Nature Reviews Cancer最新文献

{"title":"Serving sulfur to boost anti-tumour immunity","authors":"Gabrielle Brewer","doi":"10.1038/s41568-026-00955-7","DOIUrl":"10.1038/s41568-026-00955-7","url":null,"abstract":"Gut microbiome composition and metabolite profiles have previously been linked to both colorectal tumorigenesis and immune checkpoint inhibitor responsiveness. Now, Lobel et al. identify sulfur amino acid metabolism as a microorganism-derived metabolic pathway that enhances anti-tumour immunity.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 8","pages":"557-557"},"PeriodicalIF":60.7,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148322602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to give a bad talk","authors":"Itai Yanai","doi":"10.1038/s41568-026-00954-8","DOIUrl":"10.1038/s41568-026-00954-8","url":null,"abstract":"It is crucial to know how to communicate your work by delivering an effective talk, but our training for doing so is limited, so it is a skill often learned by watching others — who sometimes do it badly. Effective presentations require clarity and audience awareness. In this Comment, Itai Yanai outlines common misconceptions about presentations and how to address them to deliver more impactful and insightful talks.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 9","pages":"637-637"},"PeriodicalIF":60.7,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148305252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond oncogenesis: the unexplored benefits of viruses in cancer immunity","authors":"Xin Wei Wang, Chi-Ping Day, Eugene V. Koonin","doi":"10.1038/s41568-026-00948-6","DOIUrl":"10.1038/s41568-026-00948-6","url":null,"abstract":"The connections between viruses and cancer have historically been studied in the context of viral oncogenesis. For decades, tumour virology has focused on oncogenic viruses such as hepatitis B virus, hepatitis C virus, human papillomavirus, Epstein–Barr virus, human T cell leukaemia virus type 1, Kaposi sarcoma-associated herpesvirus and Merkel cell polyomavirus, elucidating their oncogenic mechanisms, which include mutagenesis, chronic inflammation and immune evasion. However, the human virome is vast and complex, and this oncogenesis-centred view has overshadowed the possibility that certain viral exposures enhance antitumour immunity. Through millions of years of coevolution with animal hosts, the virome, consisting of diverse bacteriophages and eukaryotic viruses, including endogenous retroviruses, appear to have evolved strategies for coexistence that shape immune development and potentiate host surveillance pathways capable of recognizing and eliminating cancer cells. Non-oncogenic viruses can prime innate and adaptive immune responses, mimic tumour antigens and modulate the expression of immune checkpoints, as exemplified by the association of the enterovirus and rhinovirus CE1 epitope with protective liver cancer immunity. Moreover, endogenous retroviruses, naturally occurring oncolytic viruses and microbiome-associated phages may act as allies in cancer control. This Review explores the emerging evidence for viral anticancer immunity, its underlying mechanisms, and implications for a virome-guided framework for cancer prevention including new approaches to risk assessment, immune-based therapeutics and applications in low-resource settings. The study of tumour virology has traditionally focused on oncogenic viruses and their associated mechanisms of cancer initiation and promotion. Yet certain viral exposures can be beneficial by enhancing antitumour immunity. In this Review, Wang et al. explore the increasingly emerging evidence of protective roles of viruses in cancer immunity and how this knowledge could be harnessed to develop a virome-guided framework for cancer immunoprevention.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 9","pages":"643-660"},"PeriodicalIF":60.7,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148278132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D multi-omics tumour atlases: from technology to biology and clinical translation","authors":"Miao Liu, Jorge Villazon, André Forjaz, Xiaolong Tian, Rong Fan, Siyuan Wang, Lingyan Shi, Denis Wirtz, Ashley L. Kiemen","doi":"10.1038/s41568-026-00940-0","DOIUrl":"10.1038/s41568-026-00940-0","url":null,"abstract":"Human tumours consist of highly heterogeneous and interacting cell types organized within a complex 3D space, forming a dynamic ecosystem that evolves through the development of pre-malignant lesions, tumour initiation, progression, invasion and metastasis. Understanding the operational principles of tumour evolution at a holistic 3D level is critical for improving the ability to intercept and treat cancer early. Emerging technologies in spatial multi-omics and the generation of 3D tumour atlases are beginning to address this critical need. These efforts aim to capture the intricate interactions within precancerous lesions, tumours and their surrounding ecosystems over space and time. In this Review, we highlight emerging tools developed within and beyond the tumour atlas community and explore their potential in constructing comprehensive 3D tumour atlases. Such atlases have the potential to reveal novel biomarkers for risk stratification, early detection, preventive intervention, and transformative diagnostic and treatment strategies. Furthermore, a 3D tumour atlas can generate new insights into the molecular and cellular mechanisms driving human tumour evolution, paving the way for future research and innovation in cancer biology. In this Review, Liu et al. describe the established and emerging tools for the generation of comprehensive 3D tumour atlases, the analysis of which has the potential to uncover novel biomarkers for risk stratification, early detection, preventive interventions, and transformative diagnostic and treatment strategies.