Nature Reviews Cancer最新文献_第2页

Making breast cancer innovation deliver for every woman 让乳腺癌创新惠及每一位女性

IF 78.5 1区医学

Nature Reviews Cancer Pub Date : 2026-09-11 DOI: 10.1038/s41568-026-00982-4

Miriam Mutebi

引用次数: 0

A guide to understanding tumour evolution through the lens of population genetics. 通过群体遗传学的视角来理解肿瘤进化的指南。

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-09-09 DOI: 10.1038/s41568-026-00973-5

Giulio Caravagna, Trevor A Graham, Andrea Sottoriva

{"title":"A guide to understanding tumour evolution through the lens of population genetics.","authors":"Giulio Caravagna, Trevor A Graham, Andrea Sottoriva","doi":"10.1038/s41568-026-00973-5","DOIUrl":"https://doi.org/10.1038/s41568-026-00973-5","url":null,"abstract":"Every cancer carries the history of its own evolution, hidden in its genome. Modern DNA sequencing can catalogue millions of mutations and profile tumours across space and time, but sequencing alone struggles to answer the questions that matter most: when did key adaptations emerge, how strongly were they selected, why do some tumours relapse whereas others do not, and how will the cancer evolve next? The reason is fundamental: sequencing is a snapshot, whereas evolution is a dynamic process. Bridging this gap requires moving beyond descriptive cancer genomics towards quantitative evolutionary inference. In this Review, we argue that population genetics provides the mathematical framework needed to extract evolutionary dynamics from cancer genomes. We show how models of mutation, selection and drift transform allele frequencies from descriptive measurements into quantitative estimates of clonal fitness and evolutionary timings. We discuss how these principles extend to epigenetic inheritance, plasticity and ecological interactions within the tumour ecosystem, and examine the assumptions and limitations for their application to modern sequencing data. By reframing cancer genomes as quantitative records of evolutionary processes rather than catalogues of mutations, researchers have used population genetics to provide a foundation for understanding - and ultimately predicting - the trajectories of cancer evolution.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":" ","pages":""},"PeriodicalIF":60.7,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reflecting on 25 years of cancer research: transformative advances and unmet expectations 回顾25年的癌症研究：变革性的进步和未满足的期望。

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-09-08 DOI: 10.1038/s41568-026-00974-4

Allan Balmain, René Bernards, Hans Clevers, Karen H. Vousden, Paul Workman, Marinka Zitnik

引用次数: 0

A single-cell lens into the co-evolution of genotypes and phenotypes in cancer. 癌症基因型和表型共同进化的单细胞透镜。

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-09-08 DOI: 10.1038/s41568-026-00970-8

Franco Izzo, Tamara Prieto, Catherine Potenski, Dan A Landau

{"title":"A single-cell lens into the co-evolution of genotypes and phenotypes in cancer.","authors":"Franco Izzo, Tamara Prieto, Catherine Potenski, Dan A Landau","doi":"10.1038/s41568-026-00970-8","DOIUrl":"https://doi.org/10.1038/s41568-026-00970-8","url":null,"abstract":"Genetic heterogeneity and clonal outgrowths are observed even in otherwise healthy human tissues, shaping the genetic composition of cell populations in non-malignant disease and during physiological ageing. This clonal mosaicism likely provides the pre-cancerous seeds for malignant transformation. Once a tumour arises, clonal evolution poses a major challenge to achieving cure, as clonal diversification provides an expanded number of substrates upon which therapy can act as a selective pressure, leading to the selection of resistant clones that ultimately fuel disease recurrence. Understanding somatic clonal evolution requires not only mapping genetic diversity but also defining the resulting phenotypes that provide a fitness advantage to mutated clones. This Review discusses multimodal single-cell technologies that enable the measurement of genotypes and additional molecular features from the same cell. These technologies unveil mutant-specific phenotypic traits, often show cell-state specificity in genotype-phenotype effects and can define therapeutic vulnerabilities for precision elimination of disease-propagating mutant cells. Furthermore, the combination of phylogenetic reconstruction with phenotypic measurements allows for the temporal mapping of clonal evolution and phenotypic plasticity. These breakthroughs have created a unique opportunity to define, directly in primary human samples, the mechanisms underlying clonal expansion in both healthy and malignant tissues.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":" ","pages":""},"PeriodicalIF":60.7,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutrophils in cancer. 癌症中的中性粒细胞。

