshaghi, Bujie Du, Maria Kanelli, Gary Li, Xunhui Wu, Linzixuan Zhang, Mehr Chaddah, Alicia Lau, Xin Yang, Robert Langer, Ana Jaklenec
{"title":"CRISPR–Cas9 delivery strategies for the modulation of immune and non-immune cells","authors":"Shahad K. Alsaiari, Behnaz Eshaghi, Bujie Du, Maria Kanelli, Gary Li, Xunhui Wu, Linzixuan Zhang, Mehr Chaddah, Alicia Lau, Xin Yang, Robert Langer, Ana Jaklenec","doi":"10.1038/s41578-024-00725-7","DOIUrl":"https://doi.org/10.1038/s41578-024-00725-7","url":null,"abstract":"<p>CRISPR–Cas9 genome editing technology is a promising tool for genetically engineering immune cells and modulating immune systems. Although ex vivo genome editing of immune cells has reached clinical trials, in vivo application is still restricted by the instability and inefficient delivery of CRISPR–Cas9 components to immune cells through circulation. In this Review, we summarize ex vivo and in vivo strategies to deliver CRISPR–Cas9 components to both non-immune and immune cells. We review the progress made in non-immune cells because it offers insights that can be applied to advancing research in immune cells. We also discuss principles and challenges of immune system modulation using CRISPR–Cas9 genome editing technology.</p>","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"1 1","pages":""},"PeriodicalIF":83.5,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142439778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"First metal part 3D printed in space","authors":"Charlotte Allard","doi":"10.1038/s41578-024-00745-3","DOIUrl":"10.1038/s41578-024-00745-3","url":null,"abstract":"","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"9 11","pages":"766-766"},"PeriodicalIF":79.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Printed electronics for cultivating plants in space","authors":"Siqing Wang, Ying Diao","doi":"10.1038/s41578-024-00742-6","DOIUrl":"10.1038/s41578-024-00742-6","url":null,"abstract":"Plants are vital to future long-term space missions as a renewable food source and ecological system for producing essential substances. NASA has been developing special chambers to grow fresh vegetables in space, and printed electronics may be the key to monitoring the health and growth of these plants with minimal human effort, resources and energy.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"9 11","pages":"762-763"},"PeriodicalIF":79.8,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142404937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Using the moisture in our midst","authors":"","doi":"10.1038/s41578-024-00735-5","DOIUrl":"10.1038/s41578-024-00735-5","url":null,"abstract":"Sorbent materials that capture and release water molecules are key to technologies that turn the Earth’s ambient moisture into drinkable water and energy.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"9 10","pages":"669-670"},"PeriodicalIF":79.8,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41578-024-00735-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142383551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ziyi Xie, Dan Liu, Can Gao, Huanli Dong, Wenping Hu
{"title":"High-mobility emissive organic semiconductors: an emerging class of multifunctional materials","authors":"Ziyi Xie, Dan Liu, Can Gao, Huanli Dong, Wenping Hu","doi":"10.1038/s41578-024-00732-8","DOIUrl":"10.1038/s41578-024-00732-8","url":null,"abstract":"High-mobility emissive organic semiconductors integrate efficient charge transport and strong emission features. The development of these materials, which have the potential to overcome performance bottlenecks in organic electroluminescent and photoelectric conversion devices, is opening up new research directions in organic optoelectronics.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"9 12","pages":"837-839"},"PeriodicalIF":79.8,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142330202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Liuliu Han, Shuya Zhu, Ziyuan Rao, Christina Scheu, Dirk Ponge, Alfred Ludwig, Hongbin Zhang, Oliver Gutfleisch, Horst Hahn, Zhiming Li, Dierk Raabe
{"title":"Multifunctional high-entropy materials","authors":"Liuliu Han, Shuya Zhu, Ziyuan Rao, Christina Scheu, Dirk Ponge, Alfred Ludwig, Hongbin Zhang, Oliver Gutfleisch, Horst Hahn, Zhiming Li, Dierk Raabe","doi":"10.1038/s41578-024-00720-y","DOIUrl":"10.1038/s41578-024-00720-y","url":null,"abstract":"Entropy-related phase stabilization can allow compositionally complex solid solutions of multiple principal elements. The massive mixing approach was originally introduced for metals and has recently been extended to ionic, semiconductor, polymer and low-dimensional materials. Multielement mixing can leverage new types of random, weakly ordered clustering and precipitation states in bulk materials as well as at interfaces and dislocations. The many possible atomic configurations offer opportunities to discover and exploit new functionalities, as well as to create new local symmetry features, ordering phenomena and interstitial configurations. This opens up a huge chemical and structural space in which uncharted phase states, defect chemistries, mechanisms and properties, some previously thought to be mutually exclusive, can be reconciled in one material. Earlier research concentrated on mechanical properties such as strength, toughness, fatigue and ductility. This Review shifts the focus towards multifunctional property profiles, including electronic, electrochemical, mechanical, magnetic, catalytic, hydrogen-related, Invar and caloric characteristics. Disruptive design opportunities lie in combining several of these features, rendering high-entropy materials multifunctional without sacrificing their unique mechanical properties. High-entropy materials leverage phase stabilization through mixing several elements and are primarily known for their mechanical strength and high toughness. This Review explores their use as a platform for multifunctional material design, in which several, even conflicting, properties can be reconciled because of the compositional tolerance inherent in the high-entropy concept, including electronic, magnetic, mechanical, catalytic, thermal expansion and hydrogen storage properties.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"9 12","pages":"846-865"},"PeriodicalIF":79.8,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142330204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Designing desorption","authors":"Ariane Vartanian","doi":"10.1038/s41578-024-00739-1","DOIUrl":"10.1038/s41578-024-00739-1","url":null,"abstract":"An article in Advanced Functional Materials uses a photothermal bridge to improve the desorption performance of a metal–organic framework sorbent.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"9 10","pages":"680-680"},"PeriodicalIF":79.8,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142317584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}