Nature Reviews Cancer最新文献

{"title":"Who gets told what is impossible?","authors":"Johanna A. Joyce","doi":"10.1038/s41568-026-00961-9","DOIUrl":"10.1038/s41568-026-00961-9","url":null,"abstract":"Women’s experiences in cancer research have changed profoundly over the past 25 years, but increased visibility should not be mistaken for equality. The next phase of progress requires redesigning the scientific ecosystems that determine who is retained, recognized, resourced and trusted. Twenty-five years after the launch of Nature Reviews Cancer, the experiences of women in cancer research have changed in important ways, with gains in visibility, representation and recognition. In this World View, Joyce reflects on the progress achieved and the persistent structural barriers that continue to impede equity.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 10","pages":"741-742"},"PeriodicalIF":60.7,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148605647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Igniting antitumour immunity with cancer cell pyroptosis","authors":"Xin Liu, Elena Goldberg, Jonathan C. Kagan, Hao Wu","doi":"10.1038/s41568-026-00959-3","DOIUrl":"10.1038/s41568-026-00959-3","url":null,"abstract":"Gasdermins (GSDMs) are a family of pore-forming proteins that execute pyroptosis, a lytic form of programmed cell death associated with membrane rupture. This function of GSDMs was initially identified from studies of gasdermin D (GSDMD), which is cleaved and activated by inflammatory caspases in the inflammasome pathway. It is now established that other eukaryotic or pathogen-encoded proteases, as well as post-translational modifications, can also activate GSDM family members independent of inflammasomes and in multiple cell types including cancer cells. T cell granzyme-mediated GSDM activation, exogenous delivery of active GSDMs, and small molecule-induced activation of GSDMs in cancer cells have been shown to promote antitumour immunity through pyroptosis. Notably, only a fraction of cancer cells needs to undergo pyroptosis to induce immune cell infiltration and antitumour immunity with tolerable toxicity. Here, we summarize current knowledge on the role of pyroptosis in antitumour immunity, discuss pyroptosis in the context of other lytic forms of cell death, and provide an outlook on how cancer cell pyroptosis may synergize with existing immunotherapies. In this Review, Liu et al. discuss how pyroptosis, executed by a family of pore-forming proteins known as gasdermins, can induce antitumour immunity, which might be therapeutically leveraged for synergy with existing cancer immunotherapies.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 10","pages":"818-829"},"PeriodicalIF":60.7,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148605450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A viral coding circRNA contributes to HPV-driven oncogenesis","authors":"J. Omar Muñoz-Bello, Marcela Lizano","doi":"10.1038/s41568-026-00962-8","DOIUrl":"10.1038/s41568-026-00962-8","url":null,"abstract":"In this Journal Club, Muñoz-Bello and Lizano discuss the discovery of circE7, a protein-coding circular RNA generated by back-splicing in high-risk HPV that drives E7 expression and tumour growth, revealing a previously unappreciated mechanism of viral oncogene regulation.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 9","pages":"642-642"},"PeriodicalIF":60.7,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148549724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GABA takes the edge off anti-tumour immunity","authors":"Gabrielle Brewer","doi":"10.1038/s41568-026-00963-7","DOIUrl":"10.1038/s41568-026-00963-7","url":null,"abstract":"Glioblastoma exhibits sex-specific differences in disease progression, incidence and immune regulation. Now, Pathak et al. identify GABA (γ-aminobutyric acid) as a key driver of granulocytic myeloid-derived suppressor cell-mediated glioblastoma progression in women.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 9","pages":"639-639"},"PeriodicalIF":60.7,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cuproptosis promotes antitumour immunity","authors":"Daniela Senft","doi":"10.1038/s41568-026-00964-6","DOIUrl":"10.1038/s41568-026-00964-6","url":null,"abstract":"In a recent study, Lei, Lu, Xu et al. identify cuproptosis as a form of immunogenic cell death that stimulates adaptive antitumour immunity. In turn, CD8⁺ T cell-derived IFNγ enhances tumour sensitivity to cuproptosis through STAT1–IRF1–FDX1 signalling, establishing a reciprocal immunometabolic circuit with important implications for cancer immunotherapy.