Nature Reviews Cancer最新文献_第3页

Origins and consequences of oncogenic 3D chromatin remodelling 致瘤性三维染色质重塑的起源和后果。

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-08-25 DOI: 10.1038/s41568-026-00969-1

Gian Marco Franceschini, Konstantina Georgakopoulou, Giovanni Ciriello, Elisa Oricchio

{"title":"Origins and consequences of oncogenic 3D chromatin remodelling","authors":"Gian Marco Franceschini, Konstantina Georgakopoulou, Giovanni Ciriello, Elisa Oricchio","doi":"10.1038/s41568-026-00969-1","DOIUrl":"10.1038/s41568-026-00969-1","url":null,"abstract":"The 3D structure of chromatin is altered in cancer. In healthy cells, the genome is folded into functional 3D structural elements, including chromosomes, chromatin compartments, domains and loops. Cancer-associated alterations can modify each of these structural elements and, sometimes, their oncogenic capacity can be explained only when accounting for their effect on chromatin 3D conformation. In this Review, we discuss multiple lines of evidence demonstrating the impact of genetic and epigenetic alterations on chromatin structural elements, and the potential for chromatin 3D architecture to favour the acquisition of specific alterations. As a result, chromatin 3D remodelling emerges as both a cause and a consequence of oncogenic alterations. Finally, we highlight outstanding questions and opportunities related to the role of chromatin 3D heterogeneity in cancer, and the possibility of exploiting chromatin 3D conformation for diagnosis and therapy. Overall, chromatin 3D conformation integrates information from multiple molecular features, and thus it may represent a key to decoding cancer phenotypes. In this Review, Franceschini and colleagues discuss how remodelling of the 3D structure of chromatin in cancer is both a cause and a consequence of genetic and epigenetic alterations and highlight how chromatin 3D conformation might be exploited for diagnosis and therapy.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 11","pages":"899-916"},"PeriodicalIF":60.7,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain barriers at the crossroads of glioma immune surveillance and immunotherapy response 脑屏障在神经胶质瘤免疫监测和免疫治疗反应的十字路口。

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-08-20 DOI: 10.1038/s41568-026-00960-w

Britta Engelhardt, Michael Platten

{"title":"Brain barriers at the crossroads of glioma immune surveillance and immunotherapy response","authors":"Britta Engelhardt, Michael Platten","doi":"10.1038/s41568-026-00960-w","DOIUrl":"10.1038/s41568-026-00960-w","url":null,"abstract":"Immunotherapies have substantially advanced cancer treatment; however, their efficacy in gliomas remains limited. This observation cannot be fully explained by tumour-intrinsic factors and may rather be linked to the distinct relationship between the central nervous system (CNS) and the immune system, commonly described as CNS immune privilege. CNS immune privilege is maintained by specialized brain barriers that divide the CNS into compartments with distinct accessibility to immune mediators and immune cells. Although maintaining homeostasis of the CNS parenchyma, these brain barriers direct CNS immune surveillance to the subarachnoid and the perivascular spaces at the CNS borders. Consequently, tumours arising in the CNS parenchyma are shielded from effective immune detection, limiting the efficacy of immunotherapies such as immune checkpoint inhibitors, cancer vaccines and adoptive T cell therapies such as chimeric antigen receptor (CAR) T cells and T cell receptor (TCR) transgenic T cells by restricting their access. Importantly, emerging evidence also indicates that gliomas actively remodel brain barrier functions to reinforce immune evasion. Failure to adequately consider brain barrier function in the context of immunotherapy strategies and clinical trial design therefore represents a major gap in the field. Understanding the orchestrated function of the brain barriers as neuroimmunological interfaces is essential for enhancing immune surveillance and improving immunotherapy responses in patients with brain tumours. Immunotherapy remains largely ineffective in gliomas despite success in other cancers. In this Review, Engelhardt and Platten outline how central nervous system immune privilege is enforced by specialized brain barriers that restrict T cell surveillance and discuss strategies to overcome these barriers to improve T cell-based immunotherapy for glioma.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 11","pages":"854-872"},"PeriodicalIF":60.7,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic changes linked to cell replication connect ageing with cancer risk 与细胞复制相关的表观遗传变化将衰老与癌症风险联系起来。

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-08-19 DOI: 10.1038/s41568-026-00972-6

Sandra Romero-Cordoba

引用次数: 0

An early shot at stopping PDAC 阻止PDAC的初步尝试。

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-08-14 DOI: 10.1038/s41568-026-00971-7

