Nature Reviews Materials最新文献

Engineering biomaterials to tailor the microenvironment for macrophage–endothelium interactions 工程生物材料定制巨噬细胞-内皮相互作用的微环境

IF 83.5 1区材料科学

Nature Reviews Materials Pub Date : 2023-09-04 DOI: 10.1038/s41578-023-00591-9

Ya Guan, Luigi Racioppi, Sharon Gerecht

{"title":"Engineering biomaterials to tailor the microenvironment for macrophage–endothelium interactions","authors":"Ya Guan, Luigi Racioppi, Sharon Gerecht","doi":"10.1038/s41578-023-00591-9","DOIUrl":"10.1038/s41578-023-00591-9","url":null,"abstract":"Macrophages and endothelial cells (ECs) have essential roles in physiological and pathological conditions by regulating inflammation, vascularization and tissue remodelling. Although the interactions between macrophages and ECs in tissue homeostasis and disease progression have been extensively studied in the past few decades, the role of the extracellular matrix in this intercellular process is less known. Here, we review the current knowledge on how microenvironmental cues, biophysical and biochemical, dictate macrophage–endothelium crosstalk in the pathology of different diseases. We summarize studies using biomaterials as extracellular matrix with tenable properties to manipulate macrophage–EC fate to regulate innate and adaptive immunity, angiogenesis and regeneration. Finally, we discuss the potential and challenges of developing novel therapeutic strategies to tailor macrophage–EC niches to restore homeostasis in various diseases. The interactions between macrophages and endothelial cells are regulated by microenvironmental cues in the extracellular matrix. This Perspective highlights recent advances in using biomaterials as extracellular matrix to mimic macrophage–endothelium niches and to regulate cell fate in tissue homeostasis and disease progression.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"8 10","pages":"688-699"},"PeriodicalIF":83.5,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46496378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Encoding autonomy in a photo- and electroactive hydrogel 在光和电活性水凝胶中编码自主性

IF 83.5 1区材料科学

Nature Reviews Materials Pub Date : 2023-08-29 DOI: 10.1038/s41578-023-00595-5

Silvia Conti

引用次数: 0

In situ self-assembly for cancer therapy and imaging 原位自组装用于癌症治疗和成像

IF 83.5 1区材料科学

Nature Reviews Materials Pub Date : 2023-08-29 DOI: 10.1038/s41578-023-00589-3

Jaewon Kim, Sungkyu Lee, Yuri Kim, Minhyeok Choi, Injun Lee, Eunji Kim, Chan Gyu Yoon, Kanyi Pu, Heemin Kang, Jong Seung Kim

{"title":"In situ self-assembly for cancer therapy and imaging","authors":"Jaewon Kim, Sungkyu Lee, Yuri Kim, Minhyeok Choi, Injun Lee, Eunji Kim, Chan Gyu Yoon, Kanyi Pu, Heemin Kang, Jong Seung Kim","doi":"10.1038/s41578-023-00589-3","DOIUrl":"10.1038/s41578-023-00589-3","url":null,"abstract":"In situ self-assembly — the in situ formation of complex materials via biochemical reactions of monomers — has enhanced the efficacy of drug delivery for cancer therapy and imaging. So far, nanomedicine has been confined to ex situ self-assembly, which is limited by poor deep-tumour penetration and poor blood circulation. By contrast, in situ self-assembly-based cancer treatments offer various advantages, including enhanced blood circulation of monomers, long-term drug delivery pharmacokinetics, low drug resistance and the ability to target deep tumours and organelles, which can result in disruption-mediated apoptosis and enable the imaging of cellular activity for effective cancer therapy and diagnosis. In this Review, we discuss the design of in situ self-assembled nanomedicines for cancer therapy and imaging based on various endogenous and exogenous stimuli in both the extracellular and the intracellular milieu. We also highlight the advantages of cancer treatment via multimodal dynamic transformations of nanostructures self-assembled in situ, including the ability to induce mechanical stress, deploy cancer-specific targeted therapies, obtain deep-tumour penetration and sustain prolonged drug retention time in the body. Finally, we discuss from a clinical viewpoint the challenges of in situ self-assembled nanomedicine and its potential to offer advanced alternatives to existing cancer therapies. In situ self-assembly is advantageous for cancer therapy and imaging because of the efficient deep-tumour targeting, enhanced blood circulation and negligible drug resistance of the resulting nanomedicines. This Review discusses extracellular and intracellular in situ self-assembly based on endogenous and exogenous stimuli for cancer therapy and imaging applications.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"8 11","pages":"710-725"},"PeriodicalIF":83.5,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47560114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Printed transistors made of 2D material-based inks 由2D材料基油墨制成的印刷晶体管

