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Unveiling the molecular and immunological drivers of antibody-drug conjugates in cancer treatment. 揭示癌症治疗中抗体-药物偶联物的分子和免疫学驱动因素。
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-10-02 DOI: 10.1038/s41568-025-00869-w
Alfred Zippelius,Sara M Tolaney,Paolo Tarantino,Joseph P Balthasar,Greg M Thurber
{"title":"Unveiling the molecular and immunological drivers of antibody-drug conjugates in cancer treatment.","authors":"Alfred Zippelius,Sara M Tolaney,Paolo Tarantino,Joseph P Balthasar,Greg M Thurber","doi":"10.1038/s41568-025-00869-w","DOIUrl":"https://doi.org/10.1038/s41568-025-00869-w","url":null,"abstract":"After decades of investment, antibody-drug conjugates (ADCs) are finally demonstrating their potential, marked by a growing number of clinical approvals, applications in earlier lines of treatment and integration into drug combinations, including immunotherapies. This progress has spurred investment in developing new ADCs and expanding the use of approved ADCs in clinical practice. The design of ADCs is complex, involving multiple molecular components that interact with both tumour and host tissue microenvironments. In this Review, we explore the molecular and immunological factors influencing ADC efficacy and toxicity. We describe how the molecular components of ADCs determine their systemic, tissue and cellular distribution, which ultimately dictates therapeutic efficacy. These interactions also determine the toxicity profile and set limitations on maximum dosing. Finally, we discuss the impact of ADC treatment on immune cells, emphasizing the distinct but interconnected roles of immunogenic cell death, activation of immune cells such as dendritic cells and antibody-Fc interactions. These mechanisms are crucial for increasing efficacy beyond the direct cytotoxic effects of the payload. By providing insights into the intricate interactions of ADCs, this Review aims to inform the rational design of combination therapies and guide the development of the next generation of clinically effective ADCs.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"13 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tamoxifen takes the wheel. 他莫昔芬起作用。
IF 66.8 1区 医学
Nature Reviews Cancer Pub Date : 2025-09-26 DOI: 10.1038/s41568-025-00881-0
Daniela Senft
{"title":"Tamoxifen takes the wheel.","authors":"Daniela Senft","doi":"10.1038/s41568-025-00881-0","DOIUrl":"https://doi.org/10.1038/s41568-025-00881-0","url":null,"abstract":"","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":" ","pages":""},"PeriodicalIF":66.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145177007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unlocking the potential of urine-based liquid biopsy through improved reporting and standardization. 通过改进报告和标准化，释放尿液液体活检的潜力。
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-09-25 DOI: 10.1038/s41568-025-00882-z
Douglas G Ward,Richard T Bryan,Aadel A Chaudhuri,James Hadfield,Jennifer Perez-Boza,Renske D M Steenbergen,Diana M Vega,Jennifer Whiting,Alexander W Wyatt,Lars Dyrskjøt
{"title":"Unlocking the potential of urine-based liquid biopsy through improved reporting and standardization.","authors":"Douglas G Ward,Richard T Bryan,Aadel A Chaudhuri,James Hadfield,Jennifer Perez-Boza,Renske D M Steenbergen,Diana M Vega,Jennifer Whiting,Alexander W Wyatt,Lars Dyrskjøt","doi":"10.1038/s41568-025-00882-z","DOIUrl":"https://doi.org/10.1038/s41568-025-00882-z","url":null,"abstract":"","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"100 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification, functional insights and therapeutic targeting of EMT tumour states. EMT肿瘤状态的识别、功能洞察和治疗靶向。
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-09-25 DOI: 10.1038/s41568-025-00873-0
Anqi Dong,Cédric Blanpain
{"title":"Identification, functional insights and therapeutic targeting of EMT tumour states.","authors":"Anqi Dong,Cédric Blanpain","doi":"10.1038/s41568-025-00873-0","DOIUrl":"https://doi.org/10.1038/s41568-025-00873-0","url":null,"abstract":"Epithelial-to-mesenchymal transition (EMT) is a cellular process during which cells lose their epithelial characteristics and acquire mesenchymal features with enhanced migration capacities. EMT has key roles in different aspects of tumorigenesis, including tumour initiation, progression, metastasis and resistance to therapy. Here, we have reviewed the recent advances in our understanding of EMT in cancer. Instead of being a binary switch as initially proposed, EMT has been shown to be composed of multiple tumour states residing in specific niches with distinct functional properties that are controlled by different gene regulatory networks. We discuss how the types of oncogenic mutations, signalling pathways, transcription factors, epigenetic regulators and microenvironmental cues regulate the different EMT states. We also highlight the mechanisms by which EMT controls resistance to anticancer therapy and how new approaches to pharmacologically target EMT in clinical settings have recently been developed.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"3 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Focusing on the complex and dynamic interplay between ageing and cancer 专注于衰老和癌症之间复杂而动态的相互作用
IF 66.8 1区 医学
Nature Reviews Cancer Pub Date : 2025-09-24 DOI: 10.1038/s41568-025-00870-3