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 10","pages":"762-789"},"PeriodicalIF":60.7,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AACR 2026","authors":"Daniela Senft","doi":"10.1038/s41568-026-00953-9","DOIUrl":"10.1038/s41568-026-00953-9","url":null,"abstract":"The 2026 annual meeting of the American Association for Cancer Research (AACR) was held under the theme ‘Precision, Partnership, Purpose: Advancing Cancer Science to Save Lives Globally’. Here, we summarize some key highlights from the meeting.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 7","pages":"478-478"},"PeriodicalIF":60.7,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148239739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PRISM enables accurate microbial discovery in cancer genomics","authors":"Bassel Ghaddar","doi":"10.1038/s41568-026-00949-5","DOIUrl":"10.1038/s41568-026-00949-5","url":null,"abstract":"In this Tools of the Trade article, Bassel Ghaddar describes the development of PRISM, an efficient computational pipeline for microbial species detection and decontamination from genomic sequencing data, enabling the study of microbial associations with cancer.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 8","pages":"556-556"},"PeriodicalIF":60.7,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148205667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mutation-centric kinase drug repurposing for rare cancers","authors":"Marina Chan, Haiching Ma, Vivek Subbiah, Taranjit S. Gujral","doi":"10.1038/s41568-026-00944-w","DOIUrl":"10.1038/s41568-026-00944-w","url":null,"abstract":"Rare cancers remain underserved by precision oncology, in part because many oncogenic variants lack matched therapies despite a growing arsenal of targeted drugs. We propose that systematic, variant-level pharmacological mapping of approved kinase inhibitors can transform this gap into an opportunity for scalable drug repurposing. Rare cancers remain underserved by precision oncology, in part because many oncogenic variants lack matched therapies despite a growing arsenal of targeted drugs. In this Comment, the authors propose that systematic, variant-level pharmacological mapping of approved kinase inhibitors can transform this gap into an opportunity for scalable drug repurposing.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 7","pages":"473-474"},"PeriodicalIF":60.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148144157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of cytokine-responsive cells using CyCLoPs","authors":"Guangqing Lu","doi":"10.1038/s41568-026-00947-7","DOIUrl":"10.1038/s41568-026-00947-7","url":null,"abstract":"In this Tools of the Trade article, Guangqing Lu describes the development and use of cytokine cellular locating platforms (CyCLoPs), a technology that enables visualization and tracking of cytokine signalling in vivo.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 8","pages":"555-555"},"PeriodicalIF":60.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148144217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An adenosine derivative for the treatment of hepatocellular carcinoma","authors":"Mauricio Díaz-Muñoz","doi":"10.1038/s41568-026-00945-9","DOIUrl":"10.1038/s41568-026-00945-9","url":null,"abstract":"In this Journal Club, Mauricio Díaz-Muñoz discusses a study showing that the adenosine derivative IFC-305 restores mitochondrial structure and bioenergetics while reducing tumour burden in a rat model of hepatocellular carcinoma.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 7","pages":"479-479"},"PeriodicalIF":60.7,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148055770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural variants disrupt chromatin architecture","authors":"Aura Stephenson-Gussinye, Mayra Furlan-Magaril","doi":"10.1038/s41568-026-00946-8","DOIUrl":"10.1038/s41568-026-00946-8","url":null,"abstract":"In this Journal Club, Stephenson-Gussinye and Furlan-Magaril discuss a study exploring how structural variants reshape three-dimensional genome architecture in cancer, explaining why only a subset lead to functional changes in gene expression.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 8","pages":"559-559"},"PeriodicalIF":60.7,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148055764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}