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Blocking cholesterol biosynthesis to clean out cancer
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-04-04 DOI: 10.1038/s41568-025-00816-9
Daniela Senft
{"title":"Blocking cholesterol biosynthesis to clean out cancer","authors":"Daniela Senft","doi":"10.1038/s41568-025-00816-9","DOIUrl":"https://doi.org/10.1038/s41568-025-00816-9","url":null,"abstract":"The mechanisms of how pH-dependent cell death, alkaliptosis, is regulated are incompletely understood. Chen et al. now demonstrate that the cholesterol biosynthesis protein CYP51A1 suppresses alkaliptosis induced by the opioid analgesic JTC801.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"24 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phosphoinositide kinases in cancer: from molecular mechanisms to therapeutic opportunities 癌症中的磷酸肌酸激酶：从分子机制到治疗机会
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-04-03 DOI: 10.1038/s41568-025-00810-1
Alicia Llorente, Gurpreet K. Arora, Rabi Murad, Brooke M. Emerling
{"title":"Phosphoinositide kinases in cancer: from molecular mechanisms to therapeutic opportunities","authors":"Alicia Llorente, Gurpreet K. Arora, Rabi Murad, Brooke M. Emerling","doi":"10.1038/s41568-025-00810-1","DOIUrl":"https://doi.org/10.1038/s41568-025-00810-1","url":null,"abstract":"<p>Phosphoinositide kinases, extending beyond the well-known phosphoinositide 3-kinase (PI3K), are key players in the dynamic and site-specific phosphorylation of lipid phosphoinositides. Unlike PI3Ks, phosphatidylinositol 4-kinases (PI4Ks) and phosphatidylinositol phosphate kinases (PIPKs) do not usually exhibit mutational alterations, but mostly show altered expression in tumours, orchestrating a broad spectrum of signalling, metabolic and immune processes, all of which are crucial in the pathogenesis of cancer. Dysregulation of PI4Ks and PIPKs has been associated with various malignancies, which has sparked considerable interest towards their therapeutic targeting. In this Review we summarize the current understanding of the lesser-studied phosphoinositide kinase families, PI4K and PIPK, focusing on their functions and relevance in cancer. In addition, we provide an overview of ongoing efforts driving the preclinical and clinical development of phosphoinositide kinase-targeting molecules.</p>","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"32 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Moonlighting functions of glucose metabolic enzymes and metabolites in cancer 癌症中葡萄糖代谢酶和代谢物的月光功能
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-04-02 DOI: 10.1038/s41568-025-00800-3
Dong Guo, Ying Meng, Gaoxiang Zhao, Qingang Wu, Zhimin Lu
{"title":"Moonlighting functions of glucose metabolic enzymes and metabolites in cancer","authors":"Dong Guo, Ying Meng, Gaoxiang Zhao, Qingang Wu, Zhimin Lu","doi":"10.1038/s41568-025-00800-3","DOIUrl":"https://doi.org/10.1038/s41568-025-00800-3","url":null,"abstract":"<p>Glucose metabolic enzymes and their metabolites not only provide energy and building blocks for synthesizing macromolecules but also possess non-canonical or moonlighting functions in response to extracellular and intracellular signalling. These moonlighting functions modulate various cellular activities, including gene expression, cell cycle progression, DNA repair, autophagy, senescence and apoptosis, cell proliferation, remodelling of the tumour microenvironment and immune responses. These functions integrate glucose metabolism with other essential cellular activities, driving cancer progression. Targeting these moonlighting functions could open new therapeutic avenues and lead to cancer-specific treatments.</p>","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"38 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Salmonella, the insidious contributor to gallbladder and colon cancers
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-04-02 DOI: 10.1038/s41568-025-00812-z
Virginie Stévenin, Jacques Neefjes
{"title":"Salmonella, the insidious contributor to gallbladder and colon cancers","authors":"Virginie Stévenin, Jacques Neefjes","doi":"10.1038/s41568-025-00812-z","DOIUrl":"https://doi.org/10.1038/s41568-025-00812-z","url":null,"abstract":"Salmonella infects hundreds of millions of people yearly, invading host cells and altering signalling pathways that can promote cancer. Owing to their biological origin, Salmonella-induced cancers may respond better to specific treatments, shedding light on different modes of bacterially driven cellular transformation and effective ways to counter them. Salmonella infections, prevalent globally, correlate with increased risk of cancer, particularly gallbladder and colon cancers. In this Comment, Stévenin and Neefjes highlight the need for further investigation into Salmonella-driven cellular transformation.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"32 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
scAtlasVAE: a deep learning framework for generating a human CD8+ T cell atlas
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-04-02 DOI: 10.1038/s41568-025-00811-0
Ziwei Xue
