{"title":"Designing supramolecular catalytic systems for mammalian synthetic metabolism","authors":"Jingjing Han, Martin Fussenegger","doi":"10.1038/s41578-025-00801-6","DOIUrl":"https://doi.org/10.1038/s41578-025-00801-6","url":null,"abstract":"<p>Synthetic biology aims to use interchangeable and independent components to develop specialized systems within cellular and cell-free environments to reconfigure natural genetic systems and create innovative tools for biomedicine and industry. Supramolecular nanocatalysts, which use various mechanisms to enhance catalytic reactions, are being explored as components of synthetic gene circuits to optimize metabolic pathways. In this Review, we discuss progress in the incorporation of supramolecular nanocatalysts into cellular systems. We focus on their design, the types of interactions that serve to maintain their supramolecular structure and especially their integration into mammalian cells, as exemplified by actual and potential applications for energy production, energy conversion and novel therapeutics. We also discuss the interactions between supramolecular nanocatalysts and cellular components in metabolic processes and the potential of such combined systems to underpin future breakthroughs in biotechnology and medicine.</p>","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"26 1","pages":""},"PeriodicalIF":83.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143884882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stabilizing condensates and coacervates all the same","authors":"Ariane Vartanian","doi":"10.1038/s41578-025-00805-2","DOIUrl":"https://doi.org/10.1038/s41578-025-00805-2","url":null,"abstract":"An article in Nature Chemistry reports a library of block polymers that can form stabilizing membranes around all kinds of synthetic coacervates and biomolecular condensates.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"82 1","pages":""},"PeriodicalIF":83.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143884897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"3D-printable photopolymers get fully recyclable","authors":"Giulia Pacchioni","doi":"10.1038/s41578-025-00807-0","DOIUrl":"https://doi.org/10.1038/s41578-025-00807-0","url":null,"abstract":"A paper in Science reports the use of a dissociative network design that results in 3D-printable polymers with good mechanical properties that can be fully recycled without loss of functionality.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"7 1","pages":""},"PeriodicalIF":83.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah K. Yorke, Zhenze Yang, Elizabeth G. Wiita, Ayaka Kamada, Tuomas P. J. Knowles, Markus J. Buehler
{"title":"Design and sustainability of polypeptide material systems","authors":"Sarah K. Yorke, Zhenze Yang, Elizabeth G. Wiita, Ayaka Kamada, Tuomas P. J. Knowles, Markus J. Buehler","doi":"10.1038/s41578-025-00793-3","DOIUrl":"https://doi.org/10.1038/s41578-025-00793-3","url":null,"abstract":"<p>Some of the highest-performance materials in nature, including spider silk and collagen, are formed through protein self-assembly. These natural materials, which combine function, performance and assembly under mild aqueous conditions, have inspired a generation of technologically useful biomaterials that use natural proteins as the molecular building blocks. The shift from oil-based feedstocks towards renewable materials has accelerated the search for plastic replacements and has stimulated work in the two major classes of abundant natural polymers, proteins and polysaccharides. Whereas polysaccharides are already used in areas from packaging to structural applications, the unique properties of proteins have not yet been fully harnessed for renewable materials. Advances over the past 15 years have highlighted the promise of protein systems for high-performance applications, enabled by a fundamental understanding of polypeptide self-assembly, emerging computational methods such as artificial intelligence, feedstocks, and materials processing. In this Review, we highlight developments in this area and provide a perspective on the potential of this important class of molecules in both fundamental materials science and sustainability.</p>","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"6 1","pages":""},"PeriodicalIF":83.5,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143827708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Molecular design for low-cost organic photovoltaic materials","authors":"Ni Yang, Shaoqing Zhang, Yong Cui, Jianqiu Wang, Shuohan Cheng, Jianhui Hou","doi":"10.1038/s41578-025-00792-4","DOIUrl":"https://doi.org/10.1038/s41578-025-00792-4","url":null,"abstract":"<p>The development of low-cost and high-performance organic photovoltaic (OPV) materials is currently a major focus of research in the OPV field because the material costs of state-of-the-art OPV cells are prohibitive for industrialization. When analysing state-of-the-art OPV materials, including polymer electron donors and small-molecule electron acceptors, the main prerequisites for high photovoltaic performance, including optoelectronic and morphological properties, are quite clear. However, low-cost materials, consisting of simpler building blocks with fewer chemical substitution positions, present challenges in simultaneously obtaining desirable optoelectronic and morphological properties. In this Review, we first summarize key factors in the molecular design of high-performance OPV materials. Subsequently, we discuss research progress and challenges faced in the molecular design of low-cost materials. Finally, we outline key thoughts and insights related to the molecular design of future low-cost OPV materials with a focus on efficiency and stability.