Advancing cancer research via comparative oncology

IF 72.5 1区医学 Q1 ONCOLOGY

Nature Reviews Cancer Pub Date : 2025-06-27 DOI:10.1038/s41568-025-00841-8

Orsolya Vincze, Benjamin Spada, David Bilder, Alex Cagan, James DeGregori, Vera Gorbunova, Carlo C. Maley, Joshua D. Schiffman, Andrei Seluanov, Mathieu Giraudeau, Thomas Pradeu

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引用次数: 0

Abstract

In the ongoing battle against cancer, the natural world provides promising inspiration for designing novel therapeutic strategies. The field of comparative oncology offers a valuable source of such inspiration. By combining evolutionary biology, ecology, veterinary medicine and clinical oncology, comparative oncology aims to better understand cancer, especially by highlighting taxa that are strongly resistant or susceptible to cancer and to identify the molecular and cellular mechanisms underlying the remarkable cancer resistance of some taxa. Such studies hold profound implications for human cancer research and treatment, and increase the probability of detecting therapeutic avenues that are non-toxic to healthy cells and tissues. This Perspective underscores the importance of comparative oncology, emphasizes its relevance, and showcases recent breakthroughs in identifying natural cancer resistance mechanisms and opportunities for clinical translation. We advocate for a better integration of cancer research on non-conventional model species into oncology and we urge enhanced cooperation between clinicians and comparative oncologists to advance cancer prevention or treatment strategies.

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通过比较肿瘤学推进癌症研究

在与癌症的持续斗争中，自然界为设计新的治疗策略提供了有希望的灵感。比较肿瘤学领域提供了这种灵感的宝贵来源。通过结合进化生物学、生态学、兽医学和临床肿瘤学，比较肿瘤学旨在更好地了解癌症，特别是通过突出对癌症具有强抗性或易感的分类群，并确定某些分类群具有显著抗癌性的分子和细胞机制。这些研究对人类癌症的研究和治疗具有深远的意义，并增加了发现对健康细胞和组织无毒的治疗途径的可能性。本展望强调了比较肿瘤学的重要性，强调了其相关性，并展示了在确定自然癌症耐药机制和临床转化机会方面的最新突破。我们提倡将非传统模型物种的癌症研究更好地整合到肿瘤学中，我们敦促临床医生和比较肿瘤学家之间加强合作，以推进癌症预防或治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Cancer 医学-肿瘤学

CiteScore

111.90

自引率

0.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Cancer, a part of the Nature Reviews portfolio of journals, aims to be the premier source of reviews and commentaries for the scientific communities it serves. The correct abbreviation for abstracting and indexing purposes is Nat. Rev. Cancer. The international standard serial numbers (ISSN) for Nature Reviews Cancer are 1474-175X (print) and 1474-1768 (online). Unlike other journals, Nature Reviews Cancer does not have an external editorial board. Instead, all editorial decisions are made by a team of full-time professional editors who are PhD-level scientists. The journal publishes Research Highlights, Comments, Reviews, and Perspectives relevant to cancer researchers, ensuring that the articles reach the widest possible audience due to their broad scope.