聚合初癌

IF 66.8 1区医学 Q1 ONCOLOGY

Nature Reviews Cancer Pub Date : 2025-09-08 DOI:10.1038/s41568-025-00876-x

Daniela Senft

引用次数: 0

摘要

在最近的一项研究中，Salomó Coll等人发现，KRAS突变的胰腺腺泡细胞er吞噬受损，导致蛋白聚集体的积累和腺泡细胞稳态的破坏，从而与致癌的KRAS协同促进细胞转化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Aggregating premalignancy

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Aggregating premalignancy

In a recent study, Salomó Coll et al. demonstrate that impaired ER-phagy in Kras-mutant pancreatic acinar cells leads to the accumulation of protein aggregates and disruption of acinar cell homeostasis, thereby cooperating with oncogenic KRAS to promote cellular transformation.

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来源期刊

Nature Reviews Cancer 医学-肿瘤学

CiteScore

111.90

自引率

0.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Cancer, a part of the Nature Reviews portfolio of journals, aims to be the premier source of reviews and commentaries for the scientific communities it serves. The correct abbreviation for abstracting and indexing purposes is Nat. Rev. Cancer. The international standard serial numbers (ISSN) for Nature Reviews Cancer are 1474-175X (print) and 1474-1768 (online). Unlike other journals, Nature Reviews Cancer does not have an external editorial board. Instead, all editorial decisions are made by a team of full-time professional editors who are PhD-level scientists. The journal publishes Research Highlights, Comments, Reviews, and Perspectives relevant to cancer researchers, ensuring that the articles reach the widest possible audience due to their broad scope.