IF 83.5 1区材料科学

Nature Reviews Materials Pub Date : 2023-08-24 DOI: 10.1038/s41578-023-00585-7

Silvia Conti, Gabriele Calabrese, Khaled Parvez, Lorenzo Pimpolari, Francesco Pieri, Giuseppe Iannaccone, Cinzia Casiraghi, Gianluca Fiori

{"title":"Printed transistors made of 2D material-based inks","authors":"Silvia Conti, Gabriele Calabrese, Khaled Parvez, Lorenzo Pimpolari, Francesco Pieri, Giuseppe Iannaccone, Cinzia Casiraghi, Gianluca Fiori","doi":"10.1038/s41578-023-00585-7","DOIUrl":"10.1038/s41578-023-00585-7","url":null,"abstract":"Large-area electronics for the Internet of Things requires a new generation of light-weight, flexible, low-power electronics, based on advanced materials able to provide high-throughput fabrication of reliable, stable and cost-effective field-effect transistors that can be easily integrated onto flexible substrates such as plastic, paper and textiles. The family of 2D materials comprises a range of crystals with different chemical composition, structures and electronic properties that can be used as building blocks in transistors. Solution processing of 2D materials does not require the use of glove boxes, can be performed with minimal chemical processing and enables the use of printing technologies for device fabrication — these factors represent a critical advantage over traditional high-performance materials in terms of ease of processing, compatibility with flexible substrates, fabrication costs, large-volume manufacturing and scalability. Nevertheless, the electronic quality of solution-processed 2D materials is a bottleneck for the development of next-generation printed and flexible devices. This Review surveys solution-processed 2D material-based transistors, discussing the figures of merit, state of art and performance limits of devices, and describes the open challenges and future perspectives of this field. Two-dimensional materials can enable a new generation of flexible and printed electronics suitable for light-weight, low-power, sustainable and cost-effective field-effect transistors. This Review surveys solution-processed transistors based on 2D materials, discussing their performance, limitations and future perspectives.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"8 10","pages":"651-667"},"PeriodicalIF":83.5,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41300339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D-printed PEDOT:PSS for soft robotics 3D打印PEDOT:PSS用于软机器人

IF 83.5 1区材料科学

Nature Reviews Materials Pub Date : 2023-08-24 DOI: 10.1038/s41578-023-00587-5

Jinhao Li, Jie Cao, Baoyang Lu, Guoying Gu

{"title":"3D-printed PEDOT:PSS for soft robotics","authors":"Jinhao Li, Jie Cao, Baoyang Lu, Guoying Gu","doi":"10.1038/s41578-023-00587-5","DOIUrl":"10.1038/s41578-023-00587-5","url":null,"abstract":"Soft robotics is an emerging technology requiring conductive materials with inherently high compliance to sense, control or actuate. Poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) is a soft and flexible conducting polymer with tunable mechanical properties, mixed ionic and electronic conductivity and excellent processability. Combining PEDOT:PSS with advanced 3D printing has ushered unprecedented opportunities in soft material engineering and soft robotics. In this Review, we aim to bridge the gap between different research areas by specifically discussing the use of PEDOT:PSS-based inks in 3D printing for soft robotics. We discuss rational PEDOT:PSS-based ink design and evaluation, 3D-printing technologies and strategies as well as applications for soft robotics. We provide insights into the theoretical background and fundamental aspects of the 3D printing of conducting polymers, with the goal of accelerating soft robotics development. Combining poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) with 3D-printing techniques enables the customization of compliant conductive materials for soft robotics, towards the goal of merging humans and robots. This Review discusses the fundamentals of 3D-printed PEDOT:PSS for soft robotics, from printable ink design and evaluation to printing strategies and promising soft robotic systems.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"8 9","pages":"604-622"},"PeriodicalIF":83.5,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41569383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-dimensional wide-bandgap semiconductors for UV photodetectors 用于紫外光电探测器的低维宽禁带半导体

