Nature Reviews Cancer最新文献_第6页

Message in a vesicle: T cells boost tumour immunity 囊泡中的信息：T细胞增强肿瘤免疫。

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-05-28 DOI: 10.1038/s41568-026-00942-y

Gabrielle Brewer

引用次数: 0

Beat it! 战胜它!

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-05-27 DOI: 10.1038/s41568-026-00943-x

Daniela Senft

引用次数: 0

Beyond sex determination: the Y chromosome in male cancers 超越性别决定：男性癌症中的Y染色体。

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-05-21 DOI: 10.1038/s41568-026-00935-x

Hany A. Abdel-Hafiz, Lena Hoelzen, Dan Theodorescu

{"title":"Beyond sex determination: the Y chromosome in male cancers","authors":"Hany A. Abdel-Hafiz, Lena Hoelzen, Dan Theodorescu","doi":"10.1038/s41568-026-00935-x","DOIUrl":"10.1038/s41568-026-00935-x","url":null,"abstract":"Loss of the Y chromosome (LOY) is the most prevalent somatic genomic alteration in males and can be detected in both blood and other tissues. Age, environmental exposures, mitotic errors and genetic predisposition converge to drive LOY, often via clonal expansion. Emerging evidence has linked LOY to susceptibility, progression and poor outcomes in multiple cancer types. Here we summarize Y-chromosome evolution, structure and gene content, which is essential for male development, transcriptional regulation, chromatin remodelling, and immune and androgen signalling. We highlight the associations of Y-encoded genes with cancer, spanning increased risk in haematological malignancies to context-dependent prognostic impact of LOY in solid tumours. We discuss functional studies, from CRISPR-induced LOY in cell lines and mouse models to bioinformatic analyses of human cohorts, demonstrating the direct effects of LOY on immune surveillance, DNA repair, metabolism and tumour immune microenvironment remodelling. Collectively, these findings indicate that LOY has context-dependent roles in cancer, but whether LOY is a causal, cooperative or passenger event remains unresolved. Advances in bulk and single-cell sequencing, together with LOY scoring algorithms and non-invasive sampling of blood, urine and buccal cells, now enable precise quantification and longitudinal monitoring, offering new opportunities to relate LOY dynamics to disease risk and progression. Finally, we discuss the implications of LOY as a biomarker for cancer risk and precision therapy, including immunotherapy response and treatment stratification. This Review by Abdel-Hafiz et al. describes the current and emerging evidence that loss of the Y chromosome is linked to susceptibility, progression and poor outcomes in multiple cancer types, as well as its potential use as a biomarker for prognosis and precision therapy.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 8","pages":"586-603"},"PeriodicalIF":60.7,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147988437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesenchymal stromal/stem cells in tumour initiation, progression and therapy 间充质间质/干细胞在肿瘤发生、发展和治疗中的作用。

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-05-20 DOI: 10.1038/s41568-026-00936-w

Geyon L. Garcia, Roja Baruwal, Swathi Suresh, Ananya Kapur Britt, Angelina Li, Huda I. Atiya, Lan Coffman

