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Combining spatial transcriptomics and AI to enhance brain tumour diagnosis. 结合空间转录组学和人工智能增强脑肿瘤诊断。
IF 72.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-07-04 DOI: 10.1038/s41568-025-00851-6
Yahaya A Yabo
{"title":"Combining spatial transcriptomics and AI to enhance brain tumour diagnosis.","authors":"Yahaya A Yabo","doi":"10.1038/s41568-025-00851-6","DOIUrl":"https://doi.org/10.1038/s41568-025-00851-6","url":null,"abstract":"","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":" ","pages":""},"PeriodicalIF":72.5,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exhausting bonding 累人的结合
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-07-02 DOI: 10.1038/s41568-025-00849-0
Daniela Senft
{"title":"Exhausting bonding","authors":"Daniela Senft","doi":"10.1038/s41568-025-00849-0","DOIUrl":"https://doi.org/10.1038/s41568-025-00849-0","url":null,"abstract":"Although disulfide stress in cancer cells under glucose starvation is known to trigger disulfidptosis, its role in the tumour microenvironment has remained unclear. A recent study in Nature Cell Biology reveals that in intratumoural CD8+ T cells, disulfidptosis promotes T cell exhaustion and thereby limits antitumour imunity.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"647 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing cancer research via comparative oncology 通过比较肿瘤学推进癌症研究
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-06-27 DOI: 10.1038/s41568-025-00841-8
Orsolya Vincze, Benjamin Spada, David Bilder, Alex Cagan, James DeGregori, Vera Gorbunova, Carlo C. Maley, Joshua D. Schiffman, Andrei Seluanov, Mathieu Giraudeau, Thomas Pradeu
{"title":"Advancing cancer research via comparative oncology","authors":"Orsolya Vincze, Benjamin Spada, David Bilder, Alex Cagan, James DeGregori, Vera Gorbunova, Carlo C. Maley, Joshua D. Schiffman, Andrei Seluanov, Mathieu Giraudeau, Thomas Pradeu","doi":"10.1038/s41568-025-00841-8","DOIUrl":"https://doi.org/10.1038/s41568-025-00841-8","url":null,"abstract":"<p>In the ongoing battle against cancer, the natural world provides promising inspiration for designing novel therapeutic strategies. The field of comparative oncology offers a valuable source of such inspiration. By combining evolutionary biology, ecology, veterinary medicine and clinical oncology, comparative oncology aims to better understand cancer, especially by highlighting taxa that are strongly resistant or susceptible to cancer and to identify the molecular and cellular mechanisms underlying the remarkable cancer resistance of some taxa. Such studies hold profound implications for human cancer research and treatment, and increase the probability of detecting therapeutic avenues that are non-toxic to healthy cells and tissues. This Perspective underscores the importance of comparative oncology, emphasizes its relevance, and showcases recent breakthroughs in identifying natural cancer resistance mechanisms and opportunities for clinical translation. We advocate for a better integration of cancer research on non-conventional model species into oncology and we urge enhanced cooperation between clinicians and comparative oncologists to advance cancer prevention or treatment strategies.</p>","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"57 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoplasmic reticulum stress responses in anticancer immunity 内质网应激在抗癌免疫中的作用
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-06-24 DOI: 10.1038/s41568-025-00836-5
Sung-Min Hwang, Shiun Chang, Paulo C. Rodriguez, Juan R. Cubillos-Ruiz
{"title":"Endoplasmic reticulum stress responses in anticancer immunity","authors":"Sung-Min Hwang, Shiun Chang, Paulo C. Rodriguez, Juan R. Cubillos-Ruiz","doi":"10.1038/s41568-025-00836-5","DOIUrl":"https://doi.org/10.1038/s41568-025-00836-5","url":null,"abstract":"<p>The endoplasmic reticulum (ER) has a central role in processes essential for mounting effective and durable antitumour immunity; this includes regulating protein synthesis, folding, modification and trafficking in immune cells. However, the tumour microenvironment imposes hostile conditions that disrupt ER homeostasis in both malignant and infiltrating immune cells, leading to chronic activation of the unfolded protein response (UPR). Dysregulated ER stress responses have emerged as critical modulators of cancer progression and immune escape, influencing the initiation, development and maintenance of antitumour immunity. In this Review, we examine how tumour-induced ER stress reshapes the functional landscape of immune cells within the tumour microenvironment. We highlight recent discoveries demonstrating how ER stress curtails endogenous antitumour immunity and reduces the efficacy of immunotherapies. Furthermore, we underscore novel therapeutic strategies targeting ER stress sensors or UPR components to restore immune function and enhance cancer immunotherapy outcomes. Together, this provides a comprehensive overview of the interplay between ER stress responses and antitumour immunity, emphasizing the potential of UPR-targeted interventions to improve immune control of cancer.</p>","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"14 19 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expanding the utility of precision oncology knowledge bases 扩大精准肿瘤学知识库的应用
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-06-23 DOI: 10.1038/s41568-025-00846-3
Sarah Suehnholz, Debyani Chakravarty