IF 83.5 1区材料科学

Nature Reviews Materials Pub Date : 2023-08-18 DOI: 10.1038/s41578-023-00583-9

Ziqing Li, Tingting Yan, Xiaosheng Fang

{"title":"Low-dimensional wide-bandgap semiconductors for UV photodetectors","authors":"Ziqing Li, Tingting Yan, Xiaosheng Fang","doi":"10.1038/s41578-023-00583-9","DOIUrl":"10.1038/s41578-023-00583-9","url":null,"abstract":"Accurate UV light detection is a crucial component in modern optoelectronic technologies. Current UV photodetectors are mainly based on wide-bandgap semiconductors (WBSs), such as III–V semiconductors. However, conventional WBSs have reached a bottleneck of low integration and inflexibility. In this regard, low-dimensional WBSs, which have suitable UV absorption, tunable performance and good compatibility, are appealing for diversified UV applications. UV photodetectors based on low-dimensional WBSs have broad application prospects in imaging, communication, multispectral and/or weak light detection and flexible and wearable electronics. This Review focuses on the progress, open challenges and outlook in the field of UV photodetectors on the basis of low-dimensional WBSs. We examine how material design, dimensionality engineering and device engineering of WBSs can control their morphological structures and properties and attempt to clarify the interplay among material growth, device structure and application scenarios. UV photodetectors based on low-dimensional wide-bandgap semiconductors offer wearable, multidimensional and intelligent functions in the scenarios of imaging, communication, multispectral and/or weak light detection and flexible electronics. This Review focuses on the material design, dimensionality engineering and device engineering of wide-bandgap semiconductors in diversified UV applications.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"8 9","pages":"587-603"},"PeriodicalIF":83.5,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42006384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Tattooing soft biological matter 纹身柔软的生物物质

IF 83.5 1区材料科学

Nature Reviews Materials Pub Date : 2023-08-18 DOI: 10.1038/s41578-023-00594-6

Charlotte Allard

引用次数: 0

MOF–ammonia working pairs in thermal energy conversion and storage MOF–热能转换和储存中的氨工作对

IF 83.5 1区材料科学

Nature Reviews Materials Pub Date : 2023-08-16 DOI: 10.1038/s41578-023-00593-7

Shao-Fei Wu, Bing-Zhi Yuan, Li-Wei Wang

引用次数: 0

Advancing scientific discourse in American Sign Language 推进美国手语的科学话语

IF 83.5 1区材料科学

Nature Reviews Materials Pub Date : 2023-08-10 DOI: 10.1038/s41578-023-00575-9

Colin P. Lualdi, Barbara Spiecker, Alicia K. Wooten, Kaitlyn Clark

{"title":"Advancing scientific discourse in American Sign Language","authors":"Colin P. Lualdi, Barbara Spiecker, Alicia K. Wooten, Kaitlyn Clark","doi":"10.1038/s41578-023-00575-9","DOIUrl":"10.1038/s41578-023-00575-9","url":null,"abstract":"Deaf scientists who use American Sign Language (ASL) need to be able to communicate specialized concepts with ease. Because deaf individuals — here we use ‘deaf’ broadly to refer to the full kaleidoscope of deaf experiences — have historically been under-represented in science, the linguistic capabilities of ASL have yet to be fully explored for scientific discourse. As a consequence, deaf scientists may not have the necessary tools to effectively articulate their work. Nowadays, with improved educational opportunities and communication access, there are more deaf ASL users who are experts in scientific fields. Through their scientific work, these researchers finally have opportunities to expand ASL by incorporating new technical signs and experimenting with best practices for communication. In this Viewpoint, four deaf scientists — a quantum physicist, a marine ecologist, an immunologist and an organic chemist — discuss their experiences in developing scientific lexicons and the resulting shift in their science communication. Deaf scientists who use American Sign Language need to be able to communicate specialized concepts with ease. In this Viewpoint, four deaf scientists — a quantum physicist, a marine ecologist, an immunologist and an organic chemist — discuss their experiences in developing scientific lexicons and the resulting shift in their science communication.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"8 10","pages":"645-650"},"PeriodicalIF":83.5,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43324801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bio-informed materials: three guiding principles for innovation informed by biology 生物知情材料：生物知情创新的三大指导原则

IF 83.5 1区材料科学

Nature Reviews Materials Pub Date : 2023-08-08 DOI: 10.1038/s41578-023-00590-w

Devi Stuart-Fox, Leslie Ng, Mark A. Elgar, Katja Hölttä-Otto, Gerd E. Schröder-Turk, Nicolas H. Voelcker, Gregory S. Watson

引用次数: 0