{"title":"Mesenchymal stromal/stem cells in tumour initiation, progression and therapy","authors":"Geyon L. Garcia, Roja Baruwal, Swathi Suresh, Ananya Kapur Britt, Angelina Li, Huda I. Atiya, Lan Coffman","doi":"10.1038/s41568-026-00936-w","DOIUrl":"10.1038/s41568-026-00936-w","url":null,"abstract":"The expanding study of mesenchymal stromal/stem cells (MSC) in cancer has amounted to a growing understanding of their underlying biology in malignant and non-malignant settings. In addition to supporting homeostasis in nearly all normal tissues, MSCs also serve as stromal support for a diverse set of malignancies, the most studied being ovarian, breast, brain, blood and colorectal cancers. Their ability to localize to and shape the stromal microenvironment of solid tumours or haematologic malignancies results in increased tumour cell growth, metastasis and survival and promotes the enrichment of the cancer stem cell population, all of which contribute to poor patient outcomes. Here we summarize the known roles MSCs have in promoting or inhibiting carcinogenesis. We highlight emerging concepts including epigenetic reprogramming of MSCs to switch from a tumour-suppressive to tumour-supportive phenotype, their role in cancer initiation, and novel mechanisms of immune modulation. We also cover advances in the development of MSC-targeted treatment modalities for cancer therapy. In addition, given their inherent adaptability, we discuss how MSCs are being co-opted as tools for drug delivery and discuss ongoing challenges in MSC-based therapies. Mesenchymal stromal/stem cells (MSCs) influence tumour initiation, progression and immune modulation across diverse cancer types. In this Review, Garcia et al. outline how tissue-dependent and context-dependent MSC plasticity underlies their tumour-supportive or tumour-restraining functions and highlight emerging mechanisms and therapeutic opportunities that position MSC biology as a promising avenue for cancer treatment.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 8","pages":"604-619"},"PeriodicalIF":60.7,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147982440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tracing disease origin with plasma cell-free chromatin 用无浆细胞染色质追踪疾病起源。

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-05-19 DOI: 10.1038/s41568-026-00939-7

Xiaoxuan Meng

引用次数: 0

Regulation of immune checkpoint molecules in cancer immune evasion and therapy 免疫检查点分子在癌症免疫逃避和治疗中的调控。

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-05-18 DOI: 10.1038/s41568-026-00934-y

Cansu Eris, Cheng Zu, Yanling Xiao, Michael Platten, Chong Sun

{"title":"Regulation of immune checkpoint molecules in cancer immune evasion and therapy","authors":"Cansu Eris, Cheng Zu, Yanling Xiao, Michael Platten, Chong Sun","doi":"10.1038/s41568-026-00934-y","DOIUrl":"10.1038/s41568-026-00934-y","url":null,"abstract":"Immune checkpoint molecules are essential regulators of immune homeostasis, maintaining the balance between activation and tolerance. In cancer, tumours exploit checkpoint pathways to suppress antitumour immunity and promote progression. The advent of immune checkpoint inhibitors, particularly those that target the clinically validated PDL1–PD1 and CTLA4 axes, has transformed cancer therapy, and the LAG3 axis has recently entered clinical practice, yet most patients experience limited or transient benefit, often because the checkpoint molecules become dysregulated. Here, we examine how multilayered regulatory mechanisms operating at the genetic, epigenetic, transcriptional, post-transcriptional, translational and post-translational levels collectively shape checkpoint abundance and function in tumour and immune cells. We further connect these regulatory processes to immune evasion and therapeutic resistance and highlight how this knowledge informs biomarker development and mechanism-guided strategies to improve immunotherapy outcomes. Tumours evade immunity by dynamically rewiring immune checkpoint expression across multiple regulatory layers. In this Review, Eris, Zu et al. synthesize how these mechanisms operate in tumour and immune cells, connect them to therapeutic resistance, and highlight emerging biomarkers and therapeutic strategies that target convergent regulatory nodes to improve immunotherapy outcomes.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 8","pages":"560-585"},"PeriodicalIF":60.7,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147974073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stem cells as an essential mediator of the exercise–tumorigenesis link 干细胞作为运动-肿瘤发生联系的重要中介。

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-05-14 DOI: 10.1038/s41568-026-00933-z

