Nature Reviews Cancer最新文献_第3页

Decoding cancer across scales with metabolomics 用代谢组学跨尺度解码癌症。

IF 66.8 1区医学

Nature Reviews Cancer Pub Date : 2026-02-20 DOI: 10.1038/s41568-026-00908-0

Joe L. Rowles III, Gary J. Patti

{"title":"Decoding cancer across scales with metabolomics","authors":"Joe L. Rowles III, Gary J. Patti","doi":"10.1038/s41568-026-00908-0","DOIUrl":"10.1038/s41568-026-00908-0","url":null,"abstract":"It is well established that malignant cells alter their metabolism to support proliferation, but the nutrients required to meet the anabolic demands of different cancers located at various anatomical sites throughout the body remain largely unknown. Moreover, the extent to which nutrients are supplied by neighbouring stromal cells or distant tissues, possibly due to metabolic reprogramming, is poorly understood. Metabolomics provides a unique biochemical approach to address these gaps in our knowledge, but cancer studies require careful consideration because it is challenging to identify appropriately matched control samples for comparison. Here, we detail a collection of metabolomics workflows designed to interrogate cancer across three discrete scales. First, we describe experiments to define the nutrient demands of cancer cells themselves. Second, we focus on identifying metabolic relationships between neighbouring cells in the tumour microenvironment. Finally, we highlight strategies to explore the metabolic crosstalk between cancer cells and distant tissues in the tumour macroenvironment. The approaches outlined span cells in culture, animal models and human specimens from patients with cancer. Special emphasis is dedicated to the application of emerging technologies and computational pipelines in the field of mass spectrometry that enable global profiling of metabolites and lipids. In this Review, Rowles and Patti present metabolomics workflows to study cancer across scales. They explore the nutrient demands of cancer cells and how those needs can be fulfilled through metabolic interactions within the tumour microenvironment or systemic crosstalk with distant tissues, and discuss the opportunities and challenges of each approach and offer insights into future research directions.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 5","pages":"312-327"},"PeriodicalIF":66.8,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146257949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence-generated synthetic data for cancer research and clinical trials 人工智能为癌症研究和临床试验生成合成数据。

IF 66.8 1区医学

Nature Reviews Cancer Pub Date : 2026-02-20 DOI: 10.1038/s41568-026-00912-4

Jan-Niklas Eckardt, Waldemar Hahn, Arsela Prelaj, Martin Bornhäuser, Jan Moritz Middeke, Jakob Nikolas Kather

{"title":"Artificial intelligence-generated synthetic data for cancer research and clinical trials","authors":"Jan-Niklas Eckardt, Waldemar Hahn, Arsela Prelaj, Martin Bornhäuser, Jan Moritz Middeke, Jakob Nikolas Kather","doi":"10.1038/s41568-026-00912-4","DOIUrl":"10.1038/s41568-026-00912-4","url":null,"abstract":"Synthetic data, generated through advanced artificial intelligence models, are gaining traction in healthcare research, particularly in high-stakes fields such as haematology and oncology. By replicating statistical properties, intervariable relationships and behaviours of real-world data, synthetic data sets can serve as valuable supplements or substitutes for conventional medical data. They offer the potential to overcome barriers to data access and sharing, democratize scientific discovery, and reduce the costs and failure rates of clinical trials. However, the lack of standardization in training data selection, model evaluation, bias mitigation, privacy preservation and quality assurance remain major challenges, limiting their reliability and safe application. In this Review, we explore the role of synthetic data in cancer research and clinical trials, present real-world examples of their use, critically examine limitations and pitfalls, and propose best practices to enhance fidelity, validity, fairness and utility. Although synthetic data are not a ‘silver bullet’ for the challenges of clinical research, with rigorous validation and oversight, they have the potential to transform data sharing, scientific collaboration and clinical trial design. Synthetic data generated by generative artificial intelligence models can serve as a substitute for real patient data. In this Review, Eckardt et al. discuss how synthetic data sets can overcome barriers to data access and sharing, democratize scientific discovery in cancer research, and reduce the costs and failure rates of cancer clinical trials. They also discuss how this will only become possible if we can overcome the challenges of a lack of standardization in training data selection, model evaluation, bias mitigation, privacy preservation and quality assurance.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 5","pages":"351-363"},"PeriodicalIF":66.8,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146259079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inherited resilience 继承了韧性。