{"title":"scAtlasVAE: a deep learning framework for generating a human CD8+ T cell atlas","authors":"Ziwei Xue","doi":"10.1038/s41568-025-00811-0","DOIUrl":"https://doi.org/10.1038/s41568-025-00811-0","url":null,"abstract":"In this Tools of the Trade article, Ziwei Xue describes the development and use of scAtlasVAE, a deep learning framework that integrates single-cell RNA-sequencing data from CD8+ T cells across studies.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"34 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sweet success in CAR T cells
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-03-27 DOI: 10.1038/s41568-025-00813-y
Gabrielle Brewer
{"title":"Sweet success in CAR T cells","authors":"Gabrielle Brewer","doi":"10.1038/s41568-025-00813-y","DOIUrl":"https://doi.org/10.1038/s41568-025-00813-y","url":null,"abstract":"Glycolysis-dependent T cell function is hindered by glucose scarcity in the tumour microenvironment. Now in Cancer Cell, Schild et al. engineered T cells to utilize fructose via GLUT5, enhancing their metabolic activity and cytotoxicity.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"18 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The fibroinflammatory response in cancer
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-03-17 DOI: 10.1038/s41568-025-00798-8
Zebin Xiao, Ellen Puré
{"title":"The fibroinflammatory response in cancer","authors":"Zebin Xiao, Ellen Puré","doi":"10.1038/s41568-025-00798-8","DOIUrl":"https://doi.org/10.1038/s41568-025-00798-8","url":null,"abstract":"<p>Fibroinflammation refers to the highly integrated fibrogenic and inflammatory responses mediated by the concerted function of fibroblasts and innate immune cells in response to tissue perturbation. This process underlies the desmoplastic remodelling of the tumour microenvironment and thus plays an important role in tumour initiation, growth and metastasis. More specifically, fibroinflammation alters the biochemical and biomechanical signalling in malignant cells to promote their proliferation and survival and further supports an immunosuppressive microenvironment by polarizing the immune status of tumours. Additionally, the presence of fibroinflammation is often associated with therapeutic resistance. As such, there is increasing interest in targeting this process to normalize the tumour microenvironment and thus enhance the treatment of solid tumours. Herein, we review advances made in unravelling the complexity of cancer-associated fibroinflammation that can inform the rational design of therapies targeting this.</p>","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"6 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ImAge: quantifying epigenetic ageing with single-cell images
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-03-13 DOI: 10.1038/s41568-025-00809-8
Kenta Ninomiya
{"title":"ImAge: quantifying epigenetic ageing with single-cell images","authors":"Kenta Ninomiya","doi":"10.1038/s41568-025-00809-8","DOIUrl":"https://doi.org/10.1038/s41568-025-00809-8","url":null,"abstract":"In this Tools of the Trade article, Kenta Ninomiya describes the development of ImAge, an imaging-based approach that captures age-related trajectories of chromatin and epigenetic marks in single nuclei for longitudinal analyses.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"54 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tissue specificity of ageing in cancer risk prediction
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-03-13 DOI: 10.1038/s41568-025-00806-x
Mark A. LaBarge, Alexandra M. Binder
{"title":"Tissue specificity of ageing in cancer risk prediction","authors":"Mark A. LaBarge, Alexandra M. Binder","doi":"10.1038/s41568-025-00806-x","DOIUrl":"https://doi.org/10.1038/s41568-025-00806-x","url":null,"abstract":"Understanding the complex relationship between ageing and cancer is crucial for cancer risk prediction. Here, we explore how tissue-specific ageing biomarkers can enhance cancer risk stratification and highlight the need for tailored approaches in assessing susceptibility across different tissues. Understanding the complex relationship between ageing and cancer is crucial for cancer risk prediction. In this Comment, LaBarge and Binder explore how tissue-specific ageing biomarkers can enhance cancer risk stratification and highlight the need for tailored approaches in assessing susceptibility across different tissues.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"68 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fighting cancer with fat 用脂肪对抗癌症
IF 72.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-03-11 DOI: 10.1038/s41568-025-00807-w
Gabrielle Brewer
{"title":"Fighting cancer with fat","authors":"Gabrielle Brewer","doi":"10.1038/s41568-025-00807-w","DOIUrl":"10.1038/s41568-025-00807-w","url":null,"abstract":"Targeting metabolic dependencies, such as glucose or lipid metabolism, is a key strategy for anti-cancer therapies. Nguyen et al. developed a new approach, adipose manipulation transplantation (AMT), in which engineered adipocytes are used to outcompete tumours for lipids and glucose to suppress cancer progression.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"25 4","pages":"222-222"},"PeriodicalIF":72.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143589698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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