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 9","pages":"640-640"},"PeriodicalIF":60.7,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148456490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A genomic and epigenomic lens into the biology of acute lymphoblastic leukaemia","authors":"Ilaria Iacobucci, Charles G. Mullighan","doi":"10.1038/s41568-026-00951-x","DOIUrl":"10.1038/s41568-026-00951-x","url":null,"abstract":"Acute lymphoblastic leukaemia (ALL) is characterized by uncontrolled proliferation of lymphoid progenitor cells. Advances in genomic and epigenomic profiling have enabled the identification of over 40 molecular subtypes defined by distinct genetic drivers, transcriptional programmes and regulatory alterations. These insights have refined the classification, particularly of B cell precursor ALL (B-ALL) and are increasingly informing risk stratification, therapeutic decision-making and disease monitoring. By contrast, the classification of T cell ALL (T-ALL) has historically relied on immunophenotypic criteria, but recent large-scale genomic studies have uncovered biologically defined subtypes driven by diverse coding and noncoding alterations. Many genomic lesions represent clinically actionable vulnerabilities, including kinase-activating alterations that have enabled the use of targeted therapies. However, treatment resistance remains a major challenge, arising through clonal evolution, acquisition of secondary mutations and adaptive transcriptional and epigenetic reprogramming. In this Review, we highlight recent advances in understanding of the biological basis of ALL, with a focus on recently identified genetic alterations, gene expression patterns, alterations in three-dimensional genome architecture and epigenetic regulation that drive ALL initiation, progression and therapeutic response. Furthermore, we discuss how genetic heterogeneity contributes to clinical variability and how integrating molecular and biological insights can improve risk stratification and therapeutic outcomes. In this Review, Iacobucci and Mullighan discuss how advances in genomic, transcriptomic and epigenomic profiling of acute lymphoblastic leukaemia have revealed molecular heterogeneity, lineage plasticity and mechanisms of treatment resistance in both B cell and T cell disease, thereby refining risk stratification and informing therapeutic decision-making.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 9","pages":"689-712"},"PeriodicalIF":60.7,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148372642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Escaping the trap","authors":"Daniela Senft","doi":"10.1038/s41568-026-00957-5","DOIUrl":"10.1038/s41568-026-00957-5","url":null,"abstract":"A recent study identifies TEX264-dependent nucleophagy as an important mechanism that mediates the clearance of trapped PARP1, thereby limiting PARP1-induced toxicity and promoting resistance to PARP inhibitors.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 8","pages":"558-558"},"PeriodicalIF":60.7,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148376472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic health impact of cancer-associated extracellular vesicles and particles","authors":"Gang Wang, Serena Lucotti, Linda Bojmar, Gabriel C. Tobias, Richard T. Piszczatowski, Shani Dror, Haiying Zhang, David Lyden","doi":"10.1038/s41568-026-00952-w","DOIUrl":"10.1038/s41568-026-00952-w","url":null,"abstract":"Cancer is a systemic disease that perturbs the homeostasis of host tissues and organs, exerting manifestations both locally and distantly. Extracellular vesicles and particles (EVPs) have a pivotal role in intercellular communication between tumours and the host by transferring bioactive cargo to recipient cells, contributing to the systemic effects of cancer. Tumour-derived EVPs prepare distant organs for future metastasis, by creating a pre-metastatic niche (PMN). Additionally, tumours manipulate multiple organ systems to support their growth and evade immune detection. This co-option of host systems leads to cascading dysfunction across multiple organs, ultimately compromising host survival. Here we review the diverse systemic impact of cancer-associated EVPs, including immune dysregulation in PMNs, thrombosis and cardiovascular disease, liver metabolic dysfunction, glucose metabolism disorders, cachexia, and paraneoplastic syndromes of the nervous