IF 66.8 1区医学

Nature Reviews Cancer Pub Date : 2026-02-10 DOI: 10.1038/s41568-026-00914-2

Daniela Senft

引用次数: 0

Carboplatin trains macrophages for cardiac defence 卡铂训练巨噬细胞进行心脏防御。

IF 66.8 1区医学

Nature Reviews Cancer Pub Date : 2026-01-29 DOI: 10.1038/s41568-026-00911-5

Gabrielle Brewer

引用次数: 0

l-Fucose: a dietary sugar with multifaceted potential in the biology and therapy of cancer L- focus：一种在生物学和癌症治疗方面具有多方面潜力的膳食糖。

IF 66.8 1区医学

Nature Reviews Cancer Pub Date : 2026-01-27 DOI: 10.1038/s41568-025-00901-z

Amirreza Bitaraf, Maria Camila Jimenez, Chinmayee Kakirde, Eric K. Lau

{"title":"l-Fucose: a dietary sugar with multifaceted potential in the biology and therapy of cancer","authors":"Amirreza Bitaraf, Maria Camila Jimenez, Chinmayee Kakirde, Eric K. Lau","doi":"10.1038/s41568-025-00901-z","DOIUrl":"10.1038/s41568-025-00901-z","url":null,"abstract":"Fucosylation, the conjugation of glycoproteins and glycolipids with the dietary sugar l-fucose, can have key functional and regulatory roles across a range of normal biological and developmental processes. Although the full repertoire of fucosylated proteins and their direct influence on signalling and cellular behaviour remains incompletely understood, it is not surprising that deregulated fucosylation has been increasingly associated with disease contexts, particularly cancer. Importantly, fucosylation regulates the biology of immune and other stromal cells, and emerging studies have elucidated how pathological aberrations in fucosylation can deregulate signalling that governs cellular interactions in the tumour microenvironment, thereby influencing tumour progression and therapeutic responses. Accordingly, fucosylated glycoproteins and glycans have been reported to exhibit potential biomarker utility, associating with cancer type and staging. Notably, fucosylation appears to be therapeutically actionable, as simply administering l-fucose orally can suffice to suppress tumour growth and stimulate antitumour immune responses in preclinical models. However, given that the blockade of fucosylation machinery can elicit similar antitumour effects reflects the diversity of cell-intrinsic and cell-extrinsic roles that fucosylation can divergently have across the tumour microenvironment. Here, we review recent glycobiology discoveries that shed light on the complexity of fucosylation, its mechanistic roles in immune and tumour biology, and how it might be strategically leveraged for the treatment of cancer. The conjugation of glycoproteins and glycolipids with the dietary sugar L-fucose is known as fucosylation. In this Progress article, Bitaraf et al. describe the latest work showing how fucosylation is deregulated in cancer, influencing tumour progression and therapeutic responses, and how it might be leveraged to treat cancer.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 4","pages":"239-255"},"PeriodicalIF":66.8,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146056381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cat viruses as windows into human oncogenesis 猫病毒是人类肿瘤发生的窗口

IF 66.8 1区医学

Nature Reviews Cancer Pub Date : 2026-01-23 DOI: 10.1038/s41568-026-00909-z

Julia A. Beatty, Thomas Tu

引用次数: 0

Radiation as an immune modulator: mechanisms and implications for combination with immunotherapy 辐射作为免疫调节剂：与免疫治疗联合的机制和意义。

