扩大精准肿瘤学知识库的应用

IF 66.8 1区医学 Q1 ONCOLOGY

Nature Reviews Cancer Pub Date : 2025-06-23 DOI:10.1038/s41568-025-00846-3

Sarah Suehnholz, Debyani Chakravarty

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引用次数: 0

摘要

精确肿瘤学知识库目前为癌症临床医生提供了对身体基因组测序结果的治疗可操作性的即时解释。在这里，我们讨论了这些知识库的主要缺陷，这些缺陷为下一代数据注释提供了机会。精确的肿瘤学知识库为癌症临床医生提供了临床基因组测序结果的治疗可操作性的即时解释。这些知识基础现在被定位为扩展到个体体细胞分子改变的注释之外，然而，重要的差距仍然存在。在这里，Suehnholz和Chakravarty讨论了当前精确肿瘤学知识库的主要缺陷，这些缺陷为下一代数据注释提供了机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Expanding the utility of precision oncology knowledge bases

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Expanding the utility of precision oncology knowledge bases

Precision oncology knowledge bases currently provide cancer clinicians with a point-of-care interpretation of the therapeutic actionability of somatic genomic sequencing results. Here, we discuss key deficiencies in these knowledge bases that present as opportunities for the next generation of data annotation. Precision oncology knowledge bases provide cancer clinicians with a point-of-care interpretation of the therapeutic actionability of clinical genomic sequencing results. These knowledge bases are now positioned to expand beyond the annotation of individual somatic molecular alterations, however, important gaps remain. Here, Suehnholz and Chakravarty discuss key deficiencies in current precision oncology knowledge bases that present opportunities for the next generation of data annotation.

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来源期刊

Nature Reviews Cancer 医学-肿瘤学

CiteScore

111.90

自引率

0.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Cancer, a part of the Nature Reviews portfolio of journals, aims to be the premier source of reviews and commentaries for the scientific communities it serves. The correct abbreviation for abstracting and indexing purposes is Nat. Rev. Cancer. The international standard serial numbers (ISSN) for Nature Reviews Cancer are 1474-175X (print) and 1474-1768 (online). Unlike other journals, Nature Reviews Cancer does not have an external editorial board. Instead, all editorial decisions are made by a team of full-time professional editors who are PhD-level scientists. The journal publishes Research Highlights, Comments, Reviews, and Perspectives relevant to cancer researchers, ensuring that the articles reach the widest possible audience due to their broad scope.