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Moonlighting functions of glucose metabolic enzymes and metabolites in cancer 癌症中葡萄糖代谢酶和代谢物的月光功能
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-04-02 DOI: 10.1038/s41568-025-00800-3
Dong Guo, Ying Meng, Gaoxiang Zhao, Qingang Wu, Zhimin Lu
{"title":"Moonlighting functions of glucose metabolic enzymes and metabolites in cancer","authors":"Dong Guo, Ying Meng, Gaoxiang Zhao, Qingang Wu, Zhimin Lu","doi":"10.1038/s41568-025-00800-3","DOIUrl":"https://doi.org/10.1038/s41568-025-00800-3","url":null,"abstract":"<p>Glucose metabolic enzymes and their metabolites not only provide energy and building blocks for synthesizing macromolecules but also possess non-canonical or moonlighting functions in response to extracellular and intracellular signalling. These moonlighting functions modulate various cellular activities, including gene expression, cell cycle progression, DNA repair, autophagy, senescence and apoptosis, cell proliferation, remodelling of the tumour microenvironment and immune responses. These functions integrate glucose metabolism with other essential cellular activities, driving cancer progression. Targeting these moonlighting functions could open new therapeutic avenues and lead to cancer-specific treatments.</p>","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"38 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Salmonella, the insidious contributor to gallbladder and colon cancers 沙门氏菌是胆囊癌和结肠癌的潜在元凶
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-04-02 DOI: 10.1038/s41568-025-00812-z
Virginie Stévenin, Jacques Neefjes
{"title":"Salmonella, the insidious contributor to gallbladder and colon cancers","authors":"Virginie Stévenin, Jacques Neefjes","doi":"10.1038/s41568-025-00812-z","DOIUrl":"https://doi.org/10.1038/s41568-025-00812-z","url":null,"abstract":"Salmonella infects hundreds of millions of people yearly, invading host cells and altering signalling pathways that can promote cancer. Owing to their biological origin, Salmonella-induced cancers may respond better to specific treatments, shedding light on different modes of bacterially driven cellular transformation and effective ways to counter them. Salmonella infections, prevalent globally, correlate with increased risk of cancer, particularly gallbladder and colon cancers. In this Comment, Stévenin and Neefjes highlight the need for further investigation into Salmonella-driven cellular transformation.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"32 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
scAtlasVAE: a deep learning framework for generating a human CD8+ T cell atlas scAtlasVAE：一个用于生成人类CD8+ T细胞图谱的深度学习框架
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-04-02 DOI: 10.1038/s41568-025-00811-0
Ziwei Xue
{"title":"scAtlasVAE: a deep learning framework for generating a human CD8+ T cell atlas","authors":"Ziwei Xue","doi":"10.1038/s41568-025-00811-0","DOIUrl":"https://doi.org/10.1038/s41568-025-00811-0","url":null,"abstract":"In this Tools of the Trade article, Ziwei Xue describes the development and use of scAtlasVAE, a deep learning framework that integrates single-cell RNA-sequencing data from CD8+ T cells across studies.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"34 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sweet success in CAR T cells CAR - T细胞的甜蜜成功
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-03-27 DOI: 10.1038/s41568-025-00813-y
Gabrielle Brewer
{"title":"Sweet success in CAR T cells","authors":"Gabrielle Brewer","doi":"10.1038/s41568-025-00813-y","DOIUrl":"https://doi.org/10.1038/s41568-025-00813-y","url":null,"abstract":"Glycolysis-dependent T cell function is hindered by glucose scarcity in the tumour microenvironment. Now in Cancer Cell, Schild et al. engineered T cells to utilize fructose via GLUT5, enhancing their metabolic activity and cytotoxicity.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"18 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The fibroinflammatory response in cancer 癌症中的纤维炎性反应
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-03-17 DOI: 10.1038/s41568-025-00798-8
Zebin Xiao, Ellen Puré
{"title":"The fibroinflammatory response in cancer","authors":"Zebin Xiao, Ellen Puré","doi":"10.1038/s41568-025-00798-8","DOIUrl":"https://doi.org/10.1038/s41568-025-00798-8","url":null,"abstract":"<p>Fibroinflammation refers to the highly integrated fibrogenic and inflammatory responses mediated by the concerted function of fibroblasts and innate immune cells in response to tissue perturbation. This process underlies the desmoplastic remodelling of the tumour microenvironment and thus plays an important role in tumour initiation, growth and metastasis. More specifically, fibroinflammation alters the biochemical and biomechanical signalling in malignant cells to promote their proliferation and survival and further supports an immunosuppressive microenvironment by polarizing the immune status of tumours. Additionally, the presence of fibroinflammation is often associated with therapeutic resistance. As such, there is increasing interest in targeting this process to normalize the tumour microenvironment and thus enhance the treatment of solid tumours. Herein, we review advances made in unravelling the complexity of cancer-associated fibroinflammation that can inform the rational design of therapies targeting this.</p>","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"6 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ImAge: quantifying epigenetic ageing with single-cell images 图像：用单细胞图像量化表观遗传老化