</p>","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"37 1","pages":""},"PeriodicalIF":83.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Baodong Wang, Guoxing Chen, Yang Dong, Heng Guo, Marc Widenmeyer, Zeai Huang, Ying Zhou, Anke Weidenkaff
{"title":"Wind turbine blade recycling for greener and sustainable wind energy","authors":"Baodong Wang, Guoxing Chen, Yang Dong, Heng Guo, Marc Widenmeyer, Zeai Huang, Ying Zhou, Anke Weidenkaff","doi":"10.1038/s41578-025-00797-z","DOIUrl":"https://doi.org/10.1038/s41578-025-00797-z","url":null,"abstract":"The rapid expansion of wind farms has led to a growing challenge: the escalating accumulation of decommissioned wind turbine blades in landfills. Addressing this issue through innovative recycling and reuse strategies is pivotal to advancing a circular economy within the wind energy sector.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"24 1","pages":""},"PeriodicalIF":83.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"New sorbents for removing forever chemicals need standardized reporting","authors":"Zicheng Su, Zhuojing Yang, Kehan Liu, Chunrong Yu, Jianhua Guo, Cheng Zhang","doi":"10.1038/s41578-025-00795-1","DOIUrl":"https://doi.org/10.1038/s41578-025-00795-1","url":null,"abstract":"Per- and polyfluoroalkyl substances (PFAS), or ‘forever chemicals’, are persistent global pollutants that require efficient sorbents for removal. We propose a minimum data standard that should be reported for any new PFAS sorbent, aiming to enhance reproducibility, facilitate quantitative sorbent comparisons and accelerate PFAS removal technologies.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"100 5 Pt 1 1","pages":""},"PeriodicalIF":83.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Forcing imines into MOFs","authors":"Ariane Vartanian","doi":"10.1038/s41578-025-00799-x","DOIUrl":"10.1038/s41578-025-00799-x","url":null,"abstract":"An article in the Journal of the American Chemical Society describes a simple mechanochemical route to imine-based metal–organic frameworks, which have long been difficult to synthesize.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"10 4","pages":"251-251"},"PeriodicalIF":79.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Semi-transparent perovskites promote radicchio growth","authors":"Charlotte Allard","doi":"10.1038/s41578-025-00796-0","DOIUrl":"10.1038/s41578-025-00796-0","url":null,"abstract":"An article in Nature Communications shows that using semi-transparent perovskite rooftops in greenhouses enhances the growth of radicchio seedlings.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"10 4","pages":"250-250"},"PeriodicalIF":79.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Understanding materials failure mechanisms for the optimization of lithium-ion battery recycling","authors":"Mengting Zheng, Ya You, Jun Lu","doi":"10.1038/s41578-025-00783-5","DOIUrl":"https://doi.org/10.1038/s41578-025-00783-5","url":null,"abstract":"<p>The pace of electrification is surging, and recycling is key towards a circular battery life cycle. However, as the usage of lithium-ion batteries (LIBs) expands in modern technologies and ever more complex elements are incorporated, complicated degradation behaviours are introduced, posing challenges for recycling. Metallurgy-based material extraction methods are independent of the complexity of materials decay but at the cost of compromised economic and environmental sustainability. Although direct regeneration is expected to reduce the environmental impact of recycling and improve its economic benefits, it cannot properly deal with failure at different scales and parameters. To effectively manage the growing stream of spent LIBs, strategies on multiple fronts are imperative. Recent developments in recycling mechanisms have highlighted the importance of understanding battery failure mechanisms to achieve environmentally friendly and sustainable recycling practices. In this Review, failure mechanisms in state-of-the-art LIBs are discussed from the particle scale to the cell scale, offering insights for navigating recycling efforts. Recent advancements in material extraction and direct regeneration are summarized, and perspectives on the most pressing challenges for recycling, optimization of recycling processes, and recycling strategies for next-generation batteries are offered.</p>","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"26 1","pages":""},"PeriodicalIF":83.5,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}