累人的结合

IF 72.5 1区医学 Q1 ONCOLOGY

Nature Reviews Cancer Pub Date : 2025-07-02 DOI:10.1038/s41568-025-00849-0

Daniela Senft

引用次数: 0

摘要

虽然已知葡萄糖饥饿下癌细胞中的二硫应激可引发二硫下垂，但其在肿瘤微环境中的作用仍不清楚。《自然细胞生物学》杂志最近的一项研究表明，在肿瘤内的CD8+ T细胞中，二硫细胞下垂促进T细胞衰竭，从而限制抗肿瘤免疫。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Exhausting bonding

Although disulfide stress in cancer cells under glucose starvation is known to trigger disulfidptosis, its role in the tumour microenvironment has remained unclear. A recent study in Nature Cell Biology reveals that in intratumoural CD8+ T cells, disulfidptosis promotes T cell exhaustion and thereby limits antitumour imunity.

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来源期刊

Nature Reviews Cancer 医学-肿瘤学

CiteScore

111.90

自引率

0.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Cancer, a part of the Nature Reviews portfolio of journals, aims to be the premier source of reviews and commentaries for the scientific communities it serves. The correct abbreviation for abstracting and indexing purposes is Nat. Rev. Cancer. The international standard serial numbers (ISSN) for Nature Reviews Cancer are 1474-175X (print) and 1474-1768 (online). Unlike other journals, Nature Reviews Cancer does not have an external editorial board. Instead, all editorial decisions are made by a team of full-time professional editors who are PhD-level scientists. The journal publishes Research Highlights, Comments, Reviews, and Perspectives relevant to cancer researchers, ensuring that the articles reach the widest possible audience due to their broad scope.