IF 66.8 1区医学

Nature Reviews Cancer Pub Date : 2026-01-23 DOI: 10.1038/s41568-025-00903-x

Laurel B. Darragh, Sana D. Karam

{"title":"Radiation as an immune modulator: mechanisms and implications for combination with immunotherapy","authors":"Laurel B. Darragh, Sana D. Karam","doi":"10.1038/s41568-025-00903-x","DOIUrl":"10.1038/s41568-025-00903-x","url":null,"abstract":"Radiation therapy can directly kill cancer cells, while simultaneously modulating the immune response. The advent of immune checkpoint blockade (ICB) provided compelling rationale for combination with radiation therapy to improve systemic tumour control. Although this strategy has improved survival in specific contexts, including cervical cancer and head and neck squamous cell carcinoma, the majority of combination trials have not demonstrated clinical benefit and predictive biomarkers remain elusive. These heterogeneous outcomes reflect fundamental gaps in understanding how radiation parameters influence immunological responses. Technological advances enabling diverse radiation delivery protocols have revealed that dose and fractionation profoundly impact the balance between immunostimulation and immunosuppression. Emerging evidence indicates that radiation protocols optimized for cytotoxic effects may not be optimal for immunological synergy with ICB. In this Review, we examine how radiation dose, fractionation and treatment volume shape local and systemic immunity, reconciling mechanistic insights with divergent clinical trial outcomes. We provide rationale for transitioning from empirical combinations towards immunologically informed radiation protocols that could help realize the full potential of radioimmunotherapy combinations. Radiation therapy induces immune responses both systemically and within the tumour microenvironment. In this Review, Darragh and Karam present preclinical and clinical evidence to highlight this complex interplay and outline strategies to enhance the immunogenic potential of radiation therapy to improve both therapeutic efficacy and patient outcomes.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 4","pages":"270-284"},"PeriodicalIF":66.8,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146033564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumour explants as next-generation models of cancer 肿瘤外植体作为下一代癌症模型。

IF 66.8 1区医学

Nature Reviews Cancer Pub Date : 2026-01-20 DOI: 10.1038/s41568-026-00907-1

Kenny Zhuoran Wu, N Gopalakrishna Iyer, Chin-Ann Johnny Ong, Eliza Li Shan Fong

引用次数: 0

The rise of spatial insights into tumour tissue architecture 对肿瘤组织结构的空间洞察的兴起。

IF 66.8 1区医学

Nature Reviews Cancer Pub Date : 2026-01-19 DOI: 10.1038/s41568-026-00906-2

Pablo Siliceo, Alfredo Rodríguez

引用次数: 0

Heterocellular crosstalk and architecture of the pancreatic tumour microenvironment 胰腺肿瘤微环境的杂细胞串扰与结构。

IF 66.8 1区医学

Nature Reviews Cancer Pub Date : 2026-01-16 DOI: 10.1038/s41568-025-00905-9

Frank Arnold, Annachiara Del Vecchio, Zainab Hussain, Mara H. Sherman

{"title":"Heterocellular crosstalk and architecture of the pancreatic tumour microenvironment","authors":"Frank Arnold, Annachiara Del Vecchio, Zainab Hussain, Mara H. Sherman","doi":"10.1038/s41568-025-00905-9","DOIUrl":"10.1038/s41568-025-00905-9","url":null,"abstract":"A fibroinflammatory microenvironment coevolves with many tumour types and profoundly influences disease progression and response to therapy. Pancreatic cancer is the archetype of a fibroinflammatory tumour, with non-malignant stromal elements comprising the volumetric majority of the tumour tissue. A convergence of three factors — technological advances enabling deep understanding of heterocellular crosstalk in these complex tumours; therapeutic advances revealing meaningful vulnerabilities in this notoriously chemoresistant, immunosuppressive disease; and conceptual advances towards distilling the conserved features and key functions of stromal elements amid this complexity — has positioned the field in a promising era for discovery, wherein our ever-improving understanding of the pancreatic tumour microenvironment is poised for translational impact. Emerging pan-cancer analyses highlight features of tumour microenvironments conserved not only among pancreatic cancer specimens but also across anatomic sites, such that lessons learnt about the organization of tumour tissue architecture and the role of oncogenic KRAS signalling in this process in other tumours have shaped our understanding of heterocellular dependencies in pancreatic cancer and vice versa. Here, we review recent developments sculpting our current understanding of the diverse features of the pancreatic tumour microenvironment and emerging means to leverage these developments for the benefit of patients with pancreatic cancer. Pancreatic ductal adenocarcinoma is defined by a fibroinflammatory microenvironment, which influences both disease progression and therapy response. In this Review, Arnold et al. outline our current understanding of the complex interplay between the stromal elements of the tumour microenvironment in pancreatic ductal adenocarcinoma and present ways we might use this knowledge to develop better therapeutic strategies for patients with pancreatic cancer.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"26 4","pages":"285-304"},"PeriodicalIF":66.8,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145986336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0