环境内分泌干扰物：重新思考早发性ER+乳腺癌的起源

IF 72.5 1区医学 Q1 ONCOLOGY

Nature Reviews Cancer Pub Date : 2025-07-22 DOI:10.1038/s41568-025-00854-3

Meadow Parrish, Charlotte Kuperwasser

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引用次数: 0

摘要

在没有遗传风险的女性中，早发性雌激素受体阳性（ER+）乳腺癌的发病率上升表明疾病生物学的转变。长期和累积暴露于干扰内分泌的化学物质中可能会诱发乳腺癌，这需要研究人员、监管机构和公共卫生领导人的紧急关注。在没有遗传风险的女性中，早发性雌激素受体阳性（ER+）乳腺癌的发病率上升表明疾病生物学的转变。内分泌干扰化学物质（EDCs）可能加速组织老化，破坏表观遗传调控和损害免疫监视。长期和累积的EDC暴露可能诱发乳房野场癌，需要引起研究人员、监管机构和公共卫生领导人的紧急关注。

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Environmental endocrine disruptors: rethinking the origins of early-onset ER+ breast cancer

Rising rates of early-onset oestrogen receptor-positive (ER+) breast cancer in women without genetic risk suggest a shift in disease biology. Chronic and cumulative exposure to endocrine-disrupting chemicals may induce field cancerization in the breast, warranting urgent attention from researchers, regulators and public health leaders. Rising rates of early-onset oestrogen receptor-positive (ER+) breast cancer in women without genetic risk suggest a shift in disease biology. Endocrine-disrupting chemicals (EDCs) may accelerate tissue ageing, destabilize epigenetic regulation and impair immune surveillance. Chronic and cumulative EDC exposure may induce field cancerization in the breast, warranting urgent attention from researchers, regulators and public health leaders.

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来源期刊

Nature Reviews Cancer 医学-肿瘤学

CiteScore

111.90

自引率

0.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Cancer, a part of the Nature Reviews portfolio of journals, aims to be the premier source of reviews and commentaries for the scientific communities it serves. The correct abbreviation for abstracting and indexing purposes is Nat. Rev. Cancer. The international standard serial numbers (ISSN) for Nature Reviews Cancer are 1474-175X (print) and 1474-1768 (online). Unlike other journals, Nature Reviews Cancer does not have an external editorial board. Instead, all editorial decisions are made by a team of full-time professional editors who are PhD-level scientists. The journal publishes Research Highlights, Comments, Reviews, and Perspectives relevant to cancer researchers, ensuring that the articles reach the widest possible audience due to their broad scope.