Xueqian Zhuang, Emily S. Wong, Tuomas Tammela, Lee W. Jones

{"title":"Stem cells as an essential mediator of the exercise–tumorigenesis link","authors":"Xueqian Zhuang, Emily S. Wong, Tuomas Tammela, Lee W. Jones","doi":"10.1038/s41568-026-00933-z","DOIUrl":"10.1038/s41568-026-00933-z","url":null,"abstract":"Aerobic exercise has a profound influence on host physiology and cancer risk, yet the mechanisms of how these are linked remain incompletely understood. Since adult stem cells (ASCs) respond to shifts in organismal (host) physiology and are also likely the cancer cells of origin, ASC function could act as an essential mediator of the link between aerobic exercise and cancer incidence. We therefore hypothesize that exercise-induced alterations in host physiology lead to sculpting of distal tissue microenvironments to augment the regenerative capacity of ASCs whilst simultaneously activating highly conserved cell-intrinsic and cell-extrinsic processes that suppress pro-tumorigenic phenotypes. In this Perspective, we dissect this hypothesis by first examining how exercise regulates host physiology through alterations in the systemic milieu and then focus on how these changes shape distant tissue landscapes in which ASCs reside. We then discuss the effects of exercise on ASC function and speculate on the cell-intrinsic and cell-extrinsic mechanisms that may explain the apparent paradox of exercise-induced enhanced stemness in the context of tumour suppression. A better understanding of how exercise-sensing pathways regulate ASC function to maintain or restore tissue homeostasis will have implications for cancer prevention as well as for other age-related conditions in which ASC degradation is complicit. Aerobic exercise influences physiology and generally reduces cancer risk, yet the mechanisms connecting these effects remain incompletely understood. In this Perspective, Zhuang and colleagues outline a model in which exercise-induced physiological adaptation regulates adult stem cell behaviour in ways that limit transformation and tumour initiation.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 8","pages":"620-635"},"PeriodicalIF":60.7,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147942152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Remembering inflammation increases cancer risk 记住炎症会增加患癌症的风险。

IF 66.8 1区医学

Nature Reviews Cancer Pub Date : 2026-05-14 DOI: 10.1038/s41568-026-00938-8

Daniela Senft

引用次数: 0

Microplastics but macro-concerns on the brain 微塑料，但对大脑的宏观关注。

IF 66.8 1区医学

Nature Reviews Cancer Pub Date : 2026-05-13 DOI: 10.1038/s41568-026-00937-9

Gabrielle Brewer

引用次数: 0

The sleeping threat: targeting cancer dormancy to transform metastasis therapy 睡眠威胁：针对癌症休眠转变转移治疗。

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-04-24 DOI: 10.1038/s41568-026-00928-w

Julio A. Aguirre-Ghiso, Jose Javier Bravo-Cordero, Wenjun Guo, Gregoire Lauvau, Maria Soledad Sosa

{"title":"The sleeping threat: targeting cancer dormancy to transform metastasis therapy","authors":"Julio A. Aguirre-Ghiso, Jose Javier Bravo-Cordero, Wenjun Guo, Gregoire Lauvau, Maria Soledad Sosa","doi":"10.1038/s41568-026-00928-w","DOIUrl":"10.1038/s41568-026-00928-w","url":null,"abstract":"Metastatic cancer cell dormancy, wherein disseminated cancer cells (DCCs) persist in a quiescent state before reactivating to fuel metastasis, has emerged as a critical determinant of cancer relapse. In this Review, we synthesize recent advances in understanding the microenvironmental drivers of dormancy, including the role of niche-derived signals and extracellular matrix composition in maintaining DCC quiescence, as well as the epigenetic and transcriptional programmes, and chromatin remodelling that enforce and sustain dormancy. We also cover the mechanisms by which dormant DCCs evade immune surveillance, highlighting both innate and adaptive immune interactions, and the strategies tumours use to escape immune-mediated clearance. Although most data come from solid cancers, we also examine the biology of residual cells in haematologic malignancies that share key dormancy and relapse mechanisms with solid tumours. We also discuss how, despite these mechanistic insights, clinical translation remains limited, as available biomarkers or therapies targeting dormancy have yet to be effectively implemented. We conclude that by outlining the challenges and opportunities for leveraging dormancy biology, we may be able to prevent metastatic recurrence and improve patient outcomes. This Review synthesizes emerging insights into how microenvironmental cues, epigenetic programmes and immune interactions govern disseminated cancer cell dormancy and outlines how advances in dormancy research could guide the development of biomarkers and therapies to prevent metastatic relapse.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 7","pages":"513-533"},"PeriodicalIF":60.7,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147739024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0