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-09-07 DOI: 10.1038/s41568-026-00968-2

Markus I Diehl, Pamela A Basto, Matthew A Abikenari, Ian L Linde, Derick Okwan-Duodu, Edgar G Engleman

引用次数: 0

The next 25 years of cancer research: emerging perspectives and priorities 未来25年的癌症研究：新兴观点和重点。

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-09-07 DOI: 10.1038/s41568-026-00975-3

Myriam Chalabi, Tim H. H. Coorens, Leanne Li, James L. Reading, Shensi Shen, Ewa Szczurek

引用次数: 0

Expanding the reach of menin inhibitors 扩大menin抑制剂的作用范围。

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-09-02 DOI: 10.1038/s41568-026-00981-5

Daniela Senft

引用次数: 0

The long return on discovery science in cancer therapeutics 癌症治疗科学发现的长期回报。

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-08-28 DOI: 10.1038/s41568-026-00978-0

Cian Murphy, Samuel Hume, Charles Swanton

引用次数: 0

Shaping the future of early-onset colorectal cancer prevention 塑造早发性结直肠癌预防的未来。

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-08-26 DOI: 10.1038/s41568-026-00965-5

Ruiyi Tian, Sina Azadnajafabad, Erika A. Waters, Emily P. Balskus, Yasmine Belkaid, Jordana T. Bell, Sarah E. Berry, Jason D. Buenrostro, Curtis Huttenhower, Anisha Patel, Gary J. Patti, Nicola Segata, Bhawna Sirohi, Tim D. Spector, Ömer H. Yilmaz, Andrew T. Chan, Yin Cao

{"title":"Shaping the future of early-onset colorectal cancer prevention","authors":"Ruiyi Tian, Sina Azadnajafabad, Erika A. Waters, Emily P. Balskus, Yasmine Belkaid, Jordana T. Bell, Sarah E. Berry, Jason D. Buenrostro, Curtis Huttenhower, Anisha Patel, Gary J. Patti, Nicola Segata, Bhawna Sirohi, Tim D. Spector, Ömer H. Yilmaz, Andrew T. Chan, Yin Cao","doi":"10.1038/s41568-026-00965-5","DOIUrl":"10.1038/s41568-026-00965-5","url":null,"abstract":"Early-onset colorectal cancer (EOCRC) among individuals under age 50 is increasing globally. Lifestyle factors such as obesity, metabolic comorbid conditions, poor diet and sedentary behaviours are linked to EOCRC, but critical gaps remain in identifying additional risk factors, with growing evidence for early-life and gut microbial-related exposures. In addition, how or when the risk factors act, individually or collectively, to initiate or promote colorectal cancer at much younger ages remains unknown. Compounding the complexity are the unique challenges of developing and implementing effective prevention strategies among younger populations. In this Roadmap, we review the progress and challenges of risk factor discovery for EOCRC, highlight opportunities for prevention and propose a transdisciplinary framework integrating population, mechanistic, behavioural and implementation sciences to accelerate causal risk factor discovery and translate insights into strategies to reverse the rising EOCRC burden. This framework, exemplified by emerging global initiatives including the Cancer Grand Challenges team PROSPECT, is broadly adaptable and intended to inspire collaborative efforts across the field. We also emphasize the critical role of patient perspectives and public engagement in shaping these efforts. With the urgency in risk factor discovery, scientists, the public and policymakers must unite to transform knowledge into life-saving solutions for future generations. Early-onset colorectal cancer is rising globally. This Roadmap examines current knowledge gaps in risk factors, proposes an integrative conceptual model for risk factor discovery and prevention, and highlights the role of transdisciplinary science and patient engagement in reversing the trend.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 10","pages":"830-848"},"PeriodicalIF":60.7,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148830891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early evidence of the carcinogenic effects of e-cigarette use. 使用电子烟致癌作用的早期证据。

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-08-26 DOI: 10.1038/s41568-026-00976-2

Yolanda I Chirino, Estefany I Medina-Reyes

引用次数: 0