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Environmental endocrine disruptors: rethinking the origins of early-onset ER+ breast cancer 环境内分泌干扰物：重新思考早发性ER+乳腺癌的起源
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-07-22 DOI: 10.1038/s41568-025-00854-3
Meadow Parrish, Charlotte Kuperwasser
{"title":"Environmental endocrine disruptors: rethinking the origins of early-onset ER+ breast cancer","authors":"Meadow Parrish, Charlotte Kuperwasser","doi":"10.1038/s41568-025-00854-3","DOIUrl":"https://doi.org/10.1038/s41568-025-00854-3","url":null,"abstract":"Rising rates of early-onset oestrogen receptor-positive (ER+) breast cancer in women without genetic risk suggest a shift in disease biology. Chronic and cumulative exposure to endocrine-disrupting chemicals may induce field cancerization in the breast, warranting urgent attention from researchers, regulators and public health leaders. Rising rates of early-onset oestrogen receptor-positive (ER+) breast cancer in women without genetic risk suggest a shift in disease biology. Endocrine-disrupting chemicals (EDCs) may accelerate tissue ageing, destabilize epigenetic regulation and impair immune surveillance. Chronic and cumulative EDC exposure may induce field cancerization in the breast, warranting urgent attention from researchers, regulators and public health leaders.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"98 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144677441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cas12a mice enable the rapid generation of highly complex tumour genotypes Cas12a小鼠能够快速产生高度复杂的肿瘤基因型
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-07-18 DOI: 10.1038/s41568-025-00859-y
Jess D. Hebert
{"title":"Cas12a mice enable the rapid generation of highly complex tumour genotypes","authors":"Jess D. Hebert","doi":"10.1038/s41568-025-00859-y","DOIUrl":"https://doi.org/10.1038/s41568-025-00859-y","url":null,"abstract":"In this Tools of the Trade article, Jess Hebert describes the development and use of Cas12a mice for the unbiased, high-throughput generation and interrogation of complex tumour genotypes.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"14 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incarceration and cancer care disparities in the USA 美国的监禁和癌症治疗差距
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-07-17 DOI: 10.1038/s41568-025-00855-2
Jingxuan Zhao, Cathy J. Bradley, Ya-Chen Tina Shih, K. Robin Yabroff
{"title":"Incarceration and cancer care disparities in the USA","authors":"Jingxuan Zhao, Cathy J. Bradley, Ya-Chen Tina Shih, K. Robin Yabroff","doi":"10.1038/s41568-025-00855-2","DOIUrl":"https://doi.org/10.1038/s41568-025-00855-2","url":null,"abstract":"People in the USA who are incarcerated, or have a history of incarceration, face worse access to cancer care, leading to poorer outcomes. Addressing these inequities requires coordinated action across research, healthcare, policy and correctional systems to ensure all individuals — regardless of incarceration history — have access to high-quality cancer care. People in the USA who are incarcerated, or have a history of incarceration, face worse access to cancer care, leading to poorer outcomes. In this Comment, Zhao and colleagues highlight the need to address these inequities through coordinated action across research, healthcare, policy and correctional systems to ensure all individuals have access to high-quality cancer care.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"102 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumour tissue: heterogeneous, but not disordered 肿瘤组织：异质性，但不杂乱
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-07-14 DOI: 10.1038/s41568-025-00852-5
Barbara T. Grünwald, Rama Khokha
{"title":"Tumour tissue: heterogeneous, but not disordered","authors":"Barbara T. Grünwald, Rama Khokha","doi":"10.1038/s41568-025-00852-5","DOIUrl":"https://doi.org/10.1038/s41568-025-00852-5","url":null,"abstract":"Recent multidimensional molecular profiling advances have begun to match the complexity of cancer, revolutionizing our appreciation of tumours as complex ecosystems. In this Comment, Grünwald and Khokha call for a shift in comprehension of tumour tissue organization; while tumour tissues are heterogeneous, they are not disordered, and, like all multicellular entities, they propagate their functions via a considerable level of self-organization. Multidimensional molecular profiling advances have begun to match the complexity of cancer, and tumours are now seen as complex ecosystems. We postulate that a shift in comprehension is needed to synthesize actionable insights — tumour tissues are heterogeneous but not disordered and propagate their functions by a considerable level of self-organization.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"671 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144629609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancer progression through the lens of age-induced metabolic reprogramming 通过年龄诱导的代谢重编程来观察癌症的进展
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-07-11 DOI: 10.1038/s41568-025-00845-4
Felicia Lazure, Ana P. Gomes
{"title":"Cancer progression through the lens of age-induced metabolic reprogramming","authors":"Felicia Lazure, Ana P. Gomes","doi":"10.1038/s41568-025-00845-4","DOIUrl":"https://doi.org/10.1038/s41568-025-00845-4","url":null,"abstract":"<p>Ageing is an important risk factor for cancer incidence and augments cancer progression. A shared hallmark of ageing and cancer is metabolic reprogramming, which has been suggested to be not only a cause but also a consequence of ageing. Strikingly, many age-regulated pathways are known to also drive tumour progression, suggesting that metabolic reprogramming connects ageing and tumorigenic processes and shapes whether malignant phenotypes manifest, thrive and evolve. With the rising average age of the world population, understanding how age-related changes in the body influence cancer progression is of paramount importance. In this Perspective, we discuss the metabolic changes that occur with ageing and their potential links with tumour initiation and progression and the development of metastatic disease. Finally, we discuss age-induced metabolic divergences that cause racial disparities and their consequences for the tumorigenic process.</p>","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"44 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modelling the ageing dependence of cancer evolutionary trajectories 癌症进化轨迹的衰老依赖性建模