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-03-13 DOI: 10.1038/s41568-025-00809-8
Kenta Ninomiya
{"title":"ImAge: quantifying epigenetic ageing with single-cell images","authors":"Kenta Ninomiya","doi":"10.1038/s41568-025-00809-8","DOIUrl":"https://doi.org/10.1038/s41568-025-00809-8","url":null,"abstract":"In this Tools of the Trade article, Kenta Ninomiya describes the development of ImAge, an imaging-based approach that captures age-related trajectories of chromatin and epigenetic marks in single nuclei for longitudinal analyses.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"54 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tissue specificity of ageing in cancer risk prediction 衰老在癌症风险预测中的组织特异性
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-03-13 DOI: 10.1038/s41568-025-00806-x
Mark A. LaBarge, Alexandra M. Binder
{"title":"Tissue specificity of ageing in cancer risk prediction","authors":"Mark A. LaBarge, Alexandra M. Binder","doi":"10.1038/s41568-025-00806-x","DOIUrl":"https://doi.org/10.1038/s41568-025-00806-x","url":null,"abstract":"Understanding the complex relationship between ageing and cancer is crucial for cancer risk prediction. Here, we explore how tissue-specific ageing biomarkers can enhance cancer risk stratification and highlight the need for tailored approaches in assessing susceptibility across different tissues. Understanding the complex relationship between ageing and cancer is crucial for cancer risk prediction. In this Comment, LaBarge and Binder explore how tissue-specific ageing biomarkers can enhance cancer risk stratification and highlight the need for tailored approaches in assessing susceptibility across different tissues.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"68 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fighting cancer with fat 用脂肪对抗癌症
IF 72.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-03-11 DOI: 10.1038/s41568-025-00807-w
Gabrielle Brewer
{"title":"Fighting cancer with fat","authors":"Gabrielle Brewer","doi":"10.1038/s41568-025-00807-w","DOIUrl":"10.1038/s41568-025-00807-w","url":null,"abstract":"Targeting metabolic dependencies, such as glucose or lipid metabolism, is a key strategy for anti-cancer therapies. Nguyen et al. developed a new approach, adipose manipulation transplantation (AMT), in which engineered adipocytes are used to outcompete tumours for lipids and glucose to suppress cancer progression.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"25 4","pages":"222-222"},"PeriodicalIF":72.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143589698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When tumour cells get excited 当肿瘤细胞兴奋时
IF 72.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-03-07 DOI: 10.1038/s41568-025-00808-9
Daniela Senft
{"title":"When tumour cells get excited","authors":"Daniela Senft","doi":"10.1038/s41568-025-00808-9","DOIUrl":"10.1038/s41568-025-00808-9","url":null,"abstract":"A recent study published in Nature finds that neuroendocrine small-cell lung cancer (SCLC) cells exhibit electrical activity that directly drives tumour progression and metastasis and shows that they rely on oxidative phosphorylation to meet the high energy demand associated with these electrophysiological processes.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"25 4","pages":"222-222"},"PeriodicalIF":72.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ALK in cancer: from function to therapeutic targeting ALK在癌症中的作用：从功能到治疗靶向
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-03-07 DOI: 10.1038/s41568-025-00797-9
Claudia Voena, Chiara Ambrogio, Fabio Iannelli, Roberto Chiarle
{"title":"ALK in cancer: from function to therapeutic targeting","authors":"Claudia Voena, Chiara Ambrogio, Fabio Iannelli, Roberto Chiarle","doi":"10.1038/s41568-025-00797-9","DOIUrl":"https://doi.org/10.1038/s41568-025-00797-9","url":null,"abstract":"<p>Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) that acts as an oncogenic driver in solid and haematological malignancies in both children and adults. Although ALK-expressing (ALK<sup>+</sup>) tumours show strong initial responses to the series of ALK inhibitors currently available, many patients will develop resistance. In this Review, we discuss recent advances in ALK oncogenic signalling, together with existing and promising new modalities to treat ALK-driven tumours, including currently approved ALK-directed therapies, namely tyrosine kinase inhibitors, and novel approaches such as ALK-specific immune therapies. Although ALK inhibitors have changed the management and clinical history of ALK<sup>+</sup> tumours, they are still insufficient to cure most of the patients. Therefore, more effort is needed to further improve outcomes and prevent the tumour resistance, recurrence and metastatic spread that many patients with ALK<sup>+</sup> tumours experience. Here, we outline how a multipronged approach directed against ALK and other essential pathways that sustain the persistence of ALK<sup>+</sup> tumours, together with potent or specific immunotherapies, could achieve this goal. We envision that the lessons learned from treating ALK<sup>+</sup> tumours in the clinic could ultimately accelerate the implementation of innovative combination therapies to treat tumours driven by other tyrosine kinases or oncogenes with similar properties.</p>","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"67 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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