system. Furthermore, we discuss the intricate communication between host-, diet- and microbiota-derived EVPs and cancer cells, highlighting the complex interplay mediated by these EVPs in cancer progression and anti-cancer treatment responses. We also explore the prospects of EVPs as a systemic therapeutic approach for anti-cancer treatment. Overall, this Review highlights the need to address the systemic effects of cancer and to adopt holistic approaches to cancer treatment, by simultaneously targeting the tumour and its multi-organ paraneoplastic effects. These strategies hold great promise in mitigating the broad impact of disease progression and comorbidities and ultimately improving the quality of life and survival of patients. In this Review, Wang et al. describe how extracellular vesicles and particles contribute to the systemic effects of cancer by providing a form of intercellular communication between tumours and the host through the transfer of bioactive cargo to recipient cells. These systemic effects include immune dysregulation in pre-metastatic niches, thrombosis and cardiovascular disease, liver metabolic dysfunction, glucose metabolism disorders and cachexia, suggesting that holistic approaches to cancer treatment are necessary to simultaneously target the tumour and its multi-organ paraneoplastic effects.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 10","pages":"790-817"},"PeriodicalIF":60.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148365153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLIM-TIME links tumour genetics to spatial immune architecture","authors":"Weiwei Hu","doi":"10.1038/s41568-026-00956-6","DOIUrl":"10.1038/s41568-026-00956-6","url":null,"abstract":"In this Tools of the Trade, Weiwei Hu describes the development and use of CLIM-TIME, a scalable in vivo platform that integrates CRISPR perturbation screens with spatially resolved transcriptomic and immune profiling to link tumour-intrinsic genetic alterations to distinct immune microenvironments.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 9","pages":"638-638"},"PeriodicalIF":60.7,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148348993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging the hallmarks of cancer","authors":"Jan Grimm, Fabian Kiessling, Kevin M. Brindle, Douglas Hanahan, Sanjay K. Jain, Philippe Lambin, Twan Lammers, King C. Li, I. Jolanda M. de Vries, Wolfgang A. Weber, Bettina Weigelin, Bernd J. Pichler","doi":"10.1038/s41568-026-00950-y","DOIUrl":"10.1038/s41568-026-00950-y","url":null,"abstract":"The hallmarks of cancer were introduced by Hanahan and Weinberg as a conceptual organizing framework to distil the complexity of tumours. This concept of cancer hallmarks has become an enduring theme in cancer research. Moreover, an increasing number of therapeutic strategies are being aimed at targeting these hallmarks. However, translating them into the clinic requires technologies to monitor their effectiveness and biomarkers that can stratify patients for the choice of specific therapies. Tumour heterogeneity and the ability of tumour cells to rapidly mutate and develop evasion strategies makes the development of non-invasive imaging capabilities to interrogate these hallmarks as biomarkers and monitor them longitudinally and quantitatively particularly important. This Review presents a holistic discussion of non-invasive diagnostic imaging capabilities related to the hallmarks of cancer; some hallmarks can be assessed with imaging probes that directly target biomolecules, whereas others can be interrogated indirectly by imaging pathophysiological processes. Additionally, visualizing the hallmarks of cancer can be addressed with artificial intelligence-assisted, multiparametric image analysis (for example, radiomics, radiogenomics and deep learning). The approaches discussed have been evaluated in a translational context, and some of them already have a substantial role in clinical practice, for example, to guide treatment strategies, including surgical resections, radiotherapy and molecularly targeted chemo-, immuno- and radiopharmaceutical therapies. In this Review, Grimm et al. describe the range of non-invasive diagnostic imaging approaches to monitor the various hallmarks of cancer and how their implementation is shaping clinical practice.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 9","pages":"661-688"},"PeriodicalIF":60.7,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148352636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}