{"title":"Focusing on the complex and dynamic interplay between ageing and cancer","authors":"","doi":"10.1038/s41568-025-00870-3","DOIUrl":"10.1038/s41568-025-00870-3","url":null,"abstract":"In the current landscape of a rapidly ageing global population, the mechanisms of ageing that contribute to cancer development, progression and treatment are of particular importance. This Focus highlights current research at this intersection between ageing and cancer, and explores how insights gained from this work may lead to better cancer prevention strategies and diagnostics, enhanced therapeutic efficacy and improvements to both patient quality of life and outcomes. This Focus issue highlights current research at the intersection of ageing and cancer, and explores how insights gained from this may lead to better cancer prevention strategies and diagnostics, enhanced therapeutic efficacy and improvements to both patient quality of life and outcomes.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"25 10","pages":"749-750"},"PeriodicalIF":66.8,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41568-025-00870-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implementing practice-changing progress for managing cancer of unknown primary. 在原发不明的癌症管理中实施改变实践的进展。
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-09-24 DOI: 10.1038/s41568-025-00877-w
F Anthony Greco
{"title":"Implementing practice-changing progress for managing cancer of unknown primary.","authors":"F Anthony Greco","doi":"10.1038/s41568-025-00877-w","DOIUrl":"https://doi.org/10.1038/s41568-025-00877-w","url":null,"abstract":"","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"2 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovering genetic interactions that cause melanoma in a non-model species. 发现非模式物种中导致黑色素瘤的基因相互作用。
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-09-24 DOI: 10.1038/s41568-025-00884-x
Alessandro Lopez-Hernandez,Diego Ortega-Del Vecchyo
{"title":"Discovering genetic interactions that cause melanoma in a non-model species.","authors":"Alessandro Lopez-Hernandez,Diego Ortega-Del Vecchyo","doi":"10.1038/s41568-025-00884-x","DOIUrl":"https://doi.org/10.1038/s41568-025-00884-x","url":null,"abstract":"","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"17 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Slaying the pre-TCR beast. 杀死tcr之前的野兽。
IF 66.8 1区 医学
Nature Reviews Cancer Pub Date : 2025-09-22 DOI: 10.1038/s41568-025-00880-1
Gabrielle Brewer
{"title":"Slaying the pre-TCR beast.","authors":"Gabrielle Brewer","doi":"10.1038/s41568-025-00880-1","DOIUrl":"https://doi.org/10.1038/s41568-025-00880-1","url":null,"abstract":"","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":" ","pages":""},"PeriodicalIF":66.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145125423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The immune microenvironment of colorectal cancer. 结直肠癌的免疫微环境。
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-09-22 DOI: 10.1038/s41568-025-00872-1
Kilian B Kennel,Florian R Greten
{"title":"The immune microenvironment of colorectal cancer.","authors":"Kilian B Kennel,Florian R Greten","doi":"10.1038/s41568-025-00872-1","DOIUrl":"https://doi.org/10.1038/s41568-025-00872-1","url":null,"abstract":"Colorectal cancer (CRC) progression depends on the close interaction of tumour cells and the tumour microenvironment (TME). Although the TME contributes to poor therapy responses and immune evasion, immune cells within the TME can be therapeutically leveraged, as exemplified by immune checkpoint blockade (ICB). Unfortunately, only a small subset of patients with CRC benefit from ICB therapy; those with immune-activated, microsatellite unstable CRC respond, whereas the predominant group of patients with CRC, those with microsatellite-stable tumours, do not. Although challenging, modulating the TME of CRC to convert these lowly immunogenic and immunosuppressed tumours into immune-activated tumours holds tremendous therapeutic potential. In this Review we provide an overview of the cellular and molecular components of immunity in the TME of CRCs at various stages of disease as well as the mechanisms of immunosuppression and immune evasion. We further describe how systemic and local therapies for CRC impact the tumour and systemic immune microenvironments, and how immunity could serve as a therapeutic and prognostic biomarker. Lastly, we highlight novel immunotherapeutic strategies and approaches that modulate the TME of CRCs to make them amenable to immunotherapy.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"40 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are GLP-1 receptor agonists a ‘magic bullet’ for cancer? GLP-1受体激动剂是治疗癌症的“魔弹”吗？
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-09-10 DOI: 10.1038/s41568-025-00874-z
James R. Hebert, E. Angela Murphy, Mary C. Playdon, Liza Makowski, Anna R. Ibele, Ciaran M. Fairman, Lorne J. Hofseth
{"title":"Are GLP-1 receptor agonists a ‘magic bullet’ for cancer?","authors":"James R. Hebert, E. Angela Murphy, Mary C. Playdon, Liza Makowski, Anna R. Ibele, Ciaran M. Fairman, Lorne J. Hofseth","doi":"10.1038/s41568-025-00874-z","DOIUrl":"https://doi.org/10.1038/s41568-025-00874-z","url":null,"abstract":"Glucagon-like peptide-1 (GLP-1) receptor agonists are widely prescribed for weight loss. Here, we discuss the need to monitor long-term use for cancer risk and to couple dietary and physical activity recommendations to prevent skeletal muscle atrophy and maintain metabolic health among people using these drugs. Glucagon-like peptide-1 (GLP-1) receptor agonists are widely prescribed for weight loss. Here, Hebert and colleagues discuss the need for long-term studies assessing the impacts of this on muscle mass and nutritional deficiencies, which may influence cancer susceptibility and metabolic health.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"66 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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