Gabrielle Brewer

引用次数: 0

Accelerated ageing confers early-onset cancer risk 加速衰老会带来早发性癌症的风险。

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-08-03 DOI: 10.1038/s41568-026-00967-3

Anna Dart

引用次数: 0

Converging engineered models of cancer and artificial intelligence 癌症和人工智能工程模型的融合。

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-08-03 DOI: 10.1038/s41568-026-00966-4

Carlos F. Guimarães, Rui L. Reis

引用次数: 0

The DNA damage response and cancer immunotherapy DNA损伤反应和癌症免疫治疗。

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-07-28 DOI: 10.1038/s41568-026-00958-4

Sheng Hong, Guo-Min Li

{"title":"The DNA damage response and cancer immunotherapy","authors":"Sheng Hong, Guo-Min Li","doi":"10.1038/s41568-026-00958-4","DOIUrl":"10.1038/s41568-026-00958-4","url":null,"abstract":"The DNA damage response (DDR) and immune system serve as critical defence mechanisms, safeguarding genomic integrity and providing host protection, respectively. Emerging research reveals their interconnection in dictating the response to cancer immunotherapy. DDR-deficient tumours or those exposed to DDR inhibitors display genomic instability that generates two key immunogenic signals: neoantigens that activate tumour-specific T cells; and cytosolic DNA that stimulates the cyclic GMP-AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway, triggering type I interferon production and immune cell recruitment. These synergistic effects drastically enhance responsiveness to immune checkpoint blockade. This Review examines the molecular mechanisms by which DDR defects potentiate immunotherapy, including recent advances in DDR-targeted combination strategies. We further analyse resistance mechanisms and discuss innovative approaches to overcome therapeutic limitations, offering a comprehensive perspective on exploiting DDR deficiencies for improved cancer treatment outcomes. In this Review, Hong and Li explore how defects in DNA damage response (DDR) pathways shape tumour immunogenicity and influence responses to immune checkpoint inhibitors. They highlight shared immunological consequences across distinct DDR alterations, discuss mechanisms of resistance and evaluate therapeutic strategies integrating DDR-targeting agents with immunotherapy to improve clinical outcomes.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 9","pages":"713-736"},"PeriodicalIF":60.7,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148605636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Who gets told what is impossible? 谁被告知什么是不可能的？

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-07-27 DOI: 10.1038/s41568-026-00961-9

Johanna A. Joyce

引用次数: 0

Igniting antitumour immunity with cancer cell pyroptosis 用癌细胞焦亡点燃抗肿瘤免疫。

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-07-27 DOI: 10.1038/s41568-026-00959-3

Xin Liu, Elena Goldberg, Jonathan C. Kagan, Hao Wu

{"title":"Igniting antitumour immunity with cancer cell pyroptosis","authors":"Xin Liu, Elena Goldberg, Jonathan C. Kagan, Hao Wu","doi":"10.1038/s41568-026-00959-3","DOIUrl":"10.1038/s41568-026-00959-3","url":null,"abstract":"Gasdermins (GSDMs) are a family of pore-forming proteins that execute pyroptosis, a lytic form of programmed cell death associated with membrane rupture. This function of GSDMs was initially identified from studies of gasdermin D (GSDMD), which is cleaved and activated by inflammatory caspases in the inflammasome pathway. It is now established that other eukaryotic or pathogen-encoded proteases, as well as post-translational modifications, can also activate GSDM family members independent of inflammasomes and in multiple cell types including cancer cells. T cell granzyme-mediated GSDM activation, exogenous delivery of active GSDMs, and small molecule-induced activation of GSDMs in cancer cells have been shown to promote antitumour immunity through pyroptosis. Notably, only a fraction of cancer cells needs to undergo pyroptosis to induce immune cell infiltration and antitumour immunity with tolerable toxicity. Here, we summarize current knowledge on the role of pyroptosis in antitumour immunity, discuss pyroptosis in the context of other lytic forms of cell death, and provide an outlook on how cancer cell pyroptosis may synergize with existing immunotherapies. In this Review, Liu et al. discuss how pyroptosis, executed by a family of pore-forming proteins known as gasdermins, can induce antitumour immunity, which might be therapeutically leveraged for synergy with existing cancer immunotherapies.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 10","pages":"818-829"},"PeriodicalIF":60.7,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148605450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A viral coding circRNA contributes to HPV-driven oncogenesis 病毒编码环状rna有助于hpv驱动的肿瘤发生。

IF 60.7 1区医学

Nature Reviews Cancer Pub Date : 2026-07-21 DOI: 10.1038/s41568-026-00962-8

J. Omar Muñoz-Bello, Marcela Lizano

引用次数: 0