{"title":"Expanding the utility of precision oncology knowledge bases","authors":"Sarah Suehnholz, Debyani Chakravarty","doi":"10.1038/s41568-025-00846-3","DOIUrl":"https://doi.org/10.1038/s41568-025-00846-3","url":null,"abstract":"Precision oncology knowledge bases&nbsp;currently provide cancer&nbsp;clinicians with a point-of-care interpretation of the therapeutic actionability of somatic&nbsp;genomic sequencing results.&nbsp;Here, we discuss key deficiencies in these knowledge bases&nbsp;that present as opportunities for the next generation of data annotation. Precision oncology knowledge bases provide cancer clinicians with a point-of-care interpretation of the therapeutic actionability of clinical genomic sequencing results. These knowledge bases are now positioned to expand beyond the annotation of individual somatic molecular alterations, however, important gaps remain. Here, Suehnholz and Chakravarty discuss key deficiencies in current precision oncology knowledge bases that present opportunities for the next generation of data annotation.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"46 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144341219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Imaging lung lymphatics in action in metastatic cancer 肺淋巴管在转移性癌中的显像作用
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-06-20 DOI: 10.1038/s41568-025-00844-5
Simon J. Cleary
{"title":"Imaging lung lymphatics in action in metastatic cancer","authors":"Simon J. Cleary","doi":"10.1038/s41568-025-00844-5","DOIUrl":"https://doi.org/10.1038/s41568-025-00844-5","url":null,"abstract":"In this Tools of the Trade article, Simon Cleary describes the development of a new stabilization window for intravital imaging, which allows the visualization of leukocytes, cancer cells and fluid moving through living lungs.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"12 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How team science tackled gender inequalities in Lynch syndrome-associated cancer care 科学团队如何解决林奇综合征相关癌症治疗中的性别不平等问题
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-06-17 DOI: 10.1038/s41568-025-00837-4
Emma J. Crosbie
{"title":"How team science tackled gender inequalities in Lynch syndrome-associated cancer care","authors":"Emma J. Crosbie","doi":"10.1038/s41568-025-00837-4","DOIUrl":"https://doi.org/10.1038/s41568-025-00837-4","url":null,"abstract":"In this World View, Emma J. Crosbie, leader of Team Womb, which was awarded the prestigious 2024 American Association for Cancer Research Team Science Award for work on Lynch syndrome-associated endometrial cancer, argues that cancer discovery and its clinical translation demands a team science approach. Team Womb, led by Emma J. Crosbie at the University of Manchester, was awarded the prestigious 2024 American Association for Cancer Research Team Science Award for work on Lynch syndrome-associated endometrial cancer. In this World View, she argues that cancer discovery and its clinical translation demand a team science approach.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"21 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuro-immune cross-talk in cancer 癌症中的神经免疫串扰
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-06-16 DOI: 10.1038/s41568-025-00831-w
Moran Amit, Tuany Eichwald, Anais Roger, Jennifer Anderson, Aeson Chang, Paola D. Vermeer, Karen O. Dixon, Nicole N. Scheff, Sebastien Talbot
{"title":"Neuro-immune cross-talk in cancer","authors":"Moran Amit, Tuany Eichwald, Anais Roger, Jennifer Anderson, Aeson Chang, Paola D. Vermeer, Karen O. Dixon, Nicole N. Scheff, Sebastien Talbot","doi":"10.1038/s41568-025-00831-w","DOIUrl":"https://doi.org/10.1038/s41568-025-00831-w","url":null,"abstract":"<p>The nervous and immune systems have co-evolved to detect and respond to internal and external threats, working together to restore homeostasis after tissue injury or infection. Sharing several receptors and ligands, they engage in direct cross-talk that substantially influences disease development. The emerging field of cancer neuro-immunity focuses on the intricate interactions between the nervous system, immune responses and tumour growth. Additional findings have revealed that nerve fibres infiltrating peripheral tumours can release neuromodulatory factors that shape both immune cell behaviour and tumour progression. Conversely, tumour-infiltrating immune cells can modify the activity of local neurons, including pain-transmitting nociceptive sensory neurons. Beyond sensory fibres, sympathetic signalling can foster immunosuppression by recruiting myeloid-derived suppressor cells and promoting T cell exhaustion. This Review summarizes current evidence on how neuronal signalling regulates peripheral antitumour immune responses within the tumour microenvironment. We describe the complex, reciprocal interactions among neurons, immune cells and malignant cells, highlighting the key parts played by the peripheral nervous system in modulating immunity against cancer. By understanding this neuro-immune axis, novel therapeutic approaches may be uncovered to strengthen antitumour immunity and enhance responses to existing cancer treatments.</p>","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"10 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144296053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Energizing leukaemia 激励白血病
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-06-11 DOI: 10.1038/s41568-025-00842-7
Anna Dart
{"title":"Energizing leukaemia","authors":"Anna Dart","doi":"10.1038/s41568-025-00842-7","DOIUrl":"https://doi.org/10.1038/s41568-025-00842-7","url":null,"abstract":"Sharma et al. discovered that bone marrow osteolineage cells are producers of taurine in the leukaemia niche, which in turn drives leukaemia stem cell survival and self-renewal.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"21 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heard immunity in CAR T cells CAR - T细胞的免疫
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2025-06-11 DOI: 10.1038/s41568-025-00839-2
Gabrielle Brewer
{"title":"Heard immunity in CAR T cells","authors":"Gabrielle Brewer","doi":"10.1038/s41568-025-00839-2","DOIUrl":"https://doi.org/10.1038/s41568-025-00839-2","url":null,"abstract":"The efficacy of chimeric antigen receptor (CAR) T cell therapies in solid tumours is still limited by on-target, off-tumour toxicities. Now, Liu, He, Wang et al. engineered EchoBack-CAR T cells, an ultrasound activated, genetically modified CAR T cell that enables precise spatiotemporal activation.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"21 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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