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-07-10 DOI: 10.1038/s41568-025-00838-3
Curtis J. Henry, James DeGregori
{"title":"Modelling the ageing dependence of cancer evolutionary trajectories","authors":"Curtis J. Henry, James DeGregori","doi":"10.1038/s41568-025-00838-3","DOIUrl":"https://doi.org/10.1038/s41568-025-00838-3","url":null,"abstract":"<p>Ageing is the single most important prognostic factor for cancer development. Despite this knowledge, experimental models of cancer have historically omitted incorporating the impact of age on cancer initiation, progression and treatment outcomes. Ageing interacts with other lifestyle factors, including cigarette smoking, obesity and physical activity, but these intersections are rarely studied in experimental models. Given that cancer-related mortality rates increase with age, there is a growing emphasis on modelling ageing-associated mutational and microenvironmental changes in cancer research. In this Review, we provide guidance on the technological advancements and experimental strategies that have increased our ability to model how ageing impacts various stages of cancer evolution, from mutation-driven clonal expansions, to pre-malignant lesions, and then to progression to more malignant phenotypes and metastasis, and responses to therapies. We discuss the benefits and limitations of methods and models used. The wider adoption of age-appropriate models of cancer will enable the development of improved approaches for the detection, prevention and therapeutic intervention of human cancers.</p>","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"10 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deviant by environment 环境偏差
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-07-10 DOI: 10.1038/s41568-025-00853-4
Gabrielle Brewer
{"title":"Deviant by environment","authors":"Gabrielle Brewer","doi":"10.1038/s41568-025-00853-4","DOIUrl":"https://doi.org/10.1038/s41568-025-00853-4","url":null,"abstract":"The presence of tertiary lymphoid structures (TLSs) in tumours is often linked with response to immunotherapy, however, the maturation status of the TLS can influence its immunological function. Now, Tang et al. uncover tryptophan metabolism as a factor determining TLS maturation status","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"11 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of digital twins for personalized oncology 数字双胞胎在个体化肿瘤学中的应用
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-07-09 DOI: 10.1038/s41568-025-00850-7
Uzma Saddia Asghar, Caroline Chung
{"title":"Application of digital twins for personalized oncology","authors":"Uzma Saddia Asghar, Caroline Chung","doi":"10.1038/s41568-025-00850-7","DOIUrl":"https://doi.org/10.1038/s41568-025-00850-7","url":null,"abstract":"Digital twins are virtual representations that evolve over time with new data inputs. Cancer applications of digital twins include the integration of molecular information and individual drug responses of patients. They can inform individualized treatment, accelerate drug development through clinical trial simulation and enable the exploration of multiscale relationships in the entire human body to drive new therapeutic discoveries. Digital twins are virtual representations that evolve over time with new data inputs. In this Comment, Asghar and Chung describe cancer applications of digital twins that include the integration of molecular information and individual drug responses of patients, and explain how they can inform individualized treatment, accelerate drug development through clinical trial simulation and enable the exploration of multiscale relationships in the entire human body to drive new therapeutic discoveries.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"697 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combining spatial transcriptomics and AI to enhance brain tumour diagnosis. 结合空间转录组学和人工智能增强脑肿瘤诊断。
IF 72.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-07-04 DOI: 10.1038/s41568-025-00851-6
Yahaya A Yabo
{"title":"Combining spatial transcriptomics and AI to enhance brain tumour diagnosis.","authors":"Yahaya A Yabo","doi":"10.1038/s41568-025-00851-6","DOIUrl":"https://doi.org/10.1038/s41568-025-00851-6","url":null,"abstract":"","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":" ","pages":""},"PeriodicalIF":72.5,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exhausting bonding 累人的结合
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-07-02 DOI: 10.1038/s41568-025-00849-0
Daniela Senft
{"title":"Exhausting bonding","authors":"Daniela Senft","doi":"10.1038/s41568-025-00849-0","DOIUrl":"https://doi.org/10.1038/s41568-025-00849-0","url":null,"abstract":"Although disulfide stress in cancer cells under glucose starvation is known to trigger disulfidptosis, its role in the tumour microenvironment has remained unclear. A recent study in Nature Cell Biology reveals that in intratumoural CD8+ T cells, disulfidptosis promotes T cell exhaustion and thereby limits antitumour imunity.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"647 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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